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Protein

Insulin-like growth factor-binding protein 1

Gene

Igfbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Growth factor binding

Enzyme and pathway databases

ReactomeiR-MMU-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Protein family/group databases

MEROPSiI31.951.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 1
Short name:
IBP-1
Short name:
IGF-binding protein 1
Short name:
IGFBP-1
Gene namesi
Name:Igfbp1
Synonyms:Igfbp-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96436. Igfbp1.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525By similarityAdd
BLAST
Chaini26 – 272247Insulin-like growth factor-binding protein 1PRO_0000014366Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi73 ↔ 86PROSITE-ProRule annotation
Disulfide bondi80 ↔ 106PROSITE-ProRule annotation
Modified residuei139 – 1391PhosphoserineBy similarity
Modified residuei157 – 1571PhosphoserineBy similarity
Modified residuei169 – 1691PhosphoserineBy similarity
Modified residuei170 – 1701PhosphothreonineBy similarity
Modified residuei171 – 1711PhosphotyrosineBy similarity
Disulfide bondi189 ↔ 219PROSITE-ProRule annotation
Disulfide bondi230 ↔ 241PROSITE-ProRule annotation
Disulfide bondi243 ↔ 264PROSITE-ProRule annotation
Modified residuei255 – 2551PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP47876.
PRIDEiP47876.

PTM databases

iPTMnetiP47876.
PhosphoSiteiP47876.

Expressioni

Gene expression databases

CleanExiMM_IGFBP1.
GenevisibleiP47876. MM.

Interactioni

Subunit structurei

Binds equally well IGF1 and IGF2.

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-60631N.
STRINGi10090.ENSMUSP00000020704.

Structurei

3D structure databases

ProteinModelPortaliP47876.
SMRiP47876. Positions 31-109, 187-269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 10982IGFBP N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini186 – 26479Thyroglobulin type-1PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi259 – 2613Cell attachment site

Sequence similaritiesi

Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IITJ. Eukaryota.
ENOG4111H9A. LUCA.
GeneTreeiENSGT00550000074457.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiP47876.
OMAiGQGACVQ.
OrthoDBiEOG74N5HG.
TreeFamiTF331211.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_.
IPR000867. IGFBP-like.
IPR022322. IGFBP1.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 1 hit.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01977. IGFBPFAMILY1.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47876-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEFLTVVSW PFLILLSFQI GVAAGAPQPW HCAPCTAERL GLCPPVPASC
60 70 80 90 100
PEISRPAGCG CCPTCALPMG AACGVATARC AQGLSCRALP GEPRPLHALT
110 120 130 140 150
RGQGACVPEP AAPATSTLFS SQHEEAKAAV VSADELSESP EMTEEQLLDS
160 170 180 190 200
FHLMAPSRED QPILWNAIST YSSMRAREIA DLKKWKEPCQ RELYKVLERL
210 220 230 240 250
AAAQQKAGDE IYKFYLPNCN KNGFYHSKQC ETSLDGEAGL CWCVYPWSGK
260 270
KIPGSLETRG DPNCHQYFNV HN
Length:272
Mass (Da):29,570
Last modified:October 3, 2012 - v2
Checksum:iCD4FCD3C5AB69B60
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231A → V in CAA57269 (PubMed:7529732).Curated
Sequence conflicti106 – 1072CV → SL in CAA47832 (PubMed:7509771).Curated
Sequence conflicti229 – 2291Q → E in CAA57269 (PubMed:7529732).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81579 mRNA. Translation: CAA57269.1.
AL607124 Genomic DNA. Translation: CAI24501.1.
CH466574 Genomic DNA. Translation: EDL40608.1.
X67493 Genomic DNA. Translation: CAA47832.1.
CCDSiCCDS24427.1.
PIRiI48600.
S25113.
RefSeqiNP_032367.3. NM_008341.4.
UniGeneiMm.21300.

Genome annotation databases

EnsembliENSMUST00000020704; ENSMUSP00000020704; ENSMUSG00000020429.
GeneIDi16006.
KEGGimmu:16006.
UCSCiuc007hzh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81579 mRNA. Translation: CAA57269.1.
AL607124 Genomic DNA. Translation: CAI24501.1.
CH466574 Genomic DNA. Translation: EDL40608.1.
X67493 Genomic DNA. Translation: CAA47832.1.
CCDSiCCDS24427.1.
PIRiI48600.
S25113.
RefSeqiNP_032367.3. NM_008341.4.
UniGeneiMm.21300.

3D structure databases

ProteinModelPortaliP47876.
SMRiP47876. Positions 31-109, 187-269.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60631N.
STRINGi10090.ENSMUSP00000020704.

Protein family/group databases

MEROPSiI31.951.

PTM databases

iPTMnetiP47876.
PhosphoSiteiP47876.

Proteomic databases

PaxDbiP47876.
PRIDEiP47876.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020704; ENSMUSP00000020704; ENSMUSG00000020429.
GeneIDi16006.
KEGGimmu:16006.
UCSCiuc007hzh.2. mouse.

Organism-specific databases

CTDi3484.
MGIiMGI:96436. Igfbp1.

Phylogenomic databases

eggNOGiENOG410IITJ. Eukaryota.
ENOG4111H9A. LUCA.
GeneTreeiENSGT00550000074457.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiP47876.
OMAiGQGACVQ.
OrthoDBiEOG74N5HG.
TreeFamiTF331211.

Enzyme and pathway databases

ReactomeiR-MMU-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Miscellaneous databases

PROiP47876.
SOURCEiSearch...

Gene expression databases

CleanExiMM_IGFBP1.
GenevisibleiP47876. MM.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_.
IPR000867. IGFBP-like.
IPR022322. IGFBP1.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 1 hit.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01977. IGFBPFAMILY1.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and mRNA expression of the six mouse insulin-like growth factor binding proteins."
    Schuller A.G.P., Groffen C., van Neck J.W., Zwarthoff E.C., Drop S.L.S.
    Mol. Cell. Endocrinol. 104:57-66(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Structure and localization of the IGFBP-1 gene and its expression during liver regeneration."
    Lee J., Greenbaum L., Haber B.A., Nagle D., Lee V., Miles V., Mohn K.L., Bucan M., Taub R.
    Hepatology 19:656-665(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-124.
    Strain: NIH Swiss.

Entry informationi

Entry nameiIBP1_MOUSE
AccessioniPrimary (citable) accession number: P47876
Secondary accession number(s): Q5SVY8, Q61732
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 3, 2012
Last modified: June 8, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.