Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P47874

- OMP_HUMAN

UniProt

P47874 - OMP_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Olfactory marker protein

Gene

OMP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May act as a modulator of the olfactory signal-transduction cascade.

GO - Molecular functioni

  1. signal transducer activity Source: Ensembl

GO - Biological processi

  1. neurogenesis Source: Ensembl
  2. sensory perception of smell Source: ProtInc
  3. signal transduction Source: ProtInc
  4. synaptic transmission Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Olfaction, Sensory transduction

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory marker protein
Alternative name(s):
Olfactory neuronal-specific protein
Gene namesi
Name:OMP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:8136. OMP.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: Ensembl
  2. cytoplasm Source: UniProtKB-KW
  3. neuronal cell body Source: Ensembl
  4. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31923.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 163162Olfactory marker proteinPRO_0000058043Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP47874.

PTM databases

PhosphoSiteiP47874.

Expressioni

Tissue specificityi

Uniquely associated with mature olfactory receptor neurons.

Gene expression databases

BgeeiP47874.
CleanExiHS_OMP.
GenevestigatoriP47874.

Interactioni

Subunit structurei

Interacts with BEX1 and BEX2.By similarity

Protein-protein interaction databases

BioGridi111023. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP47874.
SMRiP47874. Positions 1-163.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the olfactory marker protein family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000009497.
HOVERGENiHBG007595.
InParanoidiP47874.
OMAiHWTPDLT.
OrthoDBiEOG7BZVTT.
PhylomeDBiP47874.
TreeFamiTF330820.

Family and domain databases

Gene3Di2.60.120.390. 1 hit.
InterProiIPR009103. Olfactory_marker.
[Graphical view]
PANTHERiPTHR15357. PTHR15357. 1 hit.
PfamiPF06554. Olfactory_mark. 1 hit.
[Graphical view]
ProDomiPD022055. Olfactory_marker. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF63697. SSF63697. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47874-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEDRPQQPQ LDMPLVLDQG LTRQMRLRVE SLKQRGEKRQ DGEKLLQPAE
60 70 80 90 100
SVYRLNFTQQ QRLQFERWNV VLDKPGKVTI TGTSQNWTPD LTNLMTRQLL
110 120 130 140 150
DPTAIFWRKE DSDAIDWNEA DALEFGERLS DLAKIRKVMY FLVTFGEGVE
160
PANLKASVVF NQL
Length:163
Mass (Da):18,937
Last modified:January 23, 2007 - v2
Checksum:iEECD8AD16E7A328E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti26 – 261R → W.
Corresponds to variant rs2233546 [ dbSNP | Ensembl ].
VAR_051254
Natural varianti36 – 361G → R.
Corresponds to variant rs2233548 [ dbSNP | Ensembl ].
VAR_051255

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01212 Genomic DNA. Translation: AAA20485.1.
BC069115 mRNA. Translation: AAH69115.1.
BC069365 mRNA. Translation: AAH69365.1.
CCDSiCCDS53682.1.
PIRiA54261.
RefSeqiNP_006180.1. NM_006189.1.
UniGeneiHs.673853.

Genome annotation databases

EnsembliENST00000529803; ENSP00000436376; ENSG00000254550.
GeneIDi4975.
KEGGihsa:4975.
UCSCiuc010rsk.2. human.

Polymorphism databases

DMDMi1352639.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01212 Genomic DNA. Translation: AAA20485.1 .
BC069115 mRNA. Translation: AAH69115.1 .
BC069365 mRNA. Translation: AAH69365.1 .
CCDSi CCDS53682.1.
PIRi A54261.
RefSeqi NP_006180.1. NM_006189.1.
UniGenei Hs.673853.

3D structure databases

ProteinModelPortali P47874.
SMRi P47874. Positions 1-163.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111023. 1 interaction.

PTM databases

PhosphoSitei P47874.

Polymorphism databases

DMDMi 1352639.

Proteomic databases

PRIDEi P47874.

Protocols and materials databases

DNASUi 4975.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000529803 ; ENSP00000436376 ; ENSG00000254550 .
GeneIDi 4975.
KEGGi hsa:4975.
UCSCi uc010rsk.2. human.

Organism-specific databases

CTDi 4975.
GeneCardsi GC11P076813.
HGNCi HGNC:8136. OMP.
MIMi 164340. gene.
neXtProti NX_P47874.
PharmGKBi PA31923.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00390000009497.
HOVERGENi HBG007595.
InParanoidi P47874.
OMAi HWTPDLT.
OrthoDBi EOG7BZVTT.
PhylomeDBi P47874.
TreeFami TF330820.

Miscellaneous databases

GenomeRNAii 4975.
NextBioi 19150.
PROi P47874.
SOURCEi Search...

Gene expression databases

Bgeei P47874.
CleanExi HS_OMP.
Genevestigatori P47874.

Family and domain databases

Gene3Di 2.60.120.390. 1 hit.
InterProi IPR009103. Olfactory_marker.
[Graphical view ]
PANTHERi PTHR15357. PTHR15357. 1 hit.
Pfami PF06554. Olfactory_mark. 1 hit.
[Graphical view ]
ProDomi PD022055. Olfactory_marker. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF63697. SSF63697. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human and rodent OMP genes: conservation of structural and regulatory motifs and cellular localization."
    Buiakova O.I., Rama Krishna N.S., Getchell T.V., Margolis F.L.
    Genomics 20:452-462(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiOMP_HUMAN
AccessioniPrimary (citable) accession number: P47874
Secondary accession number(s): Q562G2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3