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P47874 (OMP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory marker protein
Alternative name(s):
Olfactory neuronal-specific protein
Gene names
Name:OMP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length163 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May act as a modulator of the olfactory signal-transduction cascade.

Subunit structure

Interacts with BEX1 and BEX2 By similarity.

Subcellular location

Cytoplasm.

Tissue specificity

Uniquely associated with mature olfactory receptor neurons.

Sequence similarities

Belongs to the olfactory marker protein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 163162Olfactory marker protein
PRO_0000058043

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Natural variations

Natural variant261R → W.
Corresponds to variant rs2233546 [ dbSNP | Ensembl ].
VAR_051254
Natural variant361G → R.
Corresponds to variant rs2233548 [ dbSNP | Ensembl ].
VAR_051255

Sequences

Sequence LengthMass (Da)Tools
P47874 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: EECD8AD16E7A328E

FASTA16318,937
        10         20         30         40         50         60 
MAEDRPQQPQ LDMPLVLDQG LTRQMRLRVE SLKQRGEKRQ DGEKLLQPAE SVYRLNFTQQ 

        70         80         90        100        110        120 
QRLQFERWNV VLDKPGKVTI TGTSQNWTPD LTNLMTRQLL DPTAIFWRKE DSDAIDWNEA 

       130        140        150        160 
DALEFGERLS DLAKIRKVMY FLVTFGEGVE PANLKASVVF NQL 

« Hide

References

« Hide 'large scale' references
[1]"Human and rodent OMP genes: conservation of structural and regulatory motifs and cellular localization."
Buiakova O.I., Rama Krishna N.S., Getchell T.V., Margolis F.L.
Genomics 20:452-462(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U01212 Genomic DNA. Translation: AAA20485.1.
BC069115 mRNA. Translation: AAH69115.1.
BC069365 mRNA. Translation: AAH69365.1.
CCDSCCDS53682.1.
PIRA54261.
RefSeqNP_006180.1. NM_006189.1.
UniGeneHs.673853.

3D structure databases

ProteinModelPortalP47874.
SMRP47874. Positions 1-163.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111023. 1 interaction.

PTM databases

PhosphoSiteP47874.

Polymorphism databases

DMDM1352639.

Proteomic databases

PRIDEP47874.

Protocols and materials databases

DNASU4975.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000529803; ENSP00000436376; ENSG00000254550.
ENST00000572986; ENSP00000459496; ENSG00000261941.
GeneID4975.
KEGGhsa:4975.
UCSCuc010rsk.2. human.

Organism-specific databases

CTD4975.
GeneCardsGC11P076813.
HGNCHGNC:8136. OMP.
MIM164340. gene.
neXtProtNX_P47874.
PharmGKBPA31923.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG007595.
OMAHWTPDLT.
OrthoDBEOG7BZVTT.
PhylomeDBP47874.
TreeFamTF330820.

Gene expression databases

BgeeP47874.
CleanExHS_OMP.
GenevestigatorP47874.

Family and domain databases

Gene3D2.60.120.390. 1 hit.
InterProIPR009103. Olfactory_marker.
[Graphical view]
PANTHERPTHR15357. PTHR15357. 1 hit.
PfamPF06554. Olfactory_mark. 1 hit.
[Graphical view]
ProDomPD022055. Olfactory_marker. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF63697. SSF63697. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi4975.
NextBio19150.
PROP47874.
SOURCESearch...

Entry information

Entry nameOMP_HUMAN
AccessionPrimary (citable) accession number: P47874
Secondary accession number(s): Q562G2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM