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Protein

G1/S-specific cyclin-E1

Gene

ccne1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Essential for the control of the cell cycle at the G1/S (start) transition.

GO - Molecular functioni

  • kinase activity Source: ZFIN

GO - Biological processi

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
G1/S-specific cyclin-E1
Gene namesi
Name:ccne1
Synonyms:ccne, cyce
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-980526-168. ccne1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804531 – 410G1/S-specific cyclin-E1Add BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei397PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP47794.

Interactioni

Subunit structurei

Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.

Protein-protein interaction databases

STRINGi7955.ENSDARP00000024696.

Structurei

3D structure databases

ProteinModelPortaliP47794.
SMRiP47794.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin E subfamily.Curated

Phylogenomic databases

eggNOGiKOG0655. Eukaryota.
ENOG410XS2J. LUCA.
HOGENOMiHOG000231743.
HOVERGENiHBG050834.
InParanoidiP47794.
KOiK06626.
PhylomeDBiP47794.

Family and domain databases

CDDicd00043. CYCLIN. 1 hit.
Gene3Di1.10.472.10. 2 hits.
InterProiView protein in InterPro
IPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR028858. Cyclin_E.
IPR006671. Cyclin_N.
PANTHERiPTHR10177:SF288. PTHR10177:SF288. 1 hit.
PfamiView protein in Pfam
PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
SMARTiView protein in SMART
SM00385. CYCLIN. 1 hit.
SM01332. Cyclin_C. 1 hit.
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiView protein in PROSITE
PS00292. CYCLINS. 1 hit.

Sequencei

Sequence statusi: Complete.

P47794-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSKKVLQTE HINTTDEAPK TTSVRPRKRK ADVAIHLQDP DEEVTEMTRK
60 70 80 90 100
KQCASQACWN PDTGYTSPCR RIPTPDEVEE PVAFGSVGFT QYASESIFIT
110 120 130 140 150
PTRSTPLPAL CWASKDEVWN NLLGKDKLYL RDTRVMERHP NLQPKMRAIL
160 170 180 190 200
LDWLMEVCEV YKLHRETFYL GQDYFDRFMA TQENVLKTTL QLIGISCLFI
210 220 230 240 250
AAKMEEIYPP KVHQFAYVTD GACTEDDILS MEIIIMKELN WSLSPLTPVA
260 270 280 290 300
WLNIYMQMAY LKETAEVLTA QYPQATFVQI AELLDLCILD VRSLEFSYSL
310 320 330 340 350
LAASALFHFS SLELVIKVSG LKWCDLEECV RWMVPFAMSI REAGSSALKT
360 370 380 390 400
FKGIAADDMH NIQTHVPYLE WLGKVHSYQL VDIESSQRSP VPTGVLTPPP
410
SSEKPESTIS
Length:410
Mass (Da):46,631
Last modified:February 1, 1996 - v1
Checksum:i2760F1CD30214077
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83594 mRNA. Translation: CAA58574.1.
BC045842 mRNA. Translation: AAH45842.1.
BC075747 mRNA. Translation: AAH75747.1.
PIRiS52288.
RefSeqiNP_571070.1. NM_130995.1.
UniGeneiDr.29.

Genome annotation databases

GeneIDi30188.
KEGGidre:30188.

Similar proteinsi

Entry informationi

Entry nameiCCNE1_DANRE
AccessioniPrimary (citable) accession number: P47794
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 27, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families