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Protein

Interleukin-11

Gene

Il11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:8913282). Also promotes the proliferation of hepatocytes in response to liver damage (PubMed:22253262). Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation, also in the context of various cancers (PubMed:10026196, PubMed:23948300). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3 (PubMed:23948300, PubMed:22253262).4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei168Important for interaction with IL6ST and for the stimulation of cell proliferation1 Publication1

GO - Molecular functioni

  • cytokine activity Source: MGI
  • growth factor activity Source: UniProtKB
  • interleukin-11 receptor binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Enzyme and pathway databases

ReactomeiR-MMU-6788467. IL-6-type cytokine receptor ligand interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-11
Short name:
IL-11
Gene namesi
Name:Il11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:107613. Il11.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi168W → A: Slightly increases IL11RA binding. Abolishes interaction with IL6ST. Abolishes stimulation of cell proliferation. 1 Publication1
Mutagenesisi172R → A: No effect on IL11RA binding. Decreases stimulation of cell proliferation. 1 Publication1
Mutagenesisi190R → A: Srongly reduces IL11RA binding and stimulation of cell proliferation. 1 Publication1
Mutagenesisi193L → A: Impairs IL11RA binding and mildly reduces stimulation of cell proliferation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001562022 – 199Interleukin-11Add BLAST178

Proteomic databases

PaxDbiP47873.
PRIDEiP47873.

PTM databases

PhosphoSitePlusiP47873.

Expressioni

Inductioni

Up-regulated in hepatocytes by oxidative stress caused by liver damage.1 Publication

Gene expression databases

BgeeiENSMUSG00000004371.
CleanExiMM_IL11.
ExpressionAtlasiP47873. baseline and differential.
GenevisibleiP47873. MM.

Interactioni

Subunit structurei

Interacts with IL6ST and either IL11RA1 or IL11RA2, giving rise to a multimeric signaling complex.1 Publication

GO - Molecular functioni

  • cytokine activity Source: MGI
  • growth factor activity Source: UniProtKB
  • interleukin-11 receptor binding Source: MGI

Protein-protein interaction databases

DIPiDIP-5780N.
STRINGi10090.ENSMUSP00000092492.

Structurei

3D structure databases

ProteinModelPortaliP47873.
SMRiP47873.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni182 – 190Important for interaction with IL11RA and for the stimulation of cell proliferationBy similarityCurated9

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWMH. Eukaryota.
ENOG411181Z. LUCA.
GeneTreeiENSGT00390000007165.
HOVERGENiHBG003999.
InParanoidiP47873.
KOiK05417.
OMAiNCVCHLV.
OrthoDBiEOG091G0V1V.
PhylomeDBiP47873.
TreeFamiTF337294.

Family and domain databases

InterProiIPR009079. 4_helix_cytokine-like_core.
IPR020438. IL-11.
IPR020412. IL-11_mml.
[Graphical view]
PfamiPF07400. IL11. 1 hit.
[Graphical view]
PRINTSiPR01943. INTLKN11MAML.
PR01927. INTRLEUKIN11.
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47873-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNCVCRLVLV VLSLWPDRVV APGPPAGSPR VSSDPRADLD SAVLLTRSLL
60 70 80 90 100
ADTRQLAAQM RDKFPADGDH SLDSLPTLAM SAGTLGSLQL PGVLTRLRVD
110 120 130 140 150
LMSYLRHVQW LRRAGGPSLK TLEPELGALQ ARLERLLRRL QLLMSRLALP
160 170 180 190
QAAPDQPVIP LGPPASAWGS IRAAHAILGG LHLTLDWAVR GLLLLKTRL
Length:199
Mass (Da):21,522
Last modified:February 1, 1996 - v1
Checksum:i904FF7DBA896625A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03421 mRNA. Translation: AAC52941.1.
CCDSiCCDS39740.1.
RefSeqiNP_032376.1. NM_008350.4.
UniGeneiMm.35814.

Genome annotation databases

EnsembliENSMUST00000094892; ENSMUSP00000092492; ENSMUSG00000004371.
GeneIDi16156.
KEGGimmu:16156.
UCSCiuc009eyo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03421 mRNA. Translation: AAC52941.1.
CCDSiCCDS39740.1.
RefSeqiNP_032376.1. NM_008350.4.
UniGeneiMm.35814.

3D structure databases

ProteinModelPortaliP47873.
SMRiP47873.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-5780N.
STRINGi10090.ENSMUSP00000092492.

PTM databases

PhosphoSitePlusiP47873.

Proteomic databases

PaxDbiP47873.
PRIDEiP47873.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094892; ENSMUSP00000092492; ENSMUSG00000004371.
GeneIDi16156.
KEGGimmu:16156.
UCSCiuc009eyo.2. mouse.

Organism-specific databases

CTDi3589.
MGIiMGI:107613. Il11.

Phylogenomic databases

eggNOGiENOG410IWMH. Eukaryota.
ENOG411181Z. LUCA.
GeneTreeiENSGT00390000007165.
HOVERGENiHBG003999.
InParanoidiP47873.
KOiK05417.
OMAiNCVCHLV.
OrthoDBiEOG091G0V1V.
PhylomeDBiP47873.
TreeFamiTF337294.

Enzyme and pathway databases

ReactomeiR-MMU-6788467. IL-6-type cytokine receptor ligand interactions.

Miscellaneous databases

PROiP47873.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004371.
CleanExiMM_IL11.
ExpressionAtlasiP47873. baseline and differential.
GenevisibleiP47873. MM.

Family and domain databases

InterProiIPR009079. 4_helix_cytokine-like_core.
IPR020438. IL-11.
IPR020412. IL-11_mml.
[Graphical view]
PfamiPF07400. IL11. 1 hit.
[Graphical view]
PRINTSiPR01943. INTLKN11MAML.
PR01927. INTRLEUKIN11.
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIL11_MOUSE
AccessioniPrimary (citable) accession number: P47873
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.