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Protein

Insulin-like growth factor-binding protein 6

Gene

Igfbp6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Growth factor binding

Enzyme and pathway databases

ReactomeiR-MMU-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Protein family/group databases

MEROPSiI31.952.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 6
Short name:
IBP-6
Short name:
IGF-binding protein 6
Short name:
IGFBP-6
Gene namesi
Name:Igfbp6
Synonyms:Igfbp-6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96441. Igfbp6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25By similarityAdd BLAST25
ChainiPRO_000001439026 – 238Insulin-like growth factor-binding protein 6Add BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 33PROSITE-ProRule annotation
Disulfide bondi41 ↔ 45PROSITE-ProRule annotation
Disulfide bondi58 ↔ 64PROSITE-ProRule annotation
Disulfide bondi72 ↔ 85PROSITE-ProRule annotation
Disulfide bondi79 ↔ 105PROSITE-ProRule annotation
Disulfide bondi160 ↔ 188PROSITE-ProRule annotation
Disulfide bondi199 ↔ 210PROSITE-ProRule annotation
Disulfide bondi212 ↔ 232PROSITE-ProRule annotation

Post-translational modificationi

O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP47880.
PeptideAtlasiP47880.
PRIDEiP47880.

PTM databases

PhosphoSitePlusiP47880.

Miscellaneous databases

PMAP-CutDBP47880.

Expressioni

Gene expression databases

BgeeiENSMUSG00000023046.
CleanExiMM_IGFBP6.
GenevisibleiP47880. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-60634N.
STRINGi10090.ENSMUSP00000023807.

Structurei

3D structure databases

ProteinModelPortaliP47880.
SMRiP47880.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 108IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST83
Domaini157 – 232Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IVZ3. Eukaryota.
ENOG410YQXU. LUCA.
GeneTreeiENSGT00550000074457.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiP47880.
OMAiRDQQRNP.
OrthoDBiEOG091G0L46.
TreeFamiTF331211.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_.
IPR022326. IGFBP-6.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 1 hit.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01982. IGFBPFAMILY6.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47880-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTWDGLPTQP LLMLLMLLFA AGSGSALAGC PGCGAGMQTG CRGGCVEEED
60 70 80 90 100
AGSPADGCTE AGGCLRREGQ PCGVYSPKCA PGLQCQPREN EEAPLRALLI
110 120 130 140 150
GQGRCQRARG PSEETTKESK PQGGASRSRD TNHRDRQKNP RTSAAPIRPN
160 170 180 190 200
PVQDSEMGPC RRHLDSVLQQ LQTEVFRGGA RGLYVPNCDL RGFYRKQQCR
210 220 230
SSQGNRRGPC WCVDPMGQPL PVSPDGQGST QCSARSSG
Length:238
Mass (Da):25,347
Last modified:October 3, 2012 - v2
Checksum:iDDBAFD5DB0413CF7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35A → P in CAA57274 (PubMed:7529732).Curated1
Sequence conflicti93A → T in CAA57274 (PubMed:7529732).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81584 mRNA. Translation: CAA57274.1.
AC110512 Genomic DNA. No translation available.
AC123791 Genomic DNA. No translation available.
BC012723 mRNA. Translation: AAH12723.1.
CH466550 Genomic DNA. Translation: EDL04005.1.
CCDSiCCDS27871.1.
PIRiI48605.
RefSeqiNP_032370.2. NM_008344.3.
UniGeneiMm.358609.

Genome annotation databases

EnsembliENSMUST00000023807; ENSMUSP00000023807; ENSMUSG00000023046.
GeneIDi16012.
KEGGimmu:16012.
UCSCiuc011zzz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81584 mRNA. Translation: CAA57274.1.
AC110512 Genomic DNA. No translation available.
AC123791 Genomic DNA. No translation available.
BC012723 mRNA. Translation: AAH12723.1.
CH466550 Genomic DNA. Translation: EDL04005.1.
CCDSiCCDS27871.1.
PIRiI48605.
RefSeqiNP_032370.2. NM_008344.3.
UniGeneiMm.358609.

3D structure databases

ProteinModelPortaliP47880.
SMRiP47880.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60634N.
STRINGi10090.ENSMUSP00000023807.

Protein family/group databases

MEROPSiI31.952.

PTM databases

PhosphoSitePlusiP47880.

Proteomic databases

PaxDbiP47880.
PeptideAtlasiP47880.
PRIDEiP47880.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023807; ENSMUSP00000023807; ENSMUSG00000023046.
GeneIDi16012.
KEGGimmu:16012.
UCSCiuc011zzz.1. mouse.

Organism-specific databases

CTDi3489.
MGIiMGI:96441. Igfbp6.

Phylogenomic databases

eggNOGiENOG410IVZ3. Eukaryota.
ENOG410YQXU. LUCA.
GeneTreeiENSGT00550000074457.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiP47880.
OMAiRDQQRNP.
OrthoDBiEOG091G0L46.
TreeFamiTF331211.

Enzyme and pathway databases

ReactomeiR-MMU-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Miscellaneous databases

PMAP-CutDBP47880.
PROiP47880.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023046.
CleanExiMM_IGFBP6.
GenevisibleiP47880. MM.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_.
IPR022326. IGFBP-6.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 1 hit.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01982. IGFBPFAMILY6.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIBP6_MOUSE
AccessioniPrimary (citable) accession number: P47880
Secondary accession number(s): Q91X24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.