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Protein

G1/S-specific cyclin-E1

Gene

ccne1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Essential for the control of the cell cycle at the G1/S (start) transition.

GO - Molecular functioni

  • kinase activity Source: ZFIN

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
G1/S-specific cyclin-E1
Gene namesi
Name:ccne1
Synonyms:ccne, cyce
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-980526-168. ccne1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410G1/S-specific cyclin-E1PRO_0000080453Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei397 – 3971PhosphothreonineBy similarity

Post-translational modificationi

Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP47794.

Interactioni

Subunit structurei

Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.

Protein-protein interaction databases

STRINGi7955.ENSDARP00000024696.

Structurei

3D structure databases

ProteinModelPortaliP47794.
SMRiP47794. Positions 105-374.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin E subfamily.Curated

Phylogenomic databases

eggNOGiKOG0655. Eukaryota.
ENOG410XS2J. LUCA.
HOGENOMiHOG000231743.
HOVERGENiHBG050834.
InParanoidiP47794.
KOiK06626.
PhylomeDBiP47794.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR028858. Cyclin_E.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF71. PTHR10177:SF71. 1 hit.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47794-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSKKVLQTE HINTTDEAPK TTSVRPRKRK ADVAIHLQDP DEEVTEMTRK
60 70 80 90 100
KQCASQACWN PDTGYTSPCR RIPTPDEVEE PVAFGSVGFT QYASESIFIT
110 120 130 140 150
PTRSTPLPAL CWASKDEVWN NLLGKDKLYL RDTRVMERHP NLQPKMRAIL
160 170 180 190 200
LDWLMEVCEV YKLHRETFYL GQDYFDRFMA TQENVLKTTL QLIGISCLFI
210 220 230 240 250
AAKMEEIYPP KVHQFAYVTD GACTEDDILS MEIIIMKELN WSLSPLTPVA
260 270 280 290 300
WLNIYMQMAY LKETAEVLTA QYPQATFVQI AELLDLCILD VRSLEFSYSL
310 320 330 340 350
LAASALFHFS SLELVIKVSG LKWCDLEECV RWMVPFAMSI REAGSSALKT
360 370 380 390 400
FKGIAADDMH NIQTHVPYLE WLGKVHSYQL VDIESSQRSP VPTGVLTPPP
410
SSEKPESTIS
Length:410
Mass (Da):46,631
Last modified:February 1, 1996 - v1
Checksum:i2760F1CD30214077
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83594 mRNA. Translation: CAA58574.1.
BC045842 mRNA. Translation: AAH45842.1.
BC075747 mRNA. Translation: AAH75747.1.
PIRiS52288.
RefSeqiNP_571070.1. NM_130995.1.
UniGeneiDr.29.

Genome annotation databases

GeneIDi30188.
KEGGidre:30188.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83594 mRNA. Translation: CAA58574.1.
BC045842 mRNA. Translation: AAH45842.1.
BC075747 mRNA. Translation: AAH75747.1.
PIRiS52288.
RefSeqiNP_571070.1. NM_130995.1.
UniGeneiDr.29.

3D structure databases

ProteinModelPortaliP47794.
SMRiP47794. Positions 105-374.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000024696.

Proteomic databases

PaxDbiP47794.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi30188.
KEGGidre:30188.

Organism-specific databases

CTDi898.
ZFINiZDB-GENE-980526-168. ccne1.

Phylogenomic databases

eggNOGiKOG0655. Eukaryota.
ENOG410XS2J. LUCA.
HOGENOMiHOG000231743.
HOVERGENiHBG050834.
InParanoidiP47794.
KOiK06626.
PhylomeDBiP47794.

Miscellaneous databases

NextBioi20806654.
PROiP47794.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR028858. Cyclin_E.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF71. PTHR10177:SF71. 1 hit.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Zebrafish cyclin E regulation during early embryogenesis."
    Yarden A., Geiger B.
    Dev. Dyn. 206:1-11(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: AB.
    Tissue: Embryo.

Entry informationi

Entry nameiCCNE1_DANRE
AccessioniPrimary (citable) accession number: P47794
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 11, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.