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P47849 (RF1_COXBU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptide chain release factor 1

Short name=RF-1
Gene names
Name:prfA
Ordered Locus Names:CBU_1965
OrganismCoxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]
Taxonomic identifier227377 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA By similarity. HAMAP-Rule MF_00093

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00093.

Post-translational modification

Methylated by PrmC. Methylation increases the termination efficiency of RF1 By similarity. HAMAP-Rule MF_00093

Sequence similarities

Belongs to the prokaryotic/mitochondrial release factor family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   PTMMethylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiontranslation release factor activity, codon specific

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 361361Peptide chain release factor 1 HAMAP-Rule MF_00093
PRO_0000177664

Amino acid modifications

Modified residue2371N5-methylglutamine By similarity

Experimental info

Sequence conflict991K → N in CAA55563. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P47849 [UniParc].

Last modified May 9, 2003. Version 2.
Checksum: EDB0A087C408F257

FASTA36140,763
        10         20         30         40         50         60 
MKPSLIEKLK TLTYRYSEIG GLLSDSTVIN DQDRYRELGK EYAQLEPIVK CFQQFQQNEK 

        70         80         90        100        110        120 
AIESAEEMQQ EKDPELRKLA EEELEQLTLK KEELEDQLKL LLVPKDPNDE RNVFLEIRAG 

       130        140        150        160        170        180 
TGGNEAAIFA GDLFRMYARY AETKGWRVNI VSAHEGEHGG FKEVIARVIG EGVYSQLKFE 

       190        200        210        220        230        240 
SGAHRVQRVP VTESQGRIHT SACTVAIMPE VDEIDQIKIN PAELRIDTFR ASGAGGQHVN 

       250        260        270        280        290        300 
RTDSAIRITH LPTGVVVECQ DERSQHKNKA RAMSLLQSKL LAAERAKQDQ EQAAKRKSLV 

       310        320        330        340        350        360 
GSGDRSERIR TYNFPQGRVT DHRINLTLYQ LDEVIEGDLD PVIGPLIREL QAEQLAELSG 


E 

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References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X78969 Genomic DNA. Translation: CAA55563.1.
AE016828 Genomic DNA. Translation: AAO91454.1.
PIRA61648.
RefSeqNP_820940.1. NC_002971.3.

3D structure databases

ProteinModelPortalP47849.
SMRP47849. Positions 8-356.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING227377.CBU_1965.

Proteomic databases

PRIDEP47849.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO91454; AAO91454; CBU_1965.
GeneID1209878.
KEGGcbu:CBU_1965.
PATRIC17932673. VBICoxBur82552_1953.

Phylogenomic databases

eggNOGCOG0216.
HOGENOMHOG000074815.
KOK02835.
OMAYGQLKFE.
OrthoDBEOG6TN48J.

Enzyme and pathway databases

BioCycCBUR227377:GJ7S-1939-MONOMER.

Family and domain databases

Gene3D3.30.160.20. 1 hit.
HAMAPMF_00093. Rel_fac_1.
InterProIPR014720. dsRNA-bd_dom.
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
IPR004373. PrfA.
[Graphical view]
PfamPF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
[Graphical view]
SMARTSM00937. PCRF. 1 hit.
[Graphical view]
TIGRFAMsTIGR00019. prfA. 1 hit.
PROSITEPS00745. RF_PROK_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRF1_COXBU
AccessionPrimary (citable) accession number: P47849
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 9, 2003
Last modified: May 14, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Coxiella burnetii

Coxiella burnetii (strain RSA 493): entries and gene names