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Protein

C-C chemokine receptor type 7

Gene

Ccr7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the MIP-3-beta chemokine.By similarity

GO - Molecular functioni

  1. C-C chemokine receptor activity Source: BHF-UCL
  2. C-C motif chemokine 19 receptor activity Source: MGI
  3. C-C motif chemokine 21 receptor activity Source: MGI
  4. chemokine (C-C motif) ligand 19 binding Source: BHF-UCL
  5. chemokine (C-C motif) ligand 21 binding Source: BHF-UCL
  6. G-protein coupled receptor activity Source: BHF-UCL

GO - Biological processi

  1. actin cytoskeleton organization Source: BHF-UCL
  2. activation of JUN kinase activity Source: BHF-UCL
  3. cellular response to cytokine stimulus Source: MGI
  4. chemokine (C-C motif) ligand 19 signaling pathway Source: MGI
  5. chemokine (C-C motif) ligand 21 signaling pathway Source: MGI
  6. chemotaxis Source: MGI
  7. establishment of T cell polarity Source: BHF-UCL
  8. immune response Source: MGI
  9. inflammatory response Source: BHF-UCL
  10. interleukin-12 secretion Source: BHF-UCL
  11. lymph node development Source: BHF-UCL
  12. lymphocyte chemotaxis across high endothelial venule Source: BHF-UCL
  13. lymphocyte migration into lymph node Source: BHF-UCL
  14. mature conventional dendritic cell differentiation Source: BHF-UCL
  15. myeloid dendritic cell chemotaxis Source: MGI
  16. negative regulation of leukocyte apoptotic process Source: BHF-UCL
  17. negative thymic T cell selection Source: BHF-UCL
  18. positive regulation of Cdc42 GTPase activity Source: BHF-UCL
  19. positive regulation of cell motility Source: BHF-UCL
  20. positive regulation of dendritic cell antigen processing and presentation Source: BHF-UCL
  21. positive regulation of dendritic cell chemotaxis Source: BHF-UCL
  22. positive regulation of filopodium assembly Source: BHF-UCL
  23. positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation Source: BHF-UCL
  24. positive regulation of humoral immune response Source: BHF-UCL
  25. positive regulation of hypersensitivity Source: BHF-UCL
  26. positive regulation of immunological synapse formation Source: BHF-UCL
  27. positive regulation of interleukin-12 production Source: BHF-UCL
  28. positive regulation of interleukin-1 beta secretion Source: BHF-UCL
  29. positive regulation of macrophage chemotaxis Source: BHF-UCL
  30. positive regulation of neutrophil chemotaxis Source: BHF-UCL
  31. positive regulation of phagocytosis Source: BHF-UCL
  32. positive regulation of Ras GTPase activity Source: BHF-UCL
  33. positive regulation of receptor-mediated endocytosis Source: BHF-UCL
  34. positive regulation of T cell chemotaxis Source: BHF-UCL
  35. positive regulation of T cell costimulation Source: BHF-UCL
  36. positive regulation of T cell proliferation Source: BHF-UCL
  37. positive regulation of T cell receptor signaling pathway Source: BHF-UCL
  38. positive regulation of T-helper 1 cell differentiation Source: BHF-UCL
  39. positive regulation of thymocyte migration Source: BHF-UCL
  40. positive regulation of tumor necrosis factor production Source: BHF-UCL
  41. regulation of dendritic cell dendrite assembly Source: BHF-UCL
  42. regulation of interferon-gamma production Source: BHF-UCL
  43. regulation of interleukin-1 beta secretion Source: BHF-UCL
  44. regulation of tolerance induction to self antigen Source: BHF-UCL
  45. response to lipopolysaccharide Source: BHF-UCL
  46. response to nitric oxide Source: BHF-UCL
  47. response to prostaglandin E Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_288802. Chemokine receptors bind chemokines.
REACT_331048. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 7
Short name:
C-C CKR-7
Short name:
CC-CKR-7
Short name:
CCR-7
Alternative name(s):
Epstein-Barr virus-induced G-protein coupled receptor 1
Short name:
EBI1
Short name:
EBV-induced G-protein coupled receptor 1
MIP-3 beta receptor
CD_antigen: CD197
Gene namesi
Name:Ccr7
Synonyms:Cmkbr7, Ebi1, Ebi1h
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:103011. Ccr7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 5935ExtracellularSequence AnalysisAdd
BLAST
Transmembranei60 – 8627Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini87 – 959CytoplasmicSequence Analysis
Transmembranei96 – 11621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini117 – 13014ExtracellularSequence AnalysisAdd
BLAST
Transmembranei131 – 15222Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini153 – 17018CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei171 – 19121Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini192 – 21928ExtracellularSequence AnalysisAdd
BLAST
Transmembranei220 – 24728Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini248 – 26316CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei264 – 28926Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini290 – 31324ExtracellularSequence AnalysisAdd
BLAST
Transmembranei314 – 33118Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini332 – 37847CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: MGI
  2. external side of plasma membrane Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
  4. intracellular Source: BHF-UCL
  5. plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 378354C-C chemokine receptor type 7PRO_0000012736Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi129 ↔ 210PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP47774.

PTM databases

PhosphoSiteiP47774.

Expressioni

Gene expression databases

BgeeiP47774.
CleanExiMM_CCR7.
GenevestigatoriP47774.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CD247P209632EBI-8038963,EBI-1165705From a different organism.

Protein-protein interaction databases

IntActiP47774. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP47774.
SMRiP47774. Positions 52-341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG149643.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP47774.
KOiK04182.
OMAiCFKKDVR.
OrthoDBiEOG79CXZN.
TreeFamiTF330966.

Family and domain databases

InterProiIPR001718. Chemokine_CCR7.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF29. PTHR24227:SF29. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR00641. CHEMOKINER7.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47774-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPGKPRKNV LVVALLVIFQ VCFCQDEVTD DYIGENTTVD YTLYESVCFK
60 70 80 90 100
KDVRNFKAWF LPLMYSVICF VGLLGNGLVI LTYIYFKRLK TMTDTYLLNL
110 120 130 140 150
AVADILFLLI LPFWAYSEAK SWIFGVYLCK GIFGIYKLSF FSGMLLLLCI
160 170 180 190 200
SIDRYVAIVQ AVSAHRHRAR VLLISKLSCV GIWMLALFLS IPELLYSGLQ
210 220 230 240 250
KNSGEDTLRC SLVSAQVEAL ITIQVAQMVF GFLVPMLAMS FCYLIIIRTL
260 270 280 290 300
LQARNFERNK AIKVIIAVVV VFIVFQLPYN GVVLAQTVAN FNITNSSCET
310 320 330 340 350
SKQLNIAYDV TYSLASVRCC VNPFLYAFIG VKFRSDLFKL FKDLGCLSQE
360 370
RLRHWSSCRH VRNASVSMEA ETTTTFSP
Length:378
Mass (Da):42,856
Last modified:July 27, 2011 - v2
Checksum:iF027451989B59683
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti164 – 1641A → R in AAA74232 (PubMed:7851893).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31580 mRNA. Translation: AAA74232.1.
AK037965 mRNA. Translation: BAC29909.1.
AK154349 mRNA. Translation: BAE32532.1.
AK154849 mRNA. Translation: BAE32875.1.
AL591366 Genomic DNA. Translation: CAM26977.1.
CH466556 Genomic DNA. Translation: EDL16180.1.
CCDSiCCDS25373.1.
PIRiA55735.
RefSeqiNP_001288642.1. NM_001301713.1.
NP_031745.2. NM_007719.2.
UniGeneiMm.2932.

Genome annotation databases

EnsembliENSMUST00000103134; ENSMUSP00000099423; ENSMUSG00000037944.
GeneIDi12775.
KEGGimmu:12775.
UCSCiuc007lih.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31580 mRNA. Translation: AAA74232.1.
AK037965 mRNA. Translation: BAC29909.1.
AK154349 mRNA. Translation: BAE32532.1.
AK154849 mRNA. Translation: BAE32875.1.
AL591366 Genomic DNA. Translation: CAM26977.1.
CH466556 Genomic DNA. Translation: EDL16180.1.
CCDSiCCDS25373.1.
PIRiA55735.
RefSeqiNP_001288642.1. NM_001301713.1.
NP_031745.2. NM_007719.2.
UniGeneiMm.2932.

3D structure databases

ProteinModelPortaliP47774.
SMRiP47774. Positions 52-341.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP47774. 1 interaction.

Chemistry

GuidetoPHARMACOLOGYi64.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP47774.

Proteomic databases

PRIDEiP47774.

Protocols and materials databases

DNASUi12775.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103134; ENSMUSP00000099423; ENSMUSG00000037944.
GeneIDi12775.
KEGGimmu:12775.
UCSCiuc007lih.1. mouse.

Organism-specific databases

CTDi1236.
MGIiMGI:103011. Ccr7.

Phylogenomic databases

eggNOGiNOG149643.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP47774.
KOiK04182.
OMAiCFKKDVR.
OrthoDBiEOG79CXZN.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiREACT_288802. Chemokine receptors bind chemokines.
REACT_331048. G alpha (i) signalling events.

Miscellaneous databases

NextBioi282162.
PROiP47774.
SOURCEiSearch...

Gene expression databases

BgeeiP47774.
CleanExiMM_CCR7.
GenevestigatoriP47774.

Family and domain databases

InterProiIPR001718. Chemokine_CCR7.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF29. PTHR24227:SF29. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR00641. CHEMOKINER7.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2."
    Schweickart V.L., Raport C.J., Godiska R., Byers M.G., Eddy R.L. Jr., Shows T.B., Gray P.W.
    Genomics 23:643-650(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X CBA.
    Tissue: Thymus.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Thymus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCCR7_MOUSE
AccessioniPrimary (citable) accession number: P47774
Secondary accession number(s): Q8CAS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 27, 2011
Last modified: April 1, 2015
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.