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P47853

- PGS1_RAT

UniProt

P47853 - PGS1_RAT

Protein

Biglycan

Gene

Bgn

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    May be involved in collagen fiber assembly.By similarity

    GO - Molecular functioni

    1. extracellular matrix binding Source: Ensembl
    2. glycosaminoglycan binding Source: Ensembl

    GO - Biological processi

    1. blood vessel remodeling Source: RGD
    2. peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_198577. CS/DS degradation.
    REACT_198757. ECM proteoglycans.
    REACT_198784. A tetrasaccharide linker sequence is required for GAG synthesis.
    REACT_198797. Chondroitin sulfate biosynthesis.
    REACT_198808. Dermatan sulfate biosynthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Biglycan
    Alternative name(s):
    Bone/cartilage proteoglycan I
    PG-S1
    Gene namesi
    Name:Bgn
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi2207. Bgn.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. proteinaceous extracellular matrix Source: UniProtKB-SubCell
    3. sarcolemma Source: Ensembl
    4. transport vesicle Source: Ensembl

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Propeptidei20 – 3718PRO_0000032697Add
    BLAST
    Chaini38 – 369332BiglycanPRO_0000032698Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi42 – 421O-linked (Xyl...) (glycosaminoglycan)By similarity
    Glycosylationi48 – 481O-linked (Xyl...) (glycosaminoglycan)By similarity
    Disulfide bondi64 ↔ 70By similarity
    Disulfide bondi68 ↔ 77By similarity
    Glycosylationi271 – 2711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi322 ↔ 355By similarity

    Post-translational modificationi

    The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Proteoglycan

    Proteomic databases

    PaxDbiP47853.
    PRIDEiP47853.

    Expressioni

    Tissue specificityi

    Found in several connective tissues, especially in articular cartilages.

    Gene expression databases

    GenevestigatoriP47853.

    Interactioni

    Subunit structurei

    Homodimer. Forms a ternary complex with MFAP2 and ELN By similarity.By similarity

    Protein-protein interaction databases

    IntActiP47853. 2 interactions.
    STRINGi10116.ENSRNOP00000023920.

    Structurei

    3D structure databases

    ProteinModelPortaliP47853.
    SMRiP47853. Positions 62-366.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati83 – 10321LRR 1Add
    BLAST
    Repeati104 – 12724LRR 2Add
    BLAST
    Repeati128 – 15124LRR 3Add
    BLAST
    Repeati152 – 17221LRR 4Add
    BLAST
    Repeati173 – 19624LRR 5Add
    BLAST
    Repeati197 – 22125LRR 6Add
    BLAST
    Repeati222 – 24221LRR 7Add
    BLAST
    Repeati243 – 26624LRR 8Add
    BLAST
    Repeati267 – 29024LRR 9Add
    BLAST
    Repeati291 – 31323LRR 10Add
    BLAST
    Repeati314 – 34330LRR 11Add
    BLAST
    Repeati344 – 36926LRR 12Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi64 – 7714Cys-richAdd
    BLAST

    Sequence similaritiesi

    Contains 12 LRR (leucine-rich) repeats.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG4886.
    GeneTreeiENSGT00730000110250.
    HOGENOMiHOG000261690.
    HOVERGENiHBG016052.
    InParanoidiP47853.
    KOiK08118.
    OMAiIQFGNYK.
    OrthoDBiEOG76739V.
    PhylomeDBiP47853.
    TreeFamiTF334562.

    Family and domain databases

    InterProiIPR028547. Biglycan.
    IPR001611. Leu-rich_rpt.
    IPR000372. LRR-contain_N.
    IPR016352. SLRP_I_decor/aspor/byglycan.
    [Graphical view]
    PANTHERiPTHR24369:SF6. PTHR24369:SF6. 1 hit.
    PfamiPF13855. LRR_8. 3 hits.
    PF01462. LRRNT. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002490. SLRP_I. 1 hit.
    SMARTiSM00013. LRRNT. 1 hit.
    [Graphical view]
    PROSITEiPS51450. LRR. 8 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P47853-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRPLWLLTLL LALSQALPFE QKGFWDFTLD DGLLMMNDEE ASGSDTTSGV    50
    PDLDSLTPTF SAMCPFGCHC HLRVVQCSDL GLKTVPKEIS PDTTLLDLQN 100
    NDISELRKDD FKGLQHLYAL VLVNNKISKI HEKAFSPLRK LQKLYISKNH 150
    LVEIPPNLPS SLVELRIHDN RIRKVPKGVF SGLRNMNCIE MGGNPLENSG 200
    FEPGAFDGLK LNYLRISEAK LTGIPKDLPE TLNELHLDHN KIQAIELEDL 250
    LRYSKLYRLG LGHNQIRMIE NGSLSFLPTL RELHLDNNKL SRVPAGLPDL 300
    KLLQVVYLHS NNITKVGIND FCPMGFGVKR AYYNGISLFN NPVPYWEVQP 350
    ATFRCVTDRL AIQFGNYKK 369
    Length:369
    Mass (Da):41,706
    Last modified:February 1, 1996 - v1
    Checksum:i319DC15117F2C604
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U17834 mRNA. Translation: AAA58797.1.
    BC072480 mRNA. Translation: AAH72480.1.
    PIRiPT0077.
    S32793.
    RefSeqiNP_058783.1. NM_017087.1.
    UniGeneiRn.783.

    Genome annotation databases

    EnsembliENSRNOT00000023920; ENSRNOP00000023920; ENSRNOG00000017440.
    GeneIDi25181.
    KEGGirno:25181.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U17834 mRNA. Translation: AAA58797.1 .
    BC072480 mRNA. Translation: AAH72480.1 .
    PIRi PT0077.
    S32793.
    RefSeqi NP_058783.1. NM_017087.1.
    UniGenei Rn.783.

    3D structure databases

    ProteinModelPortali P47853.
    SMRi P47853. Positions 62-366.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P47853. 2 interactions.
    STRINGi 10116.ENSRNOP00000023920.

    Proteomic databases

    PaxDbi P47853.
    PRIDEi P47853.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000023920 ; ENSRNOP00000023920 ; ENSRNOG00000017440 .
    GeneIDi 25181.
    KEGGi rno:25181.

    Organism-specific databases

    CTDi 633.
    RGDi 2207. Bgn.

    Phylogenomic databases

    eggNOGi COG4886.
    GeneTreei ENSGT00730000110250.
    HOGENOMi HOG000261690.
    HOVERGENi HBG016052.
    InParanoidi P47853.
    KOi K08118.
    OMAi IQFGNYK.
    OrthoDBi EOG76739V.
    PhylomeDBi P47853.
    TreeFami TF334562.

    Enzyme and pathway databases

    Reactomei REACT_198577. CS/DS degradation.
    REACT_198757. ECM proteoglycans.
    REACT_198784. A tetrasaccharide linker sequence is required for GAG synthesis.
    REACT_198797. Chondroitin sulfate biosynthesis.
    REACT_198808. Dermatan sulfate biosynthesis.

    Miscellaneous databases

    NextBioi 605671.
    PROi P47853.

    Gene expression databases

    Genevestigatori P47853.

    Family and domain databases

    InterProi IPR028547. Biglycan.
    IPR001611. Leu-rich_rpt.
    IPR000372. LRR-contain_N.
    IPR016352. SLRP_I_decor/aspor/byglycan.
    [Graphical view ]
    PANTHERi PTHR24369:SF6. PTHR24369:SF6. 1 hit.
    Pfami PF13855. LRR_8. 3 hits.
    PF01462. LRRNT. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002490. SLRP_I. 1 hit.
    SMARTi SM00013. LRRNT. 1 hit.
    [Graphical view ]
    PROSITEi PS51450. LRR. 8 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Vascular smooth muscle biglycan represents a highly conserved proteoglycan within the arterial wall."
      Dreher K.L., Asundi V.K., Matzura D., Cowan K.
      Eur. J. Cell Biol. 53:296-304(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Vascular smooth muscle.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.

    Entry informationi

    Entry nameiPGS1_RAT
    AccessioniPrimary (citable) accession number: P47853
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3