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P47848 (KITH_STRGC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:tdk
Ordered Locus Names:SGO_1155
OrganismStreptococcus gordonii (strain Challis / ATCC 35105 / CH1 / DL1 / V288) [Complete proteome] [HAMAP]
Taxonomic identifier29390 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length191 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP-Rule MF_00124

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00124

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00124.

Sequence similarities

Belongs to the thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   Cellular componentCytoplasm
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 191191Thymidine kinase HAMAP-Rule MF_00124
PRO_0000175030

Regions

Nucleotide binding9 – 168ATP By similarity
Nucleotide binding85 – 884ATP By similarity

Sites

Active site861Proton acceptor Potential
Metal binding1431Zinc By similarity
Metal binding1461Zinc By similarity
Metal binding1801Zinc By similarity
Metal binding1831Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
P47848 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 3F3EB8E3C5035283

FASTA19121,842
        10         20         30         40         50         60 
MAQLYYKYGT MNSGKTIEIL KVAHNYEEQG KGVVIMTSAV DTRDGVGYVS SRIGMKRQAM 

        70         80         90        100        110        120 
AIEDDTDILG YIKNLPEKPY CILIDEAQFL KRHHVYDLAR VVDELDVPVM AFGLKNDFRN 

       130        140        150        160        170        180 
ELFEGSKHLL LLADKIEEIK TICQYCSRKA TMVLRTDHGK PVYDGEQIQI GGNETYIPVC 

       190 
RKHYFKPDIN N 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and sequence analysis of thymidine kinase from the oral bacterium Streptococcus gordonii."
McNab R.
FEMS Microbiol. Lett. 135:103-110(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Genome-wide transcriptional changes in Streptococcus gordonii in response to competence signaling peptide."
Vickerman M.M., Iobst S., Jesionowski A.M., Gill S.R.
J. Bacteriol. 189:7799-7807(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Challis / ATCC 35105 / CH1 / DL1 / V288.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L40415 Genomic DNA. Translation: AAB02289.1.
CP000725 Genomic DNA. Translation: ABV10749.1.
RefSeqYP_001450442.1. NC_009785.1.

3D structure databases

ProteinModelPortalP47848.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING467705.SGO_1155.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV10749; ABV10749; SGO_1155.
GeneID5598929.
KEGGsgo:SGO_1155.
PATRIC19660269. VBIStrGor124371_1141.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1435.
HOGENOMHOG000076391.
KOK00857.
OMARTICHCG.
OrthoDBEOG69D3J2.
ProtClustDBPRK04296.

Enzyme and pathway databases

BioCycSGOR467705:GH3R-1153-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_00124. Thymidine_kinase.
InterProIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERPTHR11441. PTHR11441. 1 hit.
PfamPF00265. TK. 1 hit.
[Graphical view]
PIRSFPIRSF035805. TK_cell. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKITH_STRGC
AccessionPrimary (citable) accession number: P47848
Secondary accession number(s): A8AXD2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families