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Protein

Secretogranin-3

Gene

Scg3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Secretogranin-3
Alternative name(s):
1B1075
Secretogranin III
Short name:
SgIII
Gene namesi
Name:Scg3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621209. Scg3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic vesicle Source: RGD
  • extracellular region Source: UniProtKB-SubCell
  • transport vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000546323 – 471Secretogranin-3Add BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40PhosphoserineCombined sources1
Modified residuei365PhosphoserineBy similarity1

Keywords - PTMi

Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

PaxDbiP47868.
PRIDEiP47868.

PTM databases

iPTMnetiP47868.
PhosphoSitePlusiP47868.

Expressioni

Tissue specificityi

Expression restricted to the brain and pituitary gland. Not detected in the adrenal gland.1 Publication

Interactioni

Subunit structurei

Interacts with CHGA; this interaction is optimal in conditions mimicking the lumenal milieu of the trans-Golgi network, i.e. pH 5.5 and 10 mM Ca(+2).1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014491.

Structurei

3D structure databases

ProteinModelPortaliP47868.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHUH. Eukaryota.
ENOG4110KQ3. LUCA.
HOGENOMiHOG000247064.
HOVERGENiHBG057085.
InParanoidiP47868.
PhylomeDBiP47868.

Family and domain databases

InterProiIPR026197. SCG3.
[Graphical view]
PANTHERiPTHR17388. PTHR17388. 1 hit.
PfamiPF15467. SGIII. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47868-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFLWTGSWI LVLVLNSGPI QAFPKPEGSQ DKSLHNRELS AERPLNEQIA
60 70 80 90 100
EAEADKIKKT YPSESKPSES NFSSVDNLNL LKAITEKETV EKAKQSIRSS
110 120 130 140 150
PFDNRLNVDD ADSTKNRKLT DEYDSTKSGL DRKVQDDPDG LHQLDGTPLT
160 170 180 190 200
AEDIVHKIAT RIYEENDRGV FDKIVSKLLN LGLITESQAH TLEDEVAEAL
210 220 230 240 250
QKLISKEANN YEEAPEKPTS RTENQDGKIP EKVTPVAATQ DGFTNRENDD
260 270 280 290 300
TVSNTLTLSN GLERRTNPHR DDDFEELQYF PNFYALLTSI DSEKEAKEKE
310 320 330 340 350
TLITIMKTLI DFVKMMVKYG TISPEEGVSY LENLDETIAL QTKNKLEKNT
360 370 380 390 400
TDSKSKLFPA PPEKSHEETD STKEEAAKME KEYGSLKDST KDDNSNLGGK
410 420 430 440 450
TDEAKGKTEA YLEAIRKNIE WLKKHNKKGN KEDYDLSKMR DFINQQADAY
460 470
VEKGILDKEE ANAIKRIYSS L
Length:471
Mass (Da):53,183
Last modified:February 1, 1996 - v1
Checksum:i977B3F8885F33223
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02983 mRNA. Translation: AAA56637.1.
RefSeqiNP_446308.1. NM_053856.2.
UniGeneiRn.11093.

Genome annotation databases

GeneIDi116635.
KEGGirno:116635.
UCSCiRGD:621209. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02983 mRNA. Translation: AAA56637.1.
RefSeqiNP_446308.1. NM_053856.2.
UniGeneiRn.11093.

3D structure databases

ProteinModelPortaliP47868.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014491.

PTM databases

iPTMnetiP47868.
PhosphoSitePlusiP47868.

Proteomic databases

PaxDbiP47868.
PRIDEiP47868.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi116635.
KEGGirno:116635.
UCSCiRGD:621209. rat.

Organism-specific databases

CTDi29106.
RGDi621209. Scg3.

Phylogenomic databases

eggNOGiENOG410IHUH. Eukaryota.
ENOG4110KQ3. LUCA.
HOGENOMiHOG000247064.
HOVERGENiHBG057085.
InParanoidiP47868.
PhylomeDBiP47868.

Miscellaneous databases

PROiP47868.

Family and domain databases

InterProiIPR026197. SCG3.
[Graphical view]
PANTHERiPTHR17388. PTHR17388. 1 hit.
PfamiPF15467. SGIII. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCG3_RAT
AccessioniPrimary (citable) accession number: P47868
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.