Skip Header

 
Contribute Send feedback

Reviewed, UniProtKB/Swiss-Prot P47869 (GBRA2_HUMAN)

Last modified November 25, 2008. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Gamma-aminobutyric acid receptor subunit alpha-2
Alternative name(s):
    GABA(A) receptor subunit alpha-2
Gene names
Name: GABRA2
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length451 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Subunit structure

Binds UBQLN1 By similarity. Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.

Subcellular location

Cell junctionsynapsepostsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Polymorphism

Genetic variations in GABRA2 determine the genetic susceptibility to alcoholism [MIM:103780].

Sequence similarities

Belongs to the ligand-gated ionic channel (TC 1.A.9) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Chain29 – 451423Gamma-aminobutyric acid receptor subunit alpha-2
PRO_0000000433

Regions

Topological domain29 – 251223Extracellular Probable
Transmembrane252 – 27322 Probable
Transmembrane279 – 30022 Probable
Transmembrane313 – 33422 Probable
Topological domain335 – 41985Cytoplasmic Probable
Transmembrane420 – 44122 Probable

Amino acid modifications

Glycosylation381N-linked (GlcNAc...) Potential
Glycosylation1381N-linked (GlcNAc...) Potential
Disulfide bond166 ↔ 180 By similarity

Experimental info

Sequence conflict10 – 112MQ → IE in AAB27278. Ref.1
Sequence conflict3431A → T in AAB27278. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P47869-1 [UniParc].

Last modified February 20, 2007. Version 2.
Checksum: 43F9F708B5A00FFD

FASTA45151,326
        10         20         30         40         50         60 
MKTKLNIYNM QFLLFVFLVW DPARLVLANI QEDEAKNNIT IFTRILDRLL DGYDNRLRPG 

        70         80         90        100        110        120 
LGDSITEVFT NIYVTSFGPV SDTDMEYTID VFFRQKWKDE RLKFKGPMNI LRLNNLMASK 

       130        140        150        160        170        180 
IWTPDTFFHN GKKSVAHNMT MPNKLLRIQD DGTLLYTMRL TVQAECPMHL EDFPMDAHSC 

       190        200        210        220        230        240 
PLKFGSYAYT TSEVTYIWTY NASDSVQVAP DGSRLNQYDL LGQSIGKETI KSSTGEYTVM 

       250        260        270        280        290        300 
TAHFHLKRKI GYFVIQTYLP CIMTVILSQV SFWLNRESVP ARTVFGVTTV LTMTTLSISA 

       310        320        330        340        350        360 
RNSLPKVAYA TAMDWFIAVC YAFVFSALIE FATVNYFTKR GWAWDGKSVV NDKKKEKASV 

       370        380        390        400        410        420 
MIQNNAYAVA VANYAPNLSK DPVLSTISKS ATTPEPNKKP ENKPAEAKKT FNSVSKIDRM 

       430        440        450 
SRIVFPVLFG TFNLVYWATY LNREPVLGVS P 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acidA receptors."
Hadingham K.L., Wingrove P., le Bourdelles B., Palmer K.J., Ragan C.I., Whiting P.J.
Mol. Pharmacol. 43:970-975(1993) [PubMed: 8391122] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations."
Edenberg H.J., Dick D.M., Xuei X., Tian H., Almasy L., Bauer L.O., Crowe R.R., Goate A., Hesselbrock V., Jones K., Kwon J., Li T.-K., Nurnberger J.I. Jr., O'Connor S.J., Reich T., Rice J., Schuckit M.A., Porjesz B., Foroud T., Begleiter H.
Am. J. Hum. Genet. 74:705-714(2004) [PubMed: 15024690] [Abstract]
Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ALCOHOLISM.
+Additional computationally mapped references.

Web resources

Protein Spotlight

Forbidden fruit - Issue 56 of March 2005

Cross-references

Sequence databases

S62907 mRNA. Translation: AAB27278.1.
AB209295 mRNA. Translation: BAD92532.1. Different initiation.
PIRI57947.
RefSeqNP_000798.2.
NP_001107647.1.
UniGeneHs.116250

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSG00000151834. Homo sapiens. [Contig view]
GeneID2555.
KEGGhsa:2555.

Organism-specific databases

H-InvDBHIX0004189.
HGNCHGNC:4076. GABRA2.
HPAHPA014261.
MIM103780. phenotype.
137140. gene.
PharmGKBPA28490.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMP47869.
HOVERGENP47869.

Gene expression databases

ArrayExpressP47869.
CleanExHS_GABRA2.
GermOnlineENSG00000151834. Homo sapiens.

Family and domain databases

InterProIPR006028. GABAA_rcpt.
IPR001390. GABAAa_rcpt.
IPR005432. GABBAa2_rcpt.
IPR006029. Neu_channel_TM.
IPR006202. Neur_chan_lig_bd.
IPR006201. Neur_channel.
[Graphical view]
Gene3DG3DSA:2.70.170.10. Neur_chan_lig_bd. 1 hit.
PANTHERPTHR18945. Neur_channel. 1 hit.
PfamPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSPR01079. GABAARALPHA.
PR01615. GABAARALPHA2.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
TIGRFAMsTIGR00860. LIC. 1 hit.
PROSITEPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

DrugBankDB00404. Alprazolam.
DB01558. Bromazepam.
DB00829. Diazepam.
DB00189. Ethchlorvynol.
DB01567. Fludiazepam.
DB01544. Flunitrazepam.
DB00690. Flurazepam.
DB00186. Lorazepam.
DB00371. Meprobamate.
DB00683. Midazolam.
LinkHubP47869.
NextBio10091.
SOURCESearch...

Entry information

Entry nameGBRA2_HUMAN
AccessionPrimary (citable) accession number: P47869
Secondary accession number(s): Q59G14
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 20, 2007
Last modified: November 25, 2008
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents