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P47853

- PGS1_RAT

UniProt

P47853 - PGS1_RAT

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Protein
Biglycan
Gene
Bgn
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in collagen fiber assembly By similarity.

GO - Molecular functioni

  1. extracellular matrix binding Source: Ensembl
  2. glycosaminoglycan binding Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. blood vessel remodeling Source: RGD
  2. peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_198577. CS/DS degradation.
REACT_198757. ECM proteoglycans.
REACT_198784. A tetrasaccharide linker sequence is required for GAG synthesis.
REACT_198797. Chondroitin sulfate biosynthesis.
REACT_198808. Dermatan sulfate biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Biglycan
Alternative name(s):
Bone/cartilage proteoglycan I
PG-S1
Gene namesi
Name:Bgn
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi2207. Bgn.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. proteinaceous extracellular matrix Source: UniProtKB-SubCell
  3. sarcolemma Source: Ensembl
  4. transport vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Propeptidei20 – 3718
PRO_0000032697Add
BLAST
Chaini38 – 369332Biglycan
PRO_0000032698Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421O-linked (Xyl...) (glycosaminoglycan) By similarity
Glycosylationi48 – 481O-linked (Xyl...) (glycosaminoglycan) By similarity
Disulfide bondi64 ↔ 70 By similarity
Disulfide bondi68 ↔ 77 By similarity
Glycosylationi271 – 2711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi312 – 3121N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi322 ↔ 355 By similarity

Post-translational modificationi

The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

PaxDbiP47853.
PRIDEiP47853.

Expressioni

Tissue specificityi

Found in several connective tissues, especially in articular cartilages.

Gene expression databases

GenevestigatoriP47853.

Interactioni

Subunit structurei

Homodimer. Forms a ternary complex with MFAP2 and ELN By similarity.

Protein-protein interaction databases

IntActiP47853. 2 interactions.
STRINGi10116.ENSRNOP00000023920.

Structurei

3D structure databases

ProteinModelPortaliP47853.
SMRiP47853. Positions 62-366.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati83 – 10321LRR 1
Add
BLAST
Repeati104 – 12724LRR 2
Add
BLAST
Repeati128 – 15124LRR 3
Add
BLAST
Repeati152 – 17221LRR 4
Add
BLAST
Repeati173 – 19624LRR 5
Add
BLAST
Repeati197 – 22125LRR 6
Add
BLAST
Repeati222 – 24221LRR 7
Add
BLAST
Repeati243 – 26624LRR 8
Add
BLAST
Repeati267 – 29024LRR 9
Add
BLAST
Repeati291 – 31323LRR 10
Add
BLAST
Repeati314 – 34330LRR 11
Add
BLAST
Repeati344 – 36926LRR 12
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi64 – 7714Cys-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00730000110250.
HOGENOMiHOG000261690.
HOVERGENiHBG016052.
InParanoidiP47853.
KOiK08118.
OMAiIQFGNYK.
OrthoDBiEOG76739V.
PhylomeDBiP47853.
TreeFamiTF334562.

Family and domain databases

InterProiIPR028547. Biglycan.
IPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
IPR016352. SLRP_I_decor/aspor/byglycan.
[Graphical view]
PANTHERiPTHR24369:SF6. PTHR24369:SF6. 1 hit.
PfamiPF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
PIRSFiPIRSF002490. SLRP_I. 1 hit.
SMARTiSM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47853-1 [UniParc]FASTAAdd to Basket

« Hide

MRPLWLLTLL LALSQALPFE QKGFWDFTLD DGLLMMNDEE ASGSDTTSGV    50
PDLDSLTPTF SAMCPFGCHC HLRVVQCSDL GLKTVPKEIS PDTTLLDLQN 100
NDISELRKDD FKGLQHLYAL VLVNNKISKI HEKAFSPLRK LQKLYISKNH 150
LVEIPPNLPS SLVELRIHDN RIRKVPKGVF SGLRNMNCIE MGGNPLENSG 200
FEPGAFDGLK LNYLRISEAK LTGIPKDLPE TLNELHLDHN KIQAIELEDL 250
LRYSKLYRLG LGHNQIRMIE NGSLSFLPTL RELHLDNNKL SRVPAGLPDL 300
KLLQVVYLHS NNITKVGIND FCPMGFGVKR AYYNGISLFN NPVPYWEVQP 350
ATFRCVTDRL AIQFGNYKK 369
Length:369
Mass (Da):41,706
Last modified:February 1, 1996 - v1
Checksum:i319DC15117F2C604
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U17834 mRNA. Translation: AAA58797.1.
BC072480 mRNA. Translation: AAH72480.1.
PIRiPT0077.
S32793.
RefSeqiNP_058783.1. NM_017087.1.
UniGeneiRn.783.

Genome annotation databases

EnsembliENSRNOT00000023920; ENSRNOP00000023920; ENSRNOG00000017440.
GeneIDi25181.
KEGGirno:25181.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U17834 mRNA. Translation: AAA58797.1 .
BC072480 mRNA. Translation: AAH72480.1 .
PIRi PT0077.
S32793.
RefSeqi NP_058783.1. NM_017087.1.
UniGenei Rn.783.

3D structure databases

ProteinModelPortali P47853.
SMRi P47853. Positions 62-366.
ModBasei Search...

Protein-protein interaction databases

IntActi P47853. 2 interactions.
STRINGi 10116.ENSRNOP00000023920.

Proteomic databases

PaxDbi P47853.
PRIDEi P47853.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000023920 ; ENSRNOP00000023920 ; ENSRNOG00000017440 .
GeneIDi 25181.
KEGGi rno:25181.

Organism-specific databases

CTDi 633.
RGDi 2207. Bgn.

Phylogenomic databases

eggNOGi COG4886.
GeneTreei ENSGT00730000110250.
HOGENOMi HOG000261690.
HOVERGENi HBG016052.
InParanoidi P47853.
KOi K08118.
OMAi IQFGNYK.
OrthoDBi EOG76739V.
PhylomeDBi P47853.
TreeFami TF334562.

Enzyme and pathway databases

Reactomei REACT_198577. CS/DS degradation.
REACT_198757. ECM proteoglycans.
REACT_198784. A tetrasaccharide linker sequence is required for GAG synthesis.
REACT_198797. Chondroitin sulfate biosynthesis.
REACT_198808. Dermatan sulfate biosynthesis.

Miscellaneous databases

NextBioi 605671.
PROi P47853.

Gene expression databases

Genevestigatori P47853.

Family and domain databases

InterProi IPR028547. Biglycan.
IPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
IPR016352. SLRP_I_decor/aspor/byglycan.
[Graphical view ]
PANTHERi PTHR24369:SF6. PTHR24369:SF6. 1 hit.
Pfami PF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view ]
PIRSFi PIRSF002490. SLRP_I. 1 hit.
SMARTi SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS51450. LRR. 8 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Vascular smooth muscle biglycan represents a highly conserved proteoglycan within the arterial wall."
    Dreher K.L., Asundi V.K., Matzura D., Cowan K.
    Eur. J. Cell Biol. 53:296-304(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Vascular smooth muscle.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiPGS1_RAT
AccessioniPrimary (citable) accession number: P47853
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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