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Protein

Cysteine and glycine-rich protein 1

Gene

Csrp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Could play a role in neuronal development.

GO - Molecular functioni

GO - Biological processi

  • nervous system development Source: RGD
  • platelet aggregation Source: Ensembl

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine and glycine-rich protein 1
Alternative name(s):
Cysteine-rich protein 1
Short name:
CRP
Short name:
CRP1
Gene namesi
Name:Csrp1
Synonyms:Csrp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi62053. Csrp1.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757181 – 193Cysteine and glycine-rich protein 1Add BLAST193

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei81PhosphoserineCombined sources1
Modified residuei84N6-acetyllysineBy similarity1
Cross-linki91Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei112N6-acetyllysineBy similarity1
Modified residuei131N6-acetyllysineBy similarity1
Modified residuei137N6-acetyllysineBy similarity1
Modified residuei161N6-acetyllysineBy similarity1
Modified residuei192PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP47875.
PRIDEiP47875.

PTM databases

iPTMnetiP47875.
PhosphoSitePlusiP47875.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008937.
GenevisibleiP47875. RN.

Interactioni

Subunit structurei

Interacts with ASCC1; ASCC2 AND TRIP4.By similarity

Protein-protein interaction databases

MINTiMINT-4568744.
STRINGi10116.ENSRNOP00000011991.

Structurei

3D structure databases

ProteinModelPortaliP47875.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 61LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST52
Domaini119 – 170LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST52

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi64 – 69Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi63 – 78Gly-richAdd BLAST16
Compositional biasi176 – 187Gly-richAdd BLAST12

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiENOG410ITI1. Eukaryota.
ENOG4111F3Y. LUCA.
GeneTreeiENSGT00550000074548.
HOGENOMiHOG000111233.
HOVERGENiHBG051143.
InParanoidiP47875.
KOiK09377.
OMAiRCPRCTQ.
OrthoDBiEOG091G11RX.
PhylomeDBiP47875.
TreeFamiTF313758.

Family and domain databases

InterProiView protein in InterPro
IPR001781. Znf_LIM.
PfamiView protein in Pfam
PF00412. LIM. 2 hits.
SMARTiView protein in SMART
SM00132. LIM. 2 hits.
PROSITEiView protein in PROSITE
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.

Sequencei

Sequence statusi: Complete.

P47875-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNWGGGKKC GVCQKTVYFA EEVQCEGNSF HKSCFLCMVC KKNLDSTTVA
60 70 80 90 100
VHGEEIYCKS CYGKKYGPKG YGYGQGAGTL SMDKGESLGI KHEEAPGHRP
110 120 130 140 150
TTNPNASKFA QKIGGSERCP RCSQAVYAAE KVIGAGKSWH KSCFRCAKCG
160 170 180 190
KGLESTTLAD KDGEIYCKGC YAKNFGPKGF GFGQGAGALV HSE
Length:193
Mass (Da):20,613
Last modified:January 23, 2007 - v2
Checksum:i02421D8C6616F194
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09567 mRNA. Translation: AAC52157.1.
BC062407 mRNA. Translation: AAH62407.1.
PIRiS53580.
RefSeqiNP_058844.1. NM_017148.2.
UniGeneiRn.108075.

Genome annotation databases

EnsembliENSRNOT00000011991; ENSRNOP00000011991; ENSRNOG00000008937.
GeneIDi29276.
KEGGirno:29276.
UCSCiRGD:62053. rat.

Similar proteinsi

Entry informationi

Entry nameiCSRP1_RAT
AccessioniPrimary (citable) accession number: P47875
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome