Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P47775

- GPR12_HUMAN

UniProt

P47775 - GPR12_HUMAN

Protein

G-protein coupled receptor 12

Gene

GPR12

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Promotes neurite outgrowth and blocks myelin inhibition in neurons By similarity. Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: ProtInc
    2. phosphatidylcholine binding Source: Ensembl

    GO - Biological processi

    1. cellular calcium ion homeostasis Source: Ensembl
    2. G-protein coupled receptor signaling pathway Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G-protein coupled receptor 12
    Gene namesi
    Name:GPR12
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:4466. GPR12.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28856.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 334334G-protein coupled receptor 12PRO_0000069527Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
    Lipidationi317 – 3171S-palmitoyl cysteineBy similarity
    Modified residuei330 – 3301PhosphoserineSequence Analysis
    Modified residuei332 – 3321PhosphoserineSequence Analysis

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    PaxDbiP47775.
    PRIDEiP47775.

    Expressioni

    Gene expression databases

    ArrayExpressiP47775.
    BgeeiP47775.
    CleanExiHS_GPR12.
    GenevestigatoriP47775.

    Organism-specific databases

    HPAiHPA050972.

    Interactioni

    Protein-protein interaction databases

    BioGridi109096. 2 interactions.
    IntActiP47775. 1 interaction.
    STRINGi9606.ENSP00000370844.

    Structurei

    3D structure databases

    ProteinModelPortaliP47775.
    SMRiP47775. Positions 46-314.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4848ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini70 – 778CytoplasmicSequence Analysis
    Topological domaini99 – 11315ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini135 – 15824CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini180 – 19920ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini221 – 25232CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini274 – 2829ExtracellularSequence Analysis
    Topological domaini304 – 33431CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei49 – 6921Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei78 – 9821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei114 – 13421Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei200 – 22021Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei253 – 27321Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei283 – 30321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG309471.
    HOGENOMiHOG000294075.
    HOVERGENiHBG079561.
    InParanoidiP47775.
    KOiK04315.
    OMAiLTYNSER.
    OrthoDBiEOG7966H0.
    PhylomeDBiP47775.
    TreeFamiTF330052.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000599. GPR12.
    IPR000723. GPR_3/6/12_orphan.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00650. GPR12ORPHANR.
    PR00644. GPRORPHANR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47775-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNEDLKVNLS GLPRDYLDAA AAENISAAVS SRVPAVEPEP ELVVNPWDIV    50
    LCTSGTLISC ENAIVVLIIF HNPSLRAPMF LLIGSLALAD LLAGIGLITN 100
    FVFAYLLQSE ATKLVTIGLI VASFSASVCS LLAITVDRYL SLYYALTYHS 150
    ERTVTFTYVM LVMLWGTSIC LGLLPVMGWN CLRDESTCSV VRPLTKNNAA 200
    ILSVSFLFMF ALMLQLYIQI CKIVMRHAHQ IALQHHFLAT SHYVTTRKGV 250
    STLAIILGTF AACWMPFTLY SLIADYTYPS IYTYATLLPA TYNSIINPVI 300
    YAFRNQEIQK ALCLICCGCI PSSLAQRARS PSDV 334
    Length:334
    Mass (Da):36,730
    Last modified:February 1, 1996 - v1
    Checksum:i618334A6582D744B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18548 Genomic DNA. Translation: AAA91630.1.
    AL159978 Genomic DNA. Translation: CAI14692.1.
    BC067448 mRNA. Translation: AAH67448.1.
    BC067452 mRNA. Translation: AAH67452.1.
    BC112144 mRNA. Translation: AAI12145.1.
    BC112146 mRNA. Translation: AAI12147.1.
    CCDSiCCDS9319.1.
    RefSeqiNP_005279.1. NM_005288.3.
    UniGeneiHs.123034.

    Genome annotation databases

    EnsembliENST00000381436; ENSP00000370844; ENSG00000132975.
    ENST00000405846; ENSP00000384932; ENSG00000132975.
    GeneIDi2835.
    KEGGihsa:2835.
    UCSCiuc010aal.3. human.

    Polymorphism databases

    DMDMi1346168.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18548 Genomic DNA. Translation: AAA91630.1 .
    AL159978 Genomic DNA. Translation: CAI14692.1 .
    BC067448 mRNA. Translation: AAH67448.1 .
    BC067452 mRNA. Translation: AAH67452.1 .
    BC112144 mRNA. Translation: AAI12145.1 .
    BC112146 mRNA. Translation: AAI12147.1 .
    CCDSi CCDS9319.1.
    RefSeqi NP_005279.1. NM_005288.3.
    UniGenei Hs.123034.

    3D structure databases

    ProteinModelPortali P47775.
    SMRi P47775. Positions 46-314.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109096. 2 interactions.
    IntActi P47775. 1 interaction.
    STRINGi 9606.ENSP00000370844.

    Chemistry

    ChEMBLi CHEMBL5006.
    GuidetoPHARMACOLOGYi 86.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 1346168.

    Proteomic databases

    PaxDbi P47775.
    PRIDEi P47775.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000381436 ; ENSP00000370844 ; ENSG00000132975 .
    ENST00000405846 ; ENSP00000384932 ; ENSG00000132975 .
    GeneIDi 2835.
    KEGGi hsa:2835.
    UCSCi uc010aal.3. human.

    Organism-specific databases

    CTDi 2835.
    GeneCardsi GC13M027331.
    HGNCi HGNC:4466. GPR12.
    HPAi HPA050972.
    MIMi 600752. gene.
    neXtProti NX_P47775.
    PharmGKBi PA28856.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG309471.
    HOGENOMi HOG000294075.
    HOVERGENi HBG079561.
    InParanoidi P47775.
    KOi K04315.
    OMAi LTYNSER.
    OrthoDBi EOG7966H0.
    PhylomeDBi P47775.
    TreeFami TF330052.

    Miscellaneous databases

    GeneWikii GPR12.
    GenomeRNAii 2835.
    NextBioi 11189.
    PROi P47775.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P47775.
    Bgeei P47775.
    CleanExi HS_GPR12.
    Genevestigatori P47775.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000599. GPR12.
    IPR000723. GPR_3/6/12_orphan.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00650. GPR12ORPHANR.
    PR00644. GPRORPHANR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors."
      Song Z.-H., Modi W., Bonner T.I.
      Genomics 28:347-349(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain cortex.
    4. "Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors."
      Uhlenbrock K., Gassenhuber J., Kostenis E.
      Cell. Signal. 14:941-953(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: PRELIMINARY FUNCTION.
    5. "Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay."
      Yin H., Chu A., Li W., Wang B., Shelton F., Otero F., Nguyen D.G., Caldwell J.S., Chen Y.A.
      J. Biol. Chem. 284:12328-12338(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: LACK OF FUNCTION AS A SPHINGOSINE 1-PHOSPHATE RECEPTOR.

    Entry informationi

    Entry nameiGPR12_HUMAN
    AccessioniPrimary (citable) accession number: P47775
    Secondary accession number(s): Q5T8P3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Was originally (PubMed:12220620) thought to be a receptor for sphingosine 1-phosphate. It has been demonstrated that it is not the case in human (PubMed:19286662).2 Publications

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3