P47874 (OMP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory marker protein

Alternative name(s):
Olfactory neuronal-specific protein

Gene names

Name:

OMP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	163 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May act as a modulator of the olfactory signal-transduction cascade.
Subunit structure	Interacts with BEX1 and BEX2 By similarity.
Subcellular location	Cytoplasm.
Tissue specificity	Uniquely associated with mature olfactory receptor neurons.
Sequence similarities	Belongs to the olfactory marker protein family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	neurogenesis Inferred from electronic annotation. Source: Compara sensory perception of smell Traceable author statement PubMed 8790421. Source: ProtInc signal transduction Traceable author statement PubMed 8790421. Source: ProtInc synaptic transmission Traceable author statement PubMed 8790421. Source: ProtInc
Cellular_component	axon Inferred from electronic annotation. Source: Compara cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell neuronal cell body Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: Compara
Molecular_function	signal transducer activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 163	162	Olfactory marker protein		PRO_0000058043
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
Natural variations
	Natural variant	26	1	R → W. Corresponds to variant rs2233546 [ dbSNP | Ensembl ].		VAR_051254
	Natural variant	36	1	G → R. Corresponds to variant rs2233548 [ dbSNP | Ensembl ].		VAR_051255

Sequences

	Sequence		Length	Mass (Da)
	P47874 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: EECD8AD16E7A328E	FASTA	163	18,937
	10 20 30 40 50 60 MAEDRPQQPQ LDMPLVLDQG LTRQMRLRVE SLKQRGEKRQ DGEKLLQPAE SVYRLNFTQQ 70 80 90 100 110 120 QRLQFERWNV VLDKPGKVTI TGTSQNWTPD LTNLMTRQLL DPTAIFWRKE DSDAIDWNEA 130 140 150 160 DALEFGERLS DLAKIRKVMY FLVTFGEGVE PANLKASVVF NQL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human and rodent OMP genes: conservation of structural and regulatory motifs and cellular localization." Buiakova O.I., Rama Krishna N.S., Getchell T.V., Margolis F.L. Genomics 20:452-462(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U01212 Genomic DNA. Translation: AAA20485.1. BC069115 mRNA. Translation: AAH69115.1. BC069365 mRNA. Translation: AAH69365.1.
IPI	IPI00220343.
PIR	A54261.
RefSeq	NP_006180.1. NM_006189.1.
UniGene	Hs.673853.
3D structure databases
ProteinModelPortal	P47874.
ModBase	Search...
PTM databases
PhosphoSite	P47874.
Polymorphism databases
DMDM	1352639.
Proteomic databases
PRIDE	P47874.
Protocols and materials databases
DNASU	4975.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000529803; ENSP00000436376; ENSG00000254550. ENST00000572986; ENSP00000459496; ENSG00000261941.
GeneID	4975.
KEGG	hsa:4975.
UCSC	uc010rsk.2. human.
Organism-specific databases
CTD	4975.
GeneCards	GC11P076813.
HGNC	HGNC:8136. OMP.
MIM	164340. gene.
neXtProt	NX_P47874.
PharmGKB	PA31923.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG007595.
OMA	KVMYFLI.
PhylomeDB	P47874.
Gene expression databases
Bgee	P47874.
CleanEx	HS_OMP.
Genevestigator	P47874.
Family and domain databases
Gene3D	2.60.120.390. 1 hit.
InterPro	IPR009103. Olfactory_marker. [Graphical view]
PANTHER	PTHR15357. PTHR15357. 1 hit.
Pfam	PF06554. Olfactory_mark. 1 hit. [Graphical view]
ProDom	PD022055. Olfactory_marker. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF63697. Olfactory_marker. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	4975.
NextBio	19150.
SOURCE	Search...

Entry information

Entry name

OMP_HUMAN

Accession

Primary (citable) accession number: P47874
Secondary accession number(s): Q562G2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.