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P47806

- GLI1_MOUSE

UniProt

P47806 - GLI1_MOUSE

Protein

Zinc finger protein GLI1

Gene

Gli1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 4 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri238 – 26326C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri271 – 29828C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri304 – 32825C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri334 – 35926C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri365 – 39026C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. DNA binding Source: MGI
    3. metal ion binding Source: UniProtKB-KW
    4. microtubule binding Source: MGI
    5. protein binding Source: UniProtKB
    6. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
    7. transcription regulatory region DNA binding Source: Ensembl

    GO - Biological processi

    1. cerebellar cortex morphogenesis Source: MGI
    2. dorsal/ventral pattern formation Source: MGI
    3. epidermal cell differentiation Source: Ensembl
    4. lung development Source: MGI
    5. negative regulation of canonical Wnt signaling pathway Source: Ensembl
    6. notochord regression Source: MGI
    7. osteoblast differentiation Source: Ensembl
    8. pituitary gland development Source: MGI
    9. positive regulation of DNA replication Source: Ensembl
    10. positive regulation of smoothened signaling pathway Source: Ensembl
    11. positive regulation of transcription, DNA-templated Source: UniProtKB
    12. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    13. proximal/distal pattern formation Source: MGI
    14. signal transduction Source: MGI
    15. smoothened signaling pathway Source: MGI
    16. smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation Source: MGI
    17. spermatogenesis Source: MGI
    18. transcription from RNA polymerase II promoter Source: GOC
    19. ventral midline development Source: MGI

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Differentiation, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein GLI1
    Alternative name(s):
    Glioma-associated oncogene homolog
    Gene namesi
    Name:Gli1
    Synonyms:Gli
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:95727. Gli1.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity
    Note: Tethered in the cytoplasm by binding to SUFU. Activation and translocation to the nucleus is promoted by interaction with STK36. Phosphorylation by ULK3 may promote nuclear localization. Translocation to the nucleus is promoted by interaction with ZIC1 By similarity.By similarity

    GO - Cellular componenti

    1. cilium Source: MGI
    2. cytoplasm Source: MGI
    3. cytosol Source: Ensembl
    4. nucleus Source: MGI
    5. primary cilium Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Keywords - Diseasei

    Proto-oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11111111Zinc finger protein GLI1PRO_0000047198Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei520 – 5201N6-acetyllysineBy similarity

    Post-translational modificationi

    Phosphorylated in vitro by ULK3.
    Acetylation at Lys-520 down-regulates transcriptional activity. Deacetylated by HDAC1.

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiP47806.
    PRIDEiP47806.

    PTM databases

    PhosphoSiteiP47806.

    Expressioni

    Developmental stagei

    Is detected on days 10 through 18 of embryonic development. During gestation it is detected in meckels precartilage mesenchyme, the basis occipitus, rib mesenchymal condensations, primordial vertebral bodies, digital mesenchymal condensations in forefoot and hindfoot plates, the ependymal layer of the spinal cord, and the mesoderm of the gastrointestinal tract. Expression persists throughout gestation in developing bone and cartilage of the extremities, the ribs, and the vertebral bodies as well as the gastrointestinal tract mesoderm.

    Gene expression databases

    ArrayExpressiP47806.
    CleanExiMM_GLI1.
    GenevestigatoriP47806.

    Interactioni

    Subunit structurei

    Interacts with ZIC1; the interaction enhances transcription activation By similarity. Interacts with KIF7.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi199942. 5 interactions.
    IntActiP47806. 1 interaction.
    STRINGi10090.ENSMUSP00000026474.

    Structurei

    3D structure databases

    ProteinModelPortaliP47806.
    SMRiP47806. Positions 237-444.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1042 – 105918Asp/Glu-rich (acidic)Add
    BLAST

    Sequence similaritiesi

    Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri238 – 26326C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri271 – 29828C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri304 – 32825C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri334 – 35926C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri365 – 39026C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    GeneTreeiENSGT00740000115106.
    HOGENOMiHOG000290688.
    HOVERGENiHBG080668.
    InParanoidiP47806.
    KOiK16797.
    OMAiCPRLEHY.
    OrthoDBiEOG7X6KZ8.
    TreeFamiTF350216.

    Family and domain databases

    Gene3Di3.30.160.60. 5 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 5 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47806-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFNPMTPPQV NSYSEPCCLR PLHSQGVPSM GTEGLSGLPF CHQANFMSGS     50
    QGYGAARETS SCTEGSLFPP PPPPRSSVKL TKKRALSISP LSDASLDLQT 100
    VIRTSPSSLV AFINSRCTSP GGSYGHLSIG TMSPSLGFPP QMSHQKGTSP 150
    PYGVQPCVPH DSTRGSMMLH PQSRGPRATC QLKSELDMMV GKCPEDPLEG 200
    DMSSPNSTGT QDHLLGMLDG REDLEREEKP EPESVYETDC RWDGCSQEFD 250
    SQEQLVHHIN SEHIHGERKE FVCHWGGCSR ELRPFKAQYM LVVHMRRHTG 300
    EKPHKCTFEG CRKSYSRLEN LKTHLRSHTG EKPYMCEQEG CSKAFSNASD 350
    RAKHQNRTHS NEKPYVCKLP GCTKRYTDPS SLRKHVKTVH GPDAHVTKRH 400
    RGDGPLPRAQ PLSTVEPKRE REGGSGREES RLTVPESAMP QQSPGAQSSC 450
    SSDHSPAGSA ANTDSGVEMA GNAGGSTEDL SSLDEGPCVS ATGLSTLRRL 500
    ENLRLDQLHQ LRPIGSRGLK LPSLTHAGAP VSRRLGPPVS LDRRSSSSSS 550
    MSSAYTVSRR SSLASPFPPG TPPENGASSL PGLTPAQHYM LRARYASARG 600
    SGTPPTAAHS LDRMGGLSVP PWRSRTEYPG YNPNAGVTRR ASDPARAADH 650
    PAPARVQRFK SLGCVHTPPS VATGRNFDPH HPTSVYSPQP PSITENVAMD 700
    TRGLQEEPEV GTSVMGNGLN PYMDFSSTDT LGYGGPEGTA AEPYEARGPG 750
    SLPLGPGPPT NYGPGHCAQQ VSYPDPTPEN WGEFPSHAGV YPSNKAPGAA 800
    YSQCPRLEHY GQVQVKPEQG CPVGSDSTGL APCLNAHPSE GSPGPQPLFS 850
    HHPQLPQPQY PQSGPYPQPP HGYLSTEPRL GLNFNPSSSH STGQLKAQLV 900
    CNYVQSQQEL LWEGRNRGGL PNQELPYQSP KFLGGSQVSQ SPAKTPAAAA 950
    AAYGSGFAPA SANHKSGSYP APSPCHETFT VGVNRPSHRP AAPPRLLPPL 1000
    SPCYGPLKVG DTNPSCGHPE VGRLGAGPAL YPPPEGQVCN ALDSLDLDNT 1050
    QLDFVAILDE AQGLSPPLSH EQGDSSKNTP SPSGPPNMAV GNMSVLLGSL 1100
    PGETQFLNSS A 1111
    Length:1,111
    Mass (Da):118,560
    Last modified:October 3, 2012 - v4
    Checksum:i8A83B254DCBB9BDC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti154 – 1541V → L in AAC09169. (PubMed:9524201)Curated
    Sequence conflicti170 – 1701H → Y in AAC09169. (PubMed:9524201)Curated
    Sequence conflicti173 – 1731S → A in BAA85004. (PubMed:10433919)Curated
    Sequence conflicti179 – 1791T → I in AAC09169. (PubMed:9524201)Curated
    Sequence conflicti194 – 1941P → R in AAC09169. (PubMed:9524201)Curated
    Sequence conflicti210 – 2101T → I in BAA85004. (PubMed:10433919)Curated
    Sequence conflicti271 – 2711F → S in AAC09169. (PubMed:9524201)Curated
    Sequence conflicti474 – 4741Missing in AAC09169. (PubMed:9524201)Curated
    Sequence conflicti567 – 5693FPP → LPT in AAC09169. (PubMed:9524201)Curated
    Sequence conflicti707 – 7071E → D in AAC09169. (PubMed:9524201)Curated
    Sequence conflicti777 – 7771Missing in AAC09169. (PubMed:9524201)Curated
    Sequence conflicti864 – 8641G → V in AAC09169. (PubMed:9524201)Curated
    Sequence conflicti919 – 9202GL → RA in AAC09169. (PubMed:9524201)Curated
    Sequence conflicti936 – 9361S → Y in AAC09169. (PubMed:9524201)Curated
    Sequence conflicti947 – 9471Missing in AAC09169. (PubMed:9524201)Curated
    Sequence conflicti951 – 9522AA → RR in AAC09169. (PubMed:9524201)Curated
    Sequence conflicti967 – 9671G → R in AAC09169. (PubMed:9524201)Curated
    Sequence conflicti990 – 9901P → A in AAC09169. (PubMed:9524201)Curated
    Sequence conflicti1029 – 10291A → P in AAC09169. (PubMed:9524201)Curated
    Sequence conflicti1062 – 10632QG → R in AAC09169. (PubMed:9524201)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF026305 mRNA. Translation: AAC09169.1.
    AB025922 mRNA. Translation: BAA85004.1.
    AC114678 Genomic DNA. No translation available.
    CH466578 Genomic DNA. Translation: EDL24501.1.
    CCDSiCCDS24238.1.
    RefSeqiNP_034426.2. NM_010296.2.
    UniGeneiMm.391450.

    Genome annotation databases

    EnsembliENSMUST00000026474; ENSMUSP00000026474; ENSMUSG00000025407.
    GeneIDi14632.
    KEGGimmu:14632.
    UCSCiuc007hjf.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF026305 mRNA. Translation: AAC09169.1 .
    AB025922 mRNA. Translation: BAA85004.1 .
    AC114678 Genomic DNA. No translation available.
    CH466578 Genomic DNA. Translation: EDL24501.1 .
    CCDSi CCDS24238.1.
    RefSeqi NP_034426.2. NM_010296.2.
    UniGenei Mm.391450.

    3D structure databases

    ProteinModelPortali P47806.
    SMRi P47806. Positions 237-444.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199942. 5 interactions.
    IntActi P47806. 1 interaction.
    STRINGi 10090.ENSMUSP00000026474.

    Chemistry

    BindingDBi P47806.
    ChEMBLi CHEMBL5007.

    PTM databases

    PhosphoSitei P47806.

    Proteomic databases

    PaxDbi P47806.
    PRIDEi P47806.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026474 ; ENSMUSP00000026474 ; ENSMUSG00000025407 .
    GeneIDi 14632.
    KEGGi mmu:14632.
    UCSCi uc007hjf.1. mouse.

    Organism-specific databases

    CTDi 2735.
    MGIi MGI:95727. Gli1.

    Phylogenomic databases

    eggNOGi COG5048.
    GeneTreei ENSGT00740000115106.
    HOGENOMi HOG000290688.
    HOVERGENi HBG080668.
    InParanoidi P47806.
    KOi K16797.
    OMAi CPRLEHY.
    OrthoDBi EOG7X6KZ8.
    TreeFami TF350216.

    Miscellaneous databases

    NextBioi 286482.
    PROi P47806.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P47806.
    CleanExi MM_GLI1.
    Genevestigatori P47806.

    Family and domain databases

    Gene3Di 3.30.160.60. 5 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 5 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the promoter region and genomic organization of GLI, a member of the Sonic hedgehog-Patched signaling pathway."
      Liu C.Z., Yang J.T., Yoon J.W., Walterhouse D., Iannaccone P.
      Gene 209:1-11(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling."
      Sasaki H., Nishizaki Y., Hui C., Nakafuku M., Kondoh H.
      Development 126:3915-3924(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ICR.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "gli, a zinc finger transcription factor and oncogene, is expressed during normal mouse development."
      Waterhouse D., Ahmed M., Slusarski D., Kalamaras J., Boucher D., Holmgren R., Iannaccone P.
      Dev. Dyn. 196:91-102(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 272-837.
      Strain: CD-1.
      Tissue: Embryo.
    6. "The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development."
      Endoh-Yamagami S., Evangelista M., Wilson D., Wen X., Theunissen J.W., Phamluong K., Davis M., Scales S.J., Solloway M.J., de Sauvage F.J., Peterson A.S.
      Curr. Biol. 19:1320-1326(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KIF7.

    Entry informationi

    Entry nameiGLI1_MOUSE
    AccessioniPrimary (citable) accession number: P47806
    Secondary accession number(s): G5E857, Q9QYK1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 127 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3