Glucagon receptor precursor - Homo sapiens (Human)

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P47871 (GLR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 101. History...

Clusters with 100%, 90%, 50% identity |

Documents (7) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Glucagon receptor
Short name=GL-R

Gene names

Name:

GCGR

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	477 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 2 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Disease	Diabetes mellitus
Domain	Signal Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular response to glucagon stimulus Traceable author statement. Source: Reactome energy reserve metabolic process Traceable author statement. Source: Reactome regulation of blood pressure Traceable author statement. Source: ProtInc response to nutrient Traceable author statement. Source: ProtInc
Cellular component	integral to membrane Traceable author statement. Source: ProtInc plasma membrane Traceable author statement. Source: Reactome
Molecular function	glucagon receptor activity Traceable author statement. Source: ProtInc guanyl-nucleotide exchange factor activity Traceable author statement. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 25

Potential

Chain

26 – 477

452

Glucagon receptor

PRO_0000012832

Regions

Topological domain

26 – 142

117

Extracellular Potential

Transmembrane

143 – 166

Helical; Name=1; Potential

Topological domain

167 – 173

Cytoplasmic Potential

Transmembrane

174 – 193

Helical; Name=2; Potential

Topological domain

194 – 225

Extracellular Potential

Transmembrane

226 – 249

Helical; Name=3; Potential

Topological domain

250 – 263

Cytoplasmic Potential

Transmembrane

264 – 285

Helical; Name=4; Potential

Topological domain

286 – 303

Extracellular Potential

Transmembrane

304 – 326

Helical; Name=5; Potential

Topological domain

327 – 350

Cytoplasmic Potential

Transmembrane

351 – 369

Helical; Name=6; Potential

Topological domain

370 – 381

Extracellular Potential

Transmembrane

382 – 404

Helical; Name=7; Potential

Topological domain

405 – 477

Cytoplasmic Potential

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

43 ↔ 67

By similarity

Disulfide bond

58 ↔ 100

By similarity

Disulfide bond

81 ↔ 121

By similarity

Natural variations

Natural variant

G → S. Ref.6
Corresponds to variant rs1801483 [ dbSNP | Ensembl ].

VAR_003581

Natural variant

114

P → A.
Corresponds to variant rs5385 [ dbSNP | Ensembl ].

VAR_014837

Natural variant

303

F → C.
Corresponds to variant rs5387 [ dbSNP | Ensembl ].

VAR_033966

Sequences

Sequence

Length

Mass (Da)

Tools

P47871 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: ADBB477C6267AE6E
Show »

FASTA

477

54,009

        10         20         30         40         50         60 
MPPCQPQRPL LLLLLLLACQ PQVPSAQVMD FLFEKWKLYG DQCHHNLSLL PPPTELVCNR 

        70         80         90        100        110        120 
TFDKYSCWPD TPANTTANIS CPWYLPWHHK VQHRFVFKRC GPDGQWVRGP RGQPWRDASQ 

       130        140        150        160        170        180 
CQMDGEEIEV QKEVAKMYSS FQVMYTVGYS LSLGALLLAL AILGGLSKLH CTRNAIHANL 

       190        200        210        220        230        240 
FASFVLKASS VLVIDGLLRT RYSQKIGDDL SVSTWLSDGA VAGCRVAAVF MQYGIVANYC 

       250        260        270        280        290        300 
WLLVEGLYLH NLLGLATLPE RSFFSLYLGI GWGAPMLFVV PWAVVKCLFE NVQCWTSNDN 

       310        320        330        340        350        360 
MGFWWILRFP VFLAILINFF IFVRIVQLLV AKLRARQMHH TDYKFRLAKS TLTLIPLLGV 

       370        380        390        400        410        420 
HEVVFAFVTD EHAQGTLRSA KLFFDLFLSS FQGLLVAVLY CFLNKEVQSE LRRRWHRWRL 

       430        440        450        460        470 
GKVLWEERNT SNHRASSSPG HGPPSKELQF GRGGGSQDSS AETPLAGGLP RLAESPF

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of a human glucagon receptor." Macneil D.J., Occi J.L., Hey P.J., Strader C.D., Graziano M.P. Biochem. Biophys. Res. Commun. 198:328-334(1994) [PubMed: 7507321] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"The human glucagon receptor encoding gene: structure, cDNA sequence and chromosomal localization." Lok S., Kuijper J.L., Jelinek L.J., Kramer J.M., Whitmore T.E., Sprecher C.A., Mathewes S., Grant F.J., Biggs S.H., Rosenberg G.B. Gene 140:203-209(1994) [PubMed: 8144028] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
[4]	"Localization of the glucagon receptor gene to human chromosome band 17q25." Menzel S., Stoffel M., Espinosa R. III, Fernald A.A., Le Beau M.M., Bell G.I. Genomics 20:327-328(1994) [PubMed: 8020989] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 21-54. Tissue: Placenta.
[5]	"Conformational dimorphism of self-peptides and molecular mimicry in a disease-associated HLA-B27 subtype." Ruckert C., Fiorillo M.T., Loll B., Moretti R., Biesiadka J., Saenger W., Ziegler A., Sorrentino R., Uchanska-Ziegler B. J. Biol. Chem. 281:2306-2316(2006) [PubMed: 16221670] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.2 ANGSTROMS) OF 412-420 IN COMPLEX WITH CLASS I MHC.
[6]	"A mutation in the glucagon receptor gene (Gly40Ser): heterogeneity in the association with diabetes mellitus." Fujisawa T., Ikegami H., Yamato E., Takekawa K., Nakagawa Y., Hamada Y., Ueda H., Fukuda M., Ogihara T. Diabetologia 38:983-985(1995) [PubMed: 7589886] [Abstract] Cited for: VARIANT SER-40.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U03469 mRNA. Translation: AAC52063.1.
L20316 mRNA. Translation: AAA53628.1.
BC104854 mRNA. Translation: AAI04855.1.
BC112041 mRNA. Translation: AAI12042.1.
L24751 Genomic DNA. Translation: AAA35897.1.

IPI

IPI00412345.

PIR

JC2041.

RefSeq

NP_000151.1. NM_000160.3.

UniGene

Hs.208.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3CZF	X-ray	1.20	C	412-420	[»]

ProteinModelPortal

P47871.

SMR

P47871. Positions 26-124.

ModBase

Search...

Protein-protein interaction databases

IntAct

P47871. 2 interactions.

STRING

P47871.

Protein family/group databases

GPCRDB

Search...

PTM databases

PhosphoSite

P47871.

Polymorphism databases

DMDM

1346144.

Proteomic databases

PRIDE

P47871.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000400723; ENSP00000383558; ENSG00000215644.

GeneID

2642.

KEGG

hsa:2642.

Organism-specific databases

CTD

2642.

GeneCards

GC17P079763.

H-InvDB

HIX0039685.

HGNC

HGNC:4192. GCGR.

MIM

138033. gene.

neXtProt

NX_P47871.

PharmGKB

PA28607.

GenAtlas

Search...

Phylogenomic databases

GeneTree

ENSGT00580000081498.

HOGENOM

HBG447108.

HOVERGEN

HBG008318.

InParanoid

P47871.

OMA

GIVANYC.

OrthoDB

EOG473PRN.

PhylomeDB

P47871.

Enzyme and pathway databases

Reactome

REACT_111102. Signal Transduction.
REACT_111217. Metabolism.

Gene expression databases

ArrayExpress

P47871.

Bgee

P47871.

CleanEx

HS_GCGR.

Genevestigator

P47871.

Family and domain databases

InterPro

IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003290. GPCR_2_GLP1/glucagon_rcpt.
IPR003291. GPCR_2_glucagon_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]

K04583.

PANTHER

PTHR12011:SF71. Glucgn_rcpt. 1 hit.

Pfam

PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]

PRINTS

PR01353. GLUCAGNFAMLY.
PR01354. GLUCAGONR.
PR00249. GPCRSECRETIN.

SMART

SM00008. HormR. 1 hit.
[Graphical view]

PROSITE

PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

DrugBank

DB00040. Glucagon recombinant.

NextBio

10416.

SOURCE

Search...

Entry information

Entry name

GLR_HUMAN

Accession

Primary (citable) accession number: P47871
Secondary accession number(s): Q2M3M5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	January 25, 2012
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.