ID   OMP_HUMAN               Reviewed;         163 AA.
AC   P47874; Q562G2;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   24-JAN-2024, entry version 151.
DE   RecName: Full=Olfactory marker protein;
DE   AltName: Full=Olfactory neuronal-specific protein;
GN   Name=OMP;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8034318; DOI=10.1006/geno.1994.1200;
RA   Buiakova O.I., Rama Krishna N.S., Getchell T.V., Margolis F.L.;
RT   "Human and rodent OMP genes: conservation of structural and regulatory
RT   motifs and cellular localization.";
RL   Genomics 20:452-462(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May act as a modulator of the olfactory signal-transduction
CC       cascade.
CC   -!- SUBUNIT: Interacts with BEX1 and BEX2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- TISSUE SPECIFICITY: Uniquely associated with mature olfactory receptor
CC       neurons.
CC   -!- SIMILARITY: Belongs to the olfactory marker protein family.
CC       {ECO:0000305}.
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DR   EMBL; U01212; AAA20485.1; -; Genomic_DNA.
DR   EMBL; BC069115; AAH69115.1; -; mRNA.
DR   EMBL; BC069365; AAH69365.1; -; mRNA.
DR   CCDS; CCDS53682.1; -.
DR   PIR; A54261; A54261.
DR   RefSeq; NP_006180.1; NM_006189.1.
DR   AlphaFoldDB; P47874; -.
DR   SMR; P47874; -.
DR   BioGRID; 111023; 15.
DR   STRING; 9606.ENSP00000436376; -.
DR   iPTMnet; P47874; -.
DR   PhosphoSitePlus; P47874; -.
DR   BioMuta; OMP; -.
DR   DMDM; 1352639; -.
DR   MassIVE; P47874; -.
DR   PaxDb; 9606-ENSP00000436376; -.
DR   PeptideAtlas; P47874; -.
DR   Antibodypedia; 52917; 206 antibodies from 28 providers.
DR   DNASU; 4975; -.
DR   Ensembl; ENST00000529803.1; ENSP00000436376.1; ENSG00000254550.1.
DR   GeneID; 4975; -.
DR   KEGG; hsa:4975; -.
DR   MANE-Select; ENST00000529803.1; ENSP00000436376.1; NM_006189.1; NP_006180.1.
DR   UCSC; uc010rsk.2; human.
DR   AGR; HGNC:8136; -.
DR   CTD; 4975; -.
DR   DisGeNET; 4975; -.
DR   GeneCards; OMP; -.
DR   HGNC; HGNC:8136; OMP.
DR   HPA; ENSG00000254550; Tissue enhanced (intestine, liver).
DR   MIM; 164340; gene.
DR   neXtProt; NX_P47874; -.
DR   OpenTargets; ENSG00000254550; -.
DR   PharmGKB; PA31923; -.
DR   VEuPathDB; HostDB:ENSG00000254550; -.
DR   eggNOG; ENOG502S0KQ; Eukaryota.
DR   GeneTree; ENSGT00390000009497; -.
DR   HOGENOM; CLU_1834469_0_0_1; -.
DR   InParanoid; P47874; -.
DR   OMA; GICQLWT; -.
DR   OrthoDB; 4574626at2759; -.
DR   PhylomeDB; P47874; -.
DR   TreeFam; TF330820; -.
DR   PathwayCommons; P47874; -.
DR   SignaLink; P47874; -.
DR   BioGRID-ORCS; 4975; 20 hits in 1149 CRISPR screens.
DR   GenomeRNAi; 4975; -.
DR   Pharos; P47874; Tbio.
DR   PRO; PR:P47874; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; P47874; Protein.
DR   Bgee; ENSG00000254550; Expressed in mucosa of transverse colon and 83 other cell types or tissues.
DR   GO; GO:0030424; C:axon; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0042277; F:peptide binding; IEA:Ensembl.
DR   GO; GO:0007268; P:chemical synaptic transmission; TAS:ProtInc.
DR   GO; GO:0022008; P:neurogenesis; IEA:Ensembl.
DR   GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; TAS:ProtInc.
DR   Gene3D; 2.60.120.390; Olfactory marker; 1.
DR   InterPro; IPR009103; Olfactory_marker.
DR   InterPro; IPR036727; Olfactory_marker_sf.
DR   PANTHER; PTHR15357; OLFACTORY MARKER PROTEIN; 1.
DR   PANTHER; PTHR15357:SF0; OLFACTORY MARKER PROTEIN; 1.
DR   Pfam; PF06554; Olfactory_mark; 1.
DR   SUPFAM; SSF63697; Olfactory marker protein; 1.
DR   Genevisible; P47874; HS.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Olfaction; Reference proteome;
KW   Sensory transduction.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P08523"
FT   CHAIN           2..163
FT                   /note="Olfactory marker protein"
FT                   /id="PRO_0000058043"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:P08523"
FT   VARIANT         26
FT                   /note="R -> W (in dbSNP:rs2233546)"
FT                   /id="VAR_051254"
FT   VARIANT         36
FT                   /note="G -> R (in dbSNP:rs2233548)"
FT                   /id="VAR_051255"
SQ   SEQUENCE   163 AA;  18937 MW;  EECD8AD16E7A328E CRC64;
     MAEDRPQQPQ LDMPLVLDQG LTRQMRLRVE SLKQRGEKRQ DGEKLLQPAE SVYRLNFTQQ
     QRLQFERWNV VLDKPGKVTI TGTSQNWTPD LTNLMTRQLL DPTAIFWRKE DSDAIDWNEA
     DALEFGERLS DLAKIRKVMY FLVTFGEGVE PANLKASVVF NQL
//