Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P47872

- SCTR_HUMAN

UniProt

P47872 - SCTR_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Secretin receptor

Gene

SCTR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  1. secretin receptor activity Source: ProtInc

GO - Biological processi

  1. digestion Source: ProtInc
  2. excretion Source: ProtInc
  3. G-protein coupled receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18377. Glucagon-type ligand receptors.
REACT_19327. G alpha (s) signalling events.
SignaLinkiP47872.

Protein family/group databases

TCDBi9.A.14.4.10. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Secretin receptor
Short name:
SCT-R
Gene namesi
Name:SCTR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:10608. SCTR.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasmic microtubule Source: UniProtKB
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35018.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 440418Secretin receptorPRO_0000012852Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi291 – 2911N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP47872.
PRIDEiP47872.

Expressioni

Gene expression databases

BgeeiP47872.
CleanExiHS_SCTR.
GenevestigatoriP47872.

Organism-specific databases

HPAiHPA007269.

Interactioni

Protein-protein interaction databases

BioGridi112248. 6 interactions.
IntActiP47872. 2 interactions.
MINTiMINT-1217464.
STRINGi9606.ENSP00000019103.

Structurei

3D structure databases

ProteinModelPortaliP47872.
SMRiP47872. Positions 40-126, 142-398.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 143121ExtracellularSequence AnalysisAdd
BLAST
Topological domaini168 – 1747CytoplasmicSequence Analysis
Topological domaini195 – 21622ExtracellularSequence AnalysisAdd
BLAST
Topological domaini241 – 25414CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini277 – 29418ExtracellularSequence AnalysisAdd
BLAST
Topological domaini318 – 34326CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini363 – 3697ExtracellularSequence Analysis
Topological domaini393 – 44048CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei144 – 16724Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei175 – 19420Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei217 – 24024Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei255 – 27622Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei295 – 31723Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei344 – 36219Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei370 – 39223Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG244152.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008249.
HOVERGENiHBG008318.
InParanoidiP47872.
KOiK04588.
OMAiEEQDQCL.
OrthoDBiEOG7TF78W.
PhylomeDBiP47872.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR002144. GPCR_2_secretin_rcpt.
[Graphical view]
PANTHERiPTHR12011:SF29. PTHR12011:SF29. 1 hit.
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00490. SECRETINR.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47872-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRPHLSPPLQ QLLLPVLLAC AAHSTGALPR LCDVLQVLWE EQDQCLQELS
60 70 80 90 100
REQTGDLGTE QPVPGCEGMW DNISCWPSSV PGRMVEVECP RFLRMLTSRN
110 120 130 140 150
GSLFRNCTQD GWSETFPRPN LACGVNVNDS SNEKRHSYLL KLKVMYTVGY
160 170 180 190 200
SSSLVMLLVA LGILCAFRRL HCTRNYIHMH LFVSFILRAL SNFIKDAVLF
210 220 230 240 250
SSDDVTYCDA HRAGCKLVMV LFQYCIMANY SWLLVEGLYL HTLLAISFFS
260 270 280 290 300
ERKYLQGFVA FGWGSPAIFV ALWAIARHFL EDVGCWDINA NASIWWIIRG
310 320 330 340 350
PVILSILINF ILFINILRIL MRKLRTQETR GNEVSHYKRL ARSTLLLIPL
360 370 380 390 400
FGIHYIVFAF SPEDAMEIQL FFELALGSFQ GLVVAVLYCF LNGEVQLEVQ
410 420 430 440
KKWQQWHLRE FPLHPVASFS NSTKASHLEQ SQGTCRTSII
Length:440
Mass (Da):50,207
Last modified:November 1, 1997 - v2
Checksum:iE22CDD0EE7C0ACC1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti124 – 1241G → A in AAC50106. (PubMed:7864894)Curated
Sequence conflicti210 – 2101A → P in AAA87556. (PubMed:7612008)Curated
Sequence conflicti308 – 3081I → F in AAA64949. (PubMed:7700244)Curated
Sequence conflicti333 – 3331E → Q in AAA64949. (PubMed:7700244)Curated
Sequence conflicti377 – 3771G → A in AAC50106. (PubMed:7864894)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti110 – 1101D → N.
Corresponds to variant rs6726491 [ dbSNP | Ensembl ].
VAR_049456
Natural varianti122 – 1221A → P.
Corresponds to variant rs3731600 [ dbSNP | Ensembl ].
VAR_033970

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U20178 mRNA. Translation: AAC50106.1.
U28281 mRNA. Translation: AAA87556.1.
U13989 mRNA. Translation: AAA64949.1.
AB065660 Genomic DNA. Translation: BAC05886.1.
AY462218 mRNA. Translation: AAR25625.1.
AC013275 Genomic DNA. Translation: AAY14741.1.
CH471103 Genomic DNA. Translation: EAW95219.1.
CCDSiCCDS2127.1.
PIRiJC2532.
RefSeqiNP_002971.2. NM_002980.2.
UniGeneiHs.42091.

Genome annotation databases

EnsembliENST00000019103; ENSP00000019103; ENSG00000080293.
GeneIDi6344.
KEGGihsa:6344.
UCSCiuc002tlz.3. human.

Polymorphism databases

DMDMi2506489.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U20178 mRNA. Translation: AAC50106.1 .
U28281 mRNA. Translation: AAA87556.1 .
U13989 mRNA. Translation: AAA64949.1 .
AB065660 Genomic DNA. Translation: BAC05886.1 .
AY462218 mRNA. Translation: AAR25625.1 .
AC013275 Genomic DNA. Translation: AAY14741.1 .
CH471103 Genomic DNA. Translation: EAW95219.1 .
CCDSi CCDS2127.1.
PIRi JC2532.
RefSeqi NP_002971.2. NM_002980.2.
UniGenei Hs.42091.

3D structure databases

ProteinModelPortali P47872.
SMRi P47872. Positions 40-126, 142-398.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112248. 6 interactions.
IntActi P47872. 2 interactions.
MINTi MINT-1217464.
STRINGi 9606.ENSP00000019103.

Chemistry

BindingDBi P47872.
ChEMBLi CHEMBL1925.
DrugBanki DB00021. Secretin.
GuidetoPHARMACOLOGYi 252.

Protein family/group databases

TCDBi 9.A.14.4.10. the g-protein-coupled receptor (gpcr) family.
GPCRDBi Search...

Polymorphism databases

DMDMi 2506489.

Proteomic databases

PaxDbi P47872.
PRIDEi P47872.

Protocols and materials databases

DNASUi 6344.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000019103 ; ENSP00000019103 ; ENSG00000080293 .
GeneIDi 6344.
KEGGi hsa:6344.
UCSCi uc002tlz.3. human.

Organism-specific databases

CTDi 6344.
GeneCardsi GC02M120292.
HGNCi HGNC:10608. SCTR.
HPAi HPA007269.
MIMi 182098. gene.
neXtProti NX_P47872.
PharmGKBi PA35018.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG244152.
GeneTreei ENSGT00760000118800.
HOGENOMi HOG000008249.
HOVERGENi HBG008318.
InParanoidi P47872.
KOi K04588.
OMAi EEQDQCL.
OrthoDBi EOG7TF78W.
PhylomeDBi P47872.
TreeFami TF315710.

Enzyme and pathway databases

Reactomei REACT_18377. Glucagon-type ligand receptors.
REACT_19327. G alpha (s) signalling events.
SignaLinki P47872.

Miscellaneous databases

GeneWikii Secretin_receptor.
GenomeRNAii 6344.
NextBioi 24644.
PROi P47872.
SOURCEi Search...

Gene expression databases

Bgeei P47872.
CleanExi HS_SCTR.
Genevestigatori P47872.

Family and domain databases

InterProi IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR002144. GPCR_2_secretin_rcpt.
[Graphical view ]
PANTHERi PTHR12011:SF29. PTHR12011:SF29. 1 hit.
Pfami PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view ]
PRINTSi PR00249. GPCRSECRETIN.
PR00490. SECRETINR.
SMARTi SM00008. HormR. 1 hit.
[Graphical view ]
PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and functional expression of a human pancreatic secretin receptor."
    Jiang S., Ulrich C.D.
    Biochem. Biophys. Res. Commun. 207:883-890(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pancreas.
  2. "Molecular cloning and functional characterization of a human secretin receptor."
    Chow B.K.-C.
    Biochem. Biophys. Res. Commun. 212:204-211(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pancreas.
  3. "Molecular cloning and expression of a human secretin receptor."
    Patel D.R., Kong Y., Sreedharan S.P.
    Mol. Pharmacol. 47:467-473(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  4. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    King M.M., Aronstam R.S., Sharma S.V.
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiSCTR_HUMAN
AccessioniPrimary (citable) accession number: P47872
Secondary accession number(s): Q12961, Q13213, Q53T00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3