P47872 (SCTR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Secretin receptor
Short name=SCT-R

Gene names

Name:

SCTR

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	440 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 2 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	digestion Traceable author statement Ref.2. Source: ProtInc excretion Traceable author statement Ref.2. Source: ProtInc
Cellular_component	cytoplasmic microtubule Inferred from direct assay PubMed 23264731. Source: UniProtKB integral to plasma membrane Traceable author statement Ref.2. Source: ProtInc
Molecular_function	secretin receptor activity Traceable author statement Ref.2. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 440	418	Secretin receptor		PRO_0000012852
Regions
	Topological domain	23 – 143	121	Extracellular Potential
	Transmembrane	144 – 167	24	Helical; Name=1; Potential
	Topological domain	168 – 174	7	Cytoplasmic Potential
	Transmembrane	175 – 194	20	Helical; Name=2; Potential
	Topological domain	195 – 216	22	Extracellular Potential
	Transmembrane	217 – 240	24	Helical; Name=3; Potential
	Topological domain	241 – 254	14	Cytoplasmic Potential
	Transmembrane	255 – 276	22	Helical; Name=4; Potential
	Topological domain	277 – 294	18	Extracellular Potential
	Transmembrane	295 – 317	23	Helical; Name=5; Potential
	Topological domain	318 – 343	26	Cytoplasmic Potential
	Transmembrane	344 – 362	19	Helical; Name=6; Potential
	Topological domain	363 – 369	7	Extracellular Potential
	Transmembrane	370 – 392	23	Helical; Name=7; Potential
	Topological domain	393 – 440	48	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	72	1	N-linked (GlcNAc...) Potential
	Glycosylation	100	1	N-linked (GlcNAc...) Potential
	Glycosylation	106	1	N-linked (GlcNAc...) Potential
	Glycosylation	128	1	N-linked (GlcNAc...) Potential
	Glycosylation	291	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	110	1	D → N. Corresponds to variant rs6726491 [ dbSNP | Ensembl ].		VAR_049456
	Natural variant	122	1	A → P. Corresponds to variant rs3731600 [ dbSNP | Ensembl ].		VAR_033970
Experimental info
	Sequence conflict	124	1	G → A in AAC50106. Ref.1
	Sequence conflict	210	1	A → P in AAA87556. Ref.2
	Sequence conflict	308	1	I → F in AAA64949. Ref.3
	Sequence conflict	333	1	E → Q in AAA64949. Ref.3
	Sequence conflict	377	1	G → A in AAC50106. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P47872 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: E22CDD0EE7C0ACC1	FASTA	440	50,207
	10 20 30 40 50 60 MRPHLSPPLQ QLLLPVLLAC AAHSTGALPR LCDVLQVLWE EQDQCLQELS REQTGDLGTE 70 80 90 100 110 120 QPVPGCEGMW DNISCWPSSV PGRMVEVECP RFLRMLTSRN GSLFRNCTQD GWSETFPRPN 130 140 150 160 170 180 LACGVNVNDS SNEKRHSYLL KLKVMYTVGY SSSLVMLLVA LGILCAFRRL HCTRNYIHMH 190 200 210 220 230 240 LFVSFILRAL SNFIKDAVLF SSDDVTYCDA HRAGCKLVMV LFQYCIMANY SWLLVEGLYL 250 260 270 280 290 300 HTLLAISFFS ERKYLQGFVA FGWGSPAIFV ALWAIARHFL EDVGCWDINA NASIWWIIRG 310 320 330 340 350 360 PVILSILINF ILFINILRIL MRKLRTQETR GNEVSHYKRL ARSTLLLIPL FGIHYIVFAF 370 380 390 400 410 420 SPEDAMEIQL FFELALGSFQ GLVVAVLYCF LNGEVQLEVQ KKWQQWHLRE FPLHPVASFS 430 440 NSTKASHLEQ SQGTCRTSII

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and functional expression of a human pancreatic secretin receptor." Jiang S., Ulrich C.D. Biochem. Biophys. Res. Commun. 207:883-890(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pancreas.
[2]	"Molecular cloning and functional characterization of a human secretin receptor." Chow B.K.-C. Biochem. Biophys. Res. Commun. 212:204-211(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pancreas.
[3]	"Molecular cloning and expression of a human secretin receptor." Patel D.R., Kong Y., Sreedharan S.P. Mol. Pharmacol. 47:467-473(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung.
[4]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." King M.M., Aronstam R.S., Sharma S.V. Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[6]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U20178 mRNA. Translation: AAC50106.1. U28281 mRNA. Translation: AAA87556.1. U13989 mRNA. Translation: AAA64949.1. AB065660 Genomic DNA. Translation: BAC05886.1. AY462218 mRNA. Translation: AAR25625.1. AC013275 Genomic DNA. Translation: AAY14741.1. CH471103 Genomic DNA. Translation: EAW95219.1.
IPI	IPI00026641.
PIR	JC2532.
RefSeq	NP_002971.2. NM_002980.2.
UniGene	Hs.42091.
3D structure databases
ProteinModelPortal	P47872.
ModBase	Search...
Protein-protein interaction databases
IntAct	P47872. 2 interactions.
MINT	MINT-1217464.
STRING	9606.ENSP00000019103.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	2506489.
Proteomic databases
PaxDb	P47872.
PRIDE	P47872.
Protocols and materials databases
DNASU	6344.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000019103; ENSP00000019103; ENSG00000080293.
GeneID	6344.
KEGG	hsa:6344.
UCSC	uc002tlz.3. human.
Organism-specific databases
CTD	6344.
GeneCards	GC02M120292.
HGNC	HGNC:10608. SCTR.
HPA	HPA007269.
MIM	182098. gene.
neXtProt	NX_P47872.
PharmGKB	PA35018.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG244152.
HOGENOM	HOG000008249.
HOVERGEN	HBG008318.
InParanoid	P47872.
KO	K04588.
OMA	EEQDQCL.
OrthoDB	EOG4GTKCZ.
PhylomeDB	P47872.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	P47872.
CleanEx	HS_SCTR.
Genevestigator	P47872.
GermOnline	ENSG00000080293. Homo sapiens.
Family and domain databases
InterPro	IPR017981. GPCR_2-like. IPR001879. GPCR_2_extracellular_dom. IPR000832. GPCR_2_secretin-like. IPR017983. GPCR_2_secretin-like_CS. IPR002144. GPCR_2_secretin_rcpt. [Graphical view]
PANTHER	PTHR12011:SF29. PTHR12011:SF29. 1 hit.
Pfam	PF00002. 7tm_2. 1 hit. PF02793. HRM. 1 hit. [Graphical view]
PRINTS	PR00249. GPCRSECRETIN. PR00490. SECRETINR.
SMART	SM00008. HormR. 1 hit. [Graphical view]
PROSITE	PS00649. G_PROTEIN_RECEP_F2_1. 1 hit. PS00650. G_PROTEIN_RECEP_F2_2. 1 hit. PS50227. G_PROTEIN_RECEP_F2_3. 1 hit. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P47872.
ChEMBL	CHEMBL1925.
DrugBank	DB00021. Secretin.
GenomeRNAi	6344.
NextBio	24644.
SOURCE	Search...

Entry information

Entry name

SCTR_HUMAN

Accession

Primary (citable) accession number: P47872
Secondary accession number(s): Q12961, Q13213, Q53T00

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 113 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.