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Protein

Programmed cell death protein 2

Gene

Pdcd2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri134 – 171MYND-typePROSITE-ProRule annotationAdd BLAST38

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processApoptosis
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Programmed cell death protein 2
Alternative name(s):
Zinc finger protein Rp-8
Gene namesi
Name:Pdcd2
Synonyms:Rp8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi61887 Pdcd2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002183061 – 343Programmed cell death protein 2Add BLAST343

Post-translational modificationi

Ubiquitinated by PRKN, promoting proteasomal degradation.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiP47816
PRIDEiP47816

Expressioni

Developmental stagei

Expressed during apoptosis.

Inductioni

By irradiation and dexamethasone.

Gene expression databases

BgeeiENSRNOG00000001490
GenevisibleiP47816 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002040

Structurei

3D structure databases

SMRiP47816
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri134 – 171MYND-typePROSITE-ProRule annotationAdd BLAST38

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2061 Eukaryota
ENOG410XRI4 LUCA
GeneTreeiENSGT00530000063570
HOGENOMiHOG000237274
HOVERGENiHBG053535
InParanoidiP47816
KOiK14801
OMAiRYFPSKL
OrthoDBiEOG091G0F9T
TreeFamiTF313722

Family and domain databases

InterProiView protein in InterPro
IPR007320 PDCD2_C
IPR002893 Znf_MYND
PfamiView protein in Pfam
PF04194 PDCD2_C, 1 hit
PF01753 zf-MYND, 1 hit
PROSITEiView protein in PROSITE
PS01360 ZF_MYND_1, 1 hit
PS50865 ZF_MYND_2, 1 hit

Sequencei

Sequence statusi: Complete.

P47816-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVVPVTVE LGFVEEAPAW RLRSEQFPSK VGGRPAWLAL AELPGPGALA
60 70 80 90 100
CARCGRPLAF LLQVYAPLPG RDEAFHRSLF LFCCREPLCC AGLRVFRNQL
110 120 130 140 150
PRKNAFYSYE PPSETGASDT ECVCLQLKSG AHLCRVCGCL APMTCSRCKQ
160 170 180 190 200
AHYCSKEHQT LDWQLGHKQA CTQSDHLDHM VPDHNFLFPE FEIVTETEDE
210 220 230 240 250
IGPEVVEMED YSEVIGSMEG VPEEELDSMA KHESKEDHIF QKFKSKIALE
260 270 280 290 300
PEQILRYGRG IKPIWISGEN IPQEKDIPDC SCGAKRIFEF QVMPQLLNHL
310 320 330 340
KADRLGTSVD WGILAVFTCA ESCSLGIGYT EEFVWKQDVT ETP
Length:343
Mass (Da):38,444
Last modified:April 18, 2012 - v2
Checksum:i94A4B9540ABFD9A9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73E → D in AAA42067 (PubMed:2072913).Curated1
Sequence conflicti186F → L in AAA42067 (PubMed:2072913).Curated1
Sequence conflicti284A → V in AAA42067 (PubMed:2072913).Curated1
Sequence conflicti329Y → F in AAA42067 (PubMed:2072913).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474033 Genomic DNA Translation: EDL99815.1
M80601 mRNA Translation: AAA42067.1
PIRiA41257
RefSeqiNP_113826.1, NM_031638.1
UniGeneiRn.6959

Genome annotation databases

EnsembliENSRNOT00000002040; ENSRNOP00000002040; ENSRNOG00000001490
GeneIDi58934
KEGGirno:58934

Similar proteinsi

Entry informationi

Entry nameiPDCD2_RAT
AccessioniPrimary (citable) accession number: P47816
Secondary accession number(s): G3V666
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: April 18, 2012
Last modified: May 23, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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