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Protein

Cysteine and glycine-rich protein 1

Gene

Csrp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Could play a role in neuronal development.

GO - Molecular functioni

GO - Biological processi

  • nervous system development Source: RGD
  • platelet aggregation Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine and glycine-rich protein 1
Alternative name(s):
Cysteine-rich protein 1
Short name:
CRP
Short name:
CRP1
Gene namesi
Name:Csrp1
Synonyms:Csrp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi62053. Csrp1.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193Cysteine and glycine-rich protein 1PRO_0000075718Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei81 – 811PhosphoserineCombined sources
Modified residuei84 – 841N6-acetyllysineBy similarity
Modified residuei112 – 1121N6-acetyllysineBy similarity
Modified residuei131 – 1311N6-acetyllysineBy similarity
Modified residuei137 – 1371N6-acetyllysineBy similarity
Modified residuei161 – 1611N6-acetyllysineBy similarity
Modified residuei192 – 1921PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP47875.
PRIDEiP47875.

PTM databases

iPTMnetiP47875.
PhosphoSiteiP47875.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008937.
GenevisibleiP47875. RN.

Interactioni

Subunit structurei

Interacts with ASCC1; ASCC2 AND TRIP4.By similarity

Protein-protein interaction databases

MINTiMINT-4568744.
STRINGi10116.ENSRNOP00000011991.

Structurei

3D structure databases

ProteinModelPortaliP47875.
SMRiP47875. Positions 1-193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 6152LIM zinc-binding 1PROSITE-ProRule annotationAdd
BLAST
Domaini119 – 17052LIM zinc-binding 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi64 – 696Nuclear localization signalSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi63 – 7816Gly-richAdd
BLAST
Compositional biasi176 – 18712Gly-richAdd
BLAST

Sequence similaritiesi

Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiENOG410ITI1. Eukaryota.
ENOG4111F3Y. LUCA.
GeneTreeiENSGT00550000074548.
HOGENOMiHOG000111233.
HOVERGENiHBG051143.
InParanoidiP47875.
KOiK09377.
OMAiRCPRCTQ.
OrthoDBiEOG091G11RX.
PhylomeDBiP47875.
TreeFamiTF313758.

Family and domain databases

Gene3Di2.10.110.10. 2 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00132. LIM. 2 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47875-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNWGGGKKC GVCQKTVYFA EEVQCEGNSF HKSCFLCMVC KKNLDSTTVA
60 70 80 90 100
VHGEEIYCKS CYGKKYGPKG YGYGQGAGTL SMDKGESLGI KHEEAPGHRP
110 120 130 140 150
TTNPNASKFA QKIGGSERCP RCSQAVYAAE KVIGAGKSWH KSCFRCAKCG
160 170 180 190
KGLESTTLAD KDGEIYCKGC YAKNFGPKGF GFGQGAGALV HSE
Length:193
Mass (Da):20,613
Last modified:January 23, 2007 - v2
Checksum:i02421D8C6616F194
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09567 mRNA. Translation: AAC52157.1.
BC062407 mRNA. Translation: AAH62407.1.
PIRiS53580.
RefSeqiNP_058844.1. NM_017148.2.
UniGeneiRn.108075.

Genome annotation databases

EnsembliENSRNOT00000011991; ENSRNOP00000011991; ENSRNOG00000008937.
GeneIDi29276.
KEGGirno:29276.
UCSCiRGD:62053. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09567 mRNA. Translation: AAC52157.1.
BC062407 mRNA. Translation: AAH62407.1.
PIRiS53580.
RefSeqiNP_058844.1. NM_017148.2.
UniGeneiRn.108075.

3D structure databases

ProteinModelPortaliP47875.
SMRiP47875. Positions 1-193.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4568744.
STRINGi10116.ENSRNOP00000011991.

PTM databases

iPTMnetiP47875.
PhosphoSiteiP47875.

Proteomic databases

PaxDbiP47875.
PRIDEiP47875.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011991; ENSRNOP00000011991; ENSRNOG00000008937.
GeneIDi29276.
KEGGirno:29276.
UCSCiRGD:62053. rat.

Organism-specific databases

CTDi1465.
RGDi62053. Csrp1.

Phylogenomic databases

eggNOGiENOG410ITI1. Eukaryota.
ENOG4111F3Y. LUCA.
GeneTreeiENSGT00550000074548.
HOGENOMiHOG000111233.
HOVERGENiHBG051143.
InParanoidiP47875.
KOiK09377.
OMAiRCPRCTQ.
OrthoDBiEOG091G11RX.
PhylomeDBiP47875.
TreeFamiTF313758.

Miscellaneous databases

PROiP47875.

Gene expression databases

BgeeiENSRNOG00000008937.
GenevisibleiP47875. RN.

Family and domain databases

Gene3Di2.10.110.10. 2 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00132. LIM. 2 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSRP1_RAT
AccessioniPrimary (citable) accession number: P47875
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.