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P47877

- IBP2_MOUSE

UniProt

P47877 - IBP2_MOUSE

Protein

Insulin-like growth factor-binding protein 2

Gene

Igfbp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Inhibits IGF-mediated growth and developmental rates By similarity. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.By similarity

    GO - Molecular functioni

    1. insulin-like growth factor binding Source: MGI
    2. insulin-like growth factor I binding Source: UniProtKB
    3. insulin-like growth factor II binding Source: UniProtKB

    GO - Biological processi

    1. aging Source: Ensembl
    2. cellular response to hormone stimulus Source: Ensembl
    3. female pregnancy Source: Ensembl
    4. positive regulation of activated T cell proliferation Source: UniProtKB
    5. regulation of cell growth Source: InterPro
    6. regulation of insulin-like growth factor receptor signaling pathway Source: UniProtKB
    7. response to drug Source: Ensembl
    8. response to estradiol Source: Ensembl
    9. response to glucocorticoid Source: Ensembl
    10. response to lithium ion Source: Ensembl
    11. response to mechanical stimulus Source: Ensembl
    12. response to nutrient Source: Ensembl
    13. response to retinoic acid Source: Ensembl
    14. signal transduction Source: Ensembl

    Keywords - Biological processi

    Growth regulation

    Keywords - Ligandi

    Growth factor binding

    Protein family/group databases

    MEROPSiI31.953.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin-like growth factor-binding protein 2
    Short name:
    IBP-2
    Short name:
    IGF-binding protein 2
    Short name:
    IGFBP-2
    Short name:
    mIGFBP-2
    Gene namesi
    Name:Igfbp2
    Synonyms:Igfbp-2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:96437. Igfbp2.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. cytoplasmic vesicle Source: Ensembl
    3. extracellular region Source: UniProtKB
    4. extracellular space Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3434By similarityAdd
    BLAST
    Chaini35 – 305271Insulin-like growth factor-binding protein 2PRO_0000014371Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi207 ↔ 241PROSITE-ProRule annotation
    Disulfide bondi252 ↔ 263PROSITE-ProRule annotation
    Disulfide bondi265 ↔ 286PROSITE-ProRule annotation

    Post-translational modificationi

    O-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP47877.
    PRIDEiP47877.

    Expressioni

    Tissue specificityi

    Highly expressed in adult liver, but also in kidney, lung, brain, spleen, testis and ovary.1 Publication

    Developmental stagei

    Expressed embryos at day 11.5. Also expressed in fetal livers with expression increasing dramatically after birth. Expression decreases only slightly after postnatal day 3 and remains abundant thereafter.1 Publication

    Gene expression databases

    ArrayExpressiP47877.
    BgeeiP47877.
    CleanExiMM_IGFBP2.
    GenevestigatoriP47877.

    Interactioni

    Subunit structurei

    Binds IGF2 more than IGF1.

    Protein-protein interaction databases

    DIPiDIP-60632N.
    IntActiP47877. 1 interaction.
    MINTiMINT-4098287.

    Structurei

    3D structure databases

    ProteinModelPortaliP47877.
    SMRiP47877. Positions 200-305.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini36 – 11883IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini204 – 28683Thyroglobulin type-1PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi281 – 2833Cell attachment site

    Domaini

    The C-terminus is required for IGF-binding and growth inhibition.By similarity

    Sequence similaritiesi

    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
    Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG47500.
    GeneTreeiENSGT00550000074457.
    HOGENOMiHOG000253012.
    HOVERGENiHBG002631.
    InParanoidiQ91VK7.
    OMAiGAGTCEK.
    OrthoDBiEOG74N5HG.
    PhylomeDBiP47877.
    TreeFamiTF331211.

    Family and domain databases

    Gene3Di4.10.40.20. 1 hit.
    4.10.800.10. 1 hit.
    InterProiIPR009030. Growth_fac_rcpt_N_dom.
    IPR012210. IGFBP-2.
    IPR000867. IGFBP-like.
    IPR009168. IGFBP1-6.
    IPR022321. IGFBP_1-6_chordata.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000716. Thyroglobulin_1.
    [Graphical view]
    PANTHERiPTHR11551. PTHR11551. 1 hit.
    PTHR11551:SF5. PTHR11551:SF5. 1 hit.
    PfamiPF00219. IGFBP. 1 hit.
    PF00086. Thyroglobulin_1. 1 hit.
    [Graphical view]
    PRINTSiPR01976. IGFBPFAMILY.
    PR01978. IGFBPFAMILY2.
    SMARTiSM00121. IB. 1 hit.
    SM00211. TY. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    SSF57610. SSF57610. 1 hit.
    PROSITEiPS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P47877-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPRLGGPAL PLLLPSLLLL LLLGAGGCGP GVRAEVLFRC PPCTPERLAA    50
    CGPPPDAPCA ELVREPGCGC CSVCARQEGE ACGVYIPRCA QTLRCYPNPG 100
    SELPLKALVT GAGTCEKRRV GTTPQQVADS DDDHSEGGLV ENHVDGTMNM 150
    LGGGSSAGRK PLKSGMKELA VFREKVNEQH RQMGKGAKHL SLEEPKKLRP 200
    PPARTPCQQE LDQVLERIST MRLPDDRGPL EHLYSLHIPN CDKHGRYNLK 250
    QCKMSLNGQR GECWCVNPNT GKPIQGAPTI RGDPECHLFY NEQQETGGAH 300
    AQSVQ 305
    Length:305
    Mass (Da):32,847
    Last modified:February 10, 2009 - v2
    Checksum:i179FE6A304E93A16
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti47 – 471R → A in CAA57270. (PubMed:7529732)Curated
    Sequence conflicti133 – 1331D → H in AAB60709. (PubMed:7680327)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L05439
    , L05436, L05437, L05438 Genomic DNA. Translation: AAB60709.1.
    X81580 mRNA. Translation: CAA57270.1.
    CH466548 Genomic DNA. Translation: EDL00293.1.
    BC012724 mRNA. Translation: AAH12724.1.
    BC054473 mRNA. Translation: AAH54473.1.
    CCDSiCCDS15036.1.
    PIRiI48601.
    JN0508.
    RefSeqiNP_032368.2. NM_008342.3.
    UniGeneiMm.141936.

    Genome annotation databases

    EnsembliENSMUST00000047328; ENSMUSP00000046610; ENSMUSG00000039323.
    GeneIDi16008.
    KEGGimmu:16008.
    UCSCiuc007bkw.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L05439
    , L05436 , L05437 , L05438 Genomic DNA. Translation: AAB60709.1 .
    X81580 mRNA. Translation: CAA57270.1 .
    CH466548 Genomic DNA. Translation: EDL00293.1 .
    BC012724 mRNA. Translation: AAH12724.1 .
    BC054473 mRNA. Translation: AAH54473.1 .
    CCDSi CCDS15036.1.
    PIRi I48601.
    JN0508.
    RefSeqi NP_032368.2. NM_008342.3.
    UniGenei Mm.141936.

    3D structure databases

    ProteinModelPortali P47877.
    SMRi P47877. Positions 200-305.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60632N.
    IntActi P47877. 1 interaction.
    MINTi MINT-4098287.

    Protein family/group databases

    MEROPSi I31.953.

    Proteomic databases

    PaxDbi P47877.
    PRIDEi P47877.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000047328 ; ENSMUSP00000046610 ; ENSMUSG00000039323 .
    GeneIDi 16008.
    KEGGi mmu:16008.
    UCSCi uc007bkw.2. mouse.

    Organism-specific databases

    CTDi 3485.
    MGIi MGI:96437. Igfbp2.

    Phylogenomic databases

    eggNOGi NOG47500.
    GeneTreei ENSGT00550000074457.
    HOGENOMi HOG000253012.
    HOVERGENi HBG002631.
    InParanoidi Q91VK7.
    OMAi GAGTCEK.
    OrthoDBi EOG74N5HG.
    PhylomeDBi P47877.
    TreeFami TF331211.

    Miscellaneous databases

    ChiTaRSi IGFBP2. mouse.
    NextBioi 288814.
    PROi P47877.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P47877.
    Bgeei P47877.
    CleanExi MM_IGFBP2.
    Genevestigatori P47877.

    Family and domain databases

    Gene3Di 4.10.40.20. 1 hit.
    4.10.800.10. 1 hit.
    InterProi IPR009030. Growth_fac_rcpt_N_dom.
    IPR012210. IGFBP-2.
    IPR000867. IGFBP-like.
    IPR009168. IGFBP1-6.
    IPR022321. IGFBP_1-6_chordata.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000716. Thyroglobulin_1.
    [Graphical view ]
    PANTHERi PTHR11551. PTHR11551. 1 hit.
    PTHR11551:SF5. PTHR11551:SF5. 1 hit.
    Pfami PF00219. IGFBP. 1 hit.
    PF00086. Thyroglobulin_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01976. IGFBPFAMILY.
    PR01978. IGFBPFAMILY2.
    SMARTi SM00121. IB. 1 hit.
    SM00211. TY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    SSF57610. SSF57610. 1 hit.
    PROSITEi PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of the gene encoding murine insulin-like growth factor-binding protein-2, mIGFBP-2."
      Landwehr J., Kaupmann K., Heinrich G., Schwander J.
      Gene 124:281-286(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c.
      Tissue: Fetal liver.
    2. "cDNA cloning and mRNA expression of the six mouse insulin-like growth factor binding proteins."
      Schuller A.G.P., Groffen C., van Neck J.W., Zwarthoff E.C., Drop S.L.S.
      Mol. Cell. Endocrinol. 104:57-66(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Tissue: Liver.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N-3.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiIBP2_MOUSE
    AccessioniPrimary (citable) accession number: P47877
    Secondary accession number(s): Q61722, Q91VK7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3