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P47849

- RF1_COXBU

UniProt

P47849 - RF1_COXBU

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Protein

Peptide chain release factor 1

Gene

prfA

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.By similarity

GO - Molecular functioni

  1. translation release factor activity, codon specific Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1939-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide chain release factor 1
Short name:
RF-1
Gene namesi
Name:prfA
Ordered Locus Names:CBU_1965
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361Peptide chain release factor 1PRO_0000177664Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei237 – 2371N5-methylglutamineBy similarity

Post-translational modificationi

Methylated by PrmC. Methylation increases the termination efficiency of RF1 (By similarity).By similarity

Keywords - PTMi

Methylation

Proteomic databases

PRIDEiP47849.

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_1965.

Structurei

3D structure databases

ProteinModelPortaliP47849.
SMRiP47849. Positions 8-356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0216.
HOGENOMiHOG000074815.
KOiK02835.
OMAiYGQLKFE.
OrthoDBiEOG6TN48J.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
HAMAPiMF_00093. Rel_fac_1.
InterProiIPR014720. dsRNA-bd_dom.
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
IPR004373. PrfA.
[Graphical view]
PfamiPF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
[Graphical view]
SMARTiSM00937. PCRF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00019. prfA. 1 hit.
PROSITEiPS00745. RF_PROK_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47849-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKPSLIEKLK TLTYRYSEIG GLLSDSTVIN DQDRYRELGK EYAQLEPIVK
60 70 80 90 100
CFQQFQQNEK AIESAEEMQQ EKDPELRKLA EEELEQLTLK KEELEDQLKL
110 120 130 140 150
LLVPKDPNDE RNVFLEIRAG TGGNEAAIFA GDLFRMYARY AETKGWRVNI
160 170 180 190 200
VSAHEGEHGG FKEVIARVIG EGVYSQLKFE SGAHRVQRVP VTESQGRIHT
210 220 230 240 250
SACTVAIMPE VDEIDQIKIN PAELRIDTFR ASGAGGQHVN RTDSAIRITH
260 270 280 290 300
LPTGVVVECQ DERSQHKNKA RAMSLLQSKL LAAERAKQDQ EQAAKRKSLV
310 320 330 340 350
GSGDRSERIR TYNFPQGRVT DHRINLTLYQ LDEVIEGDLD PVIGPLIREL
360
QAEQLAELSG E
Length:361
Mass (Da):40,763
Last modified:May 9, 2003 - v2
Checksum:iEDB0A087C408F257
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti99 – 991K → N in CAA55563. (PubMed:8549730)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78969 Genomic DNA. Translation: CAA55563.1.
AE016828 Genomic DNA. Translation: AAO91454.1.
PIRiA61648.
RefSeqiNP_820940.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO91454; AAO91454; CBU_1965.
GeneIDi1209878.
KEGGicbu:CBU_1965.
PATRICi17932673. VBICoxBur82552_1953.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78969 Genomic DNA. Translation: CAA55563.1 .
AE016828 Genomic DNA. Translation: AAO91454.1 .
PIRi A61648.
RefSeqi NP_820940.1. NC_002971.3.

3D structure databases

ProteinModelPortali P47849.
SMRi P47849. Positions 8-356.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227377.CBU_1965.

Proteomic databases

PRIDEi P47849.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO91454 ; AAO91454 ; CBU_1965 .
GeneIDi 1209878.
KEGGi cbu:CBU_1965.
PATRICi 17932673. VBICoxBur82552_1953.

Phylogenomic databases

eggNOGi COG0216.
HOGENOMi HOG000074815.
KOi K02835.
OMAi YGQLKFE.
OrthoDBi EOG6TN48J.

Enzyme and pathway databases

BioCyci CBUR227377:GJ7S-1939-MONOMER.

Family and domain databases

Gene3Di 3.30.160.20. 1 hit.
HAMAPi MF_00093. Rel_fac_1.
InterProi IPR014720. dsRNA-bd_dom.
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
IPR004373. PrfA.
[Graphical view ]
Pfami PF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
[Graphical view ]
SMARTi SM00937. PCRF. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00019. prfA. 1 hit.
PROSITEi PS00745. RF_PROK_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequencing and linkage analysis of a Coxiella burnetii 2.1 kb NotI fragment."
    Willems H., Thiele D., Krauss H.
    Eur. J. Epidemiol. 11:559-561(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Nine Mile phase I.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiRF1_COXBU
AccessioniPrimary (citable) accession number: P47849
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 9, 2003
Last modified: October 29, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3