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P47774

- CCR7_MOUSE

UniProt

P47774 - CCR7_MOUSE

Protein

C-C chemokine receptor type 7

Gene

Ccr7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Receptor for the MIP-3-beta chemokine.By similarity

    GO - Molecular functioni

    1. C-C chemokine receptor activity Source: BHF-UCL
    2. C-C motif chemokine 19 receptor activity Source: Ensembl
    3. C-C motif chemokine 21 receptor activity Source: Ensembl
    4. chemokine (C-C motif) ligand 19 binding Source: BHF-UCL
    5. chemokine (C-C motif) ligand 21 binding Source: BHF-UCL
    6. G-protein coupled receptor activity Source: BHF-UCL
    7. protein binding Source: IntAct

    GO - Biological processi

    1. actin cytoskeleton organization Source: BHF-UCL
    2. activation of JUN kinase activity Source: BHF-UCL
    3. chemotaxis Source: MGI
    4. establishment of T cell polarity Source: BHF-UCL
    5. immune response Source: MGI
    6. inflammatory response Source: BHF-UCL
    7. interleukin-12 secretion Source: BHF-UCL
    8. lymph node development Source: BHF-UCL
    9. lymphocyte chemotaxis across high endothelial venule Source: BHF-UCL
    10. lymphocyte migration into lymph node Source: BHF-UCL
    11. mature dendritic cell differentiation Source: BHF-UCL
    12. negative regulation of leukocyte apoptotic process Source: BHF-UCL
    13. negative thymic T cell selection Source: BHF-UCL
    14. positive regulation of Cdc42 GTPase activity Source: BHF-UCL
    15. positive regulation of cell motility Source: BHF-UCL
    16. positive regulation of dendritic cell antigen processing and presentation Source: BHF-UCL
    17. positive regulation of dendritic cell chemotaxis Source: BHF-UCL
    18. positive regulation of filopodium assembly Source: BHF-UCL
    19. positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation Source: BHF-UCL
    20. positive regulation of humoral immune response Source: BHF-UCL
    21. positive regulation of hypersensitivity Source: BHF-UCL
    22. positive regulation of immunological synapse formation Source: BHF-UCL
    23. positive regulation of interleukin-12 production Source: BHF-UCL
    24. positive regulation of interleukin-1 beta secretion Source: BHF-UCL
    25. positive regulation of macrophage chemotaxis Source: BHF-UCL
    26. positive regulation of neutrophil chemotaxis Source: BHF-UCL
    27. positive regulation of phagocytosis Source: BHF-UCL
    28. positive regulation of Ras GTPase activity Source: BHF-UCL
    29. positive regulation of receptor-mediated endocytosis Source: BHF-UCL
    30. positive regulation of T cell chemotaxis Source: BHF-UCL
    31. positive regulation of T cell costimulation Source: BHF-UCL
    32. positive regulation of T cell proliferation Source: BHF-UCL
    33. positive regulation of T cell receptor signaling pathway Source: BHF-UCL
    34. positive regulation of T-helper 1 cell differentiation Source: BHF-UCL
    35. positive regulation of thymocyte migration Source: BHF-UCL
    36. positive regulation of tumor necrosis factor production Source: BHF-UCL
    37. regulation of dendritic cell dendrite assembly Source: BHF-UCL
    38. regulation of interferon-gamma production Source: BHF-UCL
    39. regulation of interleukin-1 beta secretion Source: BHF-UCL
    40. regulation of tolerance induction to self antigen Source: BHF-UCL
    41. response to lipopolysaccharide Source: BHF-UCL
    42. response to nitric oxide Source: BHF-UCL
    43. response to prostaglandin E Source: BHF-UCL

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C chemokine receptor type 7
    Short name:
    C-C CKR-7
    Short name:
    CC-CKR-7
    Short name:
    CCR-7
    Alternative name(s):
    Epstein-Barr virus-induced G-protein coupled receptor 1
    Short name:
    EBI1
    Short name:
    EBV-induced G-protein coupled receptor 1
    MIP-3 beta receptor
    CD_antigen: CD197
    Gene namesi
    Name:Ccr7
    Synonyms:Cmkbr7, Ebi1, Ebi1h
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:103011. Ccr7.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: MGI
    2. external side of plasma membrane Source: MGI
    3. integral component of membrane Source: UniProtKB-KW
    4. intracellular Source: BHF-UCL
    5. plasma membrane Source: BHF-UCL

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 378354C-C chemokine receptor type 7PRO_0000012736Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi129 ↔ 210PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP47774.

    PTM databases

    PhosphoSiteiP47774.

    Expressioni

    Gene expression databases

    BgeeiP47774.
    CleanExiMM_CCR7.
    GenevestigatoriP47774.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CD247P209632EBI-8038963,EBI-1165705From a different organism.

    Protein-protein interaction databases

    IntActiP47774. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP47774.
    SMRiP47774. Positions 52-341.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 5935ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini87 – 959CytoplasmicSequence Analysis
    Topological domaini117 – 13014ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini153 – 17018CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini192 – 21928ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini248 – 26316CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini290 – 31324ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini332 – 37847CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei60 – 8627Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei96 – 11621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei131 – 15222Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei171 – 19121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei220 – 24728Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei264 – 28926Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei314 – 33118Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG149643.
    GeneTreeiENSGT00730000110640.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiQ8CAS2.
    KOiK04182.
    OMAiCFKKDVR.
    OrthoDBiEOG79CXZN.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001718. Chemokine_CCR7.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF29. PTHR24227:SF29. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00657. CCCHEMOKINER.
    PR00641. CHEMOKINER7.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P47774-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPGKPRKNV LVVALLVIFQ VCFCQDEVTD DYIGENTTVD YTLYESVCFK    50
    KDVRNFKAWF LPLMYSVICF VGLLGNGLVI LTYIYFKRLK TMTDTYLLNL 100
    AVADILFLLI LPFWAYSEAK SWIFGVYLCK GIFGIYKLSF FSGMLLLLCI 150
    SIDRYVAIVQ AVSAHRHRAR VLLISKLSCV GIWMLALFLS IPELLYSGLQ 200
    KNSGEDTLRC SLVSAQVEAL ITIQVAQMVF GFLVPMLAMS FCYLIIIRTL 250
    LQARNFERNK AIKVIIAVVV VFIVFQLPYN GVVLAQTVAN FNITNSSCET 300
    SKQLNIAYDV TYSLASVRCC VNPFLYAFIG VKFRSDLFKL FKDLGCLSQE 350
    RLRHWSSCRH VRNASVSMEA ETTTTFSP 378
    Length:378
    Mass (Da):42,856
    Last modified:July 27, 2011 - v2
    Checksum:iF027451989B59683
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti164 – 1641A → R in AAA74232. (PubMed:7851893)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L31580 mRNA. Translation: AAA74232.1.
    AK037965 mRNA. Translation: BAC29909.1.
    AK154349 mRNA. Translation: BAE32532.1.
    AK154849 mRNA. Translation: BAE32875.1.
    AL591366 Genomic DNA. Translation: CAM26977.1.
    CH466556 Genomic DNA. Translation: EDL16180.1.
    CCDSiCCDS25373.1.
    PIRiA55735.
    RefSeqiNP_031745.2. NM_007719.2.
    UniGeneiMm.2932.

    Genome annotation databases

    EnsembliENSMUST00000103134; ENSMUSP00000099423; ENSMUSG00000037944.
    GeneIDi12775.
    KEGGimmu:12775.
    UCSCiuc007lih.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L31580 mRNA. Translation: AAA74232.1 .
    AK037965 mRNA. Translation: BAC29909.1 .
    AK154349 mRNA. Translation: BAE32532.1 .
    AK154849 mRNA. Translation: BAE32875.1 .
    AL591366 Genomic DNA. Translation: CAM26977.1 .
    CH466556 Genomic DNA. Translation: EDL16180.1 .
    CCDSi CCDS25373.1.
    PIRi A55735.
    RefSeqi NP_031745.2. NM_007719.2.
    UniGenei Mm.2932.

    3D structure databases

    ProteinModelPortali P47774.
    SMRi P47774. Positions 52-341.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P47774. 1 interaction.

    Chemistry

    GuidetoPHARMACOLOGYi 64.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P47774.

    Proteomic databases

    PRIDEi P47774.

    Protocols and materials databases

    DNASUi 12775.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000103134 ; ENSMUSP00000099423 ; ENSMUSG00000037944 .
    GeneIDi 12775.
    KEGGi mmu:12775.
    UCSCi uc007lih.1. mouse.

    Organism-specific databases

    CTDi 1236.
    MGIi MGI:103011. Ccr7.

    Phylogenomic databases

    eggNOGi NOG149643.
    GeneTreei ENSGT00730000110640.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi Q8CAS2.
    KOi K04182.
    OMAi CFKKDVR.
    OrthoDBi EOG79CXZN.
    TreeFami TF330966.

    Miscellaneous databases

    NextBioi 282162.
    PROi P47774.
    SOURCEi Search...

    Gene expression databases

    Bgeei P47774.
    CleanExi MM_CCR7.
    Genevestigatori P47774.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001718. Chemokine_CCR7.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF29. PTHR24227:SF29. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00657. CCCHEMOKINER.
    PR00641. CHEMOKINER7.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2."
      Schweickart V.L., Raport C.J., Godiska R., Byers M.G., Eddy R.L. Jr., Shows T.B., Gray P.W.
      Genomics 23:643-650(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6 X CBA.
      Tissue: Thymus.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Thymus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiCCR7_MOUSE
    AccessioniPrimary (citable) accession number: P47774
    Secondary accession number(s): Q8CAS2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3