Reviewed,
UniProtKB/Swiss-Prot P47796 (CTRA_GADMO)
Last modified
June 16, 2009.
Version 53.
History...
Clusters with 100%,
90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Chymotrypsin A EC=3.4.21.1 |
| Organism | Gadus morhua (Atlantic cod) |
| Taxonomic identifier | 8049 [NCBI] |
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Paracanthopterygii › Gadiformes › Gadidae › Gadus |
Protein attributes
| Sequence length | 263 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa. |
| Subcellular location | |
| Sequence similarities | Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Digestion |
| Cellular component | Secreted |
| Domain | Signal |
| Molecular function | Hydrolase Protease Serine protease |
| PTM | Disulfide bond Zymogen |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | digestion Inferred from electronic annotation. Source: UniProtKB-KW proteolysisInferred from electronic annotation. Source: InterPro |
| Cellular component | extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 18 | 18 | Ref.2 | ||||||||
| Chain | 19 – 263 | 245 | Chymotrypsin A | PRO_0000027646 | |||||||
Regions | |||||||||||
| Domain | 34 – 261 | 228 | Peptidase S1 | ||||||||
Sites | |||||||||||
| Active site | 75 | 1 | Charge relay system By similarity | ||||||||
| Active site | 120 | 1 | Charge relay system By similarity | ||||||||
| Active site | 213 | 1 | Charge relay system By similarity | ||||||||
Amino acid modifications | |||||||||||
| Disulfide bond | 19 ↔ 140 | By similarity | |||||||||
| Disulfide bond | 60 ↔ 76 | By similarity | |||||||||
| Disulfide bond | 154 ↔ 219 | By similarity | |||||||||
| Disulfide bond | 186 ↔ 200 | By similarity | |||||||||
| Disulfide bond | 209 ↔ 238 | By similarity | |||||||||
Experimental info | |||||||||||
| Sequence conflict | 21 | 1 | R → S AA sequence Ref.2 | ||||||||
| Sequence conflict | 25 | 1 | S → Q AA sequence Ref.2 | ||||||||
| Sequence conflict | 29 | 1 | T → S AA sequence Ref.2 | ||||||||
| Sequence conflict | 44 | 1 | S → T AA sequence Ref.2 | ||||||||
| Sequence conflict | 46 | 1 | S → Y AA sequence Ref.2 | ||||||||
Sequences
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References
| [1] | "Atlantic cod cDNA encoding a psychrophilic chymotrypsinogen." Gudmundsdottir A., Oskarsson S., Eakin A.E., Craik C.S., Bjarnason J.B. Biochim. Biophys. Acta 1219:211-214(1994) [PubMed: 8086467] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pyloric caecum. |
| [2] | "Structural and kinetic properties of chymotrypsin from Atlantic cod (Gadus morhua). Comparison with bovine chymotrypsin." Asgeirsson B., Bjarnason J.B. Comp. Biochem. Physiol. 99B:327-335(1991) [PubMed: 1764912] [Abstract] Cited for: PROTEIN SEQUENCE OF 19-30 AND 34-49. Tissue: Pyloric caecum. |
Cross-references
Sequence databases | |
|---|---|
| X78490 mRNA. Translation: CAA55242.1. | |
| PIR | S47537. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1EZX based on UniProtKB P00760. |
| ModBase | Search... |
Protein family/group databases | |
| MEROPS | S01.437. |
Phylogenomic databases | |
| HOVERGEN | P47796. |
Enzyme and pathway databases | |
| BRENDA | 3.4.21.1. 39336. |
Family and domain databases | |
| InterPro | IPR018114. Peptidase_S1/S6_AS. IPR001254. Peptidase_S1_S6. IPR001314. Peptidase_S1A. [Graphical view] |
| Pfam | PF00089. Trypsin. 1 hit. [Graphical view] |
| PRINTS | PR00722. CHYMOTRYPSIN. |
| SMART | SM00020. Tryp_SPc. 1 hit. [Graphical view] |
| PROSITE | PS50240. TRYPSIN_DOM. 1 hit. PS00134. TRYPSIN_HIS. 1 hit. PS00135. TRYPSIN_SER. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CTRA_GADMO | ||||||||
| Accession | Primary (citable) accession number: P47796 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Relevant documents
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

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