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Protein

Olfactory marker protein

Gene

OMP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a modulator of the olfactory signal-transduction cascade.

GO - Molecular functioni

  1. signal transducer activity Source: Ensembl

GO - Biological processi

  1. neurogenesis Source: Ensembl
  2. sensory perception of smell Source: ProtInc
  3. signal transduction Source: ProtInc
  4. synaptic transmission Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Olfaction, Sensory transduction

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory marker protein
Alternative name(s):
Olfactory neuronal-specific protein
Gene namesi
Name:OMP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:8136. OMP.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: Ensembl
  2. cytoplasm Source: UniProtKB-SubCell
  3. neuronal cell body Source: Ensembl
  4. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31923.

Polymorphism and mutation databases

BioMutaiOMP.
DMDMi1352639.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 163162Olfactory marker proteinPRO_0000058043Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP47874.

PTM databases

PhosphoSiteiP47874.

Expressioni

Tissue specificityi

Uniquely associated with mature olfactory receptor neurons.

Gene expression databases

BgeeiP47874.
CleanExiHS_OMP.
GenevestigatoriP47874.

Interactioni

Subunit structurei

Interacts with BEX1 and BEX2.By similarity

Protein-protein interaction databases

BioGridi111023. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP47874.
SMRiP47874. Positions 1-163.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the olfactory marker protein family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000009497.
HOVERGENiHBG007595.
InParanoidiP47874.
OMAiHWTPDLT.
OrthoDBiEOG7BZVTT.
PhylomeDBiP47874.
TreeFamiTF330820.

Family and domain databases

Gene3Di2.60.120.390. 1 hit.
InterProiIPR009103. Olfactory_marker.
[Graphical view]
PANTHERiPTHR15357. PTHR15357. 1 hit.
PfamiPF06554. Olfactory_mark. 1 hit.
[Graphical view]
ProDomiPD022055. Olfactory_marker. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF63697. SSF63697. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47874-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEDRPQQPQ LDMPLVLDQG LTRQMRLRVE SLKQRGEKRQ DGEKLLQPAE
60 70 80 90 100
SVYRLNFTQQ QRLQFERWNV VLDKPGKVTI TGTSQNWTPD LTNLMTRQLL
110 120 130 140 150
DPTAIFWRKE DSDAIDWNEA DALEFGERLS DLAKIRKVMY FLVTFGEGVE
160
PANLKASVVF NQL
Length:163
Mass (Da):18,937
Last modified:January 23, 2007 - v2
Checksum:iEECD8AD16E7A328E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti26 – 261R → W.
Corresponds to variant rs2233546 [ dbSNP | Ensembl ].
VAR_051254
Natural varianti36 – 361G → R.
Corresponds to variant rs2233548 [ dbSNP | Ensembl ].
VAR_051255

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01212 Genomic DNA. Translation: AAA20485.1.
BC069115 mRNA. Translation: AAH69115.1.
BC069365 mRNA. Translation: AAH69365.1.
CCDSiCCDS53682.1.
PIRiA54261.
RefSeqiNP_006180.1. NM_006189.1.
UniGeneiHs.673853.

Genome annotation databases

EnsembliENST00000529803; ENSP00000436376; ENSG00000254550.
GeneIDi4975.
KEGGihsa:4975.
UCSCiuc010rsk.2. human.

Polymorphism and mutation databases

BioMutaiOMP.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01212 Genomic DNA. Translation: AAA20485.1.
BC069115 mRNA. Translation: AAH69115.1.
BC069365 mRNA. Translation: AAH69365.1.
CCDSiCCDS53682.1.
PIRiA54261.
RefSeqiNP_006180.1. NM_006189.1.
UniGeneiHs.673853.

3D structure databases

ProteinModelPortaliP47874.
SMRiP47874. Positions 1-163.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111023. 1 interaction.

PTM databases

PhosphoSiteiP47874.

Polymorphism and mutation databases

BioMutaiOMP.
DMDMi1352639.

Proteomic databases

PRIDEiP47874.

Protocols and materials databases

DNASUi4975.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000529803; ENSP00000436376; ENSG00000254550.
GeneIDi4975.
KEGGihsa:4975.
UCSCiuc010rsk.2. human.

Organism-specific databases

CTDi4975.
GeneCardsiGC11P076813.
HGNCiHGNC:8136. OMP.
MIMi164340. gene.
neXtProtiNX_P47874.
PharmGKBiPA31923.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000009497.
HOVERGENiHBG007595.
InParanoidiP47874.
OMAiHWTPDLT.
OrthoDBiEOG7BZVTT.
PhylomeDBiP47874.
TreeFamiTF330820.

Miscellaneous databases

GenomeRNAii4975.
NextBioi19150.
PROiP47874.
SOURCEiSearch...

Gene expression databases

BgeeiP47874.
CleanExiHS_OMP.
GenevestigatoriP47874.

Family and domain databases

Gene3Di2.60.120.390. 1 hit.
InterProiIPR009103. Olfactory_marker.
[Graphical view]
PANTHERiPTHR15357. PTHR15357. 1 hit.
PfamiPF06554. Olfactory_mark. 1 hit.
[Graphical view]
ProDomiPD022055. Olfactory_marker. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF63697. SSF63697. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human and rodent OMP genes: conservation of structural and regulatory motifs and cellular localization."
    Buiakova O.I., Rama Krishna N.S., Getchell T.V., Margolis F.L.
    Genomics 20:452-462(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiOMP_HUMAN
AccessioniPrimary (citable) accession number: P47874
Secondary accession number(s): Q562G2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: April 29, 2015
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.