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Protein

Unconventional myosin-Ia

Gene

MYO1A

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Could play an important role in morphogenesis and function of intestinal microvilli.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi104 – 1118ATPSequence analysis

GO - Molecular functioni

  • ATPase activity Source: UniProtKB
  • ATP binding Source: UniProtKB-KW
  • microfilament motor activity Source: UniProtKB

GO - Biological processi

  • actin filament-based movement Source: UniProtKB
  • endosomal transport Source: UniProtKB
  • transcytosis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Ia
Alternative name(s):
Brush border myosin I
Short name:
BBM-I
Short name:
BBMI
Myosin I heavy chain
Short name:
MIHC
Gene namesi
Name:MYO1A
Synonyms:MYHL
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • actin filament Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • lamellipodium Source: UniProtKB
  • lateral plasma membrane Source: UniProtKB
  • microvillus Source: UniProtKB
  • myosin complex Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10451045Unconventional myosin-IaPRO_0000123441Add
BLAST

Proteomic databases

PRIDEiP47807.

Expressioni

Tissue specificityi

Intestine.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AJImodel-B699-731[»]
ProteinModelPortaliP47807.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 697687Myosin motorAdd
BLAST
Domaini701 – 72727IQ 1PROSITE-ProRule annotationAdd
BLAST
Domaini723 – 75028IQ 2PROSITE-ProRule annotationAdd
BLAST
Domaini746 – 77429IQ 3PROSITE-ProRule annotationAdd
BLAST
Domaini861 – 1044184TH1PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni574 – 59623Actin-bindingSequence analysisAdd
BLAST

Sequence similaritiesi

Contains 3 IQ domains.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated
Contains 1 TH1 (class I myosin tail homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG062373.
InParanoidiP47807.
KOiK10356.
PhylomeDBiP47807.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_TH1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00612. IQ. 3 hits.
PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 3 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 3 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51757. TH1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47807-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEATTSLLDA AAVGDLVMLD PLSEESLLRT LQERFSRGEI YTYIGEVVIS
60 70 80 90 100
VNPYKPLPIY TPEKVEEYHN CNFFAVKPHI YAIADDAYRS LRDRDRDQCI
110 120 130 140 150
LITGESGAGK TEASKLVMSY VAAVSSKGEE VDKVKEQLLQ SNPVLEAFGN
160 170 180 190 200
AKTIRNDNSS RFGKYMDVEF DFKGDPLGGV ISNYLLEKSR IVRHVKGERN
210 220 230 240 250
FHIFYQLLAG GSAQLLQQLK LRPDCSHYGY LNHEKSVLPG MDDAANFRAM
260 270 280 290 300
QDAMAIIGFA PAEVTALLEV TAVVLKLGNV KLSSCFQASG MEASSITEPR
310 320 330 340 350
ELQEISQLIG LDPSTLEQAL CSRTVKVRDE SVLTALSVSQ GYYGRDALAK
360 370 380 390 400
NIYSRLFDWL VNRINTSIQV KPGKQRKVMG VLDIYGFEIF QDNGFEQFII
410 420 430 440 450
NYCNEKLQQI FILMTLKEEQ EEYVREGIQW TPVEFFDNSI ICDLIENSKV
460 470 480 490 500
GILAMLDEEC LRPGTVNEDT FITKLNQIFA SHKRYESKET LNAKHVTDVS
510 520 530 540 550
LPLRCFRIHH YAGKVTYNVT GFIEKNNDLL FRDLSQAMWA ARHTLLRSLF
560 570 580 590 600
PEGDPQRPSL KLPPTTGSQF KASVATLMKN LYSKNPNYIR CIKPNDTKTA
610 620 630 640 650
MLFTPDLVLA QVRYLGLMEN VRVRRAGYAF RQLYQPFLER YKMLSRKTWP
660 670 680 690 700
RWTGGDREGA EVLLAELKFP PEELAYGHTK IFIRSPRTLF DLEKRRQQRV
710 720 730 740 750
AELATLIQKM FRGWCCRKRY QLMRKSQILI SAWFRGHMQR NRYKQMKRSV
760 770 780 790 800
LLLQAYARGW KTRRMYRRYF RSDACTRLSN FIYRRMVQKY LMGLQKNLPP
810 820 830 840 850
MAVLDRTWPP APYKFLSDAN QELKSIFYRW KCKKYREQLT PQQRAMLQAK
860 870 880 890 900
LCASELFKDK KALYAQSLQQ PFRGEYLGLT QNRKYQKLQA VAKDKLVMAE
910 920 930 940 950
AVQKVNRANG KTVPRLLLLT TEHLVLADPK AAQPKMVLSL CDIQGASVSR
960 970 980 990 1000
FSDGLLALHL KETSTAGGKG DLLLVSPHLI ELVTRLHQTL MDATAQALPL
1010 1020 1030 1040
SIADQFSTRF PKGDVAVTVV ESAKGGGDVP VCKKRGSHKM EILVH
Length:1,045
Mass (Da):119,277
Last modified:April 27, 2001 - v2
Checksum:i4C6888CA3FD669D0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461E → Q in CAA41388 (PubMed:2687288).Curated
Sequence conflicti285 – 2851C → S in CAA41388 (PubMed:2687288).Curated
Sequence conflicti297 – 2971T → A in CAA41388 (PubMed:2687288).Curated
Sequence conflicti427 – 4271G → A in CAA41388 (PubMed:2687288).Curated
Sequence conflicti852 – 8554CASE → WPRQ in CAA41388 (PubMed:2687288).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04049 mRNA. Translation: AAB38373.1.
X58479 mRNA. Translation: CAA41388.1.
PIRiA33620.
RefSeqiNP_990494.1. NM_205163.1.
UniGeneiGga.51366.
Gga.637.

Genome annotation databases

GeneIDi396072.
KEGGigga:396072.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04049 mRNA. Translation: AAB38373.1.
X58479 mRNA. Translation: CAA41388.1.
PIRiA33620.
RefSeqiNP_990494.1. NM_205163.1.
UniGeneiGga.51366.
Gga.637.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AJImodel-B699-731[»]
ProteinModelPortaliP47807.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP47807.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396072.
KEGGigga:396072.

Organism-specific databases

CTDi4640.

Phylogenomic databases

HOVERGENiHBG062373.
InParanoidiP47807.
KOiK10356.
PhylomeDBiP47807.

Miscellaneous databases

PROiP47807.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_TH1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00612. IQ. 3 hits.
PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 3 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 3 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51757. TH1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYO1A_CHICK
AccessioniPrimary (citable) accession number: P47807
Secondary accession number(s): Q90573
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: April 27, 2001
Last modified: June 8, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.