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Reviewed, UniProtKB/Swiss-Prot P47874 (OMP_HUMAN)

Last modified March 2, 2010. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
Olfactory marker protein
Alternative name(s):
Olfactory neuronal-specific protein
Gene names
Name:OMP
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length163 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

May act as a modulator of the olfactory signal-transduction cascade.

Subunit structure

Interacts with BEX1 and BEX2 By similarity.

Subcellular location

Cytoplasm.

Tissue specificity

Uniquely associated with mature olfactory receptor neurons.

Sequence similarities

Belongs to the olfactory marker protein family.

Ontologies

Keywords
   Biological processOlfaction
Sensory transduction
   Cellular componentCytoplasm
   Coding sequence diversityPolymorphism
   PTMAcetylation
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processresponse to stimulus

Inferred from electronic annotation. Source: UniProtKB-KW

sensory perception of smell

Traceable author statement. Source: ProtInc

signal transduction

Traceable author statement. Source: ProtInc

synaptic transmission

Traceable author statement. Source: ProtInc

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionprotein binding

Inferred from electronic annotation. Source: InterPro

signal transducer activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 163162Olfactory marker protein
PRO_0000058043

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Natural variations

Natural variant261R → W: dbSNP rs2233546.
VAR_051254
Natural variant361G → R: dbSNP rs2233548.
VAR_051255

Sequences

Sequence LengthMass (Da)Tools
P47874-1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: EECD8AD16E7A328E

FASTA16318,937
        10         20         30         40         50         60 
MAEDRPQQPQ LDMPLVLDQG LTRQMRLRVE SLKQRGEKRQ DGEKLLQPAE SVYRLNFTQQ 

        70         80         90        100        110        120 
QRLQFERWNV VLDKPGKVTI TGTSQNWTPD LTNLMTRQLL DPTAIFWRKE DSDAIDWNEA 

       130        140        150        160 
DALEFGERLS DLAKIRKVMY FLVTFGEGVE PANLKASVVF NQL 

« Hide

References

« Hide 'large scale' references
[1]"Human and rodent OMP genes: conservation of structural and regulatory motifs and cellular localization."
Buiakova O.I., Rama Krishna N.S., Getchell T.V., Margolis F.L.
Genomics 20:452-462(1994) [PubMed: 8034318] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U01212 Genomic DNA. Translation: AAA20485.1.
BC069115 mRNA. Translation: AAH69115.1.
BC069365 mRNA. Translation: AAH69365.1.
IPIIPI00220343.
PIRA54261.
RefSeqNP_006180.1.
UniGeneHs.673853

3D structure databases

SMRP47874. Positions 1-163.
ModBaseSearch...

Proteomic databases

PRIDEP47874.

Genome annotation databases

GeneID4975.
KEGGhsa:4975.
UCSCuc001oxz.1. human.

Organism-specific databases

CTD4975.
GeneCardsGC11P076491.
H-InvDBHIX0128352.
HIX0154381.
HGNCHGNC:8136. OMP.
MIM164340. gene.
PharmGKBPA26744.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG007595.
PhylomeDBP47874.

Gene expression databases

CleanExHS_OMP.
GenevestigatorP47874.

Family and domain databases

InterProIPR009103. Olfactory_marker.
[Graphical view]
Gene3DG3DSA:2.60.120.390. Olfactory_marker. 1 hit.
PANTHERPTHR15357. Olfactory_marker. 1 hit.
PfamPF06554. Olfactory_mark. 1 hit.
[Graphical view]
ProDomPD022055. Olfactory_marker. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF63697. Olfactory_marker. 1 hit.
ProtoNetSearch...

Other Resources

NextBio19150.
SOURCESearch...

Entry information

Entry nameOMP_HUMAN
AccessionPrimary (citable) accession number: P47874
Secondary accession number(s): Q562G2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: March 2, 2010
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents