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Protein

Eukaryotic translation initiation factor 1A, X-chromosomal

Gene

EIF1AX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • translation factor activity, RNA binding Source: ProtInc
  • translation initiation factor activity Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 1A, X-chromosomal
Short name:
eIF-1A X isoform
Alternative name(s):
Eukaryotic translation initiation factor 4C
Short name:
eIF-4C
Gene namesi
Name:EIF1AX
Synonyms:EIF1A, EIF4C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:3250. EIF1AX.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi1964.
OpenTargetsiENSG00000173674.
PharmGKBiPA27684.

Polymorphism and mutation databases

BioMutaiEIF1AX.
DMDMi1352425.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001451012 – 144Eukaryotic translation initiation factor 1A, X-chromosomalAdd BLAST143

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki88Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP47813.
MaxQBiP47813.
PaxDbiP47813.
PeptideAtlasiP47813.
PRIDEiP47813.
TopDownProteomicsiP47813.

PTM databases

iPTMnetiP47813.
PhosphoSitePlusiP47813.

Expressioni

Gene expression databases

BgeeiENSG00000173674.
CleanExiHS_EIF1AX.
ExpressionAtlasiP47813. baseline and differential.
GenevisibleiP47813. HS.

Organism-specific databases

HPAiHPA002561.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
IPO13O9482914EBI-1045377,EBI-747310

Protein-protein interaction databases

BioGridi108284. 39 interactors.
DIPiDIP-40995N.
IntActiP47813. 9 interactors.
MINTiMINT-144981.
STRINGi9606.ENSP00000368927.

Structurei

Secondary structure

1144
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 12Combined sources6
Beta strandi33 – 41Combined sources9
Beta strandi43 – 51Combined sources9
Turni52 – 54Combined sources3
Beta strandi55 – 60Combined sources6
Helixi64 – 67Combined sources4
Beta strandi76 – 80Combined sources5
Beta strandi82 – 87Combined sources6
Beta strandi90 – 95Combined sources6
Turni97 – 99Combined sources3
Helixi100 – 106Combined sources7
Beta strandi120 – 122Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D7QNMR-A2-144[»]
3ZJYX-ray3.60C1-112[»]
4KZYX-ray7.01n1-144[»]
4KZZX-ray7.03n1-144[»]
ProteinModelPortaliP47813.
SMRiP47813.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP47813.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 96S1-likeAdd BLAST75

Sequence similaritiesi

Belongs to the eIF-1A family.Curated
Contains 1 S1-like domain.Curated

Phylogenomic databases

eggNOGiKOG3403. Eukaryota.
COG0361. LUCA.
GeneTreeiENSGT00390000008256.
HOGENOMiHOG000223675.
HOVERGENiHBG001131.
InParanoidiP47813.
KOiK03236.
OMAiVWINVND.
OrthoDBiEOG091G195V.
PhylomeDBiP47813.
TreeFamiTF350394.

Family and domain databases

HAMAPiMF_00216. aIF_1A. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR006196. RNA-binding_domain_S1_IF1.
IPR001253. TIF_eIF-1A.
IPR018104. TIF_eIF-1A_CS.
[Graphical view]
PANTHERiPTHR21668. PTHR21668. 1 hit.
PfamiPF01176. eIF-1a. 1 hit.
[Graphical view]
ProDomiPD005579. TIF_eIF-1A. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00652. eIF1a. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00523. eIF-1A. 1 hit.
PROSITEiPS01262. IF1A. 1 hit.
PS50832. S1_IF1_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47813-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKNKGKGGK NRRRGKNENE SEKRELVFKE DGQEYAQVIK MLGNGRLEAM
60 70 80 90 100
CFDGVKRLCH IRGKLRKKVW INTSDIILVG LRDYQDNKAD VILKYNADEA
110 120 130 140
RSLKAYGELP EHAKINETDT FGPGDDDEIQ FDDIGDDDED IDDI
Length:144
Mass (Da):16,460
Last modified:January 23, 2007 - v2
Checksum:i1C4209855B21BFD4
GO

Sequence cautioni

The sequence CAI40551 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L18960 mRNA. Translation: AAA19812.1.
AK312320 mRNA. Translation: BAG35242.1.
BT007064 mRNA. Translation: AAP35727.1.
AL732366 Genomic DNA. Translation: CAI40550.1.
AL732366 Genomic DNA. Translation: CAI40551.1. Sequence problems.
BC000793 mRNA. Translation: AAH00793.1.
BC067851 mRNA. Translation: AAH67851.1.
CCDSiCCDS14196.1.
PIRiC53045.
RefSeqiNP_001403.1. NM_001412.3.
XP_016855198.1. XM_016999709.1.
UniGeneiHs.522590.

Genome annotation databases

EnsembliENST00000379607; ENSP00000368927; ENSG00000173674.
GeneIDi107984923.
1964.
KEGGihsa:1964.
UCSCiuc004czt.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L18960 mRNA. Translation: AAA19812.1.
AK312320 mRNA. Translation: BAG35242.1.
BT007064 mRNA. Translation: AAP35727.1.
AL732366 Genomic DNA. Translation: CAI40550.1.
AL732366 Genomic DNA. Translation: CAI40551.1. Sequence problems.
BC000793 mRNA. Translation: AAH00793.1.
BC067851 mRNA. Translation: AAH67851.1.
CCDSiCCDS14196.1.
PIRiC53045.
RefSeqiNP_001403.1. NM_001412.3.
XP_016855198.1. XM_016999709.1.
UniGeneiHs.522590.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D7QNMR-A2-144[»]
3ZJYX-ray3.60C1-112[»]
4KZYX-ray7.01n1-144[»]
4KZZX-ray7.03n1-144[»]
ProteinModelPortaliP47813.
SMRiP47813.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108284. 39 interactors.
DIPiDIP-40995N.
IntActiP47813. 9 interactors.
MINTiMINT-144981.
STRINGi9606.ENSP00000368927.

PTM databases

iPTMnetiP47813.
PhosphoSitePlusiP47813.

Polymorphism and mutation databases

BioMutaiEIF1AX.
DMDMi1352425.

Proteomic databases

EPDiP47813.
MaxQBiP47813.
PaxDbiP47813.
PeptideAtlasiP47813.
PRIDEiP47813.
TopDownProteomicsiP47813.

Protocols and materials databases

DNASUi1964.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379607; ENSP00000368927; ENSG00000173674.
GeneIDi107984923.
1964.
KEGGihsa:1964.
UCSCiuc004czt.4. human.

Organism-specific databases

CTDi1964.
DisGeNETi1964.
GeneCardsiEIF1AX.
H-InvDBHIX0028844.
HGNCiHGNC:3250. EIF1AX.
HPAiHPA002561.
MIMi300186. gene.
neXtProtiNX_P47813.
OpenTargetsiENSG00000173674.
PharmGKBiPA27684.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3403. Eukaryota.
COG0361. LUCA.
GeneTreeiENSGT00390000008256.
HOGENOMiHOG000223675.
HOVERGENiHBG001131.
InParanoidiP47813.
KOiK03236.
OMAiVWINVND.
OrthoDBiEOG091G195V.
PhylomeDBiP47813.
TreeFamiTF350394.

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.

Miscellaneous databases

ChiTaRSiEIF1AX. human.
EvolutionaryTraceiP47813.
GeneWikiiEIF1AX.
GenomeRNAii1964.
PROiP47813.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173674.
CleanExiHS_EIF1AX.
ExpressionAtlasiP47813. baseline and differential.
GenevisibleiP47813. HS.

Family and domain databases

HAMAPiMF_00216. aIF_1A. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR006196. RNA-binding_domain_S1_IF1.
IPR001253. TIF_eIF-1A.
IPR018104. TIF_eIF-1A_CS.
[Graphical view]
PANTHERiPTHR21668. PTHR21668. 1 hit.
PfamiPF01176. eIF-1a. 1 hit.
[Graphical view]
ProDomiPD005579. TIF_eIF-1A. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00652. eIF1a. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00523. eIF-1A. 1 hit.
PROSITEiPS01262. IF1A. 1 hit.
PS50832. S1_IF1_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIF1AX_HUMAN
AccessioniPrimary (citable) accession number: P47813
Secondary accession number(s): B2R5U5
, Q0VGC2, Q5JPS5, Q5JPS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 163 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Translation initiation factors
    List of translation initiation factor entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.