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P47879

- IBP4_MOUSE

UniProt

P47879 - IBP4_MOUSE

Protein

Insulin-like growth factor-binding protein 4

Gene

Igfbp4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

    GO - Molecular functioni

    1. insulin-like growth factor binding Source: MGI

    GO - Biological processi

    1. inflammatory response Source: Ensembl
    2. positive regulation of insulin-like growth factor receptor signaling pathway Source: MGI
    3. positive regulation of MAPK cascade Source: MGI
    4. regulation of cell growth Source: MGI
    5. regulation of glucose metabolic process Source: MGI
    6. regulation of growth Source: MGI
    7. type B pancreatic cell proliferation Source: MGI

    Keywords - Ligandi

    Growth factor binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin-like growth factor-binding protein 4
    Short name:
    IBP-4
    Short name:
    IGF-binding protein 4
    Short name:
    IGFBP-4
    Gene namesi
    Name:Igfbp4
    Synonyms:Igfbp-4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:96439. Igfbp4.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121By similarityAdd
    BLAST
    Chaini22 – 254233Insulin-like growth factor-binding protein 4PRO_0000014383Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi27 ↔ 53PROSITE-ProRule annotation
    Disulfide bondi30 ↔ 55PROSITE-ProRule annotation
    Disulfide bondi38 ↔ 59PROSITE-ProRule annotation
    Disulfide bondi44 ↔ 56PROSITE-ProRule annotation
    Disulfide bondi67 ↔ 80PROSITE-ProRule annotation
    Disulfide bondi74 ↔ 100PROSITE-ProRule annotation
    Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi131 ↔ 138PROSITE-ProRule annotation
    Disulfide bondi170 ↔ 200PROSITE-ProRule annotation
    Disulfide bondi211 ↔ 222PROSITE-ProRule annotation
    Disulfide bondi224 ↔ 245PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP47879.
    PaxDbiP47879.
    PRIDEiP47879.

    PTM databases

    PhosphoSiteiP47879.

    Miscellaneous databases

    PMAP-CutDBP47879.

    Expressioni

    Gene expression databases

    ArrayExpressiP47879.
    BgeeiP47879.
    CleanExiMM_IGFBP4.
    GenevestigatoriP47879.

    Interactioni

    Subunit structurei

    Binds IGF2 more than IGF1.

    Protein-protein interaction databases

    DIPiDIP-60633N.
    STRINGi10090.ENSMUSP00000017637.

    Structurei

    3D structure databases

    ProteinModelPortaliP47879.
    SMRiP47879. Positions 24-103, 168-246.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 10381IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini167 – 24579Thyroglobulin type-1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
    Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46496.
    GeneTreeiENSGT00550000074457.
    HOGENOMiHOG000253012.
    HOVERGENiHBG002631.
    InParanoidiP47879.
    OMAiKGMPCGV.
    OrthoDBiEOG74N5HG.
    PhylomeDBiP47879.
    TreeFamiTF331211.

    Family and domain databases

    Gene3Di4.10.40.20. 1 hit.
    4.10.800.10. 1 hit.
    InterProiIPR009030. Growth_fac_rcpt_N_dom.
    IPR022327. IGFBP-4.
    IPR000867. IGFBP-like.
    IPR009168. IGFBP1-6.
    IPR022321. IGFBP_1-6_chordata.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000716. Thyroglobulin_1.
    [Graphical view]
    PANTHERiPTHR11551. PTHR11551. 1 hit.
    PfamiPF00219. IGFBP. 1 hit.
    PF00086. Thyroglobulin_1. 1 hit.
    [Graphical view]
    PRINTSiPR01976. IGFBPFAMILY.
    PR01980. IGFBPFAMILY4.
    SMARTiSM00121. IB. 1 hit.
    SM00211. TY. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    SSF57610. SSF57610. 1 hit.
    PROSITEiPS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P47879-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPFGLVAAL LLAAGPRPSL GDEAIHCPPC SEEKLARCRP PVGCEELVRE    50
    PGCGCCATCA LGLGMPCGVY TPRCGSGMRC YPPRGVEKPL RTLMHGQGVC 100
    TELSEIEAIQ ESLQTSDKDE SEHPNNSFNP CSAHDHRCLQ KHMAKIRDRS 150
    KMKIVGTPRE EPRPVPQGSC QSELHRALER LAASQSRTHE DLFIIPIPNC 200
    DRNGNFHPKQ CHPALDGQRG KCWCVDRKTG VKLPGGLEPK GELDCHQLAD 250
    SFQE 254
    Length:254
    Mass (Da):27,807
    Last modified:July 15, 1998 - v2
    Checksum:i58EF89CB514AEE17
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti4 – 52FG → CS in CAA57272. (PubMed:7529732)Curated
    Sequence conflicti13 – 131A → T in CAA57272. (PubMed:7529732)Curated
    Sequence conflicti56 – 561C → S in CAA57272. (PubMed:7529732)Curated
    Sequence conflicti67 – 671C → G in CAA57272. (PubMed:7529732)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X81582 mRNA. Translation: CAA57272.1.
    X76066 Genomic DNA. Translation: CAA53667.1.
    AK150229 mRNA. Translation: BAE29395.1.
    AK165688 mRNA. Translation: BAE38340.1.
    BC019836 mRNA. Translation: AAH19836.1.
    Z95492 Genomic DNA. Translation: CAB08859.1.
    CCDSiCCDS25371.1.
    PIRiI48599.
    I48603.
    RefSeqiNP_034647.1. NM_010517.3.
    UniGeneiMm.233799.

    Genome annotation databases

    EnsembliENSMUST00000017637; ENSMUSP00000017637; ENSMUSG00000017493.
    GeneIDi16010.
    KEGGimmu:16010.
    UCSCiuc007lie.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X81582 mRNA. Translation: CAA57272.1 .
    X76066 Genomic DNA. Translation: CAA53667.1 .
    AK150229 mRNA. Translation: BAE29395.1 .
    AK165688 mRNA. Translation: BAE38340.1 .
    BC019836 mRNA. Translation: AAH19836.1 .
    Z95492 Genomic DNA. Translation: CAB08859.1 .
    CCDSi CCDS25371.1.
    PIRi I48599.
    I48603.
    RefSeqi NP_034647.1. NM_010517.3.
    UniGenei Mm.233799.

    3D structure databases

    ProteinModelPortali P47879.
    SMRi P47879. Positions 24-103, 168-246.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60633N.
    STRINGi 10090.ENSMUSP00000017637.

    PTM databases

    PhosphoSitei P47879.

    Proteomic databases

    MaxQBi P47879.
    PaxDbi P47879.
    PRIDEi P47879.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000017637 ; ENSMUSP00000017637 ; ENSMUSG00000017493 .
    GeneIDi 16010.
    KEGGi mmu:16010.
    UCSCi uc007lie.1. mouse.

    Organism-specific databases

    CTDi 3487.
    MGIi MGI:96439. Igfbp4.

    Phylogenomic databases

    eggNOGi NOG46496.
    GeneTreei ENSGT00550000074457.
    HOGENOMi HOG000253012.
    HOVERGENi HBG002631.
    InParanoidi P47879.
    OMAi KGMPCGV.
    OrthoDBi EOG74N5HG.
    PhylomeDBi P47879.
    TreeFami TF331211.

    Miscellaneous databases

    ChiTaRSi IGFBP4. mouse.
    NextBioi 288822.
    PMAP-CutDB P47879.
    PROi P47879.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P47879.
    Bgeei P47879.
    CleanExi MM_IGFBP4.
    Genevestigatori P47879.

    Family and domain databases

    Gene3Di 4.10.40.20. 1 hit.
    4.10.800.10. 1 hit.
    InterProi IPR009030. Growth_fac_rcpt_N_dom.
    IPR022327. IGFBP-4.
    IPR000867. IGFBP-like.
    IPR009168. IGFBP1-6.
    IPR022321. IGFBP_1-6_chordata.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000716. Thyroglobulin_1.
    [Graphical view ]
    PANTHERi PTHR11551. PTHR11551. 1 hit.
    Pfami PF00219. IGFBP. 1 hit.
    PF00086. Thyroglobulin_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01976. IGFBPFAMILY.
    PR01980. IGFBPFAMILY4.
    SMARTi SM00121. IB. 1 hit.
    SM00211. TY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    SSF57610. SSF57610. 1 hit.
    PROSITEi PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning and mRNA expression of the six mouse insulin-like growth factor binding proteins."
      Schuller A.G.P., Groffen C., van Neck J.W., Zwarthoff E.C., Drop S.L.S.
      Mol. Cell. Endocrinol. 104:57-66(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "Molecular cloning of mouse insulin-like growth factor binding protein 4 (IGFBP4) cDNA and expression of a fusion protein with IGF-binding activity."
      Bethel C.R., Vitullo J.C., Miller R.E., Aron D.C.
      Biochem. Mol. Biol. Int. 34:385-392(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Bone marrow.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver.
    5. "Characterization of the mouse insulin-like growth factor binding protein 4 gene regulatory region and expression studies."
      Glantschnig H., Varga F., Luegmayr E., Klaushofer K.
      DNA Cell Biol. 17:51-60(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-114.
      Strain: BALB/c.
      Tissue: Brain.

    Entry informationi

    Entry nameiIBP4_MOUSE
    AccessioniPrimary (citable) accession number: P47879
    Secondary accession number(s): O35666, Q3TMV0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3