Reviewed, UniProtKB/Swiss-Prot P47774 (CCR7_MOUSE)

Names and origin

Protein names

Recommended name:
    C-C chemokine receptor type 7
      Short name=C-C CKR-7
      Short name=CC-CKR-7
      Short name=CCR-7
Alternative name(s):
    MIP-3 beta receptor
    EBV-induced G-protein coupled receptor 1
      Short name=EBI1
    CD_antigen=CD197

Gene names

Name:	Ccr7
Synonyms:	Cmkbr7, Ebi1, Ebi1h

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	378 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Receptor for the MIP-3-beta chemokine By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Signal Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW chemotaxis Inferred from mutant phenotype. Source: MGI immune response Inferred from mutant phenotype. Source: MGI
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	C-C chemokine receptor activity Inferred from mutant phenotype. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 378	354	C-C chemokine receptor type 7		PRO_0000012736
Regions
	Topological domain	25 – 59	35	Extracellular Potential
	Transmembrane	60 – 86	27	1 Potential
	Topological domain	87 – 95	9	Cytoplasmic Potential
	Transmembrane	96 – 116	21	2 Potential
	Topological domain	117 – 130	14	Extracellular Potential
	Transmembrane	131 – 152	22	3 Potential
	Topological domain	153 – 170	18	Cytoplasmic Potential
	Transmembrane	171 – 191	21	4 Potential
	Topological domain	192 – 219	28	Extracellular Potential
	Transmembrane	220 – 247	28	5 Potential
	Topological domain	248 – 263	16	Cytoplasmic Potential
	Transmembrane	264 – 289	26	6 Potential
	Topological domain	290 – 313	24	Extracellular Potential
	Transmembrane	314 – 331	18	7 Potential
	Topological domain	332 – 378	47	Cytoplasmic Potential
Amino acid modifications
	Modified residue	151	1	Phosphoserine By similarity
	Glycosylation	36	1	N-linked (GlcNAc...) Potential
	Disulfide bond	129 ↔ 210		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P47774-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: ACB1A422CF54AA54	FASTA	378	42,941
	10 20 30 40 50 60 MDPGKPRKNV LVVALLVIFQ VCFCQDEVTD DYIGENTTVD YTLYESVCFK KDVRNFKAWF 70 80 90 100 110 120 LPLMYSVICF VGLLGNGLVI LTYIYFKRLK TMTDTYLLNL AVADILFLLI LPFWAYSEAK 130 140 150 160 170 180 SWIFGVYLCK GIFGIYKLSF FSGMLLLLCI SIDRYVAIVQ AVSRHRHRAR VLLISKLSCV 190 200 210 220 230 240 GIWMLALFLS IPELLYSGLQ KNSGEDTLRC SLVSAQVEAL ITIQVAQMVF GFLVPMLAMS 250 260 270 280 290 300 FCYLIIIRTL LQARNFERNK AIKVIIAVVV VFIVFQLPYN GVVLAQTVAN FNITNSSCET 310 320 330 340 350 360 SKQLNIAYDV TYSLASVRCC VNPFLYAFIG VKFRSDLFKL FKDLGCLSQE RLRHWSSCRH 370 VRNASVSMEA ETTTTFSP

References

[1]	"Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2." Schweickart V.L., Raport C.J., Godiska R., Byers M.G., Eddy R.L. Jr., Shows T.B., Gray P.W. Genomics 23:643-650(1994) [PubMed: 7851893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6 X CBA. Tissue: Thymus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L31580 mRNA. Translation: AAA74232.1.
IPI	IPI00308428.
PIR	A55735.
UniGene	Mm.2932
3D structure databases
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P47774.
Genome annotation databases
Ensembl	ENSMUSG00000037944. Mus musculus. [Contig view]
Organism-specific databases
MGI	MGI:103011. Ccr7.
Phylogenomic databases
HOGENOM	P47774.
HOVERGEN	P47774.
Gene expression databases
ArrayExpress	P47774.
Bgee	P47774.
CleanEx	MM_CCR7.
GermOnline	ENSMUSG00000037944. Mus musculus.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR001718. CC_7_rcpt. IPR000355. Chmkine_rcpt. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
PANTHER	PTHR19264:SF209. CC_7_rcpt. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00657. CCCHEMOKINER. PR00641. CHEMOKINER7. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

CCR7_MOUSE

Accession

Primary (citable) accession number: P47774

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	June 16, 2009
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)