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Protein

Epithelial membrane protein 1

Gene

Emp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Epithelial membrane protein 1
Short name:
EMP-1
Alternative name(s):
Tumor-associated membrane protein
Gene namesi
Name:Emp1
Synonyms:Tmp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:107941. Emp1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001646541 – 160Epithelial membrane protein 1Add BLAST160

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi35N-linked (GlcNAc...)1 Publication1
Glycosylationi43N-linked (GlcNAc...)Sequence analysis1
Glycosylationi128N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP47801.
PeptideAtlasiP47801.
PRIDEiP47801.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030208.
CleanExiMM_EMP1.
ExpressionAtlasiP47801. baseline and differential.
GenevisibleiP47801. MM.

Interactioni

Protein-protein interaction databases

IntActiP47801. 1 interactor.
STRINGi10090.ENSMUSP00000032330.

Structurei

3D structure databases

ProteinModelPortaliP47801.
SMRiP47801.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW7W. Eukaryota.
ENOG410Z5WT. LUCA.
GeneTreeiENSGT00510000046328.
HOGENOMiHOG000059542.
HOVERGENiHBG001690.
InParanoidiP47801.
OMAiCWLCILV.
OrthoDBiEOG091G0RF4.
PhylomeDBiP47801.
TreeFamiTF330414.

Family and domain databases

InterProiIPR003932. EMP_1.
IPR004031. PMP22/EMP/MP20/Claudin.
IPR004032. PMP22_EMP_MP20.
[Graphical view]
PANTHERiPTHR10671:SF6. PTHR10671:SF6. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01453. EPMEMFAMILY.
PR01454. EPMEMPROT1.
PROSITEiPS01221. PMP22_1. 1 hit.
PS01222. PMP22_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47801-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVLLAGLFV VHIATAIMLF VSTIANVWMV ADYANASVGL WKNCTGGNCD
60 70 80 90 100
GSLSYGNEDA IKAVQAFMIL SIIFSIISLV VFVFQLFTME KGNRFFLSGS
110 120 130 140 150
TMLVCWLCIL VGVSIYTHHY AHSEGNFNSS SHQGYCFILT WICFCFSFII
160
GILYMVLRKK
Length:160
Mass (Da):17,813
Last modified:November 1, 1997 - v2
Checksum:i1B91687E547A2905
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25633 mRNA. Translation: AAC52968.1.
X98403 mRNA. Translation: CAA67053.1.
X98471 Genomic DNA. Translation: CAA67106.1.
BC046299 mRNA. Translation: AAH46299.1.
BC050899 mRNA. Translation: AAH50899.1.
CCDSiCCDS20647.1.
PIRiJC5730.
RefSeqiNP_001275556.1. NM_001288627.1.
NP_001275557.1. NM_001288628.1.
NP_034258.1. NM_010128.4.
XP_006505565.1. XM_006505502.1.
UniGeneiMm.182785.

Genome annotation databases

EnsembliENSMUST00000032330; ENSMUSP00000032330; ENSMUSG00000030208.
ENSMUST00000111907; ENSMUSP00000107538; ENSMUSG00000030208.
ENSMUST00000205156; ENSMUSP00000145069; ENSMUSG00000030208.
GeneIDi13730.
KEGGimmu:13730.
UCSCiuc009elo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25633 mRNA. Translation: AAC52968.1.
X98403 mRNA. Translation: CAA67053.1.
X98471 Genomic DNA. Translation: CAA67106.1.
BC046299 mRNA. Translation: AAH46299.1.
BC050899 mRNA. Translation: AAH50899.1.
CCDSiCCDS20647.1.
PIRiJC5730.
RefSeqiNP_001275556.1. NM_001288627.1.
NP_001275557.1. NM_001288628.1.
NP_034258.1. NM_010128.4.
XP_006505565.1. XM_006505502.1.
UniGeneiMm.182785.

3D structure databases

ProteinModelPortaliP47801.
SMRiP47801.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP47801. 1 interactor.
STRINGi10090.ENSMUSP00000032330.

Proteomic databases

PaxDbiP47801.
PeptideAtlasiP47801.
PRIDEiP47801.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032330; ENSMUSP00000032330; ENSMUSG00000030208.
ENSMUST00000111907; ENSMUSP00000107538; ENSMUSG00000030208.
ENSMUST00000205156; ENSMUSP00000145069; ENSMUSG00000030208.
GeneIDi13730.
KEGGimmu:13730.
UCSCiuc009elo.1. mouse.

Organism-specific databases

CTDi2012.
MGIiMGI:107941. Emp1.

Phylogenomic databases

eggNOGiENOG410IW7W. Eukaryota.
ENOG410Z5WT. LUCA.
GeneTreeiENSGT00510000046328.
HOGENOMiHOG000059542.
HOVERGENiHBG001690.
InParanoidiP47801.
OMAiCWLCILV.
OrthoDBiEOG091G0RF4.
PhylomeDBiP47801.
TreeFamiTF330414.

Miscellaneous databases

ChiTaRSiEmp1. mouse.
PROiP47801.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030208.
CleanExiMM_EMP1.
ExpressionAtlasiP47801. baseline and differential.
GenevisibleiP47801. MM.

Family and domain databases

InterProiIPR003932. EMP_1.
IPR004031. PMP22/EMP/MP20/Claudin.
IPR004032. PMP22_EMP_MP20.
[Graphical view]
PANTHERiPTHR10671:SF6. PTHR10671:SF6. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01453. EPMEMFAMILY.
PR01454. EPMEMPROT1.
PROSITEiPS01221. PMP22_1. 1 hit.
PS01222. PMP22_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEMP1_MOUSE
AccessioniPrimary (citable) accession number: P47801
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.