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P47796 (CTRA_GADMO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.

Subcellular location

Secretedextracellular space.

Sequence similarities

Belongs to the peptidase S1 family.

Contains 1 peptidase S1 domain.

Ontologies

Keywords
   Biological processDigestion
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
Protease
Serine protease
   PTMDisulfide bond
Zymogen
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processdigestion

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Ref.2
Chain19 – 263245Chymotrypsin A
PRO_0000027646

Regions

Domain34 – 261228Peptidase S1

Sites

Active site751Charge relay system By similarity
Active site1201Charge relay system By similarity
Active site2131Charge relay system By similarity

Amino acid modifications

Disulfide bond19 ↔ 140 By similarity
Disulfide bond60 ↔ 76 By similarity
Disulfide bond154 ↔ 219 By similarity
Disulfide bond186 ↔ 200 By similarity
Disulfide bond209 ↔ 238 By similarity

Experimental info

Sequence conflict211R → S AA sequence Ref.2
Sequence conflict251S → Q AA sequence Ref.2
Sequence conflict291T → S AA sequence Ref.2
Sequence conflict441S → T AA sequence Ref.2
Sequence conflict461S → Y AA sequence Ref.2

Sequences

Sequence LengthMass (Da)Tools
P47796 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 47AAC699A0A64FBB

FASTA26328,294
        10         20         30         40         50         60 
MGHEVDSVLP GLFRRTYGCG RPAISPVITG YSRIVNGEEA VPHSWSWQVS LQDQTGFHFC 

        70         80         90        100        110        120 
GGSLINENWV VTAAHCNVKN YHRVVLGEHD RSSNSEGVQV MTVGQVFKHP RYNGFTINND 

       130        140        150        160        170        180 
ILLVKLATPA TLNMRVSPVC LAETDDVFEG GMKCVTSGWG LTRYNAADTP ALLQQAALPL 

       190        200        210        220        230        240 
LTNEQCKKFW GNKISDLMIC AGAAGASSCM GDSGGPLVCQ KAGSWTLVGI VSWGSGTCTP 

       250        260 
TMPGVYARVT ELRAWVDQTI AAN 

« Hide

References

[1]"Atlantic cod cDNA encoding a psychrophilic chymotrypsinogen."
Gudmundsdottir A., Oskarsson S., Eakin A.E., Craik C.S., Bjarnason J.B.
Biochim. Biophys. Acta 1219:211-214(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pyloric caecum.
[2]"Structural and kinetic properties of chymotrypsin from Atlantic cod (Gadus morhua). Comparison with bovine chymotrypsin."
Asgeirsson B., Bjarnason J.B.
Comp. Biochem. Physiol. 99B:327-335(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 19-30 AND 34-49.
Tissue: Pyloric caecum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X78490 mRNA. Translation: CAA55242.1.
PIRS47537.

3D structure databases

ProteinModelPortalP47796.
SMRP47796. Positions 19-263.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS01.437.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG013304.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCTRA_GADMO
AccessionPrimary (citable) accession number: P47796
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 11, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries