Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Unconventional myosin-Ia

Gene

MYO1A

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Could play an important role in morphogenesis and function of intestinal microvilli.

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi104 – 111ATPSequence analysis8

GO - Molecular functioni

  • actin binding Source: UniProtKB-KW
  • ATPase activity Source: UniProtKB
  • ATP binding Source: UniProtKB-KW
  • calmodulin binding Source: UniProtKB-KW
  • microfilament motor activity Source: UniProtKB
  • microtubule binding Source: InterPro
  • microtubule motor activity Source: InterPro

GO - Biological processi

  • actin filament-based movement Source: UniProtKB
  • endosomal transport Source: UniProtKB
  • microtubule-based movement Source: InterPro
  • transcytosis Source: UniProtKB

Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Myosin
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Ia
Alternative name(s):
Brush border myosin I
Short name:
BBM-I
Short name:
BBMI
Myosin I heavy chain
Short name:
MIHC
Gene namesi
Name:MYO1A
Synonyms:MYHL
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001234411 – 1045Unconventional myosin-IaAdd BLAST1045

Proteomic databases

PRIDEiP47807

Expressioni

Tissue specificityi

Intestine.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AJImodel-B699-731[»]
ProteinModelPortaliP47807
SMRiP47807
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 697Myosin motorPROSITE-ProRule annotationAdd BLAST687
Domaini701 – 727IQ 1PROSITE-ProRule annotationAdd BLAST27
Domaini723 – 750IQ 2PROSITE-ProRule annotationAdd BLAST28
Domaini746 – 774IQ 3PROSITE-ProRule annotationAdd BLAST29
Domaini861 – 1044TH1PROSITE-ProRule annotationAdd BLAST184

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni574 – 596Actin-bindingSequence analysisAdd BLAST23

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG062373
InParanoidiP47807
KOiK10356
PhylomeDBiP47807

Family and domain databases

CDDicd01378 MYSc_Myo1, 1 hit
Gene3Di3.40.850.10, 3 hits
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR010926 Myosin_TH1
IPR036072 MYSc_Myo1
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00612 IQ, 3 hits
PF00063 Myosin_head, 1 hit
PF06017 Myosin_TH1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00015 IQ, 3 hits
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 3 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51757 TH1, 1 hit

Sequencei

Sequence statusi: Complete.

P47807-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEATTSLLDA AAVGDLVMLD PLSEESLLRT LQERFSRGEI YTYIGEVVIS
60 70 80 90 100
VNPYKPLPIY TPEKVEEYHN CNFFAVKPHI YAIADDAYRS LRDRDRDQCI
110 120 130 140 150
LITGESGAGK TEASKLVMSY VAAVSSKGEE VDKVKEQLLQ SNPVLEAFGN
160 170 180 190 200
AKTIRNDNSS RFGKYMDVEF DFKGDPLGGV ISNYLLEKSR IVRHVKGERN
210 220 230 240 250
FHIFYQLLAG GSAQLLQQLK LRPDCSHYGY LNHEKSVLPG MDDAANFRAM
260 270 280 290 300
QDAMAIIGFA PAEVTALLEV TAVVLKLGNV KLSSCFQASG MEASSITEPR
310 320 330 340 350
ELQEISQLIG LDPSTLEQAL CSRTVKVRDE SVLTALSVSQ GYYGRDALAK
360 370 380 390 400
NIYSRLFDWL VNRINTSIQV KPGKQRKVMG VLDIYGFEIF QDNGFEQFII
410 420 430 440 450
NYCNEKLQQI FILMTLKEEQ EEYVREGIQW TPVEFFDNSI ICDLIENSKV
460 470 480 490 500
GILAMLDEEC LRPGTVNEDT FITKLNQIFA SHKRYESKET LNAKHVTDVS
510 520 530 540 550
LPLRCFRIHH YAGKVTYNVT GFIEKNNDLL FRDLSQAMWA ARHTLLRSLF
560 570 580 590 600
PEGDPQRPSL KLPPTTGSQF KASVATLMKN LYSKNPNYIR CIKPNDTKTA
610 620 630 640 650
MLFTPDLVLA QVRYLGLMEN VRVRRAGYAF RQLYQPFLER YKMLSRKTWP
660 670 680 690 700
RWTGGDREGA EVLLAELKFP PEELAYGHTK IFIRSPRTLF DLEKRRQQRV
710 720 730 740 750
AELATLIQKM FRGWCCRKRY QLMRKSQILI SAWFRGHMQR NRYKQMKRSV
760 770 780 790 800
LLLQAYARGW KTRRMYRRYF RSDACTRLSN FIYRRMVQKY LMGLQKNLPP
810 820 830 840 850
MAVLDRTWPP APYKFLSDAN QELKSIFYRW KCKKYREQLT PQQRAMLQAK
860 870 880 890 900
LCASELFKDK KALYAQSLQQ PFRGEYLGLT QNRKYQKLQA VAKDKLVMAE
910 920 930 940 950
AVQKVNRANG KTVPRLLLLT TEHLVLADPK AAQPKMVLSL CDIQGASVSR
960 970 980 990 1000
FSDGLLALHL KETSTAGGKG DLLLVSPHLI ELVTRLHQTL MDATAQALPL
1010 1020 1030 1040
SIADQFSTRF PKGDVAVTVV ESAKGGGDVP VCKKRGSHKM EILVH
Length:1,045
Mass (Da):119,277
Last modified:April 27, 2001 - v2
Checksum:i4C6888CA3FD669D0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46E → Q in CAA41388 (PubMed:2687288).Curated1
Sequence conflicti285C → S in CAA41388 (PubMed:2687288).Curated1
Sequence conflicti297T → A in CAA41388 (PubMed:2687288).Curated1
Sequence conflicti427G → A in CAA41388 (PubMed:2687288).Curated1
Sequence conflicti852 – 855CASE → WPRQ in CAA41388 (PubMed:2687288).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04049 mRNA Translation: AAB38373.1
X58479 mRNA Translation: CAA41388.1
PIRiA33620
RefSeqiNP_990494.1, NM_205163.1
UniGeneiGga.51366
Gga.637

Genome annotation databases

GeneIDi396072
KEGGigga:396072

Similar proteinsi

Entry informationi

Entry nameiMYO1A_CHICK
AccessioniPrimary (citable) accession number: P47807
Secondary accession number(s): Q90573
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: April 27, 2001
Last modified: March 28, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health