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Protein

Secretin receptor

Gene

SCTR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  • secretin receptor activity Source: ProtInc

GO - Biological processi

  • cell surface receptor signaling pathway Source: InterPro
  • digestion Source: ProtInc
  • excretion Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000080293-MONOMER.
ReactomeiR-HSA-418555. G alpha (s) signalling events.
R-HSA-420092. Glucagon-type ligand receptors.
SignaLinkiP47872.

Protein family/group databases

TCDBi9.A.14.4.10. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Secretin receptor
Short name:
SCT-R
Gene namesi
Name:SCTR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:10608. SCTR.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 143ExtracellularSequence analysisAdd BLAST121
Transmembranei144 – 167Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini168 – 174CytoplasmicSequence analysis7
Transmembranei175 – 194Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini195 – 216ExtracellularSequence analysisAdd BLAST22
Transmembranei217 – 240Helical; Name=3Sequence analysisAdd BLAST24
Topological domaini241 – 254CytoplasmicSequence analysisAdd BLAST14
Transmembranei255 – 276Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini277 – 294ExtracellularSequence analysisAdd BLAST18
Transmembranei295 – 317Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini318 – 343CytoplasmicSequence analysisAdd BLAST26
Transmembranei344 – 362Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini363 – 369ExtracellularSequence analysis7
Transmembranei370 – 392Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini393 – 440CytoplasmicSequence analysisAdd BLAST48

GO - Cellular componenti

  • cytoplasmic microtubule Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6344.
OpenTargetsiENSG00000080293.
PharmGKBiPA35018.

Chemistry databases

ChEMBLiCHEMBL1925.
DrugBankiDB00021. Secretin.
GuidetoPHARMACOLOGYi252.

Polymorphism and mutation databases

BioMutaiSCTR.
DMDMi2506489.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001285223 – 440Secretin receptorAdd BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...)Sequence analysis1
Glycosylationi100N-linked (GlcNAc...)Sequence analysis1
Glycosylationi106N-linked (GlcNAc...)Sequence analysis1
Glycosylationi128N-linked (GlcNAc...)Sequence analysis1
Glycosylationi291N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP47872.
PeptideAtlasiP47872.
PRIDEiP47872.

PTM databases

iPTMnetiP47872.
PhosphoSitePlusiP47872.

Expressioni

Gene expression databases

BgeeiENSG00000080293.
CleanExiHS_SCTR.
ExpressionAtlasiP47872. baseline and differential.
GenevisibleiP47872. HS.

Organism-specific databases

HPAiHPA007269.

Interactioni

Protein-protein interaction databases

BioGridi112248. 6 interactors.
IntActiP47872. 2 interactors.
MINTiMINT-1217464.
STRINGi9606.ENSP00000019103.

Chemistry databases

BindingDBiP47872.

Structurei

3D structure databases

ProteinModelPortaliP47872.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008249.
HOVERGENiHBG008318.
InParanoidiP47872.
KOiK04588.
OMAiFLENNGC.
OrthoDBiEOG091G0NF8.
PhylomeDBiP47872.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR002144. GPCR_2_secretin_rcpt.
[Graphical view]
PANTHERiPTHR12011:SF29. PTHR12011:SF29. 1 hit.
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00490. SECRETINR.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47872-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPHLSPPLQ QLLLPVLLAC AAHSTGALPR LCDVLQVLWE EQDQCLQELS
60 70 80 90 100
REQTGDLGTE QPVPGCEGMW DNISCWPSSV PGRMVEVECP RFLRMLTSRN
110 120 130 140 150
GSLFRNCTQD GWSETFPRPN LACGVNVNDS SNEKRHSYLL KLKVMYTVGY
160 170 180 190 200
SSSLVMLLVA LGILCAFRRL HCTRNYIHMH LFVSFILRAL SNFIKDAVLF
210 220 230 240 250
SSDDVTYCDA HRAGCKLVMV LFQYCIMANY SWLLVEGLYL HTLLAISFFS
260 270 280 290 300
ERKYLQGFVA FGWGSPAIFV ALWAIARHFL EDVGCWDINA NASIWWIIRG
310 320 330 340 350
PVILSILINF ILFINILRIL MRKLRTQETR GNEVSHYKRL ARSTLLLIPL
360 370 380 390 400
FGIHYIVFAF SPEDAMEIQL FFELALGSFQ GLVVAVLYCF LNGEVQLEVQ
410 420 430 440
KKWQQWHLRE FPLHPVASFS NSTKASHLEQ SQGTCRTSII
Length:440
Mass (Da):50,207
Last modified:November 1, 1997 - v2
Checksum:iE22CDD0EE7C0ACC1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124G → A in AAC50106 (PubMed:7864894).Curated1
Sequence conflicti210A → P in AAA87556 (PubMed:7612008).Curated1
Sequence conflicti308I → F in AAA64949 (PubMed:7700244).Curated1
Sequence conflicti333E → Q in AAA64949 (PubMed:7700244).Curated1
Sequence conflicti377G → A in AAC50106 (PubMed:7864894).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049456110D → N.Corresponds to variant rs6726491dbSNPEnsembl.1
Natural variantiVAR_033970122A → P.Corresponds to variant rs3731600dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20178 mRNA. Translation: AAC50106.1.
U28281 mRNA. Translation: AAA87556.1.
U13989 mRNA. Translation: AAA64949.1.
AB065660 Genomic DNA. Translation: BAC05886.1.
AY462218 mRNA. Translation: AAR25625.1.
AC013275 Genomic DNA. Translation: AAY14741.1.
CH471103 Genomic DNA. Translation: EAW95219.1.
CCDSiCCDS2127.1.
PIRiJC2532.
RefSeqiNP_002971.2. NM_002980.2.
UniGeneiHs.42091.

Genome annotation databases

EnsembliENST00000019103; ENSP00000019103; ENSG00000080293.
GeneIDi6344.
KEGGihsa:6344.
UCSCiuc002tma.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20178 mRNA. Translation: AAC50106.1.
U28281 mRNA. Translation: AAA87556.1.
U13989 mRNA. Translation: AAA64949.1.
AB065660 Genomic DNA. Translation: BAC05886.1.
AY462218 mRNA. Translation: AAR25625.1.
AC013275 Genomic DNA. Translation: AAY14741.1.
CH471103 Genomic DNA. Translation: EAW95219.1.
CCDSiCCDS2127.1.
PIRiJC2532.
RefSeqiNP_002971.2. NM_002980.2.
UniGeneiHs.42091.

3D structure databases

ProteinModelPortaliP47872.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112248. 6 interactors.
IntActiP47872. 2 interactors.
MINTiMINT-1217464.
STRINGi9606.ENSP00000019103.

Chemistry databases

BindingDBiP47872.
ChEMBLiCHEMBL1925.
DrugBankiDB00021. Secretin.
GuidetoPHARMACOLOGYi252.

Protein family/group databases

TCDBi9.A.14.4.10. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

PTM databases

iPTMnetiP47872.
PhosphoSitePlusiP47872.

Polymorphism and mutation databases

BioMutaiSCTR.
DMDMi2506489.

Proteomic databases

PaxDbiP47872.
PeptideAtlasiP47872.
PRIDEiP47872.

Protocols and materials databases

DNASUi6344.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000019103; ENSP00000019103; ENSG00000080293.
GeneIDi6344.
KEGGihsa:6344.
UCSCiuc002tma.4. human.

Organism-specific databases

CTDi6344.
DisGeNETi6344.
GeneCardsiSCTR.
HGNCiHGNC:10608. SCTR.
HPAiHPA007269.
MIMi182098. gene.
neXtProtiNX_P47872.
OpenTargetsiENSG00000080293.
PharmGKBiPA35018.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008249.
HOVERGENiHBG008318.
InParanoidiP47872.
KOiK04588.
OMAiFLENNGC.
OrthoDBiEOG091G0NF8.
PhylomeDBiP47872.
TreeFamiTF315710.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000080293-MONOMER.
ReactomeiR-HSA-418555. G alpha (s) signalling events.
R-HSA-420092. Glucagon-type ligand receptors.
SignaLinkiP47872.

Miscellaneous databases

GeneWikiiSecretin_receptor.
GenomeRNAii6344.
PROiP47872.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000080293.
CleanExiHS_SCTR.
ExpressionAtlasiP47872. baseline and differential.
GenevisibleiP47872. HS.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR002144. GPCR_2_secretin_rcpt.
[Graphical view]
PANTHERiPTHR12011:SF29. PTHR12011:SF29. 1 hit.
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00490. SECRETINR.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCTR_HUMAN
AccessioniPrimary (citable) accession number: P47872
Secondary accession number(s): Q12961, Q13213, Q53T00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.