Zinc finger protein GLI1 - Mus musculus (Mouse)

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Reviewed, UniProtKB/Swiss-Prot P47806 (GLI1_MOUSE)

Last modified November 25, 2008. Version 71. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
Zinc finger protein GLI1
Alternative name(s):
Glioma-associated oncogene homolog

Gene names

Name:	Gli1
Synonyms:	Gli

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length	1111 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation By similarity.
Subcellular location	CytoplasmBy similarity. NucleusBy similarity. Note= Tethered in the cytoplasm by binding to SUFU. Activation and translocation to the nucleus is promoted by interaction with STK36 By similarity.
Tissue specificity	Uterus, brain, testis and limb.
Developmental stage	Is detected on days 10 through 18 of embryonic development. During gestation it is detected in meckels precartilage mesenchyme, the basis occipitus, rib mesenchymal condensations, primordial vertebral bodies, digital mesenchymal condensations in forefoot and hindfoot plates, the ependymal layer of the spinal cord, and the mesoderm of the gastrointestinal tract. Expression persists throughout gestation in developing bone and cartilage of the extremities, the ribs, and the vertebral bodies as well as the gastrointestinal tract mesoderm.
Sequence similarities	Belongs to the GLI C2H2-type zinc-finger protein family. Contains 5 C2H2-type zinc fingers.

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Ontologies

Keywords
Biological process	Differentiation Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW cerebellar cortex morphogenesis Inferred from genetic interaction. Source: MGI dorsal/ventral pattern formation Inferred from genetic interaction. Source: MGI lung development Inferred from genetic interaction. Source: MGI notochord regression Inferred from genetic interaction. Source: MGI pituitary gland development Inferred from genetic interaction. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay. Source: MGI proximal/distal pattern formation Inferred from genetic interaction. Source: MGI smoothened signaling pathway involved in regulation of granule cell precursor cell proliferation Inferred from genetic interaction. Source: MGI spermatogenesis Inferred from direct assay. Source: MGI ventral midline development Inferred from genetic interaction. Source: MGI
Cellular component	cytoplasm Inferred from direct assay. Source: MGI nucleus Inferred from direct assay. Source: MGI
Molecular function	DNA binding Inferred from direct assay. Source: MGI chromatin binding Inferred from direct assay. Source: MGI microtubule binding Inferred from direct assay. Source: MGI transcription activator activity Inferred from direct assay. Source: MGI zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1111

1111

Zinc finger protein GLI1

PRO_0000047198

Regions

Zinc finger

238 – 263

C2H2-type 1

Zinc finger

271 – 298

C2H2-type 2

Zinc finger

304 – 328

C2H2-type 3

Zinc finger

334 – 359

C2H2-type 4

Zinc finger

365 – 390

C2H2-type 5

Compositional bias

1042 – 1059

Asp/Glu-rich (acidic)

Experimental info

Sequence conflict

154

V → L in AAC09169. Ref.1

Sequence conflict

170

H → Y in AAC09169. Ref.1

Sequence conflict

173

A → S in AAC09169. Ref.1

Sequence conflict

179

T → I in AAC09169. Ref.1

Sequence conflict

194

P → R in AAC09169. Ref.1

Sequence conflict

210

I → T in AAC09169. Ref.1

Sequence conflict

271

F → S in AAC09169. Ref.1

Sequence conflict

475

Missing Ref.1 Ref.3

Sequence conflict

567 – 569

FPP → LPT Ref.1 Ref.3

Sequence conflict

707

E → D Ref.1 Ref.3

Sequence conflict

777

Missing Ref.1 Ref.3

Sequence conflict

837

H → P Ref.3

Sequence conflict

864

G → V in AAC09169. Ref.1

Sequence conflict

919 – 920

GL → RA in AAC09169. Ref.1

Sequence conflict

936

S → Y in AAC09169. Ref.1

Sequence conflict

950 – 952

AAA → RR Ref.1

Sequence conflict

967

G → R in AAC09169. Ref.1

Sequence conflict

990

P → A in AAC09169. Ref.1

Sequence conflict

1029

A → P in AAC09169. Ref.1

Sequence conflict

1062 – 1063

QG → R in AAC09169. Ref.1

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Sequences

Sequence

Length

Mass (Da)

Tools

P47806-1 [UniParc].

Last modified December 1, 2000. Version 3.
Checksum: 0DBAB163CAF27289
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FASTA

1,111

118,556

        10         20         30         40         50         60 
MFNPMTPPQV NSYSEPCCLR PLHSQGVPSM GTEGLSGLPF CHQANFMSGS QGYGAARETS 

        70         80         90        100        110        120 
SCTEGSLFPP PPPPRSSVKL TKKRALSISP LSDASLDLQT VIRTSPSSLV AFINSRCTSP 

       130        140        150        160        170        180 
GGSYGHLSIG TMSPSLGFPP QMSHQKGTSP PYGVQPCVPH DSTRGSMMLH PQARGPRATC 

       190        200        210        220        230        240 
QLKSELDMMV GKCPEDPLEG DMSSPNSTGI QDHLLGMLDG REDLEREEKP EPESVYETDC 

       250        260        270        280        290        300 
RWDGCSQEFD SQEQLVHHIN SEHIHGERKE FVCHWGGCSR ELRPFKAQYM LVVHMRRHTG 

       310        320        330        340        350        360 
EKPHKCTFEG CRKSYSRLEN LKTHLRSHTG EKPYMCEQEG CSKAFSNASD RAKHQNRTHS 

       370        380        390        400        410        420 
NEKPYVCKLP GCTKRYTDPS SLRKHVKTVH GPDAHVTKRH RGDGPLPRAQ PLSTVEPKRE 

       430        440        450        460        470        480 
REGGSGREES RLTVPESAMP QQSPGAQSSC SSDHSPAGSA ANTDSGVEMA GNAGGSTEDL 

       490        500        510        520        530        540 
SSLDEGPCVS ATGLSTLRRL ENLRLDQLHQ LRPIGSRGLK LPSLTHAGAP VSRRLGPPVS 

       550        560        570        580        590        600 
LDRRSSSSSS MSSAYTVSRR SSLASPFPPG TPPENGASSL PGLTPAQHYM LRARYASARG 

       610        620        630        640        650        660 
SGTPPTAAHS LDRMGGLSVP PWRSRTEYPG YNPNAGVTRR ASDPARAADH PAPARVQRFK 

       670        680        690        700        710        720 
SLGCVHTPPS VATGRNFDPH HPTSVYSPQP PSITENVAMD TRGLQEEPEV GTSVMGNGLN 

       730        740        750        760        770        780 
PYMDFSSTDT LGYGGPEGTA AEPYEARGPG SLPLGPGPPT NYGPGHCAQQ VSYPDPTPEN 

       790        800        810        820        830        840 
WGEFPSHAGV YPSNKAPGAA YSQCPRLEHY GQVQVKPEQG CPVGSDSTGL APCLNAHPSE 

       850        860        870        880        890        900 
GSPGPQPLFS HHPQLPQPQY PQSGPYPQPP HGYLSTEPRL GLNFNPSSSH STGQLKAQLV 

       910        920        930        940        950        960 
CNYVQSQQEL LWEGRNRGGL PNQELPYQSP KFLGGSQVSQ SPAKTPAAAA AAYGSGFAPA 

       970        980        990       1000       1010       1020 
SANHKSGSYP APSPCHETFT VGVNRPSHRP AAPPRLLPPL SPCYGPLKVG DTNPSCGHPE 

      1030       1040       1050       1060       1070       1080 
VGRLGAGPAL YPPPEGQVCN ALDSLDLDNT QLDFVAILDE AQGLSPPLSH EQGDSSKNTP 

      1090       1100       1110 
SPSGPPNMAV GNMSVLLGSL PGETQFLNSS A

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References

[1]	"Characterization of the promoter region and genomic organization of GLI, a member of the Sonic hedgehog-Patched signaling pathway." Liu C.Z., Yang J.T., Yoon J.W., Walterhouse D., Iannaccone P. Gene 209:1-11(1998) [PubMed: 9524201] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling." Sasaki H., Nishizaki Y., Hui C., Nakafuku M., Kondoh H. Development 126:3915-3924(1999) [PubMed: 10433919] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ICR.
[3]	"gli, a zinc finger transcription factor and oncogene, is expressed during normal mouse development." Waterhouse D., Ahmed M., Slusarski D., Kalamaras J., Boucher D., Holmgren R., Iannaccone P. Dev. Dyn. 196:91-102(1993) [PubMed: 8364225] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 272-837. Strain: CD-1. Tissue: Embryo.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	AF026305 mRNA. Translation: AAC09169.1. AB025922 mRNA. Translation: BAA85004.1.
RefSeq	NP_034426.2.
UniGene	Mm.391450
3D structure databases
HSSP	HSSP built from PDB template 2GLI based on UniProtKB P08151.
ModBase	Search...
PTM databases
PhosphoSite	P47806.
Genome annotation databases
Ensembl	ENSMUSG00000025407. Mus musculus. [Contig view]
GeneID	14632.
KEGG	mmu:14632.
Organism-specific databases
MGI	MGI:95727. Gli1.
Phylogenomic databases
HOGENOM	P47806.
HOVERGEN	P47806.
Gene expression databases
ArrayExpress	P47806.
CleanEx	MM_GLI1.
GermOnline	ENSMUSG00000025407. Mus musculus.
Family and domain databases
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 4 hits.
Pfam	PF00096. zf-C2H2. 5 hits. [Graphical view]
ProDom	PD000003. Znf_C2H2. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00355. ZnF_C2H2. 5 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 4 hits. PS50157. ZINC_FINGER_C2H2_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	286482.
SOURCE	Search...

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Entry information

Entry name

GLI1_MOUSE

Accession

Primary (citable) accession number: P47806
Secondary accession number(s): Q9QYK1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	December 1, 2000
Last modified:	November 25, 2008
This is version 71 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Keywords

Gene Ontology (GO)

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents