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P47872

- SCTR_HUMAN

UniProt

P47872 - SCTR_HUMAN

Protein

Secretin receptor

Gene

SCTR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

    GO - Molecular functioni

    1. secretin receptor activity Source: ProtInc

    GO - Biological processi

    1. digestion Source: ProtInc
    2. excretion Source: ProtInc
    3. G-protein coupled receptor signaling pathway Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_18377. Glucagon-type ligand receptors.
    REACT_19327. G alpha (s) signalling events.
    SignaLinkiP47872.

    Protein family/group databases

    TCDBi9.A.14.4.10. the g-protein-coupled receptor (gpcr) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Secretin receptor
    Short name:
    SCT-R
    Gene namesi
    Name:SCTR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:10608. SCTR.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic microtubule Source: UniProtKB
    2. integral component of plasma membrane Source: ProtInc
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35018.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 440418Secretin receptorPRO_0000012852Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi291 – 2911N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP47872.
    PRIDEiP47872.

    Expressioni

    Gene expression databases

    BgeeiP47872.
    CleanExiHS_SCTR.
    GenevestigatoriP47872.

    Organism-specific databases

    HPAiHPA007269.

    Interactioni

    Protein-protein interaction databases

    BioGridi112248. 6 interactions.
    IntActiP47872. 2 interactions.
    MINTiMINT-1217464.
    STRINGi9606.ENSP00000019103.

    Structurei

    3D structure databases

    ProteinModelPortaliP47872.
    SMRiP47872. Positions 40-126, 142-398.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 143121ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini168 – 1747CytoplasmicSequence Analysis
    Topological domaini195 – 21622ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini241 – 25414CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini277 – 29418ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini318 – 34326CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini363 – 3697ExtracellularSequence Analysis
    Topological domaini393 – 44048CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei144 – 16724Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei175 – 19420Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei217 – 24024Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei255 – 27622Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei295 – 31723Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei344 – 36219Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei370 – 39223Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG244152.
    HOGENOMiHOG000008249.
    HOVERGENiHBG008318.
    InParanoidiP47872.
    KOiK04588.
    OMAiEEQDQCL.
    OrthoDBiEOG7TF78W.
    PhylomeDBiP47872.
    TreeFamiTF315710.

    Family and domain databases

    InterProiIPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR002144. GPCR_2_secretin_rcpt.
    [Graphical view]
    PANTHERiPTHR12011:SF29. PTHR12011:SF29. 1 hit.
    PfamiPF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view]
    PRINTSiPR00249. GPCRSECRETIN.
    PR00490. SECRETINR.
    SMARTiSM00008. HormR. 1 hit.
    [Graphical view]
    PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P47872-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRPHLSPPLQ QLLLPVLLAC AAHSTGALPR LCDVLQVLWE EQDQCLQELS    50
    REQTGDLGTE QPVPGCEGMW DNISCWPSSV PGRMVEVECP RFLRMLTSRN 100
    GSLFRNCTQD GWSETFPRPN LACGVNVNDS SNEKRHSYLL KLKVMYTVGY 150
    SSSLVMLLVA LGILCAFRRL HCTRNYIHMH LFVSFILRAL SNFIKDAVLF 200
    SSDDVTYCDA HRAGCKLVMV LFQYCIMANY SWLLVEGLYL HTLLAISFFS 250
    ERKYLQGFVA FGWGSPAIFV ALWAIARHFL EDVGCWDINA NASIWWIIRG 300
    PVILSILINF ILFINILRIL MRKLRTQETR GNEVSHYKRL ARSTLLLIPL 350
    FGIHYIVFAF SPEDAMEIQL FFELALGSFQ GLVVAVLYCF LNGEVQLEVQ 400
    KKWQQWHLRE FPLHPVASFS NSTKASHLEQ SQGTCRTSII 440
    Length:440
    Mass (Da):50,207
    Last modified:November 1, 1997 - v2
    Checksum:iE22CDD0EE7C0ACC1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti124 – 1241G → A in AAC50106. (PubMed:7864894)Curated
    Sequence conflicti210 – 2101A → P in AAA87556. (PubMed:7612008)Curated
    Sequence conflicti308 – 3081I → F in AAA64949. (PubMed:7700244)Curated
    Sequence conflicti333 – 3331E → Q in AAA64949. (PubMed:7700244)Curated
    Sequence conflicti377 – 3771G → A in AAC50106. (PubMed:7864894)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti110 – 1101D → N.
    Corresponds to variant rs6726491 [ dbSNP | Ensembl ].
    VAR_049456
    Natural varianti122 – 1221A → P.
    Corresponds to variant rs3731600 [ dbSNP | Ensembl ].
    VAR_033970

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U20178 mRNA. Translation: AAC50106.1.
    U28281 mRNA. Translation: AAA87556.1.
    U13989 mRNA. Translation: AAA64949.1.
    AB065660 Genomic DNA. Translation: BAC05886.1.
    AY462218 mRNA. Translation: AAR25625.1.
    AC013275 Genomic DNA. Translation: AAY14741.1.
    CH471103 Genomic DNA. Translation: EAW95219.1.
    CCDSiCCDS2127.1.
    PIRiJC2532.
    RefSeqiNP_002971.2. NM_002980.2.
    UniGeneiHs.42091.

    Genome annotation databases

    EnsembliENST00000019103; ENSP00000019103; ENSG00000080293.
    GeneIDi6344.
    KEGGihsa:6344.
    UCSCiuc002tlz.3. human.

    Polymorphism databases

    DMDMi2506489.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U20178 mRNA. Translation: AAC50106.1 .
    U28281 mRNA. Translation: AAA87556.1 .
    U13989 mRNA. Translation: AAA64949.1 .
    AB065660 Genomic DNA. Translation: BAC05886.1 .
    AY462218 mRNA. Translation: AAR25625.1 .
    AC013275 Genomic DNA. Translation: AAY14741.1 .
    CH471103 Genomic DNA. Translation: EAW95219.1 .
    CCDSi CCDS2127.1.
    PIRi JC2532.
    RefSeqi NP_002971.2. NM_002980.2.
    UniGenei Hs.42091.

    3D structure databases

    ProteinModelPortali P47872.
    SMRi P47872. Positions 40-126, 142-398.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112248. 6 interactions.
    IntActi P47872. 2 interactions.
    MINTi MINT-1217464.
    STRINGi 9606.ENSP00000019103.

    Chemistry

    BindingDBi P47872.
    ChEMBLi CHEMBL1925.
    DrugBanki DB00021. Secretin.
    GuidetoPHARMACOLOGYi 252.

    Protein family/group databases

    TCDBi 9.A.14.4.10. the g-protein-coupled receptor (gpcr) family.
    GPCRDBi Search...

    Polymorphism databases

    DMDMi 2506489.

    Proteomic databases

    PaxDbi P47872.
    PRIDEi P47872.

    Protocols and materials databases

    DNASUi 6344.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000019103 ; ENSP00000019103 ; ENSG00000080293 .
    GeneIDi 6344.
    KEGGi hsa:6344.
    UCSCi uc002tlz.3. human.

    Organism-specific databases

    CTDi 6344.
    GeneCardsi GC02M120292.
    HGNCi HGNC:10608. SCTR.
    HPAi HPA007269.
    MIMi 182098. gene.
    neXtProti NX_P47872.
    PharmGKBi PA35018.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG244152.
    HOGENOMi HOG000008249.
    HOVERGENi HBG008318.
    InParanoidi P47872.
    KOi K04588.
    OMAi EEQDQCL.
    OrthoDBi EOG7TF78W.
    PhylomeDBi P47872.
    TreeFami TF315710.

    Enzyme and pathway databases

    Reactomei REACT_18377. Glucagon-type ligand receptors.
    REACT_19327. G alpha (s) signalling events.
    SignaLinki P47872.

    Miscellaneous databases

    GeneWikii Secretin_receptor.
    GenomeRNAii 6344.
    NextBioi 24644.
    PROi P47872.
    SOURCEi Search...

    Gene expression databases

    Bgeei P47872.
    CleanExi HS_SCTR.
    Genevestigatori P47872.

    Family and domain databases

    InterProi IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR002144. GPCR_2_secretin_rcpt.
    [Graphical view ]
    PANTHERi PTHR12011:SF29. PTHR12011:SF29. 1 hit.
    Pfami PF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view ]
    PRINTSi PR00249. GPCRSECRETIN.
    PR00490. SECRETINR.
    SMARTi SM00008. HormR. 1 hit.
    [Graphical view ]
    PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and functional expression of a human pancreatic secretin receptor."
      Jiang S., Ulrich C.D.
      Biochem. Biophys. Res. Commun. 207:883-890(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pancreas.
    2. "Molecular cloning and functional characterization of a human secretin receptor."
      Chow B.K.-C.
      Biochem. Biophys. Res. Commun. 212:204-211(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pancreas.
    3. "Molecular cloning and expression of a human secretin receptor."
      Patel D.R., Kong Y., Sreedharan S.P.
      Mol. Pharmacol. 47:467-473(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    4. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      King M.M., Aronstam R.S., Sharma S.V.
      Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiSCTR_HUMAN
    AccessioniPrimary (citable) accession number: P47872
    Secondary accession number(s): Q12961, Q13213, Q53T00
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3