Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Matrix Gla protein

Gene

MGP

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix Gla protein
Short name:
MGP
Gene namesi
Name:MGP
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 8

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Chaini20 – 10384Matrix Gla proteinPRO_0000011115Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 2114-carboxyglutamatePROSITE-ProRule annotationBy similarity
Modified residuei22 – 221PhosphoserineBy similarity
Modified residuei25 – 251PhosphoserineBy similarity
Modified residuei28 – 281PhosphoserineBy similarity
Modified residuei56 – 5614-carboxyglutamatePROSITE-ProRule annotationBy similarity
Modified residuei60 – 6014-carboxyglutamatePROSITE-ProRule annotationBy similarity
Modified residuei67 – 6714-carboxyglutamatePROSITE-ProRule annotationBy similarity
Modified residuei71 – 7114-carboxyglutamatePROSITE-ProRule annotationBy similarity
Disulfide bondi73 ↔ 79PROSITE-ProRule annotation

Post-translational modificationi

Requires vitamin K-dependent gamma-carboxylation for its function.

Keywords - PTMi

Disulfide bond, Gamma-carboxyglutamic acid, Phosphoprotein

Proteomic databases

PRIDEiP47841.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000014573.

Structurei

3D structure databases

ProteinModelPortaliP47841.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 9747GlaPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZCH. Eukaryota.
ENOG410Y2RM. LUCA.
GeneTreeiENSGT00390000003753.
HOGENOMiHOG000113581.
HOVERGENiHBG006353.
InParanoidiP47841.
KOiK19481.
OMAiAALCYES.
OrthoDBiEOG718KFT.
TreeFamiTF330920.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR027118. MGP.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PANTHERiPTHR10109. PTHR10109. 1 hit.
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47841-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSLLLLTVL AALVVAILCY ESHESMESYE INPFINRRNA NTFMSPQQRW
60 70 80 90 100
MAKAQERVRE QRKPAYELNR EACDDYKLCE RYAMVYGYNA AYNRYFRQRR

RAE
Length:103
Mass (Da):12,441
Last modified:February 1, 1996 - v1
Checksum:i45DA80D234DDA905
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D21265 mRNA. Translation: BAA04805.1.
PIRiJX0354. GERBM1.
RefSeqiNP_001075669.1. NM_001082200.1.
UniGeneiOcu.6218.

Genome annotation databases

EnsembliENSOCUT00000016959; ENSOCUP00000014573; ENSOCUG00000016964.
GeneIDi100008989.
KEGGiocu:100008989.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D21265 mRNA. Translation: BAA04805.1.
PIRiJX0354. GERBM1.
RefSeqiNP_001075669.1. NM_001082200.1.
UniGeneiOcu.6218.

3D structure databases

ProteinModelPortaliP47841.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000014573.

Proteomic databases

PRIDEiP47841.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000016959; ENSOCUP00000014573; ENSOCUG00000016964.
GeneIDi100008989.
KEGGiocu:100008989.

Organism-specific databases

CTDi4256.

Phylogenomic databases

eggNOGiENOG410IZCH. Eukaryota.
ENOG410Y2RM. LUCA.
GeneTreeiENSGT00390000003753.
HOGENOMiHOG000113581.
HOVERGENiHBG006353.
InParanoidiP47841.
KOiK19481.
OMAiAALCYES.
OrthoDBiEOG718KFT.
TreeFamiTF330920.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR027118. MGP.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PANTHERiPTHR10109. PTHR10109. 1 hit.
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression of mRNA for matrix gamma-carboxyglutamic acid protein during progression of atherosclerosis in aortae of Watanabe heritable hyperlipidemic rabbits."
    Sohma Y., Suzuki T., Sasano H., Nagura H., Nose M., Yamamoto T.
    J. Biochem. 116:747-751(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Aorta.

Entry informationi

Entry nameiMGP_RABIT
AccessioniPrimary (citable) accession number: P47841
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 11, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.