Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P47871

- GLR_HUMAN

UniProt

P47871 - GLR_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glucagon receptor

Gene

GCGR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.5 Publications

GO - Molecular functioni

  1. glucagon receptor activity Source: UniProtKB
  2. guanyl-nucleotide exchange factor activity Source: Reactome
  3. peptide hormone binding Source: Ensembl

GO - Biological processi

  1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
  2. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: UniProtKB
  3. cellular response to glucagon stimulus Source: UniProtKB
  4. energy reserve metabolic process Source: Reactome
  5. exocytosis Source: Ensembl
  6. generation of precursor metabolites and energy Source: ProtInc
  7. glucose homeostasis Source: UniProtKB
  8. hormone-mediated signaling pathway Source: Ensembl
  9. positive regulation of GTPase activity Source: GOC
  10. regulation of blood pressure Source: ProtInc
  11. regulation of glycogen metabolic process Source: UniProtKB
  12. response to nutrient Source: ProtInc
  13. response to starvation Source: UniProtKB
  14. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_1665. Glucagon signaling in metabolic regulation.
REACT_18283. G alpha (q) signalling events.
REACT_18377. Glucagon-type ligand receptors.
REACT_19327. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucagon receptor
Short name:
GL-R
Gene namesi
Name:GCGR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:4192. GCGR.

Subcellular locationi

Cell membrane 4 Publications; Multi-pass membrane protein 4 Publications
Note: Is rapidly internalized after ligand-binding.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 136111ExtracellularAdd
BLAST
Transmembranei137 – 16125Helical; Name=1Add
BLAST
Topological domaini162 – 17312CytoplasmicAdd
BLAST
Transmembranei174 – 19825Helical; Name=2Add
BLAST
Topological domaini199 – 22527ExtracellularAdd
BLAST
Transmembranei226 – 24924Helical; Name=3Add
BLAST
Topological domaini250 – 26314CytoplasmicAdd
BLAST
Transmembranei264 – 28522Helical; Name=4Add
BLAST
Topological domaini286 – 30318ExtracellularAdd
BLAST
Transmembranei304 – 32623Helical; Name=5Add
BLAST
Topological domaini327 – 35024CytoplasmicAdd
BLAST
Transmembranei351 – 36919Helical; Name=6Add
BLAST
Topological domaini370 – 38112ExtracellularAdd
BLAST
Transmembranei382 – 40221Helical; Name=7Add
BLAST
Topological domaini403 – 47775CytoplasmicAdd
BLAST

GO - Cellular componenti

  1. endosome Source: Ensembl
  2. integral component of membrane Source: ProtInc
  3. integral component of plasma membrane Source: UniProtKB
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi36 – 361W → A: Abolishes glucagon binding. 1 Publication
Mutagenesisi63 – 631D → A: Abolishes glucagon binding. 1 Publication
Mutagenesisi65 – 651Y → A: Strongly reduced affinity for glucagon. Increased constitutive signaling via G-proteins. 1 Publication
Mutagenesisi113 – 1131Q → A or N: No effect on affinity for glucagon. 1 Publication
Mutagenesisi113 – 1131Q → E: Strongly reduced affinity for glucagon. 1 Publication
Mutagenesisi135 – 1351A → P: Abolishes glucagon binding. 1 Publication
Mutagenesisi145 – 1451Y → A: Abolishes glucagon binding. 1 Publication
Mutagenesisi149 – 1491Y → A: Abolishes expression at cell surface and glucagon binding. 1 Publication
Mutagenesisi198 – 1981L → A: Abolishes glucagon binding. 1 Publication
Mutagenesisi201 – 2011R → D: Abolishes glucagon binding. 1 Publication
Mutagenesisi202 – 2021Y → A: Abolishes glucagon binding. 1 Publication
Mutagenesisi208 – 2081D → Q: Abolishes glucagon binding. 1 Publication
Mutagenesisi215 – 2151W → L: Abolishes glucagon binding. 1 Publication
Mutagenesisi232 – 2321Q → L: Abolishes expression at cell surface and glucagon binding. 1 Publication
Mutagenesisi233 – 2331Y → A: Abolishes glucagon binding. Strongly reduces expression at the cell surface. 1 Publication
Mutagenesisi286 – 2861K → L: Abolishes glucagon binding. 1 Publication
Mutagenesisi290 – 2901E → A: Abolishes glucagon binding. 1 Publication
Mutagenesisi294 – 2941C → A or S: Abolishes glucagon binding. 1 Publication
Mutagenesisi295 – 2951W → A or H: Abolishes glucagon binding. 1 Publication
Mutagenesisi304 – 3041W → Q: Abolishes glucagon binding. 1 Publication
Mutagenesisi382 – 3821L → A: Abolishes glucagon binding. 1 Publication
Mutagenesisi386 – 3861L → F: Abolishes glucagon binding. 1 Publication

Keywords - Diseasei

Diabetes mellitus

Organism-specific databases

PharmGKBiPA28607.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 477452Glucagon receptorPRO_0000012832Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 67
Glycosylationi46 – 461N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi58 ↔ 100
Glycosylationi59 – 591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi74 – 741N-linked (GlcNAc...)1 Publication
Glycosylationi78 – 781N-linked (GlcNAc...)1 Publication
Disulfide bondi81 ↔ 121

Post-translational modificationi

Ligand-binding promotes phosphorylation of serine residues in the C-terminal cytoplasmic domain. Phosphorylation is important for receptor endocytosis after ligand-binding.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP47871.
PRIDEiP47871.

PTM databases

PhosphoSiteiP47871.

Expressioni

Gene expression databases

BgeeiP47871.
CleanExiHS_GCGR.
ExpressionAtlasiP47871. baseline.
GenevestigatoriP47871.

Interactioni

Protein-protein interaction databases

BioGridi108912. 3 interactions.
IntActiP47871. 4 interactions.
STRINGi9606.ENSP00000383558.

Structurei

Secondary structure

1
477
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi31 – 4919Combined sources
Beta strandi54 – 585Combined sources
Beta strandi64 – 685Combined sources
Beta strandi75 – 806Combined sources
Turni86 – 905Combined sources
Beta strandi95 – 1006Combined sources
Beta strandi104 – 1063Combined sources
Helixi119 – 1213Combined sources
Helixi127 – 16337Combined sources
Beta strandi164 – 1685Combined sources
Helixi173 – 1764Combined sources
Turni177 – 1793Combined sources
Helixi180 – 19718Combined sources
Helixi218 – 2214Combined sources
Turni222 – 2265Combined sources
Helixi227 – 24721Combined sources
Helixi250 – 2545Combined sources
Helixi263 – 2664Combined sources
Helixi271 – 2733Combined sources
Helixi274 – 2774Combined sources
Helixi281 – 2899Combined sources
Beta strandi293 – 2953Combined sources
Helixi301 – 3066Combined sources
Helixi308 – 32922Combined sources
Helixi331 – 3344Combined sources
Helixi343 – 3519Combined sources
Turni352 – 3543Combined sources
Helixi357 – 3615Combined sources
Turni362 – 3687Combined sources
Helixi375 – 39016Combined sources
Helixi392 – 4009Combined sources
Turni401 – 4033Combined sources
Helixi405 – 42824Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2A83X-ray1.40C412-420[»]
3CZFX-ray1.20C412-420[»]
4ERSX-ray2.64A28-123[»]
4L6RX-ray3.30A123-432[»]
4LF3X-ray2.74C/F29-123[»]
ProteinModelPortaliP47871.
SMRiP47871. Positions 28-429.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP47871.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG263329.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008250.
HOVERGENiHBG008318.
InParanoidiP47871.
KOiK04583.
OrthoDBiEOG7TF78W.
PhylomeDBiP47871.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003290. GPCR_2_GLP1/glucagon_rcpt.
IPR003291. GPCR_2_glucagon_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01353. GLUCAGNFAMLY.
PR01354. GLUCAGONR.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47871-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPPCQPQRPL LLLLLLLACQ PQVPSAQVMD FLFEKWKLYG DQCHHNLSLL
60 70 80 90 100
PPPTELVCNR TFDKYSCWPD TPANTTANIS CPWYLPWHHK VQHRFVFKRC
110 120 130 140 150
GPDGQWVRGP RGQPWRDASQ CQMDGEEIEV QKEVAKMYSS FQVMYTVGYS
160 170 180 190 200
LSLGALLLAL AILGGLSKLH CTRNAIHANL FASFVLKASS VLVIDGLLRT
210 220 230 240 250
RYSQKIGDDL SVSTWLSDGA VAGCRVAAVF MQYGIVANYC WLLVEGLYLH
260 270 280 290 300
NLLGLATLPE RSFFSLYLGI GWGAPMLFVV PWAVVKCLFE NVQCWTSNDN
310 320 330 340 350
MGFWWILRFP VFLAILINFF IFVRIVQLLV AKLRARQMHH TDYKFRLAKS
360 370 380 390 400
TLTLIPLLGV HEVVFAFVTD EHAQGTLRSA KLFFDLFLSS FQGLLVAVLY
410 420 430 440 450
CFLNKEVQSE LRRRWHRWRL GKVLWEERNT SNHRASSSPG HGPPSKELQF
460 470
GRGGGSQDSS AETPLAGGLP RLAESPF
Length:477
Mass (Da):54,009
Last modified:February 1, 1996 - v1
Checksum:iADBB477C6267AE6E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti40 – 401G → S.1 Publication
Corresponds to variant rs1801483 [ dbSNP | Ensembl ].
VAR_003581
Natural varianti86 – 861P → S Abolishes glucagon binding. 1 Publication
VAR_069815
Natural varianti114 – 1141P → A.
Corresponds to variant rs5385 [ dbSNP | Ensembl ].
VAR_014837
Natural varianti303 – 3031F → C.
Corresponds to variant rs5387 [ dbSNP | Ensembl ].
VAR_033966

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03469 mRNA. Translation: AAC52063.1.
L20316 mRNA. Translation: AAA53628.1.
BC104854 mRNA. Translation: AAI04855.1.
BC112041 mRNA. Translation: AAI12042.1.
L24751 Genomic DNA. Translation: AAA35897.1.
CCDSiCCDS54177.1.
PIRiJC2041.
RefSeqiNP_000151.1. NM_000160.4.
XP_006722340.1. XM_006722277.1.
UniGeneiHs.208.

Genome annotation databases

EnsembliENST00000400723; ENSP00000383558; ENSG00000215644.
GeneIDi2642.
KEGGihsa:2642.
UCSCiuc010wuw.2. human.

Polymorphism databases

DMDMi1346144.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03469 mRNA. Translation: AAC52063.1 .
L20316 mRNA. Translation: AAA53628.1 .
BC104854 mRNA. Translation: AAI04855.1 .
BC112041 mRNA. Translation: AAI12042.1 .
L24751 Genomic DNA. Translation: AAA35897.1 .
CCDSi CCDS54177.1.
PIRi JC2041.
RefSeqi NP_000151.1. NM_000160.4.
XP_006722340.1. XM_006722277.1.
UniGenei Hs.208.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2A83 X-ray 1.40 C 412-420 [» ]
3CZF X-ray 1.20 C 412-420 [» ]
4ERS X-ray 2.64 A 28-123 [» ]
4L6R X-ray 3.30 A 123-432 [» ]
4LF3 X-ray 2.74 C/F 29-123 [» ]
ProteinModelPortali P47871.
SMRi P47871. Positions 28-429.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108912. 3 interactions.
IntActi P47871. 4 interactions.
STRINGi 9606.ENSP00000383558.

Chemistry

BindingDBi P47871.
ChEMBLi CHEMBL1985.
DrugBanki DB00040. Glucagon recombinant.
GuidetoPHARMACOLOGYi 251.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P47871.

Polymorphism databases

DMDMi 1346144.

Proteomic databases

PaxDbi P47871.
PRIDEi P47871.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000400723 ; ENSP00000383558 ; ENSG00000215644 .
GeneIDi 2642.
KEGGi hsa:2642.
UCSCi uc010wuw.2. human.

Organism-specific databases

CTDi 2642.
GeneCardsi GC17P079763.
HGNCi HGNC:4192. GCGR.
MIMi 138033. gene.
neXtProti NX_P47871.
PharmGKBi PA28607.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG263329.
GeneTreei ENSGT00760000118800.
HOGENOMi HOG000008250.
HOVERGENi HBG008318.
InParanoidi P47871.
KOi K04583.
OrthoDBi EOG7TF78W.
PhylomeDBi P47871.
TreeFami TF315710.

Enzyme and pathway databases

Reactomei REACT_1665. Glucagon signaling in metabolic regulation.
REACT_18283. G alpha (q) signalling events.
REACT_18377. Glucagon-type ligand receptors.
REACT_19327. G alpha (s) signalling events.

Miscellaneous databases

EvolutionaryTracei P47871.
GeneWikii Glucagon_receptor.
GenomeRNAii 2642.
NextBioi 10416.
PROi P47871.
SOURCEi Search...

Gene expression databases

Bgeei P47871.
CleanExi HS_GCGR.
ExpressionAtlasi P47871. baseline.
Genevestigatori P47871.

Family and domain databases

InterProi IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003290. GPCR_2_GLP1/glucagon_rcpt.
IPR003291. GPCR_2_glucagon_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view ]
PRINTSi PR01353. GLUCAGNFAMLY.
PR01354. GLUCAGONR.
PR00249. GPCRSECRETIN.
SMARTi SM00008. HormR. 1 hit.
[Graphical view ]
PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
    Tissue: Liver.
  2. "The human glucagon receptor encoding gene: structure, cDNA sequence and chromosomal localization."
    Lok S., Kuijper J.L., Jelinek L.J., Kramer J.M., Whitmore T.E., Sprecher C.A., Mathewes S., Grant F.J., Biggs S.H., Rosenberg G.B.
    Gene 140:203-209(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  4. "Localization of the glucagon receptor gene to human chromosome band 17q25."
    Menzel S., Stoffel M., Espinosa R. III, Fernald A.A., Le Beau M.M., Bell G.I.
    Genomics 20:327-328(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 21-54.
    Tissue: Placenta.
  5. "Role of the glucagon receptor COOH-terminal domain in glucagon-mediated signaling and receptor internalization."
    Buggy J.J., Heurich R.O., MacDougall M., Kelley K.A., Livingston J.N., Yoo-Warren H., Rossomando A.J.
    Diabetes 46:1400-1405(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION.
  6. "Conformational dimorphism of self-peptides and molecular mimicry in a disease-associated HLA-B27 subtype."
    Ruckert C., Fiorillo M.T., Loll B., Moretti R., Biesiadka J., Saenger W., Ziegler A., Sorrentino R., Uchanska-Ziegler B.
    J. Biol. Chem. 281:2306-2316(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.2 ANGSTROMS) OF 412-420 IN COMPLEX WITH CLASS I MHC.
  7. Cited for: X-RAY CRYSTALLOGRAPHY (2.64 ANGSTROMS) OF 28-123, FUNCTION, MUTAGENESIS OF TYR-65 AND GLN-113, DISULFIDE BONDS, GLYCOSYLATION AT ASN-74 AND ASN-78.
  8. Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 123-432, FUNCTION, SUBCELLULAR LOCATION, DISULFIDE BONDS, MEMBRANE TOPOLOGY, MUTAGENESIS OF TRP-36; ASP-63; ALA-135; TYR-145; TYR-149; LEU-198; ARG-201; TYR-202; ASP-208; TRP-215; GLN-232; TYR-233; LYS-286; GLU-290; CYS-294; TRP-295; TRP-304; LEU-382 AND LEU-386, CHARACTERIZATION OF VARIANT SER-86.
  9. "A mutation in the glucagon receptor gene (Gly40Ser): heterogeneity in the association with diabetes mellitus."
    Fujisawa T., Ikegami H., Yamato E., Takekawa K., Nakagawa Y., Hamada Y., Ueda H., Fukuda M., Ogihara T.
    Diabetologia 38:983-985(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT SER-40.
  10. "Homozygous P86S mutation of the human glucagon receptor is associated with hyperglucagonemia, alpha cell hyperplasia, and islet cell tumor."
    Zhou C., Dhall D., Nissen N.N., Chen C.R., Yu R.
    Pancreas 38:941-946(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT SER-86, FUNCTION, SUBCELLULAR LOCATION, CHARACTERIZATION OF VARIANT SER-86.

Entry informationi

Entry nameiGLR_HUMAN
AccessioniPrimary (citable) accession number: P47871
Secondary accession number(s): Q2M3M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3