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Reviewed, UniProtKB/Swiss-Prot P47806 (GLI1_MOUSE)

Last modified November 25, 2008. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Zinc finger protein GLI1
Alternative name(s):
    Glioma-associated oncogene homolog
Gene names
Name: Gli1
Synonyms: Gli
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length1111 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation By similarity.

Subcellular location

CytoplasmBy similarity. NucleusBy similarity. Note= Tethered in the cytoplasm by binding to SUFU. Activation and translocation to the nucleus is promoted by interaction with STK36 By similarity.

Tissue specificity

Uterus, brain, testis and limb.

Developmental stage

Is detected on days 10 through 18 of embryonic development. During gestation it is detected in meckels precartilage mesenchyme, the basis occipitus, rib mesenchymal condensations, primordial vertebral bodies, digital mesenchymal condensations in forefoot and hindfoot plates, the ependymal layer of the spinal cord, and the mesoderm of the gastrointestinal tract. Expression persists throughout gestation in developing bone and cartilage of the extremities, the ribs, and the vertebral bodies as well as the gastrointestinal tract mesoderm.

Sequence similarities

Belongs to the GLI C2H2-type zinc-finger protein family.

Contains 5 C2H2-type zinc fingers.

Ontologies

Keywords

   Biological processDifferentiation
Transcription
Transcription regulation
   Cellular componentCytoplasm
Nucleus
   DomainZinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionDevelopmental protein

Gene Ontology (GO)

   Biological processcell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

cerebellar cortex morphogenesis

Inferred from genetic interaction. Source: MGI

dorsal/ventral pattern formation

Inferred from genetic interaction. Source: MGI

lung development

Inferred from genetic interaction. Source: MGI

notochord regression

Inferred from genetic interaction. Source: MGI

pituitary gland development

Inferred from genetic interaction. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay. Source: MGI

proximal/distal pattern formation

Inferred from genetic interaction. Source: MGI

smoothened signaling pathway involved in regulation of granule cell precursor cell proliferation

Inferred from genetic interaction. Source: MGI

spermatogenesis

Inferred from direct assay. Source: MGI

ventral midline development

Inferred from genetic interaction. Source: MGI

   Cellular componentcytoplasm

Inferred from direct assay. Source: MGI

nucleus

Inferred from direct assay. Source: MGI

   Molecular functionDNA binding

Inferred from direct assay. Source: MGI

chromatin binding

Inferred from direct assay. Source: MGI

microtubule binding

Inferred from direct assay. Source: MGI

transcription activator activity

Inferred from direct assay. Source: MGI

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11111111Zinc finger protein GLI1
PRO_0000047198

Regions

Zinc finger238 – 26326C2H2-type 1
Zinc finger271 – 29828C2H2-type 2
Zinc finger304 – 32825C2H2-type 3
Zinc finger334 – 35926C2H2-type 4
Zinc finger365 – 39026C2H2-type 5
Compositional bias1042 – 105918Asp/Glu-rich (acidic)

Experimental info

Sequence conflict1541V → L in AAC09169. Ref.1
Sequence conflict1701H → Y in AAC09169. Ref.1
Sequence conflict1731A → S in AAC09169. Ref.1
Sequence conflict1791T → I in AAC09169. Ref.1
Sequence conflict1941P → R in AAC09169. Ref.1
Sequence conflict2101I → T in AAC09169. Ref.1
Sequence conflict2711F → S in AAC09169. Ref.1
Sequence conflict4751Missing Ref.1 Ref.3
Sequence conflict567 – 5693FPP → LPT Ref.1 Ref.3
Sequence conflict7071E → D Ref.1 Ref.3
Sequence conflict7771Missing Ref.1 Ref.3
Sequence conflict8371H → P Ref.3
Sequence conflict8641G → V in AAC09169. Ref.1
Sequence conflict919 – 9202GL → RA in AAC09169. Ref.1
Sequence conflict9361S → Y in AAC09169. Ref.1
Sequence conflict950 – 9523AAA → RR Ref.1
Sequence conflict9671G → R in AAC09169. Ref.1
Sequence conflict9901P → A in AAC09169. Ref.1
Sequence conflict10291A → P in AAC09169. Ref.1
Sequence conflict1062 – 10632QG → R in AAC09169. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P47806-1 [UniParc].

Last modified December 1, 2000. Version 3.
Checksum: 0DBAB163CAF27289

FASTA1,111118,556
        10         20         30         40         50         60 
MFNPMTPPQV NSYSEPCCLR PLHSQGVPSM GTEGLSGLPF CHQANFMSGS QGYGAARETS 

        70         80         90        100        110        120 
SCTEGSLFPP PPPPRSSVKL TKKRALSISP LSDASLDLQT VIRTSPSSLV AFINSRCTSP 

       130        140        150        160        170        180 
GGSYGHLSIG TMSPSLGFPP QMSHQKGTSP PYGVQPCVPH DSTRGSMMLH PQARGPRATC 

       190        200        210        220        230        240 
QLKSELDMMV GKCPEDPLEG DMSSPNSTGI QDHLLGMLDG REDLEREEKP EPESVYETDC 

       250        260        270        280        290        300 
RWDGCSQEFD SQEQLVHHIN SEHIHGERKE FVCHWGGCSR ELRPFKAQYM LVVHMRRHTG 

       310        320        330        340        350        360 
EKPHKCTFEG CRKSYSRLEN LKTHLRSHTG EKPYMCEQEG CSKAFSNASD RAKHQNRTHS 

       370        380        390        400        410        420 
NEKPYVCKLP GCTKRYTDPS SLRKHVKTVH GPDAHVTKRH RGDGPLPRAQ PLSTVEPKRE 

       430        440        450        460        470        480 
REGGSGREES RLTVPESAMP QQSPGAQSSC SSDHSPAGSA ANTDSGVEMA GNAGGSTEDL 

       490        500        510        520        530        540 
SSLDEGPCVS ATGLSTLRRL ENLRLDQLHQ LRPIGSRGLK LPSLTHAGAP VSRRLGPPVS 

       550        560        570        580        590        600 
LDRRSSSSSS MSSAYTVSRR SSLASPFPPG TPPENGASSL PGLTPAQHYM LRARYASARG 

       610        620        630        640        650        660 
SGTPPTAAHS LDRMGGLSVP PWRSRTEYPG YNPNAGVTRR ASDPARAADH PAPARVQRFK 

       670        680        690        700        710        720 
SLGCVHTPPS VATGRNFDPH HPTSVYSPQP PSITENVAMD TRGLQEEPEV GTSVMGNGLN 

       730        740        750        760        770        780 
PYMDFSSTDT LGYGGPEGTA AEPYEARGPG SLPLGPGPPT NYGPGHCAQQ VSYPDPTPEN 

       790        800        810        820        830        840 
WGEFPSHAGV YPSNKAPGAA YSQCPRLEHY GQVQVKPEQG CPVGSDSTGL APCLNAHPSE 

       850        860        870        880        890        900 
GSPGPQPLFS HHPQLPQPQY PQSGPYPQPP HGYLSTEPRL GLNFNPSSSH STGQLKAQLV 

       910        920        930        940        950        960 
CNYVQSQQEL LWEGRNRGGL PNQELPYQSP KFLGGSQVSQ SPAKTPAAAA AAYGSGFAPA 

       970        980        990       1000       1010       1020 
SANHKSGSYP APSPCHETFT VGVNRPSHRP AAPPRLLPPL SPCYGPLKVG DTNPSCGHPE 

      1030       1040       1050       1060       1070       1080 
VGRLGAGPAL YPPPEGQVCN ALDSLDLDNT QLDFVAILDE AQGLSPPLSH EQGDSSKNTP 

      1090       1100       1110 
SPSGPPNMAV GNMSVLLGSL PGETQFLNSS A 

« Hide

References

[1]"Characterization of the promoter region and genomic organization of GLI, a member of the Sonic hedgehog-Patched signaling pathway."
Liu C.Z., Yang J.T., Yoon J.W., Walterhouse D., Iannaccone P.
Gene 209:1-11(1998) [PubMed: 9524201] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling."
Sasaki H., Nishizaki Y., Hui C., Nakafuku M., Kondoh H.
Development 126:3915-3924(1999) [PubMed: 10433919] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: ICR.
[3]"gli, a zinc finger transcription factor and oncogene, is expressed during normal mouse development."
Waterhouse D., Ahmed M., Slusarski D., Kalamaras J., Boucher D., Holmgren R., Iannaccone P.
Dev. Dyn. 196:91-102(1993) [PubMed: 8364225] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 272-837.
Strain: CD-1.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

AF026305 mRNA. Translation: AAC09169.1.
AB025922 mRNA. Translation: BAA85004.1.
RefSeqNP_034426.2.
UniGeneMm.391450

3D structure databases

HSSPHSSP built from PDB template 2GLI based on UniProtKB P08151.
ModBaseSearch...

PTM databases

PhosphoSiteP47806.

Genome annotation databases

EnsemblENSMUSG00000025407. Mus musculus. [Contig view]
GeneID14632.
KEGGmmu:14632.

Organism-specific databases

MGIMGI:95727. Gli1.

Phylogenomic databases

HOGENOMP47806.
HOVERGENP47806.

Gene expression databases

ArrayExpressP47806.
CleanExMM_GLI1.
GermOnlineENSMUSG00000025407. Mus musculus.

Family and domain databases

InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
Gene3DG3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 4 hits.
PfamPF00096. zf-C2H2. 5 hits.
[Graphical view]
ProDomPD000003. Znf_C2H2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio286482.
SOURCESearch...

Entry information

Entry nameGLI1_MOUSE
AccessionPrimary (citable) accession number: P47806
Secondary accession number(s): Q9QYK1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 1, 2000
Last modified: November 25, 2008
This is version 71 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents