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Protein

Galectin-3

Gene

LGALS3

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation, Immunity, Innate immunity, mRNA processing, mRNA splicing

Keywords - Ligandi

IgE-binding protein, Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-3
Short name:
Gal-3
Alternative name(s):
35 kDa lectin
Carbohydrate-binding protein 35
Short name:
CBP 35
Galactose-specific lectin 3
IgE-binding protein
Laminin-binding protein
Lectin L-29
Mac-2 antigen
Gene namesi
Name:LGALS3
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 17

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity
  • Secreted By similarity

  • Note: Secreted by a non-classical secretory pathway and associates with the cell surface.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 242241Galectin-3PRO_0000076932Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei6 – 61Phosphoserine; by CK1By similarity
Modified residuei12 – 121PhosphoserineBy similarity
Disulfide bondi165 – 165InterchainBy similarity

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

PRIDEiP47845.

Interactioni

Subunit structurei

Probably forms homo- or heterodimers. Interacts with DMBT1 (By similarity). Interacts with CD6 and ALCAM. Forms a complex with the ITGA3, ITGB1 and CSPG4. Interacts with LGALS3BP, LYPD3, CYHR1 and UACA (By similarity).By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000002537.

Structurei

3D structure databases

ProteinModelPortaliP47845.
SMRiP47845. Positions 106-242.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati35 – 4391
Repeati44 – 5292
Repeati53 – 6193
Repeati62 – 7094
Repeati71 – 80105; approximate
Repeati81 – 92126; approximateAdd
BLAST
Repeati93 – 9867; truncated
Domaini110 – 240131GalectinPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni35 – 98647 X 9 AA tandem repeats of Y-P-G-X(3)-P-[GS]-AAdd
BLAST
Regioni173 – 1819Beta-galactoside bindingBy similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi218 – 23316Nuclear export signalBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 galectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3587. Eukaryota.
ENOG4111EA0. LUCA.
GeneTreeiENSGT00760000119105.
HOGENOMiHOG000246423.
HOVERGENiHBG006255.
InParanoidiP47845.
KOiK06831.
OMAiWGKEERH.
OrthoDBiEOG73Z2TM.
TreeFamiTF315551.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR015534. Galectin_3.
IPR001079. Galectin_CRD.
[Graphical view]
PANTHERiPTHR11346:SF26. PTHR11346:SF26. 1 hit.
PfamiPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51304. GALECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47845-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADGFSLNDA LSGSGHPPNQ GWPGPWGNQP AGPGGYPGAA YPGAYPGHAP
60 70 80 90 100
GAYPGQAPPG PYPGPGAHGA YPGQPGGPGA YPSPGQPSGA GAYPGASPYS
110 120 130 140 150
ASAGPLPVPY DLPLPGGVMP RMLITIVGTV KPNANRLALD FKRGNDVAFH
160 170 180 190 200
FNPRFNENNR RVIVCNTKVD NNWGREERQT TFPFEIGKPF KIQVLVEPDH
210 220 230 240
FKVAVNDAHL LQYNHRMRNL KEINKLGISG DIQLTSASHA MI
Length:242
Mass (Da):25,502
Last modified:January 23, 2007 - v2
Checksum:i3EE396446074CF22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06470 mRNA. Translation: AAC48491.1.
PIRiJC4300.
RefSeqiNP_001075807.1. NM_001082338.1.
UniGeneiOcu.1223.

Genome annotation databases

EnsembliENSOCUT00000002920; ENSOCUP00000002537; ENSOCUG00000002924.
GeneIDi100009187.
KEGGiocu:100009187.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06470 mRNA. Translation: AAC48491.1.
PIRiJC4300.
RefSeqiNP_001075807.1. NM_001082338.1.
UniGeneiOcu.1223.

3D structure databases

ProteinModelPortaliP47845.
SMRiP47845. Positions 106-242.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000002537.

Proteomic databases

PRIDEiP47845.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000002920; ENSOCUP00000002537; ENSOCUG00000002924.
GeneIDi100009187.
KEGGiocu:100009187.

Organism-specific databases

CTDi3958.

Phylogenomic databases

eggNOGiKOG3587. Eukaryota.
ENOG4111EA0. LUCA.
GeneTreeiENSGT00760000119105.
HOGENOMiHOG000246423.
HOVERGENiHBG006255.
InParanoidiP47845.
KOiK06831.
OMAiWGKEERH.
OrthoDBiEOG73Z2TM.
TreeFamiTF315551.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR015534. Galectin_3.
IPR001079. Galectin_CRD.
[Graphical view]
PANTHERiPTHR11346:SF26. PTHR11346:SF26. 1 hit.
PfamiPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51304. GALECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of the cDNA encoding rabbit galectin-3."
    Gaudin J.-C., Monsigny M., Legrand A.
    Gene 163:249-252(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: New Zealand white.
    Tissue: Aorta.

Entry informationi

Entry nameiLEG3_RABIT
AccessioniPrimary (citable) accession number: P47845
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.