P47848 (KITH_STRGC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidine kinase
EC=2.7.1.21

Gene names

Name:	tdk
Ordered Locus Names:	SGO_1155

Organism

Streptococcus gordonii (strain Challis / ATCC 35105 / CH1 / DL1 / V288) [Complete proteome] [HAMAP]

Taxonomic identifier

29390 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus gordonii

Protein attributes

Sequence length	191 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP-Rule MF_00124
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_00124.
Sequence similarities	Belongs to the thymidine kinase family.

Ontologies

Keywords
Biological process	DNA synthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP thymidine kinase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 191	191	Thymidine kinase HAMAP-Rule MF_00124		PRO_0000175030
Regions
	Nucleotide binding	9 – 16	8	ATP By similarity
	Nucleotide binding	85 – 88	4	ATP By similarity
Sites
	Active site	86	1	Proton acceptor Potential
	Metal binding	143	1	Zinc By similarity
	Metal binding	146	1	Zinc By similarity
	Metal binding	180	1	Zinc By similarity
	Metal binding	183	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	P47848 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 3F3EB8E3C5035283	FASTA	191	21,842
	10 20 30 40 50 60 MAQLYYKYGT MNSGKTIEIL KVAHNYEEQG KGVVIMTSAV DTRDGVGYVS SRIGMKRQAM 70 80 90 100 110 120 AIEDDTDILG YIKNLPEKPY CILIDEAQFL KRHHVYDLAR VVDELDVPVM AFGLKNDFRN 130 140 150 160 170 180 ELFEGSKHLL LLADKIEEIK TICQYCSRKA TMVLRTDHGK PVYDGEQIQI GGNETYIPVC 190 RKHYFKPDIN N

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and sequence analysis of thymidine kinase from the oral bacterium Streptococcus gordonii." McNab R. FEMS Microbiol. Lett. 135:103-110(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Genome-wide transcriptional changes in Streptococcus gordonii in response to competence signaling peptide." Vickerman M.M., Iobst S., Jesionowski A.M., Gill S.R. J. Bacteriol. 189:7799-7807(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Challis / ATCC 35105 / CH1 / DL1 / V288.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L40415 Genomic DNA. Translation: AAB02289.1. CP000725 Genomic DNA. Translation: ABV10749.1.
RefSeq	YP_001450442.1. NC_009785.1.
3D structure databases
ProteinModelPortal	P47848.
ModBase	Search...
Protein-protein interaction databases
STRING	467705.SGO_1155.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABV10749; ABV10749; SGO_1155.
GeneID	5598929.
KEGG	sgo:SGO_1155.
PATRIC	19660269. VBIStrGor124371_1141.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1435.
HOGENOM	HOG000076391.
KO	K00857.
OMA	FRYGAMN.
ProtClustDB	PRK04296.
Enzyme and pathway databases
BioCyc	SGOR467705:GH3R-1211-MONOMER.
Family and domain databases
HAMAP	MF_00124. Thymidine_kinase.
InterPro	IPR001267. Thymidine_kinase. IPR020633. Thymidine_kinase_CS. IPR020634. Thymidine_kinase_subgr. [Graphical view]
PANTHER	PTHR11441. PTHR11441. 1 hit.
Pfam	PF00265. TK. 1 hit. [Graphical view]
PIRSF	PIRSF035805. TK_cell. 1 hit.
PROSITE	PS00603. TK_CELLULAR_TYPE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KITH_STRGC

Accession

Primary (citable) accession number: P47848
Secondary accession number(s): A8AXD2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program