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P47849

- RF1_COXBU

UniProt

P47849 - RF1_COXBU

Protein

Peptide chain release factor 1

Gene

prfA

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (09 May 2003)
      Previous versions | rss
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    Functioni

    Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.By similarity

    GO - Molecular functioni

    1. translation release factor activity, codon specific Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Protein biosynthesis

    Enzyme and pathway databases

    BioCyciCBUR227377:GJ7S-1939-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide chain release factor 1
    Short name:
    RF-1
    Gene namesi
    Name:prfA
    Ordered Locus Names:CBU_1965
    OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
    Taxonomic identifieri227377 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000002671: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 361361Peptide chain release factor 1PRO_0000177664Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei237 – 2371N5-methylglutamineBy similarity

    Post-translational modificationi

    Methylated by PrmC. Methylation increases the termination efficiency of RF1 By similarity.By similarity

    Keywords - PTMi

    Methylation

    Proteomic databases

    PRIDEiP47849.

    Interactioni

    Protein-protein interaction databases

    STRINGi227377.CBU_1965.

    Structurei

    3D structure databases

    ProteinModelPortaliP47849.
    SMRiP47849. Positions 8-356.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0216.
    HOGENOMiHOG000074815.
    KOiK02835.
    OMAiYGQLKFE.
    OrthoDBiEOG6TN48J.

    Family and domain databases

    Gene3Di3.30.160.20. 1 hit.
    HAMAPiMF_00093. Rel_fac_1.
    InterProiIPR014720. dsRNA-bd_dom.
    IPR005139. PCRF.
    IPR000352. Pep_chain_release_fac_I_II.
    IPR004373. PrfA.
    [Graphical view]
    PfamiPF03462. PCRF. 1 hit.
    PF00472. RF-1. 1 hit.
    [Graphical view]
    SMARTiSM00937. PCRF. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00019. prfA. 1 hit.
    PROSITEiPS00745. RF_PROK_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47849-1 [UniParc]FASTAAdd to Basket

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    MKPSLIEKLK TLTYRYSEIG GLLSDSTVIN DQDRYRELGK EYAQLEPIVK    50
    CFQQFQQNEK AIESAEEMQQ EKDPELRKLA EEELEQLTLK KEELEDQLKL 100
    LLVPKDPNDE RNVFLEIRAG TGGNEAAIFA GDLFRMYARY AETKGWRVNI 150
    VSAHEGEHGG FKEVIARVIG EGVYSQLKFE SGAHRVQRVP VTESQGRIHT 200
    SACTVAIMPE VDEIDQIKIN PAELRIDTFR ASGAGGQHVN RTDSAIRITH 250
    LPTGVVVECQ DERSQHKNKA RAMSLLQSKL LAAERAKQDQ EQAAKRKSLV 300
    GSGDRSERIR TYNFPQGRVT DHRINLTLYQ LDEVIEGDLD PVIGPLIREL 350
    QAEQLAELSG E 361
    Length:361
    Mass (Da):40,763
    Last modified:May 9, 2003 - v2
    Checksum:iEDB0A087C408F257
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti99 – 991K → N in CAA55563. (PubMed:8549730)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78969 Genomic DNA. Translation: CAA55563.1.
    AE016828 Genomic DNA. Translation: AAO91454.1.
    PIRiA61648.
    RefSeqiNP_820940.1. NC_002971.3.

    Genome annotation databases

    EnsemblBacteriaiAAO91454; AAO91454; CBU_1965.
    GeneIDi1209878.
    KEGGicbu:CBU_1965.
    PATRICi17932673. VBICoxBur82552_1953.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78969 Genomic DNA. Translation: CAA55563.1 .
    AE016828 Genomic DNA. Translation: AAO91454.1 .
    PIRi A61648.
    RefSeqi NP_820940.1. NC_002971.3.

    3D structure databases

    ProteinModelPortali P47849.
    SMRi P47849. Positions 8-356.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 227377.CBU_1965.

    Proteomic databases

    PRIDEi P47849.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO91454 ; AAO91454 ; CBU_1965 .
    GeneIDi 1209878.
    KEGGi cbu:CBU_1965.
    PATRICi 17932673. VBICoxBur82552_1953.

    Phylogenomic databases

    eggNOGi COG0216.
    HOGENOMi HOG000074815.
    KOi K02835.
    OMAi YGQLKFE.
    OrthoDBi EOG6TN48J.

    Enzyme and pathway databases

    BioCyci CBUR227377:GJ7S-1939-MONOMER.

    Family and domain databases

    Gene3Di 3.30.160.20. 1 hit.
    HAMAPi MF_00093. Rel_fac_1.
    InterProi IPR014720. dsRNA-bd_dom.
    IPR005139. PCRF.
    IPR000352. Pep_chain_release_fac_I_II.
    IPR004373. PrfA.
    [Graphical view ]
    Pfami PF03462. PCRF. 1 hit.
    PF00472. RF-1. 1 hit.
    [Graphical view ]
    SMARTi SM00937. PCRF. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00019. prfA. 1 hit.
    PROSITEi PS00745. RF_PROK_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequencing and linkage analysis of a Coxiella burnetii 2.1 kb NotI fragment."
      Willems H., Thiele D., Krauss H.
      Eur. J. Epidemiol. 11:559-561(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Nine Mile phase I.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RSA 493 / Nine Mile phase I.

    Entry informationi

    Entry nameiRF1_COXBU
    AccessioniPrimary (citable) accession number: P47849
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: May 9, 2003
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Coxiella burnetii
      Coxiella burnetii (strain RSA 493): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3