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Protein

Secretogranin-3

Gene

Scg3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Secretogranin-3
Alternative name(s):
Secretogranin III
Short name:
SgIII
Gene namesi
Name:Scg3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:103032. Scg3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 471449Secretogranin-3PRO_0000005462Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei40 – 401PhosphoserineCombined sources
Modified residuei365 – 3651PhosphoserineCombined sources

Keywords - PTMi

Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

PaxDbiP47867.
PeptideAtlasiP47867.
PRIDEiP47867.

PTM databases

iPTMnetiP47867.
PhosphoSiteiP47867.

Expressioni

Tissue specificityi

Expressed in various brain areas, with highest levels in the arcuate nucleus and the lateral hypothalamic area, as well as the paraventricular nucleus and the ventromedial hypothalamus (at protein level).1 Publication

Gene expression databases

BgeeiP47867.
CleanExiMM_SCG3.
GenevisibleiP47867. MM.

Interactioni

Subunit structurei

Interacts with CHGA; this interaction is optimal in conditions mimicking the lumenal milieu of the trans-Golgi network, i.e. pH 5.5 and 10 mM Ca(+2).1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034699.

Structurei

3D structure databases

ProteinModelPortaliP47867.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHUH. Eukaryota.
ENOG4110KQ3. LUCA.
GeneTreeiENSGT00390000005488.
HOGENOMiHOG000247064.
HOVERGENiHBG057085.
InParanoidiP47867.
OMAiANNYEED.
OrthoDBiEOG7G1V64.
PhylomeDBiP47867.
TreeFamiTF331266.

Family and domain databases

InterProiIPR026197. SCG3.
[Graphical view]
PANTHERiPTHR17388. PTHR17388. 1 hit.
PfamiPF15467. SGIII. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P47867-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGFLWTGSWI LVLVLNSGPI QAFPKPEGSQ DKSLHNRELS AERPLNEQIA
60 70 80 90 100
EAEADKIKKA FPSESKPSES NYSSVDNLNL LRAITEKETV EKERQSIRSP
110 120 130 140 150
PFDNQLNVED ADSTKNRKLI DEYDSTKSGL DHKFQDDPDG LHQLDGTPLT
160 170 180 190 200
AEDIVHKIAT RIYEENDRGV FDKIVSKLLN LGLITESQAH TLEDEVAEAL
210 220 230 240 250
QKLISKEANN YEETLDKPTS RTENQDGKIP EKVTPVAAVQ DGFTNRENDE
260 270 280 290 300
TVSNTLTLSN GLERRTNPHR EDDFEELQYF PNFYALLTSI DSEKEAKEKE
310 320 330 340 350
TLITIMKTLI DFVKMMVKYG TISPEEGVSY LENLDETIAL QTKNKLEKNT
360 370 380 390 400
TDSKSKLFPA PPEKSQEETD STKEEAAKME KEYGSLKDST KDDNSNLGGK
410 420 430 440 450
TDEATGKTEA YLEAIRKNIE WLKKHNKKGN KEDYDLSKMR DFINQQADAY
460 470
VEKGILDKEE ANAIKRIYSS L
Length:471
Mass (Da):53,326
Last modified:February 1, 1996 - v1
Checksum:iFC1E9C381AFCA564
GO
Isoform 2 (identifier: P47867-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     355-360: SKLFPA → T

Show »
Length:466
Mass (Da):52,784
Checksum:iAB1CB9667276315C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei355 – 3606SKLFPA → T in isoform 2. 2 PublicationsVSP_042877

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02982 mRNA. Translation: AAA56636.1.
AK133655 mRNA. Translation: BAE21767.1.
AK139140 mRNA. Translation: BAE23899.1.
AK158315 mRNA. Translation: BAE34456.1.
AK164089 mRNA. Translation: BAE37620.1.
CH466522 Genomic DNA. Translation: EDL26334.1.
BC024785 mRNA. Translation: AAH24785.1.
CCDSiCCDS23347.1. [P47867-1]
RefSeqiNP_001158262.1. NM_001164790.1. [P47867-2]
NP_033156.1. NM_009130.3. [P47867-1]
UniGeneiMm.2386.

Genome annotation databases

EnsembliENSMUST00000034699; ENSMUSP00000034699; ENSMUSG00000032181. [P47867-1]
GeneIDi20255.
KEGGimmu:20255.
UCSCiuc009qss.2. mouse. [P47867-1]
uc009qst.2. mouse. [P47867-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02982 mRNA. Translation: AAA56636.1.
AK133655 mRNA. Translation: BAE21767.1.
AK139140 mRNA. Translation: BAE23899.1.
AK158315 mRNA. Translation: BAE34456.1.
AK164089 mRNA. Translation: BAE37620.1.
CH466522 Genomic DNA. Translation: EDL26334.1.
BC024785 mRNA. Translation: AAH24785.1.
CCDSiCCDS23347.1. [P47867-1]
RefSeqiNP_001158262.1. NM_001164790.1. [P47867-2]
NP_033156.1. NM_009130.3. [P47867-1]
UniGeneiMm.2386.

3D structure databases

ProteinModelPortaliP47867.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034699.

PTM databases

iPTMnetiP47867.
PhosphoSiteiP47867.

Proteomic databases

PaxDbiP47867.
PeptideAtlasiP47867.
PRIDEiP47867.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034699; ENSMUSP00000034699; ENSMUSG00000032181. [P47867-1]
GeneIDi20255.
KEGGimmu:20255.
UCSCiuc009qss.2. mouse. [P47867-1]
uc009qst.2. mouse. [P47867-2]

Organism-specific databases

CTDi29106.
MGIiMGI:103032. Scg3.

Phylogenomic databases

eggNOGiENOG410IHUH. Eukaryota.
ENOG4110KQ3. LUCA.
GeneTreeiENSGT00390000005488.
HOGENOMiHOG000247064.
HOVERGENiHBG057085.
InParanoidiP47867.
OMAiANNYEED.
OrthoDBiEOG7G1V64.
PhylomeDBiP47867.
TreeFamiTF331266.

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.

Miscellaneous databases

PROiP47867.
SOURCEiSearch...

Gene expression databases

BgeeiP47867.
CleanExiMM_SCG3.
GenevisibleiP47867. MM.

Family and domain databases

InterProiIPR026197. SCG3.
[Graphical view]
PANTHERiPTHR17388. PTHR17388. 1 hit.
PfamiPF15467. SGIII. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure of mouse secretogranin III and its absence from deficient mice."
    Dopazo A., Lovenberg T.W., Danielson P.E., Ottiger H.-P., Sutcliffe J.G.
    J. Mol. Neurosci. 4:225-233(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Cerebellum, Embryonic spinal cord, Inner ear and Pituitary.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Retina.
  5. "Identification of a chromogranin A domain that mediates binding to secretogranin III and targeting to secretory granules in pituitary cells and pancreatic beta-cells."
    Hosaka M., Watanabe T., Sakai Y., Uchiyama Y., Takeuchi T.
    Mol. Biol. Cell 13:3388-3399(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CHGA, SUBCELLULAR LOCATION.
  6. Cited for: TISSUE SPECIFICITY.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40 AND SER-365, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain and Pancreas.

Entry informationi

Entry nameiSCG3_MOUSE
AccessioniPrimary (citable) accession number: P47867
Secondary accession number(s): Q3UTT1, Q3UZT8, Q8R1D7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 6, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.