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Protein

C-C chemokine receptor type 7

Gene

Ccr7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the MIP-3-beta chemokine.By similarity

GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton organization Source: BHF-UCL
  • activation of JUN kinase activity Source: BHF-UCL
  • cellular response to cytokine stimulus Source: MGI
  • chemotaxis Source: MGI
  • establishment of T cell polarity Source: BHF-UCL
  • homeostasis of number of cells Source: MGI
  • immune response Source: MGI
  • inflammatory response Source: BHF-UCL
  • interleukin-12 secretion Source: BHF-UCL
  • lymph node development Source: BHF-UCL
  • lymphocyte chemotaxis across high endothelial venule Source: BHF-UCL
  • lymphocyte migration into lymph node Source: BHF-UCL
  • mature conventional dendritic cell differentiation Source: BHF-UCL
  • myeloid dendritic cell chemotaxis Source: MGI
  • negative regulation of leukocyte apoptotic process Source: BHF-UCL
  • negative thymic T cell selection Source: BHF-UCL
  • positive regulation of cell motility Source: BHF-UCL
  • positive regulation of dendritic cell antigen processing and presentation Source: BHF-UCL
  • positive regulation of dendritic cell chemotaxis Source: BHF-UCL
  • positive regulation of filopodium assembly Source: BHF-UCL
  • positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation Source: BHF-UCL
  • positive regulation of GTPase activity Source: BHF-UCL
  • positive regulation of humoral immune response Source: BHF-UCL
  • positive regulation of hypersensitivity Source: BHF-UCL
  • positive regulation of immunological synapse formation Source: BHF-UCL
  • positive regulation of interleukin-12 production Source: BHF-UCL
  • positive regulation of interleukin-1 beta secretion Source: BHF-UCL
  • positive regulation of macrophage chemotaxis Source: BHF-UCL
  • positive regulation of neutrophil chemotaxis Source: BHF-UCL
  • positive regulation of phagocytosis Source: BHF-UCL
  • positive regulation of receptor-mediated endocytosis Source: BHF-UCL
  • positive regulation of T cell chemotaxis Source: BHF-UCL
  • positive regulation of T cell costimulation Source: BHF-UCL
  • positive regulation of T cell proliferation Source: BHF-UCL
  • positive regulation of T cell receptor signaling pathway Source: BHF-UCL
  • positive regulation of T-helper 1 cell differentiation Source: BHF-UCL
  • positive regulation of thymocyte migration Source: BHF-UCL
  • positive regulation of tumor necrosis factor production Source: BHF-UCL
  • regulation of dendritic cell dendrite assembly Source: BHF-UCL
  • regulation of interferon-gamma production Source: BHF-UCL
  • regulation of interleukin-1 beta secretion Source: BHF-UCL
  • regulation of tolerance induction to self antigen Source: BHF-UCL
  • response to lipopolysaccharide Source: BHF-UCL
  • response to nitric oxide Source: BHF-UCL
  • response to prostaglandin E Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 7
Short name:
C-C CKR-7
Short name:
CC-CKR-7
Short name:
CCR-7
Alternative name(s):
Epstein-Barr virus-induced G-protein coupled receptor 1
Short name:
EBI1
Short name:
EBV-induced G-protein coupled receptor 1
MIP-3 beta receptor
CD_antigen: CD197
Gene namesi
Name:Ccr7
Synonyms:Cmkbr7, Ebi1, Ebi1h
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:103011. Ccr7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 59ExtracellularSequence analysisAdd BLAST35
Transmembranei60 – 86Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini87 – 95CytoplasmicSequence analysis9
Transmembranei96 – 116Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini117 – 130ExtracellularSequence analysisAdd BLAST14
Transmembranei131 – 152Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini153 – 170CytoplasmicSequence analysisAdd BLAST18
Transmembranei171 – 191Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini192 – 219ExtracellularSequence analysisAdd BLAST28
Transmembranei220 – 247Helical; Name=5Sequence analysisAdd BLAST28
Topological domaini248 – 263CytoplasmicSequence analysisAdd BLAST16
Transmembranei264 – 289Helical; Name=6Sequence analysisAdd BLAST26
Topological domaini290 – 313ExtracellularSequence analysisAdd BLAST24
Transmembranei314 – 331Helical; Name=7Sequence analysisAdd BLAST18
Topological domaini332 – 378CytoplasmicSequence analysisAdd BLAST47

GO - Cellular componenti

  • cell surface Source: MGI
  • external side of plasma membrane Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: BHF-UCL
  • plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001273625 – 378C-C chemokine receptor type 7Add BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi36N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi129 ↔ 210PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP47774.
PaxDbiP47774.
PRIDEiP47774.

PTM databases

PhosphoSitePlusiP47774.

Expressioni

Gene expression databases

BgeeiENSMUSG00000037944.
CleanExiMM_CCR7.
GenevisibleiP47774. MM.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CD247P209632EBI-8038963,EBI-1165705From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

IntActiP47774. 1 interactor.
STRINGi10090.ENSMUSP00000099423.

Structurei

3D structure databases

ProteinModelPortaliP47774.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IMBE. Eukaryota.
ENOG4110ZGY. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP47774.
KOiK04182.
OMAiVMLTYIY.
OrthoDBiEOG091G0BDV.
TreeFamiTF330966.

Family and domain databases

InterProiIPR001718. Chemokine_CCR7.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR00641. CHEMOKINER7.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47774-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPGKPRKNV LVVALLVIFQ VCFCQDEVTD DYIGENTTVD YTLYESVCFK
60 70 80 90 100
KDVRNFKAWF LPLMYSVICF VGLLGNGLVI LTYIYFKRLK TMTDTYLLNL
110 120 130 140 150
AVADILFLLI LPFWAYSEAK SWIFGVYLCK GIFGIYKLSF FSGMLLLLCI
160 170 180 190 200
SIDRYVAIVQ AVSAHRHRAR VLLISKLSCV GIWMLALFLS IPELLYSGLQ
210 220 230 240 250
KNSGEDTLRC SLVSAQVEAL ITIQVAQMVF GFLVPMLAMS FCYLIIIRTL
260 270 280 290 300
LQARNFERNK AIKVIIAVVV VFIVFQLPYN GVVLAQTVAN FNITNSSCET
310 320 330 340 350
SKQLNIAYDV TYSLASVRCC VNPFLYAFIG VKFRSDLFKL FKDLGCLSQE
360 370
RLRHWSSCRH VRNASVSMEA ETTTTFSP
Length:378
Mass (Da):42,856
Last modified:July 27, 2011 - v2
Checksum:iF027451989B59683
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti164A → R in AAA74232 (PubMed:7851893).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31580 mRNA. Translation: AAA74232.1.
AK037965 mRNA. Translation: BAC29909.1.
AK154349 mRNA. Translation: BAE32532.1.
AK154849 mRNA. Translation: BAE32875.1.
AL591366 Genomic DNA. Translation: CAM26977.1.
CH466556 Genomic DNA. Translation: EDL16180.1.
CCDSiCCDS25373.1.
PIRiA55735.
RefSeqiNP_001288642.1. NM_001301713.1.
NP_031745.2. NM_007719.2.
UniGeneiMm.2932.

Genome annotation databases

EnsembliENSMUST00000103134; ENSMUSP00000099423; ENSMUSG00000037944.
GeneIDi12775.
KEGGimmu:12775.
UCSCiuc007lih.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31580 mRNA. Translation: AAA74232.1.
AK037965 mRNA. Translation: BAC29909.1.
AK154349 mRNA. Translation: BAE32532.1.
AK154849 mRNA. Translation: BAE32875.1.
AL591366 Genomic DNA. Translation: CAM26977.1.
CH466556 Genomic DNA. Translation: EDL16180.1.
CCDSiCCDS25373.1.
PIRiA55735.
RefSeqiNP_001288642.1. NM_001301713.1.
NP_031745.2. NM_007719.2.
UniGeneiMm.2932.

3D structure databases

ProteinModelPortaliP47774.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP47774. 1 interactor.
STRINGi10090.ENSMUSP00000099423.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP47774.

Proteomic databases

EPDiP47774.
PaxDbiP47774.
PRIDEiP47774.

Protocols and materials databases

DNASUi12775.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103134; ENSMUSP00000099423; ENSMUSG00000037944.
GeneIDi12775.
KEGGimmu:12775.
UCSCiuc007lih.1. mouse.

Organism-specific databases

CTDi1236.
MGIiMGI:103011. Ccr7.

Phylogenomic databases

eggNOGiENOG410IMBE. Eukaryota.
ENOG4110ZGY. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP47774.
KOiK04182.
OMAiVMLTYIY.
OrthoDBiEOG091G0BDV.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiP47774.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037944.
CleanExiMM_CCR7.
GenevisibleiP47774. MM.

Family and domain databases

InterProiIPR001718. Chemokine_CCR7.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR00641. CHEMOKINER7.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCR7_MOUSE
AccessioniPrimary (citable) accession number: P47774
Secondary accession number(s): Q8CAS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.