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P47874

- OMP_HUMAN

UniProt

P47874 - OMP_HUMAN

Protein

Olfactory marker protein

Gene

OMP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    May act as a modulator of the olfactory signal-transduction cascade.

    GO - Molecular functioni

    1. signal transducer activity Source: Ensembl

    GO - Biological processi

    1. neurogenesis Source: Ensembl
    2. sensory perception of smell Source: ProtInc
    3. signal transduction Source: ProtInc
    4. synaptic transmission Source: ProtInc

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory marker protein
    Alternative name(s):
    Olfactory neuronal-specific protein
    Gene namesi
    Name:OMP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:8136. OMP.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. cytoplasm Source: UniProtKB-SubCell
    3. neuronal cell body Source: Ensembl
    4. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31923.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 163162Olfactory marker proteinPRO_0000058043Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiP47874.

    PTM databases

    PhosphoSiteiP47874.

    Expressioni

    Tissue specificityi

    Uniquely associated with mature olfactory receptor neurons.

    Gene expression databases

    BgeeiP47874.
    CleanExiHS_OMP.
    GenevestigatoriP47874.

    Interactioni

    Subunit structurei

    Interacts with BEX1 and BEX2.By similarity

    Protein-protein interaction databases

    BioGridi111023. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP47874.
    SMRiP47874. Positions 1-163.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the olfactory marker protein family.Curated

    Phylogenomic databases

    HOVERGENiHBG007595.
    OMAiHWTPDLT.
    OrthoDBiEOG7BZVTT.
    PhylomeDBiP47874.
    TreeFamiTF330820.

    Family and domain databases

    Gene3Di2.60.120.390. 1 hit.
    InterProiIPR009103. Olfactory_marker.
    [Graphical view]
    PANTHERiPTHR15357. PTHR15357. 1 hit.
    PfamiPF06554. Olfactory_mark. 1 hit.
    [Graphical view]
    ProDomiPD022055. Olfactory_marker. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF63697. SSF63697. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P47874-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEDRPQQPQ LDMPLVLDQG LTRQMRLRVE SLKQRGEKRQ DGEKLLQPAE    50
    SVYRLNFTQQ QRLQFERWNV VLDKPGKVTI TGTSQNWTPD LTNLMTRQLL 100
    DPTAIFWRKE DSDAIDWNEA DALEFGERLS DLAKIRKVMY FLVTFGEGVE 150
    PANLKASVVF NQL 163
    Length:163
    Mass (Da):18,937
    Last modified:January 23, 2007 - v2
    Checksum:iEECD8AD16E7A328E
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti26 – 261R → W.
    Corresponds to variant rs2233546 [ dbSNP | Ensembl ].
    VAR_051254
    Natural varianti36 – 361G → R.
    Corresponds to variant rs2233548 [ dbSNP | Ensembl ].
    VAR_051255

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U01212 Genomic DNA. Translation: AAA20485.1.
    BC069115 mRNA. Translation: AAH69115.1.
    BC069365 mRNA. Translation: AAH69365.1.
    CCDSiCCDS53682.1.
    PIRiA54261.
    RefSeqiNP_006180.1. NM_006189.1.
    UniGeneiHs.673853.

    Genome annotation databases

    EnsembliENST00000529803; ENSP00000436376; ENSG00000254550.
    GeneIDi4975.
    KEGGihsa:4975.
    UCSCiuc010rsk.2. human.

    Polymorphism databases

    DMDMi1352639.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U01212 Genomic DNA. Translation: AAA20485.1 .
    BC069115 mRNA. Translation: AAH69115.1 .
    BC069365 mRNA. Translation: AAH69365.1 .
    CCDSi CCDS53682.1.
    PIRi A54261.
    RefSeqi NP_006180.1. NM_006189.1.
    UniGenei Hs.673853.

    3D structure databases

    ProteinModelPortali P47874.
    SMRi P47874. Positions 1-163.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111023. 1 interaction.

    PTM databases

    PhosphoSitei P47874.

    Polymorphism databases

    DMDMi 1352639.

    Proteomic databases

    PRIDEi P47874.

    Protocols and materials databases

    DNASUi 4975.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000529803 ; ENSP00000436376 ; ENSG00000254550 .
    GeneIDi 4975.
    KEGGi hsa:4975.
    UCSCi uc010rsk.2. human.

    Organism-specific databases

    CTDi 4975.
    GeneCardsi GC11P076813.
    HGNCi HGNC:8136. OMP.
    MIMi 164340. gene.
    neXtProti NX_P47874.
    PharmGKBi PA31923.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG007595.
    OMAi HWTPDLT.
    OrthoDBi EOG7BZVTT.
    PhylomeDBi P47874.
    TreeFami TF330820.

    Miscellaneous databases

    GenomeRNAii 4975.
    NextBioi 19150.
    PROi P47874.
    SOURCEi Search...

    Gene expression databases

    Bgeei P47874.
    CleanExi HS_OMP.
    Genevestigatori P47874.

    Family and domain databases

    Gene3Di 2.60.120.390. 1 hit.
    InterProi IPR009103. Olfactory_marker.
    [Graphical view ]
    PANTHERi PTHR15357. PTHR15357. 1 hit.
    Pfami PF06554. Olfactory_mark. 1 hit.
    [Graphical view ]
    ProDomi PD022055. Olfactory_marker. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF63697. SSF63697. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Human and rodent OMP genes: conservation of structural and regulatory motifs and cellular localization."
      Buiakova O.I., Rama Krishna N.S., Getchell T.V., Margolis F.L.
      Genomics 20:452-462(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiOMP_HUMAN
    AccessioniPrimary (citable) accession number: P47874
    Secondary accession number(s): Q562G2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3