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Protein

Programmed cell death protein 2

Gene

Pdcd2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri134 – 17138MYND-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Programmed cell death protein 2
Alternative name(s):
Zinc finger protein Rp-8
Gene namesi
Name:Pdcd2
Synonyms:Rp8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi61887. Pdcd2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: InterPro
  • extracellular exosome Source: Ensembl
  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Programmed cell death protein 2PRO_0000218306Add
BLAST

Post-translational modificationi

Ubiquitinated by PARK2, promoting proteasomal degradation.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiP47816.

Expressioni

Developmental stagei

Expressed during apoptosis.

Inductioni

By irradiation and dexamethasone.

Gene expression databases

BgeeiENSRNOG00000001490.
GenevisibleiP47816. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002040.

Family & Domainsi

Sequence similaritiesi

Contains 1 MYND-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri134 – 17138MYND-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2061. Eukaryota.
ENOG410XRI4. LUCA.
GeneTreeiENSGT00530000063570.
HOGENOMiHOG000237274.
HOVERGENiHBG053535.
InParanoidiP47816.
KOiK14801.
OMAiIHYCSSE.
OrthoDBiEOG091G0F9T.
TreeFamiTF313722.

Family and domain databases

InterProiIPR007320. PDCD2_C.
IPR002893. Znf_MYND.
[Graphical view]
PfamiPF04194. PDCD2_C. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view]
PROSITEiPS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47816-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVVPVTVE LGFVEEAPAW RLRSEQFPSK VGGRPAWLAL AELPGPGALA
60 70 80 90 100
CARCGRPLAF LLQVYAPLPG RDEAFHRSLF LFCCREPLCC AGLRVFRNQL
110 120 130 140 150
PRKNAFYSYE PPSETGASDT ECVCLQLKSG AHLCRVCGCL APMTCSRCKQ
160 170 180 190 200
AHYCSKEHQT LDWQLGHKQA CTQSDHLDHM VPDHNFLFPE FEIVTETEDE
210 220 230 240 250
IGPEVVEMED YSEVIGSMEG VPEEELDSMA KHESKEDHIF QKFKSKIALE
260 270 280 290 300
PEQILRYGRG IKPIWISGEN IPQEKDIPDC SCGAKRIFEF QVMPQLLNHL
310 320 330 340
KADRLGTSVD WGILAVFTCA ESCSLGIGYT EEFVWKQDVT ETP
Length:343
Mass (Da):38,444
Last modified:April 18, 2012 - v2
Checksum:i94A4B9540ABFD9A9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti73 – 731E → D in AAA42067 (PubMed:2072913).Curated
Sequence conflicti186 – 1861F → L in AAA42067 (PubMed:2072913).Curated
Sequence conflicti284 – 2841A → V in AAA42067 (PubMed:2072913).Curated
Sequence conflicti329 – 3291Y → F in AAA42067 (PubMed:2072913).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474033 Genomic DNA. Translation: EDL99815.1.
M80601 mRNA. Translation: AAA42067.1.
PIRiA41257.
RefSeqiNP_113826.1. NM_031638.1.
UniGeneiRn.6959.

Genome annotation databases

EnsembliENSRNOT00000002040; ENSRNOP00000002040; ENSRNOG00000001490.
GeneIDi58934.
KEGGirno:58934.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474033 Genomic DNA. Translation: EDL99815.1.
M80601 mRNA. Translation: AAA42067.1.
PIRiA41257.
RefSeqiNP_113826.1. NM_031638.1.
UniGeneiRn.6959.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002040.

Proteomic databases

PaxDbiP47816.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000002040; ENSRNOP00000002040; ENSRNOG00000001490.
GeneIDi58934.
KEGGirno:58934.

Organism-specific databases

CTDi5134.
RGDi61887. Pdcd2.

Phylogenomic databases

eggNOGiKOG2061. Eukaryota.
ENOG410XRI4. LUCA.
GeneTreeiENSGT00530000063570.
HOGENOMiHOG000237274.
HOVERGENiHBG053535.
InParanoidiP47816.
KOiK14801.
OMAiIHYCSSE.
OrthoDBiEOG091G0F9T.
TreeFamiTF313722.

Miscellaneous databases

PROiP47816.

Gene expression databases

BgeeiENSRNOG00000001490.
GenevisibleiP47816. RN.

Family and domain databases

InterProiIPR007320. PDCD2_C.
IPR002893. Znf_MYND.
[Graphical view]
PfamiPF04194. PDCD2_C. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view]
PROSITEiPS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPDCD2_RAT
AccessioniPrimary (citable) accession number: P47816
Secondary accession number(s): G3V666
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: April 18, 2012
Last modified: September 7, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.