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Protein

G-protein coupled receptor 12

Gene

GPR12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production.By similarity

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • phosphatidylcholine binding Source: Ensembl

GO - Biological processi

  • cellular calcium ion homeostasis Source: Ensembl
  • G-protein coupled receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000132975-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 12
Gene namesi
Name:GPR12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:4466. GPR12.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 48ExtracellularSequence analysisAdd BLAST48
Transmembranei49 – 69Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini70 – 77CytoplasmicSequence analysis8
Transmembranei78 – 98Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini99 – 113ExtracellularSequence analysisAdd BLAST15
Transmembranei114 – 134Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini135 – 158CytoplasmicSequence analysisAdd BLAST24
Transmembranei159 – 179Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini180 – 199ExtracellularSequence analysisAdd BLAST20
Transmembranei200 – 220Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini221 – 252CytoplasmicSequence analysisAdd BLAST32
Transmembranei253 – 273Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini274 – 282ExtracellularSequence analysis9
Transmembranei283 – 303Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini304 – 334CytoplasmicSequence analysisAdd BLAST31

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2835.
OpenTargetsiENSG00000132975.
PharmGKBiPA28856.

Chemistry databases

ChEMBLiCHEMBL5006.
GuidetoPHARMACOLOGYi86.

Polymorphism and mutation databases

BioMutaiGPR12.
DMDMi1346168.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695271 – 334G-protein coupled receptor 12Add BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...)Sequence analysis1
Glycosylationi24N-linked (GlcNAc...)Sequence analysis1
Lipidationi317S-palmitoyl cysteineBy similarity1
Modified residuei330PhosphoserineSequence analysis1
Modified residuei332PhosphoserineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP47775.
PRIDEiP47775.

PTM databases

iPTMnetiP47775.
PhosphoSitePlusiP47775.

Expressioni

Gene expression databases

BgeeiENSG00000132975.
CleanExiHS_GPR12.
ExpressionAtlasiP47775. baseline and differential.
GenevisibleiP47775. HS.

Organism-specific databases

HPAiHPA050972.

Interactioni

Protein-protein interaction databases

BioGridi109096. 2 interactors.
IntActiP47775. 1 interactor.
STRINGi9606.ENSP00000370844.

Structurei

3D structure databases

ProteinModelPortaliP47775.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000294075.
HOVERGENiHBG079561.
InParanoidiP47775.
KOiK04315.
OMAiCTSGTLM.
OrthoDBiEOG091G0CNB.
PhylomeDBiP47775.
TreeFamiTF330052.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000599. GPR12.
IPR000723. GPR_3/6/12_orphan.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00650. GPR12ORPHANR.
PR00644. GPRORPHANR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47775-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEDLKVNLS GLPRDYLDAA AAENISAAVS SRVPAVEPEP ELVVNPWDIV
60 70 80 90 100
LCTSGTLISC ENAIVVLIIF HNPSLRAPMF LLIGSLALAD LLAGIGLITN
110 120 130 140 150
FVFAYLLQSE ATKLVTIGLI VASFSASVCS LLAITVDRYL SLYYALTYHS
160 170 180 190 200
ERTVTFTYVM LVMLWGTSIC LGLLPVMGWN CLRDESTCSV VRPLTKNNAA
210 220 230 240 250
ILSVSFLFMF ALMLQLYIQI CKIVMRHAHQ IALQHHFLAT SHYVTTRKGV
260 270 280 290 300
STLAIILGTF AACWMPFTLY SLIADYTYPS IYTYATLLPA TYNSIINPVI
310 320 330
YAFRNQEIQK ALCLICCGCI PSSLAQRARS PSDV
Length:334
Mass (Da):36,730
Last modified:February 1, 1996 - v1
Checksum:i618334A6582D744B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18548 Genomic DNA. Translation: AAA91630.1.
AL159978 Genomic DNA. Translation: CAI14692.1.
BC067448 mRNA. Translation: AAH67448.1.
BC067452 mRNA. Translation: AAH67452.1.
BC112144 mRNA. Translation: AAI12145.1.
BC112146 mRNA. Translation: AAI12147.1.
CCDSiCCDS9319.1.
RefSeqiNP_005279.1. NM_005288.3.
UniGeneiHs.123034.

Genome annotation databases

EnsembliENST00000381436; ENSP00000370844; ENSG00000132975.
ENST00000405846; ENSP00000384932; ENSG00000132975.
GeneIDi2835.
KEGGihsa:2835.
UCSCiuc010aal.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18548 Genomic DNA. Translation: AAA91630.1.
AL159978 Genomic DNA. Translation: CAI14692.1.
BC067448 mRNA. Translation: AAH67448.1.
BC067452 mRNA. Translation: AAH67452.1.
BC112144 mRNA. Translation: AAI12145.1.
BC112146 mRNA. Translation: AAI12147.1.
CCDSiCCDS9319.1.
RefSeqiNP_005279.1. NM_005288.3.
UniGeneiHs.123034.

3D structure databases

ProteinModelPortaliP47775.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109096. 2 interactors.
IntActiP47775. 1 interactor.
STRINGi9606.ENSP00000370844.

Chemistry databases

ChEMBLiCHEMBL5006.
GuidetoPHARMACOLOGYi86.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP47775.
PhosphoSitePlusiP47775.

Polymorphism and mutation databases

BioMutaiGPR12.
DMDMi1346168.

Proteomic databases

PaxDbiP47775.
PRIDEiP47775.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381436; ENSP00000370844; ENSG00000132975.
ENST00000405846; ENSP00000384932; ENSG00000132975.
GeneIDi2835.
KEGGihsa:2835.
UCSCiuc010aal.5. human.

Organism-specific databases

CTDi2835.
DisGeNETi2835.
GeneCardsiGPR12.
HGNCiHGNC:4466. GPR12.
HPAiHPA050972.
MIMi600752. gene.
neXtProtiNX_P47775.
OpenTargetsiENSG00000132975.
PharmGKBiPA28856.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000294075.
HOVERGENiHBG079561.
InParanoidiP47775.
KOiK04315.
OMAiCTSGTLM.
OrthoDBiEOG091G0CNB.
PhylomeDBiP47775.
TreeFamiTF330052.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000132975-MONOMER.

Miscellaneous databases

GeneWikiiGPR12.
GenomeRNAii2835.
PROiP47775.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132975.
CleanExiHS_GPR12.
ExpressionAtlasiP47775. baseline and differential.
GenevisibleiP47775. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000599. GPR12.
IPR000723. GPR_3/6/12_orphan.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00650. GPR12ORPHANR.
PR00644. GPRORPHANR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR12_HUMAN
AccessioniPrimary (citable) accession number: P47775
Secondary accession number(s): Q5T8P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally (PubMed:12220620) thought to be a receptor for sphingosine 1-phosphate. It has been demonstrated that it is not the case in human (PubMed:19286662).2 Publications

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.