Olfactory marker protein - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot P47874 (OMP_HUMAN)

Last modified March 2, 2010. Version 66. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
Olfactory marker protein

Alternative name(s):
Olfactory neuronal-specific protein

Gene names

Name:

OMP

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	163 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	May act as a modulator of the olfactory signal-transduction cascade.
Subunit structure	Interacts with BEX1 and BEX2 By similarity.
Subcellular location	Cytoplasm.
Tissue specificity	Uniquely associated with mature olfactory receptor neurons.
Sequence similarities	Belongs to the olfactory marker protein family.

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Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
PTM	Acetylation
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW sensory perception of smell Traceable author statement. Source: ProtInc signal transduction Traceable author statement. Source: ProtInc synaptic transmission Traceable author statement. Source: ProtInc
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from electronic annotation. Source: InterPro signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed By similarity

Chain

2 – 163

162

Olfactory marker protein

PRO_0000058043

Amino acid modifications

Modified residue

N-acetylalanine By similarity

Natural variations

Natural variant

R → W: dbSNP rs2233546.

VAR_051254

Natural variant

G → R: dbSNP rs2233548.

VAR_051255

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Sequences

Sequence

Length

Mass (Da)

Tools

P47874-1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: EECD8AD16E7A328E
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FASTA

163

18,937

        10         20         30         40         50         60 
MAEDRPQQPQ LDMPLVLDQG LTRQMRLRVE SLKQRGEKRQ DGEKLLQPAE SVYRLNFTQQ 

        70         80         90        100        110        120 
QRLQFERWNV VLDKPGKVTI TGTSQNWTPD LTNLMTRQLL DPTAIFWRKE DSDAIDWNEA 

       130        140        150        160 
DALEFGERLS DLAKIRKVMY FLVTFGEGVE PANLKASVVF NQL

« Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human and rodent OMP genes: conservation of structural and regulatory motifs and cellular localization." Buiakova O.I., Rama Krishna N.S., Getchell T.V., Margolis F.L. Genomics 20:452-462(1994) [PubMed: 8034318] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

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Cross-references

Sequence databases
EMBL GenBank DDBJ	U01212 Genomic DNA. Translation: AAA20485.1. BC069115 mRNA. Translation: AAH69115.1. BC069365 mRNA. Translation: AAH69365.1.
IPI	IPI00220343.
PIR	A54261.
RefSeq	NP_006180.1.
UniGene	Hs.673853
3D structure databases
SMR	P47874. Positions 1-163.
ModBase	Search...
Proteomic databases
PRIDE	P47874.
Genome annotation databases
GeneID	4975.
KEGG	hsa:4975.
UCSC	uc001oxz.1. human.
Organism-specific databases
CTD	4975.
GeneCards	GC11P076491.
H-InvDB	HIX0128352. HIX0154381.
HGNC	HGNC:8136. OMP.
MIM	164340. gene.
PharmGKB	PA26744.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG007595.
PhylomeDB	P47874.
Gene expression databases
CleanEx	HS_OMP.
Genevestigator	P47874.
Family and domain databases
InterPro	IPR009103. Olfactory_marker. [Graphical view]
Gene3D	G3DSA:2.60.120.390. Olfactory_marker. 1 hit.
PANTHER	PTHR15357. Olfactory_marker. 1 hit.
Pfam	PF06554. Olfactory_mark. 1 hit. [Graphical view]
ProDom	PD022055. Olfactory_marker. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF63697. Olfactory_marker. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	19150.
SOURCE	Search...

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Entry information

Entry name

OMP_HUMAN

Accession

Primary (citable) accession number: P47874
Secondary accession number(s): Q562G2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	January 23, 2007
Last modified:	March 2, 2010
This is version 66 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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