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P47796

- CTRA_GADMO

UniProt

P47796 - CTRA_GADMO

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Protein

Chymotrypsin A

Gene
N/A
Organism
Gadus morhua (Atlantic cod)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei75 – 751Charge relay systemBy similarity
Active sitei120 – 1201Charge relay systemBy similarity
Active sitei213 – 2131Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  1. digestion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Digestion

Protein family/group databases

MEROPSiS01.437.

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin A (EC:3.4.21.1)
OrganismiGadus morhua (Atlantic cod)
Taxonomic identifieri8049 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataZeiogadariaGadariaeGadiformesGadoideiGadidaeGadus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18181 PublicationAdd
BLAST
Chaini19 – 263245Chymotrypsin APRO_0000027646Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi19 ↔ 140PROSITE-ProRule annotation
Disulfide bondi60 ↔ 76PROSITE-ProRule annotation
Disulfide bondi154 ↔ 219PROSITE-ProRule annotation
Disulfide bondi186 ↔ 200PROSITE-ProRule annotation
Disulfide bondi209 ↔ 238PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Structurei

3D structure databases

ProteinModelPortaliP47796.
SMRiP47796. Positions 19-263.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 261228Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG013304.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47796-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGHEVDSVLP GLFRRTYGCG RPAISPVITG YSRIVNGEEA VPHSWSWQVS
60 70 80 90 100
LQDQTGFHFC GGSLINENWV VTAAHCNVKN YHRVVLGEHD RSSNSEGVQV
110 120 130 140 150
MTVGQVFKHP RYNGFTINND ILLVKLATPA TLNMRVSPVC LAETDDVFEG
160 170 180 190 200
GMKCVTSGWG LTRYNAADTP ALLQQAALPL LTNEQCKKFW GNKISDLMIC
210 220 230 240 250
AGAAGASSCM GDSGGPLVCQ KAGSWTLVGI VSWGSGTCTP TMPGVYARVT
260
ELRAWVDQTI AAN
Length:263
Mass (Da):28,294
Last modified:February 1, 1996 - v1
Checksum:i47AAC699A0A64FBB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211R → S AA sequence (PubMed:1764912)Curated
Sequence conflicti25 – 251S → Q AA sequence (PubMed:1764912)Curated
Sequence conflicti29 – 291T → S AA sequence (PubMed:1764912)Curated
Sequence conflicti44 – 441S → T AA sequence (PubMed:1764912)Curated
Sequence conflicti46 – 461S → Y AA sequence (PubMed:1764912)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78490 mRNA. Translation: CAA55242.1.
PIRiS47537.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78490 mRNA. Translation: CAA55242.1 .
PIRi S47537.

3D structure databases

ProteinModelPortali P47796.
SMRi P47796. Positions 19-263.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S01.437.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG013304.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Atlantic cod cDNA encoding a psychrophilic chymotrypsinogen."
    Gudmundsdottir A., Oskarsson S., Eakin A.E., Craik C.S., Bjarnason J.B.
    Biochim. Biophys. Acta 1219:211-214(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pyloric caecum.
  2. "Structural and kinetic properties of chymotrypsin from Atlantic cod (Gadus morhua). Comparison with bovine chymotrypsin."
    Asgeirsson B., Bjarnason J.B.
    Comp. Biochem. Physiol. 99B:327-335(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 19-30 AND 34-49.
    Tissue: Pyloric caecum.

Entry informationi

Entry nameiCTRA_GADMO
AccessioniPrimary (citable) accession number: P47796
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3