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P47870

- GBRB2_HUMAN

UniProt

P47870 - GBRB2_HUMAN

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Protein

Gamma-aminobutyric acid receptor subunit beta-2

Gene

GABRB2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei224 – 2241AgonistBy similarity

GO - Molecular functioni

  1. chloride channel activity Source: UniProtKB
  2. GABA-A receptor activity Source: BHF-UCL
  3. inhibitory extracellular ligand-gated ion channel activity Source: Ensembl

GO - Biological processi

  1. cellular response to histamine Source: UniProtKB
  2. chloride transmembrane transport Source: UniProtKB
  3. cochlea development Source: Ensembl
  4. gamma-aminobutyric acid signaling pathway Source: ProtInc
  5. inner ear receptor cell development Source: Ensembl
  6. innervation Source: Ensembl
  7. ion transmembrane transport Source: Reactome
  8. negative regulation of neuron apoptotic process Source: Ensembl
  9. sensory perception of sound Source: Ensembl
  10. synaptic transmission Source: Reactome
  11. synaptic transmission, GABAergic Source: BHF-UCL
  12. transmembrane transport Source: Reactome
  13. transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiREACT_24987. GABA A receptor activation.
REACT_25387. Ligand-gated ion channel transport.
REACT_267716. Orphan transporters.

Protein family/group databases

TCDBi1.A.9.5.2. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit beta-2
Alternative name(s):
GABA(A) receptor subunit beta-2
Gene namesi
Name:GABRB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:4082. GABRB2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 244219ExtracellularCuratedAdd
BLAST
Transmembranei245 – 26622HelicalCuratedAdd
BLAST
Transmembranei270 – 29223HelicalCuratedAdd
BLAST
Transmembranei304 – 32623HelicalCuratedAdd
BLAST
Topological domaini327 – 489163CytoplasmicCuratedAdd
BLAST
Transmembranei490 – 51122HelicalCuratedAdd
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. chloride channel complex Source: UniProtKB-KW
  3. cytosol Source: Ensembl
  4. extracellular vesicular exosome Source: UniProt
  5. GABA-A receptor complex Source: UniProtKB
  6. integral component of plasma membrane Source: UniProtKB
  7. plasma membrane Source: Reactome
  8. postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi389 – 3891T → A: Displays reduced current rundown following repeated receptor activation. 1 Publication

Organism-specific databases

PharmGKBiPA28496.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525By similarityAdd
BLAST
Chaini26 – 512487Gamma-aminobutyric acid receptor subunit beta-2PRO_0000000459Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi32 – 321N-linked (GlcNAc...)Sequence Analysis
Cross-linki45 – 45Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi160 ↔ 174By similarity
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
Modified residuei441 – 4411PhosphotyrosineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP47870.
PeptideAtlasiP47870.
PRIDEiP47870.

PTM databases

PhosphoSiteiP47870.

Expressioni

Tissue specificityi

Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression.2 Publications

Gene expression databases

BgeeiP47870.
CleanExiHS_GABRB2.
ExpressionAtlasiP47870. baseline and differential.
GenevestigatoriP47870.

Organism-specific databases

HPAiCAB001964.

Interactioni

Subunit structurei

Binds UBQLN1. Interacts with KCTD8, KCTD12 and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents (By similarity). Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains.By similarity1 Publication

Protein-protein interaction databases

BioGridi108835. 4 interactions.
IntActiP47870. 1 interaction.
MINTiMINT-268409.
STRINGi9606.ENSP00000274547.

Structurei

3D structure databases

ProteinModelPortaliP47870.
SMRiP47870. Positions 25-337, 486-512.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni119 – 1213Agonist bindingBy similarity
Regioni179 – 1813Agonist bindingBy similarity
Regioni289 – 31022Allosteric effector bindingBy similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG77438.
GeneTreeiENSGT00760000118821.
HOVERGENiHBG051707.
InParanoidiP47870.
KOiK05181.
OMAiHMTQKKS.
OrthoDBiEOG712TVZ.
PhylomeDBiP47870.
TreeFamiTF315453.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR002289. GABAAb_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR01160. GABAARBETA.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 2 hits.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P47870-2) [UniParc]FASTAAdd to Basket

Also known as: Long, Beta-2L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWRVRKRGYF GIWSFPLIIA AVCAQSVNDP SNMSLVKETV DRLLKGYDIR
60 70 80 90 100
LRPDFGGPPV AVGMNIDIAS IDMVSEVNMD YTLTMYFQQA WRDKRLSYNV
110 120 130 140 150
IPLNLTLDNR VADQLWVPDT YFLNDKKSFV HGVTVKNRMI RLHPDGTVLY
160 170 180 190 200
GLRITTTAAC MMDLRRYPLD EQNCTLEIES YGYTTDDIEF YWRGDDNAVT
210 220 230 240 250
GVTKIELPQF SIVDYKLITK KVVFSTGSYP RLSLSFKLKR NIGYFILQTY
260 270 280 290 300
MPSILITILS WVSFWINYDA SAARVALGIT TVLTMTTINT HLRETLPKIP
310 320 330 340 350
YVKAIDMYLM GCFVFVFMAL LEYALVNYIF FGRGPQRQKK AAEKAASANN
360 370 380 390 400
EKMRLDVNKI FYKDIKQNGT QYRSLWDPTG NLSPTRRTTN YDFSLYTMDP
410 420 430 440 450
HENILLSTLE IKNEMATSEA VMGLGDPRST MLAYDASSIQ YRKAGLPRHS
460 470 480 490 500
FGRNALERHV AQKKSRLRRR ASQLKITIPD LTDVNAIDRW SRIFFPVVFS
510
FFNIVYWLYY VN
Length:512
Mass (Da):59,150
Last modified:March 23, 2010 - v2
Checksum:iC390A0C92815DD89
GO
Isoform 2 (identifier: P47870-1) [UniParc]FASTAAdd to Basket

Also known as: Short, Beta-2S

The sequence of this isoform differs from the canonical sequence as follows:
     360-397: Missing.

Show »
Length:474
Mass (Da):54,606
Checksum:i1390A982EB616332
GO
Isoform 3 (identifier: P47870-3) [UniParc]FASTAAdd to Basket

Also known as: Beta-2S1

The sequence of this isoform differs from the canonical sequence as follows:
     1-63: Missing.
     360-376: IFYKDIKQNGTQYRSLW → VNSEGKPSLLLKLMEEC
     377-512: Missing.

Show »
Length:313
Mass (Da):36,086
Checksum:i5914B38B94A611B2
GO
Isoform 4 (identifier: P47870-4) [UniParc]FASTAAdd to Basket

Also known as: Beta-2S2

The sequence of this isoform differs from the canonical sequence as follows:
     360-397: Missing.
     410-410: E → D
     411-512: Missing.

Show »
Length:372
Mass (Da):42,741
Checksum:i0550692E2DD2662C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti336 – 3361Q → L in BAF82419. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6363Missing in isoform 3. 1 PublicationVSP_038823Add
BLAST
Alternative sequencei360 – 39738Missing in isoform 2 and isoform 4. 5 PublicationsVSP_038825Add
BLAST
Alternative sequencei360 – 37617IFYKD…YRSLW → VNSEGKPSLLLKLMEEC in isoform 3. 1 PublicationVSP_038824Add
BLAST
Alternative sequencei377 – 512136Missing in isoform 3. 1 PublicationVSP_038828Add
BLAST
Alternative sequencei410 – 4101E → D in isoform 4. 1 PublicationVSP_038826
Alternative sequencei411 – 512102Missing in isoform 4. 1 PublicationVSP_038827Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S67368 mRNA. Translation: AAB29370.1.
S77554 mRNA. Translation: AAB33983.1.
S77553 mRNA. Translation: AAB33982.1.
GU086163 mRNA. Translation: ACY69094.1.
GU086164 mRNA. Translation: ACY69095.1.
AK289730 mRNA. Translation: BAF82419.1.
AK289815 mRNA. Translation: BAF82504.1.
CH471062 Genomic DNA. Translation: EAW61543.1.
BC099705 mRNA. Translation: AAH99705.1.
BC099719 mRNA. Translation: AAH99719.1.
BC105639 mRNA. Translation: AAI05640.1.
CCDSiCCDS4354.1. [P47870-1]
CCDS4355.1. [P47870-2]
PIRiI52656.
RefSeqiNP_000804.1. NM_000813.2. [P47870-1]
NP_068711.1. NM_021911.2. [P47870-2]
UniGeneiHs.303527.

Genome annotation databases

EnsembliENST00000274547; ENSP00000274547; ENSG00000145864. [P47870-2]
ENST00000353437; ENSP00000274546; ENSG00000145864. [P47870-1]
ENST00000393959; ENSP00000377531; ENSG00000145864. [P47870-2]
ENST00000520240; ENSP00000429320; ENSG00000145864. [P47870-1]
ENST00000612710; ENSP00000480066; ENSG00000145864. [P47870-3]
GeneIDi2561.
KEGGihsa:2561.
UCSCiuc003lyr.1. human. [P47870-1]
uc003lys.1. human. [P47870-2]
uc021yhg.1. human. [P47870-3]

Polymorphism databases

DMDMi292495010.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Protein Spotlight

Forbidden fruit - Issue 56 of March 2005

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S67368 mRNA. Translation: AAB29370.1 .
S77554 mRNA. Translation: AAB33983.1 .
S77553 mRNA. Translation: AAB33982.1 .
GU086163 mRNA. Translation: ACY69094.1 .
GU086164 mRNA. Translation: ACY69095.1 .
AK289730 mRNA. Translation: BAF82419.1 .
AK289815 mRNA. Translation: BAF82504.1 .
CH471062 Genomic DNA. Translation: EAW61543.1 .
BC099705 mRNA. Translation: AAH99705.1 .
BC099719 mRNA. Translation: AAH99719.1 .
BC105639 mRNA. Translation: AAI05640.1 .
CCDSi CCDS4354.1. [P47870-1 ]
CCDS4355.1. [P47870-2 ]
PIRi I52656.
RefSeqi NP_000804.1. NM_000813.2. [P47870-1 ]
NP_068711.1. NM_021911.2. [P47870-2 ]
UniGenei Hs.303527.

3D structure databases

ProteinModelPortali P47870.
SMRi P47870. Positions 25-337, 486-512.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108835. 4 interactions.
IntActi P47870. 1 interaction.
MINTi MINT-268409.
STRINGi 9606.ENSP00000274547.

Chemistry

BindingDBi P47870.
ChEMBLi CHEMBL2111339.
DrugBanki DB00659. Acamprosate.
DB00546. Adinazolam.
DB00404. Alprazolam.
DB00543. Amoxapine.
DB01558. Bromazepam.
DB00237. Butabarbital.
DB00241. Butalbital.
DB00475. Chlordiazepoxide.
DB01594. Cinolazepam.
DB00349. Clobazam.
DB01068. Clonazepam.
DB00628. Clorazepate.
DB01559. Clotiazepam.
DB01189. Desflurane.
DB00829. Diazepam.
DB00228. Enflurane.
DB01049. Ergoloid mesylate.
DB01215. Estazolam.
DB00402. Eszopiclone.
DB00189. Ethchlorvynol.
DB00292. Etomidate.
DB01567. Fludiazepam.
DB01205. Flumazenil.
DB00690. Flurazepam.
DB06716. Fospropofol.
DB01381. Ginkgo biloba.
DB01437. Glutethimide.
DB00801. Halazepam.
DB01159. Halothane.
DB00753. Isoflurane.
DB00186. Lorazepam.
DB00371. Meprobamate.
DB01028. Methoxyflurane.
DB01107. Methyprylon.
DB00683. Midazolam.
DB01595. Nitrazepam.
DB00334. Olanzapine.
DB00842. Oxazepam.
DB00312. Pentobarbital.
DB01588. Prazepam.
DB00794. Primidone.
DB00818. Propofol.
DB01589. Quazepam.
DB01236. Sevoflurane.
DB00306. Talbutal.
DB00231. Temazepam.
DB00273. Topiramate.
DB00897. Triazolam.
GuidetoPHARMACOLOGYi 411.

Protein family/group databases

TCDBi 1.A.9.5.2. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

PTM databases

PhosphoSitei P47870.

Polymorphism databases

DMDMi 292495010.

Proteomic databases

PaxDbi P47870.
PeptideAtlasi P47870.
PRIDEi P47870.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000274547 ; ENSP00000274547 ; ENSG00000145864 . [P47870-2 ]
ENST00000353437 ; ENSP00000274546 ; ENSG00000145864 . [P47870-1 ]
ENST00000393959 ; ENSP00000377531 ; ENSG00000145864 . [P47870-2 ]
ENST00000520240 ; ENSP00000429320 ; ENSG00000145864 . [P47870-1 ]
ENST00000612710 ; ENSP00000480066 ; ENSG00000145864 . [P47870-3 ]
GeneIDi 2561.
KEGGi hsa:2561.
UCSCi uc003lyr.1. human. [P47870-1 ]
uc003lys.1. human. [P47870-2 ]
uc021yhg.1. human. [P47870-3 ]

Organism-specific databases

CTDi 2561.
GeneCardsi GC05M160715.
HGNCi HGNC:4082. GABRB2.
HPAi CAB001964.
MIMi 600232. gene.
neXtProti NX_P47870.
PharmGKBi PA28496.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG77438.
GeneTreei ENSGT00760000118821.
HOVERGENi HBG051707.
InParanoidi P47870.
KOi K05181.
OMAi HMTQKKS.
OrthoDBi EOG712TVZ.
PhylomeDBi P47870.
TreeFami TF315453.

Enzyme and pathway databases

Reactomei REACT_24987. GABA A receptor activation.
REACT_25387. Ligand-gated ion channel transport.
REACT_267716. Orphan transporters.

Miscellaneous databases

GeneWikii GABRB2.
GenomeRNAii 2561.
NextBioi 10115.
PROi P47870.
SOURCEi Search...

Gene expression databases

Bgeei P47870.
CleanExi HS_GABRB2.
ExpressionAtlasi P47870. baseline and differential.
Genevestigatori P47870.

Family and domain databases

Gene3Di 2.70.170.10. 1 hit.
InterProi IPR006028. GABAA/Glycine_rcpt.
IPR002289. GABAAb_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view ]
PANTHERi PTHR18945. PTHR18945. 1 hit.
Pfami PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view ]
PRINTSi PR01160. GABAARBETA.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMi SSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 2 hits.
TIGRFAMsi TIGR00860. LIC. 1 hit.
PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors."
    Hadingham K.L., Wingrove P.B., Wafford K.A., Bain C., Kemp J.A., Palmer K.J., Wilson A.W., Wilcox A.S., Sikela J.M., Ragan C.I.
    Mol. Pharmacol. 44:1211-1218(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, SUBCELLULAR LOCATION, SUBUNIT.
    Tissue: Brain.
  2. "Cloning, sequence analysis and expression of two forms of mRNA coding for the human beta 2 subunit of the GABAA receptor."
    McKinley D.D., Lennon D.J., Carter D.B.
    Brain Res. Mol. Brain Res. 28:175-179(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  3. "Alternative-splicing in the exon-10 region of GABA(A) receptor beta(2) subunit gene: relationships between novel isoforms and psychotic disorders."
    Zhao C., Xu Z., Wang F., Chen J., Ng S.K., Wong P.W., Yu Z., Pun F.W., Ren L., Lo W.S., Tsang S.Y., Xue H.
    PLoS ONE 4:E6977-E6977(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), TISSUE SPECIFICITY, MUTAGENESIS OF THR-389, FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING.
    Tissue: Brain.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  7. "Two isoforms of GABA(A) receptor beta2 subunit with different electrophysiological properties: Differential expression and genotypical correlations in schizophrenia."
    Zhao C., Xu Z., Chen J., Yu Z., Tong K.L., Lo W.S., Pun F.W., Ng S.K., Tsang S.Y., Xue H.
    Mol. Psychiatry 11:1092-1105(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
    Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.
    Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-45.
    Tissue: Mammary cancer.

Entry informationi

Entry nameiGBRB2_HUMAN
AccessioniPrimary (citable) accession number: P47870
Secondary accession number(s): A8K115
, A8K1A0, D1LYT0, D1LYT1, Q16323, Q4FZB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: March 23, 2010
Last modified: November 26, 2014
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

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