C-C chemokine receptor type 7 precursor

Preferred order of sections

Names and origin

Protein names

Recommended name:
C-C chemokine receptor type 7
Short name=C-C CKR-7
Short name=CC-CKR-7
Short name=CCR-7

Alternative name(s):
Epstein-Barr virus-induced G-protein coupled receptor 1
Short name=EBI1
Short name=EBV-induced G-protein coupled receptor 1
MIP-3 beta receptor
CD_antigen=CD197

Gene names

Name:	Ccr7
Synonyms:	Cmkbr7, Ebi1, Ebi1h

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	378 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for the MIP-3-beta chemokine By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Signal Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	actin cytoskeleton organization Traceable author statement PubMed 16621978. Source: BHF-UCL activation of JUN kinase activity Inferred by curator PubMed 16027136. Source: BHF-UCL elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: InterPro establishment of T cell polarity Traceable author statement PubMed 16621978. Source: BHF-UCL immune response Inferred from mutant phenotype PubMed 10520991. Source: MGI inflammatory response Non-traceable author statement PubMed 20638137. Source: BHF-UCL interleukin-12 secretion Inferred from mutant phenotype PubMed 20176793. Source: BHF-UCL lymph node development Traceable author statement PubMed 12732660. Source: BHF-UCL lymphocyte chemotaxis across high endothelial venule Traceable author statement PubMed 21051556. Source: BHF-UCL lymphocyte migration into lymph node Traceable author statement PubMed 18379575. Source: BHF-UCL mature dendritic cell differentiation Inferred from mutant phenotype PubMed 15845453. Source: BHF-UCL negative regulation of leukocyte apoptotic process Traceable author statement PubMed 16621978. Source: BHF-UCL negative thymic T cell selection Inferred from mutant phenotype PubMed 17785582. Source: BHF-UCL positive regulation of Cdc42 GTPase activity Inferred by curator PubMed 12609829. Source: BHF-UCL positive regulation of T cell chemotaxis Traceable author statement PubMed 21051556. Source: BHF-UCL positive regulation of T cell costimulation Inferred from mutant phenotype PubMed 15845453. Source: BHF-UCL positive regulation of T cell proliferation Inferred by curator PubMed 15845453. Source: BHF-UCL positive regulation of T cell receptor signaling pathway Inferred from mutant phenotype PubMed 17785582. Source: BHF-UCL positive regulation of T-helper 1 cell differentiation Inferred by curator PubMed 15845453. Source: BHF-UCL positive regulation of dendritic cell antigen processing and presentation Inferred from direct assay PubMed 15845453. Source: BHF-UCL positive regulation of dendritic cell chemotaxis Inferred from mutant phenotype PubMed 10520991. Source: BHF-UCL positive regulation of filopodium assembly Traceable author statement PubMed 16621978. Source: BHF-UCL positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation Inferred from mutant phenotype PubMed 15845453. Source: BHF-UCL positive regulation of humoral immune response Inferred from mutant phenotype PubMed 10520991. Source: BHF-UCL positive regulation of hypersensitivity Inferred from mutant phenotype PubMed 10520991. Source: BHF-UCL positive regulation of immunological synapse formation Inferred from mutant phenotype PubMed 15845453. Source: BHF-UCL positive regulation of interleukin-1 beta secretion Inferred by curator PubMed 15845453. Source: BHF-UCL positive regulation of interleukin-12 production Inferred from mutant phenotype PubMed 15845453. Source: BHF-UCL positive regulation of macrophage chemotaxis Non-traceable author statement PubMed 20605225. Source: BHF-UCL positive regulation of neutrophil chemotaxis Inferred from mutant phenotype PubMed 21051556. Source: BHF-UCL positive regulation of phagocytosis Non-traceable author statement PubMed 15965301. Source: BHF-UCL positive regulation of receptor-mediated endocytosis Inferred by curator PubMed 12609829. Source: BHF-UCL positive regulation of thymocyte migration Traceable author statement PubMed 11700037. Source: BHF-UCL positive regulation of tumor necrosis factor production Inferred by curator PubMed 15845453. Source: BHF-UCL regulation of dendritic cell dendrite assembly Inferred by curator PubMed 12200351. Source: BHF-UCL regulation of interferon-gamma production Inferred from mutant phenotype PubMed 20176793. Source: BHF-UCL regulation of tolerance induction to self antigen Traceable author statement PubMed 17785582. Source: BHF-UCL response to lipopolysaccharide Inferred from direct assay PubMed 20638137. Source: BHF-UCL response to nitric oxide Traceable author statement PubMed 16621978. Source: BHF-UCL response to prostaglandin E stimulus Traceable author statement PubMed 16621978. Source: BHF-UCL
Cellular_component	external side of plasma membrane Inferred from direct assay PubMed 19008373. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW intracellular Inferred from direct assay PubMed 21051556. Source: BHF-UCL
Molecular_function	C-C chemokine receptor activity Inferred from mutant phenotype PubMed 10520991. Source: BHF-UCL C-C motif chemokine 19 receptor activity Inferred from electronic annotation. Source: Compara C-C motif chemokine 21 receptor activity Inferred from electronic annotation. Source: Compara chemokine (C-C motif) ligand 19 binding Inferred from sequence or structural similarity. Source: BHF-UCL chemokine (C-C motif) ligand 21 binding Inferred from sequence or structural similarity. Source: BHF-UCL
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 24

24

Potential

Chain

25 – 378

354

C-C chemokine receptor type 7

PRO_0000012736

Regions

Topological domain

25 – 59

35

Extracellular Potential

Transmembrane

60 – 86

27

Helical; Name=1; Potential

Topological domain

87 – 95

9

Cytoplasmic Potential

Transmembrane

96 – 116

21

Helical; Name=2; Potential

Topological domain

117 – 130

14

Extracellular Potential

Transmembrane

131 – 152

22

Helical; Name=3; Potential

Topological domain

153 – 170

18

Cytoplasmic Potential

Transmembrane

171 – 191

21

Helical; Name=4; Potential

Topological domain

192 – 219

28

Extracellular Potential

Transmembrane

220 – 247

28

Helical; Name=5; Potential

Topological domain

248 – 263

16

Cytoplasmic Potential

Transmembrane

264 – 289

26

Helical; Name=6; Potential

Topological domain

290 – 313

24

Extracellular Potential

Transmembrane

314 – 331

18

Helical; Name=7; Potential

Topological domain

332 – 378

47

Cytoplasmic Potential

Amino acid modifications

Glycosylation

36

1

N-linked (GlcNAc...) Potential

Disulfide bond

129 ↔ 210

By similarity

Experimental info

Sequence conflict

164

1

A → R in AAA74232. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

P47774 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: F027451989B59683
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FASTA

378

42,856

        10         20         30         40         50         60 
MDPGKPRKNV LVVALLVIFQ VCFCQDEVTD DYIGENTTVD YTLYESVCFK KDVRNFKAWF 

        70         80         90        100        110        120 
LPLMYSVICF VGLLGNGLVI LTYIYFKRLK TMTDTYLLNL AVADILFLLI LPFWAYSEAK 

       130        140        150        160        170        180 
SWIFGVYLCK GIFGIYKLSF FSGMLLLLCI SIDRYVAIVQ AVSAHRHRAR VLLISKLSCV 

       190        200        210        220        230        240 
GIWMLALFLS IPELLYSGLQ KNSGEDTLRC SLVSAQVEAL ITIQVAQMVF GFLVPMLAMS 

       250        260        270        280        290        300 
FCYLIIIRTL LQARNFERNK AIKVIIAVVV VFIVFQLPYN GVVLAQTVAN FNITNSSCET 

       310        320        330        340        350        360 
SKQLNIAYDV TYSLASVRCC VNPFLYAFIG VKFRSDLFKL FKDLGCLSQE RLRHWSSCRH 

       370 
VRNASVSMEA ETTTTFSP

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2." Schweickart V.L., Raport C.J., Godiska R., Byers M.G., Eddy R.L. Jr., Shows T.B., Gray P.W. Genomics 23:643-650(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6 X CBA. Tissue: Thymus.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J and NOD. Tissue: Thymus.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[4]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L31580 mRNA. Translation: AAA74232.1. AK037965 mRNA. Translation: BAC29909.1. AK154349 mRNA. Translation: BAE32532.1. AK154849 mRNA. Translation: BAE32875.1. AL591366 Genomic DNA. Translation: CAM26977.1. CH466556 Genomic DNA. Translation: EDL16180.1.
IPI	IPI00308428.
PIR	A55735.
RefSeq	NP_031745.2. NM_007719.2.
UniGene	Mm.2932.
3D structure databases
ProteinModelPortal	P47774.
SMR	P47774. Positions 52-341.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P47774.
Proteomic databases
PRIDE	P47774.
Protocols and materials databases
DNASU	12775.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000103134; ENSMUSP00000099423; ENSMUSG00000037944.
GeneID	12775.
KEGG	mmu:12775.
Organism-specific databases
CTD	1236.
MGI	MGI:103011. Ccr7.
Phylogenomic databases
eggNOG	NOG149643.
GeneTree	ENSGT00690000101668.
HOGENOM	HOG000234122.
HOVERGEN	HBG106917.
InParanoid	Q8CAS2.
KO	K04182.
OMA	CFKKDVR.
OrthoDB	EOG43TZW4.
Gene expression databases
Bgee	P47774.
CleanEx	MM_CCR7.
Genevestigator	P47774.
GermOnline	ENSMUSG00000037944. Mus musculus.
Family and domain databases
InterPro	IPR001718. Chemokine_CCR7. IPR000355. Chemokine_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00657. CCCHEMOKINER. PR00641. CHEMOKINER7. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	282162.
SOURCE	Search...

Entry information

Entry name

CCR7_MOUSE

Accession

Primary (citable) accession number: P47774
Secondary accession number(s): Q8CAS2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 103 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents