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P47853 (PGS1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Biglycan
Alternative name(s):
Bone/cartilage proteoglycan I
PG-S1
Gene names
Name:Bgn
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length369 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in collagen fiber assembly By similarity.

Subunit structure

Homodimer. Forms a ternary complex with MFAP2 and ELN By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity.

Tissue specificity

Found in several connective tissues, especially in articular cartilages.

Post-translational modification

The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate By similarity.

Sequence similarities

Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.

Contains 12 LRR (leucine-rich) repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Propeptide20 – 3718
PRO_0000032697
Chain38 – 369332Biglycan
PRO_0000032698

Regions

Repeat83 – 10321LRR 1
Repeat104 – 12724LRR 2
Repeat128 – 15124LRR 3
Repeat152 – 17221LRR 4
Repeat173 – 19624LRR 5
Repeat197 – 22125LRR 6
Repeat222 – 24221LRR 7
Repeat243 – 26624LRR 8
Repeat267 – 29024LRR 9
Repeat291 – 31323LRR 10
Repeat314 – 34330LRR 11
Repeat344 – 36926LRR 12
Compositional bias64 – 7714Cys-rich

Amino acid modifications

Glycosylation421O-linked (Xyl...) (glycosaminoglycan) By similarity
Glycosylation481O-linked (Xyl...) (glycosaminoglycan) By similarity
Glycosylation2711N-linked (GlcNAc...) Potential
Glycosylation3121N-linked (GlcNAc...) Potential
Disulfide bond64 ↔ 70 By similarity
Disulfide bond68 ↔ 77 By similarity
Disulfide bond322 ↔ 355 By similarity

Sequences

Sequence LengthMass (Da)Tools
P47853 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 319DC15117F2C604

FASTA36941,706
        10         20         30         40         50         60 
MRPLWLLTLL LALSQALPFE QKGFWDFTLD DGLLMMNDEE ASGSDTTSGV PDLDSLTPTF 

        70         80         90        100        110        120 
SAMCPFGCHC HLRVVQCSDL GLKTVPKEIS PDTTLLDLQN NDISELRKDD FKGLQHLYAL 

       130        140        150        160        170        180 
VLVNNKISKI HEKAFSPLRK LQKLYISKNH LVEIPPNLPS SLVELRIHDN RIRKVPKGVF 

       190        200        210        220        230        240 
SGLRNMNCIE MGGNPLENSG FEPGAFDGLK LNYLRISEAK LTGIPKDLPE TLNELHLDHN 

       250        260        270        280        290        300 
KIQAIELEDL LRYSKLYRLG LGHNQIRMIE NGSLSFLPTL RELHLDNNKL SRVPAGLPDL 

       310        320        330        340        350        360 
KLLQVVYLHS NNITKVGIND FCPMGFGVKR AYYNGISLFN NPVPYWEVQP ATFRCVTDRL 


AIQFGNYKK 

« Hide

References

« Hide 'large scale' references
[1]"Vascular smooth muscle biglycan represents a highly conserved proteoglycan within the arterial wall."
Dreher K.L., Asundi V.K., Matzura D., Cowan K.
Eur. J. Cell Biol. 53:296-304(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Vascular smooth muscle.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U17834 mRNA. Translation: AAA58797.1.
BC072480 mRNA. Translation: AAH72480.1.
PIRPT0077.
S32793.
RefSeqNP_058783.1. NM_017087.1.
UniGeneRn.783.

3D structure databases

ProteinModelPortalP47853.
SMRP47853. Positions 62-366.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP47853. 2 interactions.
STRING10116.ENSRNOP00000023920.

Proteomic databases

PaxDbP47853.
PRIDEP47853.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000023920; ENSRNOP00000023920; ENSRNOG00000017440.
GeneID25181.
KEGGrno:25181.

Organism-specific databases

CTD633.
RGD2207. Bgn.

Phylogenomic databases

eggNOGCOG4886.
GeneTreeENSGT00730000110250.
HOGENOMHOG000261690.
HOVERGENHBG016052.
InParanoidP47853.
KOK08118.
OMAIQFGNYK.
OrthoDBEOG76739V.
PhylomeDBP47853.
TreeFamTF334562.

Gene expression databases

GenevestigatorP47853.

Family and domain databases

InterProIPR028547. Biglycan.
IPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
IPR016352. SLRP_I_decor/aspor/byglycan.
[Graphical view]
PANTHERPTHR24369:SF6. PTHR24369:SF6. 1 hit.
PfamPF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
PIRSFPIRSF002490. SLRP_I. 1 hit.
SMARTSM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEPS51450. LRR. 8 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio605671.
PROP47853.

Entry information

Entry namePGS1_RAT
AccessionPrimary (citable) accession number: P47853
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 14, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families