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Protein

Thromboxane-A synthase

Gene

TBXAS1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9-alpha,11-alpha-epoxy-15-hydroxythromboxa-5,13-dienoate.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi480Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Monooxygenase, Oxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-SSC-211979 Eicosanoids
R-SSC-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

Names & Taxonomyi

Protein namesi
Recommended name:
Thromboxane-A synthase (EC:5.3.99.5)
Short name:
TXA synthase
Short name:
TXS
Alternative name(s):
Cytochrome P450 5A1
Gene namesi
Name:TBXAS1
Synonyms:CYP5, CYP5A1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 75LumenalSequence analysisAdd BLAST44
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Topological domaini97 – 223CytoplasmicSequence analysisAdd BLAST127
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Topological domaini245 – 336LumenalSequence analysisAdd BLAST92
Transmembranei337 – 357HelicalSequence analysisAdd BLAST21
Topological domaini358 – 534CytoplasmicSequence analysisAdd BLAST177

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000522581 – 534Thromboxane-A synthaseAdd BLAST534

Proteomic databases

PaxDbiP47787
PeptideAtlasiP47787
PRIDEiP47787

Expressioni

Gene expression databases

ExpressionAtlasiP47787 baseline and differential

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi1149247, 1 interactor
STRINGi9823.ENSSSCP00000017486

Structurei

3D structure databases

ProteinModelPortaliP47787
SMRiP47787
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0158 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140779
HOGENOMiHOG000039127
HOVERGENiHBG108567
InParanoidiP47787
KOiK01832

Family and domain databases

InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 2 hits
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 2 hits
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

P47787-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVLGFLSPE LNGPMVTMAL AVVLLALLKW YSTSAFSRLE KLGIRHPKPS
60 70 80 90 100
PFIGNLTFFR QGFWESHMEL RKQYGPLSGY YLGRRMIVVI SDPDMIKQVL
110 120 130 140 150
AEKFSNFTNR MATGLESKPV ADSILFLRDK RWEEVRSVLT SAFSPKKLNK
160 170 180 190 200
LTPLISQACD LLLAHLERYA ESGDAFDIQR CYCCYTTDVV ASVAFGTQVN
210 220 230 240 250
SSEEPEHPFV KHCRRFFAFS VPRLILVLIL SFPSIMVPLA RILPNKKRDE
260 270 280 290 300
VNGFFNKLIR NVIALRDQQA AEERRQDFLQ MVLDLRHSAP SVGVENFDIV
310 320 330 340 350
RQAFSSAKGC PADPSQPHLP RPLSKPLTVD EVVGQAFLFL IAGYEIITNT
360 370 380 390 400
LSFVTYLLAT NPDCQEKLLR EVDDFSKKHP SPEHCSLQQG LPYLDMVLSE
410 420 430 440 450
TLRMYPPAFR FTREAARDCE VLGQRIPAGT VLEVAVGALH HDPKHWPHPE
460 470 480 490 500
TFDPERFTAE AQRLQQPFTY LPFGAGPRSC LGVQLGLLEI KLTLLHILRK
510 520 530
FRFEACPETQ VPLQLESKSA LSPKNGVYIR IVPR
Length:534
Mass (Da):60,485
Last modified:February 1, 1996 - v1
Checksum:i635347A1B3508715
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13128 mRNA Translation: AAA31127.1
RefSeqiNP_999211.1, NM_214046.1
UniGeneiSsc.158

Genome annotation databases

EnsembliENSSSCT00000017968; ENSSSCP00000017486; ENSSSCG00000016504
GeneIDi397112
KEGGissc:397112

Entry informationi

Entry nameiTHAS_PIG
AccessioniPrimary (citable) accession number: P47787
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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