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Protein

Peptide chain release factor 1

Gene

prfA

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide chain release factor 1
Short name:
RF-1
Gene namesi
Name:prfA
Ordered Locus Names:CBU_1965
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001776641 – 361Peptide chain release factor 1Add BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei237N5-methylglutamineBy similarity1

Post-translational modificationi

Methylated by PrmC. Methylation increases the termination efficiency of RF1 (By similarity).By similarity

Keywords - PTMi

Methylation

Proteomic databases

PRIDEiP47849.

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_1965.

Structurei

3D structure databases

ProteinModelPortaliP47849.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C8K. Bacteria.
COG0216. LUCA.
HOGENOMiHOG000074815.
KOiK02835.
OMAiWRKVQDD.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
HAMAPiMF_00093. Rel_fac_1. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
IPR004373. PrfA.
[Graphical view]
PfamiPF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
[Graphical view]
SMARTiSM00937. PCRF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00019. prfA. 1 hit.
PROSITEiPS00745. RF_PROK_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47849-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPSLIEKLK TLTYRYSEIG GLLSDSTVIN DQDRYRELGK EYAQLEPIVK
60 70 80 90 100
CFQQFQQNEK AIESAEEMQQ EKDPELRKLA EEELEQLTLK KEELEDQLKL
110 120 130 140 150
LLVPKDPNDE RNVFLEIRAG TGGNEAAIFA GDLFRMYARY AETKGWRVNI
160 170 180 190 200
VSAHEGEHGG FKEVIARVIG EGVYSQLKFE SGAHRVQRVP VTESQGRIHT
210 220 230 240 250
SACTVAIMPE VDEIDQIKIN PAELRIDTFR ASGAGGQHVN RTDSAIRITH
260 270 280 290 300
LPTGVVVECQ DERSQHKNKA RAMSLLQSKL LAAERAKQDQ EQAAKRKSLV
310 320 330 340 350
GSGDRSERIR TYNFPQGRVT DHRINLTLYQ LDEVIEGDLD PVIGPLIREL
360
QAEQLAELSG E
Length:361
Mass (Da):40,763
Last modified:May 9, 2003 - v2
Checksum:iEDB0A087C408F257
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti99K → N in CAA55563 (PubMed:8549730).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78969 Genomic DNA. Translation: CAA55563.1.
AE016828 Genomic DNA. Translation: AAO91454.1.
PIRiA61648.
RefSeqiNP_820940.1. NC_002971.3.
WP_005772919.1. NZ_CDBG01000001.1.

Genome annotation databases

EnsemblBacteriaiAAO91454; AAO91454; CBU_1965.
GeneIDi1209878.
KEGGicbu:CBU_1965.
PATRICi17932673. VBICoxBur82552_1953.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78969 Genomic DNA. Translation: CAA55563.1.
AE016828 Genomic DNA. Translation: AAO91454.1.
PIRiA61648.
RefSeqiNP_820940.1. NC_002971.3.
WP_005772919.1. NZ_CDBG01000001.1.

3D structure databases

ProteinModelPortaliP47849.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227377.CBU_1965.

Proteomic databases

PRIDEiP47849.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO91454; AAO91454; CBU_1965.
GeneIDi1209878.
KEGGicbu:CBU_1965.
PATRICi17932673. VBICoxBur82552_1953.

Phylogenomic databases

eggNOGiENOG4105C8K. Bacteria.
COG0216. LUCA.
HOGENOMiHOG000074815.
KOiK02835.
OMAiWRKVQDD.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
HAMAPiMF_00093. Rel_fac_1. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
IPR004373. PrfA.
[Graphical view]
PfamiPF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
[Graphical view]
SMARTiSM00937. PCRF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00019. prfA. 1 hit.
PROSITEiPS00745. RF_PROK_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRF1_COXBU
AccessioniPrimary (citable) accession number: P47849
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 9, 2003
Last modified: November 2, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.