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P47870

- GBRB2_HUMAN

UniProt

P47870 - GBRB2_HUMAN

Protein

Gamma-aminobutyric acid receptor subunit beta-2

Gene

GABRB2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 2 (23 Mar 2010)
      Previous versions | rss
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    Functioni

    Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei224 – 2241AgonistBy similarity

    GO - Molecular functioni

    1. chloride channel activity Source: UniProtKB
    2. GABA-A receptor activity Source: BHF-UCL
    3. inhibitory extracellular ligand-gated ion channel activity Source: Ensembl

    GO - Biological processi

    1. cellular response to histamine Source: UniProtKB
    2. chloride transmembrane transport Source: UniProtKB
    3. cochlea development Source: Ensembl
    4. gamma-aminobutyric acid signaling pathway Source: ProtInc
    5. inner ear receptor cell development Source: Ensembl
    6. innervation Source: Ensembl
    7. ion transmembrane transport Source: Reactome
    8. negative regulation of neuron apoptotic process Source: Ensembl
    9. sensory perception of sound Source: Ensembl
    10. synaptic transmission Source: Reactome
    11. synaptic transmission, GABAergic Source: BHF-UCL
    12. transmembrane transport Source: Reactome
    13. transport Source: ProtInc

    Keywords - Molecular functioni

    Chloride channel, Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Chloride

    Enzyme and pathway databases

    ReactomeiREACT_24987. GABA A receptor activation.
    REACT_25387. Ligand-gated ion channel transport.

    Protein family/group databases

    TCDBi1.A.9.5.2. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-aminobutyric acid receptor subunit beta-2
    Alternative name(s):
    GABA(A) receptor subunit beta-2
    Gene namesi
    Name:GABRB2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:4082. GABRB2.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. chloride channel complex Source: UniProtKB-KW
    3. cytosol Source: Ensembl
    4. extracellular vesicular exosome Source: UniProt
    5. GABA-A receptor complex Source: UniProtKB
    6. integral component of plasma membrane Source: UniProtKB
    7. plasma membrane Source: Reactome
    8. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi389 – 3891T → A: Displays reduced current rundown following repeated receptor activation. 1 Publication

    Organism-specific databases

    PharmGKBiPA28496.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525By similarityAdd
    BLAST
    Chaini26 – 512487Gamma-aminobutyric acid receptor subunit beta-2PRO_0000000459Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi32 – 321N-linked (GlcNAc...)Sequence Analysis
    Cross-linki45 – 45Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi160 ↔ 174By similarity
    Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
    Modified residuei441 – 4411PhosphotyrosineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiP47870.
    PeptideAtlasiP47870.
    PRIDEiP47870.

    PTM databases

    PhosphoSiteiP47870.

    Expressioni

    Tissue specificityi

    Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression.2 Publications

    Gene expression databases

    ArrayExpressiP47870.
    BgeeiP47870.
    CleanExiHS_GABRB2.
    GenevestigatoriP47870.

    Organism-specific databases

    HPAiCAB001964.

    Interactioni

    Subunit structurei

    Binds UBQLN1. Interacts with KCTD8, KCTD12 and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents By similarity. Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi108835. 4 interactions.
    IntActiP47870. 1 interaction.
    MINTiMINT-268409.
    STRINGi9606.ENSP00000274547.

    Structurei

    3D structure databases

    ProteinModelPortaliP47870.
    SMRiP47870. Positions 46-340.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 244219ExtracellularCuratedAdd
    BLAST
    Topological domaini327 – 489163CytoplasmicCuratedAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei245 – 26622HelicalCuratedAdd
    BLAST
    Transmembranei270 – 29223HelicalCuratedAdd
    BLAST
    Transmembranei304 – 32623HelicalCuratedAdd
    BLAST
    Transmembranei490 – 51122HelicalCuratedAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni119 – 1213Agonist bindingBy similarity
    Regioni179 – 1813Agonist bindingBy similarity
    Regioni289 – 31022Allosteric effector bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG77438.
    HOVERGENiHBG051707.
    KOiK05181.
    OMAiHMTQKKS.
    OrthoDBiEOG712TVZ.
    PhylomeDBiP47870.
    TreeFamiTF315453.

    Family and domain databases

    Gene3Di2.70.170.10. 1 hit.
    InterProiIPR006028. GABAA/Glycine_rcpt.
    IPR002289. GABAAb_rcpt.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view]
    PRINTSiPR01160. GABAARBETA.
    PR00253. GABAARECEPTR.
    PR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 2 hits.
    TIGRFAMsiTIGR00860. LIC. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P47870-2) [UniParc]FASTAAdd to Basket

    Also known as: Long, Beta-2L

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MWRVRKRGYF GIWSFPLIIA AVCAQSVNDP SNMSLVKETV DRLLKGYDIR    50
    LRPDFGGPPV AVGMNIDIAS IDMVSEVNMD YTLTMYFQQA WRDKRLSYNV 100
    IPLNLTLDNR VADQLWVPDT YFLNDKKSFV HGVTVKNRMI RLHPDGTVLY 150
    GLRITTTAAC MMDLRRYPLD EQNCTLEIES YGYTTDDIEF YWRGDDNAVT 200
    GVTKIELPQF SIVDYKLITK KVVFSTGSYP RLSLSFKLKR NIGYFILQTY 250
    MPSILITILS WVSFWINYDA SAARVALGIT TVLTMTTINT HLRETLPKIP 300
    YVKAIDMYLM GCFVFVFMAL LEYALVNYIF FGRGPQRQKK AAEKAASANN 350
    EKMRLDVNKI FYKDIKQNGT QYRSLWDPTG NLSPTRRTTN YDFSLYTMDP 400
    HENILLSTLE IKNEMATSEA VMGLGDPRST MLAYDASSIQ YRKAGLPRHS 450
    FGRNALERHV AQKKSRLRRR ASQLKITIPD LTDVNAIDRW SRIFFPVVFS 500
    FFNIVYWLYY VN 512
    Length:512
    Mass (Da):59,150
    Last modified:March 23, 2010 - v2
    Checksum:iC390A0C92815DD89
    GO
    Isoform 2 (identifier: P47870-1) [UniParc]FASTAAdd to Basket

    Also known as: Short, Beta-2S

    The sequence of this isoform differs from the canonical sequence as follows:
         360-397: Missing.

    Show »
    Length:474
    Mass (Da):54,606
    Checksum:i1390A982EB616332
    GO
    Isoform 3 (identifier: P47870-3) [UniParc]FASTAAdd to Basket

    Also known as: Beta-2S1

    The sequence of this isoform differs from the canonical sequence as follows:
         1-63: Missing.
         360-376: IFYKDIKQNGTQYRSLW → VNSEGKPSLLLKLMEEC
         377-512: Missing.

    Show »
    Length:313
    Mass (Da):36,086
    Checksum:i5914B38B94A611B2
    GO
    Isoform 4 (identifier: P47870-4) [UniParc]FASTAAdd to Basket

    Also known as: Beta-2S2

    The sequence of this isoform differs from the canonical sequence as follows:
         360-397: Missing.
         410-410: E → D
         411-512: Missing.

    Show »
    Length:372
    Mass (Da):42,741
    Checksum:i0550692E2DD2662C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti336 – 3361Q → L in BAF82419. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6363Missing in isoform 3. 1 PublicationVSP_038823Add
    BLAST
    Alternative sequencei360 – 39738Missing in isoform 2 and isoform 4. 5 PublicationsVSP_038825Add
    BLAST
    Alternative sequencei360 – 37617IFYKD…YRSLW → VNSEGKPSLLLKLMEEC in isoform 3. 1 PublicationVSP_038824Add
    BLAST
    Alternative sequencei377 – 512136Missing in isoform 3. 1 PublicationVSP_038828Add
    BLAST
    Alternative sequencei410 – 4101E → D in isoform 4. 1 PublicationVSP_038826
    Alternative sequencei411 – 512102Missing in isoform 4. 1 PublicationVSP_038827Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S67368 mRNA. Translation: AAB29370.1.
    S77554 mRNA. Translation: AAB33983.1.
    S77553 mRNA. Translation: AAB33982.1.
    GU086163 mRNA. Translation: ACY69094.1.
    GU086164 mRNA. Translation: ACY69095.1.
    AK289730 mRNA. Translation: BAF82419.1.
    AK289815 mRNA. Translation: BAF82504.1.
    CH471062 Genomic DNA. Translation: EAW61543.1.
    BC099705 mRNA. Translation: AAH99705.1.
    BC099719 mRNA. Translation: AAH99719.1.
    BC105639 mRNA. Translation: AAI05640.1.
    CCDSiCCDS4354.1. [P47870-1]
    CCDS4355.1. [P47870-2]
    PIRiI52656.
    RefSeqiNP_000804.1. NM_000813.2. [P47870-1]
    NP_068711.1. NM_021911.2. [P47870-2]
    UniGeneiHs.303527.

    Genome annotation databases

    EnsembliENST00000274547; ENSP00000274547; ENSG00000145864. [P47870-2]
    ENST00000353437; ENSP00000274546; ENSG00000145864. [P47870-1]
    ENST00000393959; ENSP00000377531; ENSG00000145864. [P47870-2]
    ENST00000520240; ENSP00000429320; ENSG00000145864. [P47870-1]
    GeneIDi2561.
    KEGGihsa:2561.
    UCSCiuc003lyr.1. human. [P47870-1]
    uc003lys.1. human. [P47870-2]
    uc021yhg.1. human. [P47870-3]

    Polymorphism databases

    DMDMi292495010.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Forbidden fruit - Issue 56 of March 2005

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S67368 mRNA. Translation: AAB29370.1 .
    S77554 mRNA. Translation: AAB33983.1 .
    S77553 mRNA. Translation: AAB33982.1 .
    GU086163 mRNA. Translation: ACY69094.1 .
    GU086164 mRNA. Translation: ACY69095.1 .
    AK289730 mRNA. Translation: BAF82419.1 .
    AK289815 mRNA. Translation: BAF82504.1 .
    CH471062 Genomic DNA. Translation: EAW61543.1 .
    BC099705 mRNA. Translation: AAH99705.1 .
    BC099719 mRNA. Translation: AAH99719.1 .
    BC105639 mRNA. Translation: AAI05640.1 .
    CCDSi CCDS4354.1. [P47870-1 ]
    CCDS4355.1. [P47870-2 ]
    PIRi I52656.
    RefSeqi NP_000804.1. NM_000813.2. [P47870-1 ]
    NP_068711.1. NM_021911.2. [P47870-2 ]
    UniGenei Hs.303527.

    3D structure databases

    ProteinModelPortali P47870.
    SMRi P47870. Positions 46-340.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108835. 4 interactions.
    IntActi P47870. 1 interaction.
    MINTi MINT-268409.
    STRINGi 9606.ENSP00000274547.

    Chemistry

    BindingDBi P47870.
    ChEMBLi CHEMBL2093872.
    DrugBanki DB00659. Acamprosate.
    DB00546. Adinazolam.
    DB00404. Alprazolam.
    DB00543. Amoxapine.
    DB01558. Bromazepam.
    DB00237. Butabarbital.
    DB00241. Butalbital.
    DB00475. Chlordiazepoxide.
    DB01594. Cinolazepam.
    DB00349. Clobazam.
    DB01068. Clonazepam.
    DB00628. Clorazepate.
    DB01559. Clotiazepam.
    DB01189. Desflurane.
    DB00829. Diazepam.
    DB00228. Enflurane.
    DB01049. Ergoloid mesylate.
    DB01215. Estazolam.
    DB00402. Eszopiclone.
    DB00189. Ethchlorvynol.
    DB00292. Etomidate.
    DB01567. Fludiazepam.
    DB01205. Flumazenil.
    DB00690. Flurazepam.
    DB06716. Fospropofol.
    DB01381. Ginkgo biloba.
    DB01437. Glutethimide.
    DB00801. Halazepam.
    DB01159. Halothane.
    DB00753. Isoflurane.
    DB00186. Lorazepam.
    DB00371. Meprobamate.
    DB01028. Methoxyflurane.
    DB01107. Methyprylon.
    DB00683. Midazolam.
    DB01595. Nitrazepam.
    DB00334. Olanzapine.
    DB00842. Oxazepam.
    DB00312. Pentobarbital.
    DB01588. Prazepam.
    DB00794. Primidone.
    DB00818. Propofol.
    DB01589. Quazepam.
    DB01236. Sevoflurane.
    DB00306. Talbutal.
    DB00231. Temazepam.
    DB00273. Topiramate.
    DB00897. Triazolam.
    GuidetoPHARMACOLOGYi 411.

    Protein family/group databases

    TCDBi 1.A.9.5.2. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

    PTM databases

    PhosphoSitei P47870.

    Polymorphism databases

    DMDMi 292495010.

    Proteomic databases

    PaxDbi P47870.
    PeptideAtlasi P47870.
    PRIDEi P47870.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000274547 ; ENSP00000274547 ; ENSG00000145864 . [P47870-2 ]
    ENST00000353437 ; ENSP00000274546 ; ENSG00000145864 . [P47870-1 ]
    ENST00000393959 ; ENSP00000377531 ; ENSG00000145864 . [P47870-2 ]
    ENST00000520240 ; ENSP00000429320 ; ENSG00000145864 . [P47870-1 ]
    GeneIDi 2561.
    KEGGi hsa:2561.
    UCSCi uc003lyr.1. human. [P47870-1 ]
    uc003lys.1. human. [P47870-2 ]
    uc021yhg.1. human. [P47870-3 ]

    Organism-specific databases

    CTDi 2561.
    GeneCardsi GC05M160715.
    HGNCi HGNC:4082. GABRB2.
    HPAi CAB001964.
    MIMi 600232. gene.
    neXtProti NX_P47870.
    PharmGKBi PA28496.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG77438.
    HOVERGENi HBG051707.
    KOi K05181.
    OMAi HMTQKKS.
    OrthoDBi EOG712TVZ.
    PhylomeDBi P47870.
    TreeFami TF315453.

    Enzyme and pathway databases

    Reactomei REACT_24987. GABA A receptor activation.
    REACT_25387. Ligand-gated ion channel transport.

    Miscellaneous databases

    GeneWikii GABRB2.
    GenomeRNAii 2561.
    NextBioi 10115.
    PROi P47870.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P47870.
    Bgeei P47870.
    CleanExi HS_GABRB2.
    Genevestigatori P47870.

    Family and domain databases

    Gene3Di 2.70.170.10. 1 hit.
    InterProi IPR006028. GABAA/Glycine_rcpt.
    IPR002289. GABAAb_rcpt.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view ]
    PRINTSi PR01160. GABAARBETA.
    PR00253. GABAARECEPTR.
    PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 2 hits.
    TIGRFAMsi TIGR00860. LIC. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors."
      Hadingham K.L., Wingrove P.B., Wafford K.A., Bain C., Kemp J.A., Palmer K.J., Wilson A.W., Wilcox A.S., Sikela J.M., Ragan C.I.
      Mol. Pharmacol. 44:1211-1218(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, SUBCELLULAR LOCATION, SUBUNIT.
      Tissue: Brain.
    2. "Cloning, sequence analysis and expression of two forms of mRNA coding for the human beta 2 subunit of the GABAA receptor."
      McKinley D.D., Lennon D.J., Carter D.B.
      Brain Res. Mol. Brain Res. 28:175-179(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain.
    3. "Alternative-splicing in the exon-10 region of GABA(A) receptor beta(2) subunit gene: relationships between novel isoforms and psychotic disorders."
      Zhao C., Xu Z., Wang F., Chen J., Ng S.K., Wong P.W., Yu Z., Pun F.W., Ren L., Lo W.S., Tsang S.Y., Xue H.
      PLoS ONE 4:E6977-E6977(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), TISSUE SPECIFICITY, MUTAGENESIS OF THR-389, FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING.
      Tissue: Brain.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    7. "Two isoforms of GABA(A) receptor beta2 subunit with different electrophysiological properties: Differential expression and genotypical correlations in schizophrenia."
      Zhao C., Xu Z., Chen J., Yu Z., Tong K.L., Lo W.S., Pun F.W., Ng S.K., Tsang S.Y., Xue H.
      Mol. Psychiatry 11:1092-1105(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    8. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
      Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.
      Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-45.
      Tissue: Mammary cancer.

    Entry informationi

    Entry nameiGBRB2_HUMAN
    AccessioniPrimary (citable) accession number: P47870
    Secondary accession number(s): A8K115
    , A8K1A0, D1LYT0, D1LYT1, Q16323, Q4FZB2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: March 23, 2010
    Last modified: October 1, 2014
    This is version 138 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3