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Protein

Protein translocase subunit SecA 1

Gene

secA1

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: May bind 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi821ZincUniRule annotation1
Metal bindingi823ZincUniRule annotation1
Metal bindingi832ZincUniRule annotation1
Metal bindingi833ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi100 – 107ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciLMON169963:G1GTA-2687-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecA 1UniRule annotation
Gene namesi
Name:secA1UniRule annotation
Ordered Locus Names:lmo2510
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000000817 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation
  • Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001095901 – 837Protein translocase subunit SecA 1Add BLAST837

Proteomic databases

PaxDbiP47847

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.UniRule annotation

Protein-protein interaction databases

STRINGi169963.lmo2510

Structurei

3D structure databases

ProteinModelPortaliP47847
SMRiP47847
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI6 Bacteria
COG0653 LUCA
HOGENOMiHOG000218169
KOiK03070
OMAiFEYDEVM
PhylomeDBiP47847

Family and domain databases

HAMAPiMF_01382 SecA, 1 hit
InterProiView protein in InterPro
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR004027 SEC_C_motif
IPR000185 SecA
IPR020937 SecA_CS
IPR011115 SecA_DEAD
IPR014018 SecA_motor_DEAD
IPR011130 SecA_preprotein_X-link_dom
IPR011116 SecA_Wing/Scaffold
IPR036266 SecA_Wing/Scaffold_sf
IPR036670 SecA_X-link_sf
PANTHERiPTHR30612 PTHR30612, 2 hits
PfamiView protein in Pfam
PF02810 SEC-C, 1 hit
PF07517 SecA_DEAD, 1 hit
PF01043 SecA_PP_bind, 1 hit
PF07516 SecA_SW, 1 hit
PRINTSiPR00906 SECA
SMARTiView protein in SMART
SM00490 HELICc, 1 hit
SM00957 SecA_DEAD, 1 hit
SM00958 SecA_PP_bind, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits
SSF81767 SSF81767, 1 hit
SSF81886 SSF81886, 1 hit
TIGRFAMsiTIGR00963 secA, 1 hit
PROSITEiView protein in PROSITE
PS01312 SECA, 1 hit
PS51196 SECA_MOTOR_DEAD, 1 hit

Sequencei

Sequence statusi: Complete.

P47847-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLLKKIFE SGKKDVKYLE RKADEIIALA DETAALSDDA LREKTVEFKE
60 70 80 90 100
RVQKGETLDD LLVEAFAVAR EGAKRALGLY PFKVQLMGGI VLHEGNIAEM
110 120 130 140 150
KTGEGKTLTA TLPVYLNALS GEGVHVVTVN EYLAHRDAEE MGVLYNFLGL
160 170 180 190 200
SVGLNLNALS STEKREAYAC DITYSTNNEL GFDYLRDNMV VYKEEMVQRP
210 220 230 240 250
LAFAVIDEVD SILVDEARTP LIISGEAEKS TILYVRANTF VRTLTEEEDY
260 270 280 290 300
TVDIKTKSVQ LTEDGMTKGE NYFDVENLFD LENTVILHHI AQALKANYTM
310 320 330 340 350
SLDVDYVVQD DEVLIVDQFT GRIMKGRRFS EGLHQALEAK EGVTIQNESK
360 370 380 390 400
TMATITFQNY FRMYKKLAGM TGTAKTEEEE FRDIYNMRVI EIPTNKVIIR
410 420 430 440 450
DDRPDLIYTT IEAKFNAVVE DIAERHAKGQ PVLVGTVAIE TSELISSKLK
460 470 480 490 500
RKGIKHDVLN AKQHEREADI IKHAGERGAV VIATNMAGRG TDIKLGEGTI
510 520 530 540 550
EAGGLAVIGT ERHESRRIDN QLRGRSGRQG DPGVTQFYLS MEDELMRRFG
560 570 580 590 600
SDNMKSMMER FGMAEDAIQS KMVSRAVESA QRRVEGNNFD SRKQVLQYDD
610 620 630 640 650
VLRQQREVIY KQRYEVINAE NSLREIIEQM IQRTVNFIVS SNASSHEPEE
660 670 680 690 700
AWNLQGIIDY VDANLLPEGT ITLEDLQNRT SEDIQNLILD KIKAAYDEKE
710 720 730 740 750
TLLPPEEFNE FEKVVLLRVV DTKWVDHIDA MDHLRDGIHL RAYGQIDPLR
760 770 780 790 800
EYQSEGFEMF EAMVSSIDED VARYIMKAEI RQNLEREQVA KGEAINPAEG
810 820 830
KPEAKRQPIR KDQHIGRNDP CPCGSGKKYK NCHGKEA
Length:837
Mass (Da):94,659
Last modified:December 5, 2001 - v2
Checksum:i29F11A81980DBD02
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95G → D in AAA50286 (Ref. 1) Curated1
Sequence conflicti411I → M in AAA50286 (Ref. 1) Curated1
Sequence conflicti439 – 442IETS → MNI in AAA50286 (Ref. 1) Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L32090 Genomic DNA Translation: AAA50286.1
AL591983 Genomic DNA Translation: CAD00588.1
PIRiAF1388
RefSeqiNP_466033.1, NC_003210.1
WP_003722642.1, NC_003210.1

Genome annotation databases

EnsemblBacteriaiCAD00588; CAD00588; CAD00588
GeneIDi985470
KEGGilmo:lmo2510
PATRICifig|169963.11.peg.2570

Similar proteinsi

Entry informationi

Entry nameiSECA1_LISMO
AccessioniPrimary (citable) accession number: P47847
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 5, 2001
Last modified: May 23, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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