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Protein

Thromboxane-A synthase

Gene

TBXAS1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9-alpha,11-alpha-epoxy-15-hydroxythromboxa-5,13-dienoate.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi480Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Monooxygenase, Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thromboxane-A synthase (EC:5.3.99.5)
Short name:
TXA synthase
Short name:
TXS
Alternative name(s):
Cytochrome P450 5A1
Gene namesi
Name:TBXAS1
Synonyms:CYP5, CYP5A1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 75LumenalSequence analysisAdd BLAST44
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Topological domaini97 – 223CytoplasmicSequence analysisAdd BLAST127
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Topological domaini245 – 336LumenalSequence analysisAdd BLAST92
Transmembranei337 – 357HelicalSequence analysisAdd BLAST21
Topological domaini358 – 534CytoplasmicSequence analysisAdd BLAST177

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000522581 – 534Thromboxane-A synthaseAdd BLAST534

Proteomic databases

PaxDbiP47787.
PeptideAtlasiP47787.
PRIDEiP47787.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi1149247. 1 interactor.
STRINGi9823.ENSSSCP00000017486.

Structurei

3D structure databases

ProteinModelPortaliP47787.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0158. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000039127.
HOVERGENiHBG108567.
InParanoidiP47787.
KOiK01832.

Family and domain databases

Gene3Di1.10.630.10. 2 hits.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 2 hits.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 2 hits.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47787-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVLGFLSPE LNGPMVTMAL AVVLLALLKW YSTSAFSRLE KLGIRHPKPS
60 70 80 90 100
PFIGNLTFFR QGFWESHMEL RKQYGPLSGY YLGRRMIVVI SDPDMIKQVL
110 120 130 140 150
AEKFSNFTNR MATGLESKPV ADSILFLRDK RWEEVRSVLT SAFSPKKLNK
160 170 180 190 200
LTPLISQACD LLLAHLERYA ESGDAFDIQR CYCCYTTDVV ASVAFGTQVN
210 220 230 240 250
SSEEPEHPFV KHCRRFFAFS VPRLILVLIL SFPSIMVPLA RILPNKKRDE
260 270 280 290 300
VNGFFNKLIR NVIALRDQQA AEERRQDFLQ MVLDLRHSAP SVGVENFDIV
310 320 330 340 350
RQAFSSAKGC PADPSQPHLP RPLSKPLTVD EVVGQAFLFL IAGYEIITNT
360 370 380 390 400
LSFVTYLLAT NPDCQEKLLR EVDDFSKKHP SPEHCSLQQG LPYLDMVLSE
410 420 430 440 450
TLRMYPPAFR FTREAARDCE VLGQRIPAGT VLEVAVGALH HDPKHWPHPE
460 470 480 490 500
TFDPERFTAE AQRLQQPFTY LPFGAGPRSC LGVQLGLLEI KLTLLHILRK
510 520 530
FRFEACPETQ VPLQLESKSA LSPKNGVYIR IVPR
Length:534
Mass (Da):60,485
Last modified:February 1, 1996 - v1
Checksum:i635347A1B3508715
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13128 mRNA. Translation: AAA31127.1.
RefSeqiNP_999211.1. NM_214046.1.
UniGeneiSsc.158.

Genome annotation databases

GeneIDi397112.
KEGGissc:397112.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13128 mRNA. Translation: AAA31127.1.
RefSeqiNP_999211.1. NM_214046.1.
UniGeneiSsc.158.

3D structure databases

ProteinModelPortaliP47787.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1149247. 1 interactor.
STRINGi9823.ENSSSCP00000017486.

Proteomic databases

PaxDbiP47787.
PeptideAtlasiP47787.
PRIDEiP47787.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397112.
KEGGissc:397112.

Organism-specific databases

CTDi6916.

Phylogenomic databases

eggNOGiKOG0158. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000039127.
HOVERGENiHBG108567.
InParanoidiP47787.
KOiK01832.

Family and domain databases

Gene3Di1.10.630.10. 2 hits.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 2 hits.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 2 hits.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHAS_PIG
AccessioniPrimary (citable) accession number: P47787
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 5, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.