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Protein

Insulin-like growth factor-binding protein 2

Gene

Igfbp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits IGF-mediated growth and developmental rates (By similarity). IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.By similarity

GO - Molecular functioni

  1. insulin-like growth factor binding Source: MGI
  2. insulin-like growth factor I binding Source: UniProtKB
  3. insulin-like growth factor II binding Source: UniProtKB

GO - Biological processi

  1. aging Source: Ensembl
  2. cellular response to hormone stimulus Source: Ensembl
  3. female pregnancy Source: Ensembl
  4. positive regulation of activated T cell proliferation Source: UniProtKB
  5. regulation of cell growth Source: InterPro
  6. regulation of insulin-like growth factor receptor signaling pathway Source: UniProtKB
  7. response to drug Source: Ensembl
  8. response to estradiol Source: Ensembl
  9. response to glucocorticoid Source: Ensembl
  10. response to lithium ion Source: Ensembl
  11. response to mechanical stimulus Source: Ensembl
  12. response to nutrient Source: Ensembl
  13. response to retinoic acid Source: Ensembl
  14. signal transduction Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Growth regulation

Keywords - Ligandi

Growth factor binding

Enzyme and pathway databases

ReactomeiREACT_331346. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Protein family/group databases

MEROPSiI31.953.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 2
Short name:
IBP-2
Short name:
IGF-binding protein 2
Short name:
IGFBP-2
Short name:
mIGFBP-2
Gene namesi
Name:Igfbp2
Synonyms:Igfbp-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:96437. Igfbp2.

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. cytoplasmic vesicle Source: Ensembl
  3. extracellular region Source: UniProtKB
  4. extracellular space Source: MGI
  5. extracellular vesicular exosome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434By similarityAdd
BLAST
Chaini35 – 305271Insulin-like growth factor-binding protein 2PRO_0000014371Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi207 ↔ 241PROSITE-ProRule annotation
Disulfide bondi252 ↔ 263PROSITE-ProRule annotation
Disulfide bondi265 ↔ 286PROSITE-ProRule annotation

Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP47877.
PaxDbiP47877.
PRIDEiP47877.

Expressioni

Tissue specificityi

Highly expressed in adult liver, but also in kidney, lung, brain, spleen, testis and ovary.1 Publication

Developmental stagei

Expressed embryos at day 11.5. Also expressed in fetal livers with expression increasing dramatically after birth. Expression decreases only slightly after postnatal day 3 and remains abundant thereafter.1 Publication

Gene expression databases

BgeeiP47877.
CleanExiMM_IGFBP2.
ExpressionAtlasiP47877. baseline and differential.
GenevestigatoriP47877.

Interactioni

Subunit structurei

Binds IGF2 more than IGF1.

Protein-protein interaction databases

DIPiDIP-60632N.
IntActiP47877. 1 interaction.
MINTiMINT-4098287.

Structurei

3D structure databases

ProteinModelPortaliP47877.
SMRiP47877. Positions 200-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 11883IGFBP N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini204 – 28683Thyroglobulin type-1PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi281 – 2833Cell attachment site

Domaini

The C-terminus is required for IGF-binding and growth inhibition.By similarity

Sequence similaritiesi

Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47500.
GeneTreeiENSGT00550000074457.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiP47877.
OMAiGAGTCEK.
OrthoDBiEOG74N5HG.
PhylomeDBiP47877.
TreeFamiTF331211.

Family and domain databases

Gene3Di4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR012210. IGFBP-2.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 1 hit.
PTHR11551:SF5. PTHR11551:SF5. 1 hit.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01978. IGFBPFAMILY2.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47877-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPRLGGPAL PLLLPSLLLL LLLGAGGCGP GVRAEVLFRC PPCTPERLAA
60 70 80 90 100
CGPPPDAPCA ELVREPGCGC CSVCARQEGE ACGVYIPRCA QTLRCYPNPG
110 120 130 140 150
SELPLKALVT GAGTCEKRRV GTTPQQVADS DDDHSEGGLV ENHVDGTMNM
160 170 180 190 200
LGGGSSAGRK PLKSGMKELA VFREKVNEQH RQMGKGAKHL SLEEPKKLRP
210 220 230 240 250
PPARTPCQQE LDQVLERIST MRLPDDRGPL EHLYSLHIPN CDKHGRYNLK
260 270 280 290 300
QCKMSLNGQR GECWCVNPNT GKPIQGAPTI RGDPECHLFY NEQQETGGAH

AQSVQ
Length:305
Mass (Da):32,847
Last modified:February 9, 2009 - v2
Checksum:i179FE6A304E93A16
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti47 – 471R → A in CAA57270 (PubMed:7529732).Curated
Sequence conflicti133 – 1331D → H in AAB60709 (PubMed:7680327).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05439
, L05436, L05437, L05438 Genomic DNA. Translation: AAB60709.1.
X81580 mRNA. Translation: CAA57270.1.
CH466548 Genomic DNA. Translation: EDL00293.1.
BC012724 mRNA. Translation: AAH12724.1.
BC054473 mRNA. Translation: AAH54473.1.
CCDSiCCDS15036.1.
PIRiI48601.
JN0508.
RefSeqiNP_032368.2. NM_008342.3.
UniGeneiMm.141936.

Genome annotation databases

EnsembliENSMUST00000047328; ENSMUSP00000046610; ENSMUSG00000039323.
GeneIDi16008.
KEGGimmu:16008.
UCSCiuc007bkw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05439
, L05436, L05437, L05438 Genomic DNA. Translation: AAB60709.1.
X81580 mRNA. Translation: CAA57270.1.
CH466548 Genomic DNA. Translation: EDL00293.1.
BC012724 mRNA. Translation: AAH12724.1.
BC054473 mRNA. Translation: AAH54473.1.
CCDSiCCDS15036.1.
PIRiI48601.
JN0508.
RefSeqiNP_032368.2. NM_008342.3.
UniGeneiMm.141936.

3D structure databases

ProteinModelPortaliP47877.
SMRiP47877. Positions 200-305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60632N.
IntActiP47877. 1 interaction.
MINTiMINT-4098287.

Protein family/group databases

MEROPSiI31.953.

Proteomic databases

MaxQBiP47877.
PaxDbiP47877.
PRIDEiP47877.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047328; ENSMUSP00000046610; ENSMUSG00000039323.
GeneIDi16008.
KEGGimmu:16008.
UCSCiuc007bkw.2. mouse.

Organism-specific databases

CTDi3485.
MGIiMGI:96437. Igfbp2.

Phylogenomic databases

eggNOGiNOG47500.
GeneTreeiENSGT00550000074457.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiP47877.
OMAiGAGTCEK.
OrthoDBiEOG74N5HG.
PhylomeDBiP47877.
TreeFamiTF331211.

Enzyme and pathway databases

ReactomeiREACT_331346. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Miscellaneous databases

ChiTaRSiIgfbp2. mouse.
NextBioi288814.
PROiP47877.
SOURCEiSearch...

Gene expression databases

BgeeiP47877.
CleanExiMM_IGFBP2.
ExpressionAtlasiP47877. baseline and differential.
GenevestigatoriP47877.

Family and domain databases

Gene3Di4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR012210. IGFBP-2.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 1 hit.
PTHR11551:SF5. PTHR11551:SF5. 1 hit.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01978. IGFBPFAMILY2.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the gene encoding murine insulin-like growth factor-binding protein-2, mIGFBP-2."
    Landwehr J., Kaupmann K., Heinrich G., Schwander J.
    Gene 124:281-286(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
    Tissue: Fetal liver.
  2. "cDNA cloning and mRNA expression of the six mouse insulin-like growth factor binding proteins."
    Schuller A.G.P., Groffen C., van Neck J.W., Zwarthoff E.C., Drop S.L.S.
    Mol. Cell. Endocrinol. 104:57-66(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Liver.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Mammary gland.

Entry informationi

Entry nameiIBP2_MOUSE
AccessioniPrimary (citable) accession number: P47877
Secondary accession number(s): Q61722, Q91VK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 1996
Last sequence update: February 9, 2009
Last modified: March 31, 2015
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.