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P47877 (IBP2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Insulin-like growth factor-binding protein 2

Short name=IBP-2
Short name=IGF-binding protein 2
Short name=IGFBP-2
Short name=mIGFBP-2
Gene names
Name:Igfbp2
Synonyms:Igfbp-2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibits IGF-mediated growth and developmental rates By similarity. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Subunit structure

Binds IGF2 more than IGF1.

Subcellular location

Secreted.

Tissue specificity

Highly expressed in adult liver, but also in kidney, lung, brain, spleen, testis and ovary. Ref.2

Developmental stage

Expressed embryos at day 11.5. Also expressed in fetal livers with expression increasing dramatically after birth. Expression decreases only slightly after postnatal day 3 and remains abundant thereafter. Ref.2

Domain

The C-terminus is required for IGF-binding and growth inhibition By similarity.

Post-translational modification

O-glycosylated By similarity.

Sequence similarities

Contains 1 IGFBP N-terminal domain.

Contains 1 thyroglobulin type-1 domain.

Ontologies

Keywords
   Biological processGrowth regulation
   Cellular componentSecreted
   DomainSignal
   LigandGrowth factor binding
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaging

Inferred from electronic annotation. Source: Ensembl

cellular response to hormone stimulus

Inferred from electronic annotation. Source: Ensembl

female pregnancy

Inferred from electronic annotation. Source: Ensembl

positive regulation of activated T cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of cell growth

Inferred from electronic annotation. Source: InterPro

regulation of insulin-like growth factor receptor signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

response to drug

Inferred from electronic annotation. Source: Ensembl

response to estradiol

Inferred from electronic annotation. Source: Ensembl

response to glucocorticoid

Inferred from electronic annotation. Source: Ensembl

response to lithium ion

Inferred from electronic annotation. Source: Ensembl

response to mechanical stimulus

Inferred from electronic annotation. Source: Ensembl

response to nutrient

Inferred from electronic annotation. Source: Ensembl

response to retinoic acid

Inferred from electronic annotation. Source: Ensembl

signal transduction

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentapical plasma membrane

Inferred from electronic annotation. Source: Ensembl

cytoplasmic vesicle

Inferred from electronic annotation. Source: Ensembl

extracellular region

Inferred from sequence or structural similarity. Source: UniProtKB

extracellular space

Inferred from direct assay PubMed 7510770PubMed 7679139. Source: MGI

   Molecular_functioninsulin-like growth factor I binding

Inferred from sequence or structural similarity. Source: UniProtKB

insulin-like growth factor II binding

Inferred from sequence or structural similarity. Source: UniProtKB

insulin-like growth factor binding

Inferred from physical interaction PubMed 7679139. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434 By similarity
Chain35 – 305271Insulin-like growth factor-binding protein 2
PRO_0000014371

Regions

Domain36 – 11883IGFBP N-terminal
Domain204 – 28683Thyroglobulin type-1
Motif281 – 2833Cell attachment site

Amino acid modifications

Disulfide bond207 ↔ 241 By similarity
Disulfide bond252 ↔ 263 By similarity
Disulfide bond265 ↔ 286 By similarity

Experimental info

Sequence conflict471R → A in CAA57270. Ref.2
Sequence conflict1331D → H in AAB60709. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P47877 [UniParc].

Last modified February 10, 2009. Version 2.
Checksum: 179FE6A304E93A16

FASTA30532,847
        10         20         30         40         50         60 
MLPRLGGPAL PLLLPSLLLL LLLGAGGCGP GVRAEVLFRC PPCTPERLAA CGPPPDAPCA 

        70         80         90        100        110        120 
ELVREPGCGC CSVCARQEGE ACGVYIPRCA QTLRCYPNPG SELPLKALVT GAGTCEKRRV 

       130        140        150        160        170        180 
GTTPQQVADS DDDHSEGGLV ENHVDGTMNM LGGGSSAGRK PLKSGMKELA VFREKVNEQH 

       190        200        210        220        230        240 
RQMGKGAKHL SLEEPKKLRP PPARTPCQQE LDQVLERIST MRLPDDRGPL EHLYSLHIPN 

       250        260        270        280        290        300 
CDKHGRYNLK QCKMSLNGQR GECWCVNPNT GKPIQGAPTI RGDPECHLFY NEQQETGGAH 


AQSVQ 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of the gene encoding murine insulin-like growth factor-binding protein-2, mIGFBP-2."
Landwehr J., Kaupmann K., Heinrich G., Schwander J.
Gene 124:281-286(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: BALB/c.
Tissue: Fetal liver.
[2]"cDNA cloning and mRNA expression of the six mouse insulin-like growth factor binding proteins."
Schuller A.G.P., Groffen C., van Neck J.W., Zwarthoff E.C., Drop S.L.S.
Mol. Cell. Endocrinol. 104:57-66(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Tissue: Liver.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N-3.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L05439 expand/collapse EMBL AC list , L05436, L05437, L05438 Genomic DNA. Translation: AAB60709.1.
X81580 mRNA. Translation: CAA57270.1.
CH466548 Genomic DNA. Translation: EDL00293.1.
BC012724 mRNA. Translation: AAH12724.1.
BC054473 mRNA. Translation: AAH54473.1.
PIRI48601.
JN0508.
RefSeqNP_032368.2. NM_008342.3.
UniGeneMm.141936.

3D structure databases

ProteinModelPortalP47877.
SMRP47877. Positions 38-117, 200-305.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-60632N.
IntActP47877. 1 interaction.
MINTMINT-4098287.

Protein family/group databases

MEROPSI31.953.

Proteomic databases

PaxDbP47877.
PRIDEP47877.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000047328; ENSMUSP00000046610; ENSMUSG00000039323.
GeneID16008.
KEGGmmu:16008.
UCSCuc007bkw.2. mouse.

Organism-specific databases

CTD3485.
MGIMGI:96437. Igfbp2.

Phylogenomic databases

eggNOGNOG47500.
GeneTreeENSGT00550000074457.
HOGENOMHOG000253012.
HOVERGENHBG002631.
InParanoidQ91VK7.
OMAGAGTCEK.
OrthoDBEOG74N5HG.
PhylomeDBP47877.
TreeFamTF331211.

Gene expression databases

ArrayExpressP47877.
BgeeP47877.
CleanExMM_IGFBP2.
GenevestigatorP47877.

Family and domain databases

Gene3D4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProIPR009030. Growth_fac_rcpt_N_dom.
IPR012210. IGFBP-2.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERPTHR11551. PTHR11551. 1 hit.
PTHR11551:SF5. PTHR11551:SF5. 1 hit.
PfamPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSPR01976. IGFBPFAMILY.
PR01978. IGFBPFAMILY2.
SMARTSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSIGFBP2. mouse.
NextBio288814.
PROP47877.
SOURCESearch...

Entry information

Entry nameIBP2_MOUSE
AccessionPrimary (citable) accession number: P47877
Secondary accession number(s): Q61722, Q91VK7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 10, 2009
Last modified: April 16, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot