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Protein

Aquaporin-5

Gene

Aqp5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells.By similarity

GO - Molecular functioni

  • glycerol channel activity Source: GO_Central
  • water channel activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-RNO-432047. Passive transport by Aquaporins.

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-5
Short name:
AQP-5
Gene namesi
Name:Aqp5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi2144. Aqp5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Topological domaini34 – 36ExtracellularSequence analysis3
Transmembranei37 – 57HelicalSequence analysisAdd BLAST21
Topological domaini58 – 87CytoplasmicSequence analysisAdd BLAST30
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 126ExtracellularSequence analysisAdd BLAST18
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Topological domaini148 – 161CytoplasmicSequence analysisAdd BLAST14
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183 – 205ExtracellularSequence analysisAdd BLAST23
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Topological domaini227 – 265CytoplasmicSequence analysisAdd BLAST39

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000639531 – 265Aquaporin-5Add BLAST265

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi124N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP47864.
PRIDEiP47864.

PTM databases

iPTMnetiP47864.
PhosphoSitePlusiP47864.

Expressioni

Tissue specificityi

Salivary glands, lacrimal glands, corneal epithelium in eye, trachea and lung.

Gene expression databases

BgeeiENSRNOG00000017685.
GenevisibleiP47864. RN.

Interactioni

Subunit structurei

Interacts with TRPV4; the interaction is probably indirect and regulates TRPV4 activation by hypotonicity.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024102.

Structurei

3D structure databases

ProteinModelPortaliP47864.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi69 – 71NPA 13
Motifi185 – 187NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0223. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00760000119223.
HOVERGENiHBG000312.
InParanoidiP47864.
KOiK09867.
OMAiNISGCHV.
OrthoDBiEOG091G166T.
TreeFamiTF312940.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR023276. Aquaporin_5.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR02017. AQUAPORIN5.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47864-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKEVCSLAF FKAVFAEFLA TLIFVFFGLG SALKWPSALP TILQISIAFG
60 70 80 90 100
LAIGTLAQAL GPVSGGHINP AITLALLIGN QISLLRAVFY VAAQLVGAIA
110 120 130 140 150
GAGILYWLAP LNARGNLAVN ALNNNTTPGK AMVVELILTF QLALCIFSST
160 170 180 190 200
DSRRTSPVGS PALSIGLSVT LGHLVGIYFT GCSMNPARSF GPAVVMNRFS
210 220 230 240 250
PSHWVFWVGP IVGAMLAAIL YFYLLFPSSL SLHDRVAVVK GTYEPEEDWE
260
DHREERKKTI ELTAH
Length:265
Mass (Da):28,421
Last modified:February 1, 1996 - v1
Checksum:iDE0F1BED9D2C0600
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16245 mRNA. Translation: AAA66221.1.
BC092572 mRNA. Translation: AAH92572.2.
BC110045 mRNA. Translation: AAI10046.1.
PIRiA55630.
RefSeqiNP_036911.1. NM_012779.1.
UniGeneiRn.10066.

Genome annotation databases

EnsembliENSRNOT00000084911; ENSRNOP00000073596; ENSRNOG00000051970.
GeneIDi25241.
KEGGirno:25241.
UCSCiRGD:2144. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16245 mRNA. Translation: AAA66221.1.
BC092572 mRNA. Translation: AAH92572.2.
BC110045 mRNA. Translation: AAI10046.1.
PIRiA55630.
RefSeqiNP_036911.1. NM_012779.1.
UniGeneiRn.10066.

3D structure databases

ProteinModelPortaliP47864.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024102.

PTM databases

iPTMnetiP47864.
PhosphoSitePlusiP47864.

Proteomic databases

PaxDbiP47864.
PRIDEiP47864.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000084911; ENSRNOP00000073596; ENSRNOG00000051970.
GeneIDi25241.
KEGGirno:25241.
UCSCiRGD:2144. rat.

Organism-specific databases

CTDi362.
RGDi2144. Aqp5.

Phylogenomic databases

eggNOGiKOG0223. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00760000119223.
HOVERGENiHBG000312.
InParanoidiP47864.
KOiK09867.
OMAiNISGCHV.
OrthoDBiEOG091G166T.
TreeFamiTF312940.

Enzyme and pathway databases

ReactomeiR-RNO-432047. Passive transport by Aquaporins.

Miscellaneous databases

PROiP47864.

Gene expression databases

BgeeiENSRNOG00000017685.
GenevisibleiP47864. RN.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR023276. Aquaporin_5.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR02017. AQUAPORIN5.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAQP5_RAT
AccessioniPrimary (citable) accession number: P47864
Secondary accession number(s): Q2YDV0, Q569C5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.