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P47806

- GLI1_MOUSE

UniProt

P47806 - GLI1_MOUSE

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Protein

Zinc finger protein GLI1

Gene

Gli1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri238 – 26326C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29828C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri304 – 32825C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri334 – 35926C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri365 – 39026C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. DNA binding Source: MGI
  3. metal ion binding Source: UniProtKB-KW
  4. microtubule binding Source: MGI
  5. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
  6. transcription regulatory region DNA binding Source: Ensembl

GO - Biological processi

  1. cerebellar cortex morphogenesis Source: MGI
  2. dorsal/ventral pattern formation Source: MGI
  3. epidermal cell differentiation Source: Ensembl
  4. lung development Source: MGI
  5. negative regulation of canonical Wnt signaling pathway Source: Ensembl
  6. notochord regression Source: MGI
  7. osteoblast differentiation Source: Ensembl
  8. pituitary gland development Source: MGI
  9. positive regulation of DNA replication Source: Ensembl
  10. positive regulation of smoothened signaling pathway Source: Ensembl
  11. positive regulation of transcription, DNA-templated Source: UniProtKB
  12. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  13. proximal/distal pattern formation Source: MGI
  14. signal transduction Source: MGI
  15. smoothened signaling pathway Source: MGI
  16. smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation Source: MGI
  17. spermatogenesis Source: MGI
  18. transcription from RNA polymerase II promoter Source: GOC
  19. ventral midline development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein GLI1
Alternative name(s):
Glioma-associated oncogene homolog
Gene namesi
Name:Gli1
Synonyms:Gli
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:95727. Gli1.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity
Note: Tethered in the cytoplasm by binding to SUFU. Activation and translocation to the nucleus is promoted by interaction with STK36. Phosphorylation by ULK3 may promote nuclear localization. Translocation to the nucleus is promoted by interaction with ZIC1 (By similarity).By similarity

GO - Cellular componenti

  1. cilium Source: MGI
  2. cytoplasm Source: MGI
  3. cytosol Source: Ensembl
  4. nucleus Source: MGI
  5. primary cilium Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11111111Zinc finger protein GLI1PRO_0000047198Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei520 – 5201N6-acetyllysineBy similarity

Post-translational modificationi

Phosphorylated in vitro by ULK3.
Acetylation at Lys-520 down-regulates transcriptional activity. Deacetylated by HDAC1.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP47806.
PRIDEiP47806.

PTM databases

PhosphoSiteiP47806.

Expressioni

Developmental stagei

Is detected on days 10 through 18 of embryonic development. During gestation it is detected in meckels precartilage mesenchyme, the basis occipitus, rib mesenchymal condensations, primordial vertebral bodies, digital mesenchymal condensations in forefoot and hindfoot plates, the ependymal layer of the spinal cord, and the mesoderm of the gastrointestinal tract. Expression persists throughout gestation in developing bone and cartilage of the extremities, the ribs, and the vertebral bodies as well as the gastrointestinal tract mesoderm.

Gene expression databases

CleanExiMM_GLI1.
ExpressionAtlasiP47806. baseline and differential.
GenevestigatoriP47806.

Interactioni

Subunit structurei

Interacts with ZIC1; the interaction enhances transcription activation (By similarity). Interacts with KIF7.By similarity1 Publication

Protein-protein interaction databases

BioGridi199942. 5 interactions.
IntActiP47806. 1 interaction.
STRINGi10090.ENSMUSP00000026474.

Structurei

3D structure databases

ProteinModelPortaliP47806.
SMRiP47806. Positions 237-449.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1042 – 105918Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri238 – 26326C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29828C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri304 – 32825C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri334 – 35926C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri365 – 39026C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118771.
HOGENOMiHOG000290688.
HOVERGENiHBG080668.
InParanoidiP47806.
KOiK16797.
OMAiCPRLEHY.
OrthoDBiEOG7X6KZ8.
TreeFamiTF350216.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47806-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFNPMTPPQV NSYSEPCCLR PLHSQGVPSM GTEGLSGLPF CHQANFMSGS
60 70 80 90 100
QGYGAARETS SCTEGSLFPP PPPPRSSVKL TKKRALSISP LSDASLDLQT
110 120 130 140 150
VIRTSPSSLV AFINSRCTSP GGSYGHLSIG TMSPSLGFPP QMSHQKGTSP
160 170 180 190 200
PYGVQPCVPH DSTRGSMMLH PQSRGPRATC QLKSELDMMV GKCPEDPLEG
210 220 230 240 250
DMSSPNSTGT QDHLLGMLDG REDLEREEKP EPESVYETDC RWDGCSQEFD
260 270 280 290 300
SQEQLVHHIN SEHIHGERKE FVCHWGGCSR ELRPFKAQYM LVVHMRRHTG
310 320 330 340 350
EKPHKCTFEG CRKSYSRLEN LKTHLRSHTG EKPYMCEQEG CSKAFSNASD
360 370 380 390 400
RAKHQNRTHS NEKPYVCKLP GCTKRYTDPS SLRKHVKTVH GPDAHVTKRH
410 420 430 440 450
RGDGPLPRAQ PLSTVEPKRE REGGSGREES RLTVPESAMP QQSPGAQSSC
460 470 480 490 500
SSDHSPAGSA ANTDSGVEMA GNAGGSTEDL SSLDEGPCVS ATGLSTLRRL
510 520 530 540 550
ENLRLDQLHQ LRPIGSRGLK LPSLTHAGAP VSRRLGPPVS LDRRSSSSSS
560 570 580 590 600
MSSAYTVSRR SSLASPFPPG TPPENGASSL PGLTPAQHYM LRARYASARG
610 620 630 640 650
SGTPPTAAHS LDRMGGLSVP PWRSRTEYPG YNPNAGVTRR ASDPARAADH
660 670 680 690 700
PAPARVQRFK SLGCVHTPPS VATGRNFDPH HPTSVYSPQP PSITENVAMD
710 720 730 740 750
TRGLQEEPEV GTSVMGNGLN PYMDFSSTDT LGYGGPEGTA AEPYEARGPG
760 770 780 790 800
SLPLGPGPPT NYGPGHCAQQ VSYPDPTPEN WGEFPSHAGV YPSNKAPGAA
810 820 830 840 850
YSQCPRLEHY GQVQVKPEQG CPVGSDSTGL APCLNAHPSE GSPGPQPLFS
860 870 880 890 900
HHPQLPQPQY PQSGPYPQPP HGYLSTEPRL GLNFNPSSSH STGQLKAQLV
910 920 930 940 950
CNYVQSQQEL LWEGRNRGGL PNQELPYQSP KFLGGSQVSQ SPAKTPAAAA
960 970 980 990 1000
AAYGSGFAPA SANHKSGSYP APSPCHETFT VGVNRPSHRP AAPPRLLPPL
1010 1020 1030 1040 1050
SPCYGPLKVG DTNPSCGHPE VGRLGAGPAL YPPPEGQVCN ALDSLDLDNT
1060 1070 1080 1090 1100
QLDFVAILDE AQGLSPPLSH EQGDSSKNTP SPSGPPNMAV GNMSVLLGSL
1110
PGETQFLNSS A
Length:1,111
Mass (Da):118,560
Last modified:October 3, 2012 - v4
Checksum:i8A83B254DCBB9BDC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti154 – 1541V → L in AAC09169. (PubMed:9524201)Curated
Sequence conflicti170 – 1701H → Y in AAC09169. (PubMed:9524201)Curated
Sequence conflicti173 – 1731S → A in BAA85004. (PubMed:10433919)Curated
Sequence conflicti179 – 1791T → I in AAC09169. (PubMed:9524201)Curated
Sequence conflicti194 – 1941P → R in AAC09169. (PubMed:9524201)Curated
Sequence conflicti210 – 2101T → I in BAA85004. (PubMed:10433919)Curated
Sequence conflicti271 – 2711F → S in AAC09169. (PubMed:9524201)Curated
Sequence conflicti474 – 4741Missing in AAC09169. (PubMed:9524201)Curated
Sequence conflicti567 – 5693FPP → LPT in AAC09169. (PubMed:9524201)Curated
Sequence conflicti707 – 7071E → D in AAC09169. (PubMed:9524201)Curated
Sequence conflicti777 – 7771Missing in AAC09169. (PubMed:9524201)Curated
Sequence conflicti864 – 8641G → V in AAC09169. (PubMed:9524201)Curated
Sequence conflicti919 – 9202GL → RA in AAC09169. (PubMed:9524201)Curated
Sequence conflicti936 – 9361S → Y in AAC09169. (PubMed:9524201)Curated
Sequence conflicti947 – 9471Missing in AAC09169. (PubMed:9524201)Curated
Sequence conflicti951 – 9522AA → RR in AAC09169. (PubMed:9524201)Curated
Sequence conflicti967 – 9671G → R in AAC09169. (PubMed:9524201)Curated
Sequence conflicti990 – 9901P → A in AAC09169. (PubMed:9524201)Curated
Sequence conflicti1029 – 10291A → P in AAC09169. (PubMed:9524201)Curated
Sequence conflicti1062 – 10632QG → R in AAC09169. (PubMed:9524201)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF026305 mRNA. Translation: AAC09169.1.
AB025922 mRNA. Translation: BAA85004.1.
AC114678 Genomic DNA. No translation available.
CH466578 Genomic DNA. Translation: EDL24501.1.
CCDSiCCDS24238.1.
RefSeqiNP_034426.2. NM_010296.2.
UniGeneiMm.391450.

Genome annotation databases

EnsembliENSMUST00000026474; ENSMUSP00000026474; ENSMUSG00000025407.
GeneIDi14632.
KEGGimmu:14632.
UCSCiuc007hjf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF026305 mRNA. Translation: AAC09169.1 .
AB025922 mRNA. Translation: BAA85004.1 .
AC114678 Genomic DNA. No translation available.
CH466578 Genomic DNA. Translation: EDL24501.1 .
CCDSi CCDS24238.1.
RefSeqi NP_034426.2. NM_010296.2.
UniGenei Mm.391450.

3D structure databases

ProteinModelPortali P47806.
SMRi P47806. Positions 237-449.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199942. 5 interactions.
IntActi P47806. 1 interaction.
STRINGi 10090.ENSMUSP00000026474.

Chemistry

BindingDBi P47806.
ChEMBLi CHEMBL5007.

PTM databases

PhosphoSitei P47806.

Proteomic databases

PaxDbi P47806.
PRIDEi P47806.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000026474 ; ENSMUSP00000026474 ; ENSMUSG00000025407 .
GeneIDi 14632.
KEGGi mmu:14632.
UCSCi uc007hjf.1. mouse.

Organism-specific databases

CTDi 2735.
MGIi MGI:95727. Gli1.

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000118771.
HOGENOMi HOG000290688.
HOVERGENi HBG080668.
InParanoidi P47806.
KOi K16797.
OMAi CPRLEHY.
OrthoDBi EOG7X6KZ8.
TreeFami TF350216.

Miscellaneous databases

NextBioi 286482.
PROi P47806.
SOURCEi Search...

Gene expression databases

CleanExi MM_GLI1.
ExpressionAtlasi P47806. baseline and differential.
Genevestigatori P47806.

Family and domain databases

Gene3Di 3.30.160.60. 5 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 5 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the promoter region and genomic organization of GLI, a member of the Sonic hedgehog-Patched signaling pathway."
    Liu C.Z., Yang J.T., Yoon J.W., Walterhouse D., Iannaccone P.
    Gene 209:1-11(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling."
    Sasaki H., Nishizaki Y., Hui C., Nakafuku M., Kondoh H.
    Development 126:3915-3924(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "gli, a zinc finger transcription factor and oncogene, is expressed during normal mouse development."
    Waterhouse D., Ahmed M., Slusarski D., Kalamaras J., Boucher D., Holmgren R., Iannaccone P.
    Dev. Dyn. 196:91-102(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 272-837.
    Strain: CD-1.
    Tissue: Embryo.
  6. "The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development."
    Endoh-Yamagami S., Evangelista M., Wilson D., Wen X., Theunissen J.W., Phamluong K., Davis M., Scales S.J., Solloway M.J., de Sauvage F.J., Peterson A.S.
    Curr. Biol. 19:1320-1326(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KIF7.

Entry informationi

Entry nameiGLI1_MOUSE
AccessioniPrimary (citable) accession number: P47806
Secondary accession number(s): G5E857, Q9QYK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 3, 2012
Last modified: October 29, 2014
This is version 128 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3