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P47796

- CTRA_GADMO

UniProt

P47796 - CTRA_GADMO

Protein

Chymotrypsin A

Gene
N/A
Organism
Gadus morhua (Atlantic cod)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei75 – 751Charge relay systemBy similarity
    Active sitei120 – 1201Charge relay systemBy similarity
    Active sitei213 – 2131Charge relay systemBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    GO - Biological processi

    1. digestion Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Biological processi

    Digestion

    Protein family/group databases

    MEROPSiS01.437.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chymotrypsin A (EC:3.4.21.1)
    OrganismiGadus morhua (Atlantic cod)
    Taxonomic identifieri8049 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataZeiogadariaGadariaeGadiformesGadoideiGadidaeGadus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 18181 PublicationAdd
    BLAST
    Chaini19 – 263245Chymotrypsin APRO_0000027646Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi19 ↔ 140PROSITE-ProRule annotation
    Disulfide bondi60 ↔ 76PROSITE-ProRule annotation
    Disulfide bondi154 ↔ 219PROSITE-ProRule annotation
    Disulfide bondi186 ↔ 200PROSITE-ProRule annotation
    Disulfide bondi209 ↔ 238PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Zymogen

    Structurei

    3D structure databases

    ProteinModelPortaliP47796.
    SMRiP47796. Positions 19-263.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 261228Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG013304.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P47796-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGHEVDSVLP GLFRRTYGCG RPAISPVITG YSRIVNGEEA VPHSWSWQVS    50
    LQDQTGFHFC GGSLINENWV VTAAHCNVKN YHRVVLGEHD RSSNSEGVQV 100
    MTVGQVFKHP RYNGFTINND ILLVKLATPA TLNMRVSPVC LAETDDVFEG 150
    GMKCVTSGWG LTRYNAADTP ALLQQAALPL LTNEQCKKFW GNKISDLMIC 200
    AGAAGASSCM GDSGGPLVCQ KAGSWTLVGI VSWGSGTCTP TMPGVYARVT 250
    ELRAWVDQTI AAN 263
    Length:263
    Mass (Da):28,294
    Last modified:February 1, 1996 - v1
    Checksum:i47AAC699A0A64FBB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti21 – 211R → S AA sequence (PubMed:1764912)Curated
    Sequence conflicti25 – 251S → Q AA sequence (PubMed:1764912)Curated
    Sequence conflicti29 – 291T → S AA sequence (PubMed:1764912)Curated
    Sequence conflicti44 – 441S → T AA sequence (PubMed:1764912)Curated
    Sequence conflicti46 – 461S → Y AA sequence (PubMed:1764912)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78490 mRNA. Translation: CAA55242.1.
    PIRiS47537.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78490 mRNA. Translation: CAA55242.1 .
    PIRi S47537.

    3D structure databases

    ProteinModelPortali P47796.
    SMRi P47796. Positions 19-263.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S01.437.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG013304.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Atlantic cod cDNA encoding a psychrophilic chymotrypsinogen."
      Gudmundsdottir A., Oskarsson S., Eakin A.E., Craik C.S., Bjarnason J.B.
      Biochim. Biophys. Acta 1219:211-214(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pyloric caecum.
    2. "Structural and kinetic properties of chymotrypsin from Atlantic cod (Gadus morhua). Comparison with bovine chymotrypsin."
      Asgeirsson B., Bjarnason J.B.
      Comp. Biochem. Physiol. 99B:327-335(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 19-30 AND 34-49.
      Tissue: Pyloric caecum.

    Entry informationi

    Entry nameiCTRA_GADMO
    AccessioniPrimary (citable) accession number: P47796
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3