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P47877

- IBP2_MOUSE

UniProt

P47877 - IBP2_MOUSE

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Protein

Insulin-like growth factor-binding protein 2

Gene

Igfbp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Inhibits IGF-mediated growth and developmental rates (By similarity). IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.By similarity

GO - Molecular functioni

  1. insulin-like growth factor binding Source: MGI
  2. insulin-like growth factor I binding Source: UniProtKB
  3. insulin-like growth factor II binding Source: UniProtKB

GO - Biological processi

  1. aging Source: Ensembl
  2. cellular response to hormone stimulus Source: Ensembl
  3. female pregnancy Source: Ensembl
  4. positive regulation of activated T cell proliferation Source: UniProtKB
  5. regulation of cell growth Source: InterPro
  6. regulation of insulin-like growth factor receptor signaling pathway Source: UniProtKB
  7. response to drug Source: Ensembl
  8. response to estradiol Source: Ensembl
  9. response to glucocorticoid Source: Ensembl
  10. response to lithium ion Source: Ensembl
  11. response to mechanical stimulus Source: Ensembl
  12. response to nutrient Source: Ensembl
  13. response to retinoic acid Source: Ensembl
  14. signal transduction Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Growth regulation

Keywords - Ligandi

Growth factor binding

Protein family/group databases

MEROPSiI31.953.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 2
Short name:
IBP-2
Short name:
IGF-binding protein 2
Short name:
IGFBP-2
Short name:
mIGFBP-2
Gene namesi
Name:Igfbp2
Synonyms:Igfbp-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:96437. Igfbp2.

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. cytoplasmic vesicle Source: Ensembl
  3. extracellular region Source: UniProtKB
  4. extracellular space Source: MGI
  5. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434By similarityAdd
BLAST
Chaini35 – 305271Insulin-like growth factor-binding protein 2PRO_0000014371Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi207 ↔ 241PROSITE-ProRule annotation
Disulfide bondi252 ↔ 263PROSITE-ProRule annotation
Disulfide bondi265 ↔ 286PROSITE-ProRule annotation

Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP47877.
PaxDbiP47877.
PRIDEiP47877.

Expressioni

Tissue specificityi

Highly expressed in adult liver, but also in kidney, lung, brain, spleen, testis and ovary.1 Publication

Developmental stagei

Expressed embryos at day 11.5. Also expressed in fetal livers with expression increasing dramatically after birth. Expression decreases only slightly after postnatal day 3 and remains abundant thereafter.1 Publication

Gene expression databases

BgeeiP47877.
CleanExiMM_IGFBP2.
ExpressionAtlasiP47877. baseline and differential.
GenevestigatoriP47877.

Interactioni

Subunit structurei

Binds IGF2 more than IGF1.

Protein-protein interaction databases

DIPiDIP-60632N.
IntActiP47877. 1 interaction.
MINTiMINT-4098287.

Structurei

3D structure databases

ProteinModelPortaliP47877.
SMRiP47877. Positions 200-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 11883IGFBP N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini204 – 28683Thyroglobulin type-1PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi281 – 2833Cell attachment site

Domaini

The C-terminus is required for IGF-binding and growth inhibition.By similarity

Sequence similaritiesi

Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47500.
GeneTreeiENSGT00550000074457.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiP47877.
OMAiGAGTCEK.
OrthoDBiEOG74N5HG.
PhylomeDBiP47877.
TreeFamiTF331211.

Family and domain databases

Gene3Di4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR012210. IGFBP-2.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 1 hit.
PTHR11551:SF5. PTHR11551:SF5. 1 hit.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01978. IGFBPFAMILY2.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47877-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLPRLGGPAL PLLLPSLLLL LLLGAGGCGP GVRAEVLFRC PPCTPERLAA
60 70 80 90 100
CGPPPDAPCA ELVREPGCGC CSVCARQEGE ACGVYIPRCA QTLRCYPNPG
110 120 130 140 150
SELPLKALVT GAGTCEKRRV GTTPQQVADS DDDHSEGGLV ENHVDGTMNM
160 170 180 190 200
LGGGSSAGRK PLKSGMKELA VFREKVNEQH RQMGKGAKHL SLEEPKKLRP
210 220 230 240 250
PPARTPCQQE LDQVLERIST MRLPDDRGPL EHLYSLHIPN CDKHGRYNLK
260 270 280 290 300
QCKMSLNGQR GECWCVNPNT GKPIQGAPTI RGDPECHLFY NEQQETGGAH

AQSVQ
Length:305
Mass (Da):32,847
Last modified:February 10, 2009 - v2
Checksum:i179FE6A304E93A16
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti47 – 471R → A in CAA57270. (PubMed:7529732)Curated
Sequence conflicti133 – 1331D → H in AAB60709. (PubMed:7680327)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L05439
, L05436, L05437, L05438 Genomic DNA. Translation: AAB60709.1.
X81580 mRNA. Translation: CAA57270.1.
CH466548 Genomic DNA. Translation: EDL00293.1.
BC012724 mRNA. Translation: AAH12724.1.
BC054473 mRNA. Translation: AAH54473.1.
CCDSiCCDS15036.1.
PIRiI48601.
JN0508.
RefSeqiNP_032368.2. NM_008342.3.
UniGeneiMm.141936.

Genome annotation databases

EnsembliENSMUST00000047328; ENSMUSP00000046610; ENSMUSG00000039323.
GeneIDi16008.
KEGGimmu:16008.
UCSCiuc007bkw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L05439
, L05436 , L05437 , L05438 Genomic DNA. Translation: AAB60709.1 .
X81580 mRNA. Translation: CAA57270.1 .
CH466548 Genomic DNA. Translation: EDL00293.1 .
BC012724 mRNA. Translation: AAH12724.1 .
BC054473 mRNA. Translation: AAH54473.1 .
CCDSi CCDS15036.1.
PIRi I48601.
JN0508.
RefSeqi NP_032368.2. NM_008342.3.
UniGenei Mm.141936.

3D structure databases

ProteinModelPortali P47877.
SMRi P47877. Positions 200-305.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-60632N.
IntActi P47877. 1 interaction.
MINTi MINT-4098287.

Protein family/group databases

MEROPSi I31.953.

Proteomic databases

MaxQBi P47877.
PaxDbi P47877.
PRIDEi P47877.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000047328 ; ENSMUSP00000046610 ; ENSMUSG00000039323 .
GeneIDi 16008.
KEGGi mmu:16008.
UCSCi uc007bkw.2. mouse.

Organism-specific databases

CTDi 3485.
MGIi MGI:96437. Igfbp2.

Phylogenomic databases

eggNOGi NOG47500.
GeneTreei ENSGT00550000074457.
HOGENOMi HOG000253012.
HOVERGENi HBG002631.
InParanoidi P47877.
OMAi GAGTCEK.
OrthoDBi EOG74N5HG.
PhylomeDBi P47877.
TreeFami TF331211.

Miscellaneous databases

ChiTaRSi IGFBP2. mouse.
NextBioi 288814.
PROi P47877.
SOURCEi Search...

Gene expression databases

Bgeei P47877.
CleanExi MM_IGFBP2.
ExpressionAtlasi P47877. baseline and differential.
Genevestigatori P47877.

Family and domain databases

Gene3Di 4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProi IPR009030. Growth_fac_rcpt_N_dom.
IPR012210. IGFBP-2.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view ]
PANTHERi PTHR11551. PTHR11551. 1 hit.
PTHR11551:SF5. PTHR11551:SF5. 1 hit.
Pfami PF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view ]
PRINTSi PR01976. IGFBPFAMILY.
PR01978. IGFBPFAMILY2.
SMARTi SM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEi PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the gene encoding murine insulin-like growth factor-binding protein-2, mIGFBP-2."
    Landwehr J., Kaupmann K., Heinrich G., Schwander J.
    Gene 124:281-286(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
    Tissue: Fetal liver.
  2. "cDNA cloning and mRNA expression of the six mouse insulin-like growth factor binding proteins."
    Schuller A.G.P., Groffen C., van Neck J.W., Zwarthoff E.C., Drop S.L.S.
    Mol. Cell. Endocrinol. 104:57-66(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Liver.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Mammary gland.

Entry informationi

Entry nameiIBP2_MOUSE
AccessioniPrimary (citable) accession number: P47877
Secondary accession number(s): Q61722, Q91VK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 10, 2009
Last modified: October 29, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3