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Protein

Aldehyde dehydrogenase [NAD(P)+] 1

Gene

ALD2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytoplasmic aldehyde dehydrogenase involved in ethanol oxidation. Required for pantothenic acid production through the conversion of 3-aminopropanal to beta-alanine, an intermediate in pantothenic acid (vitamin B5) and coenzyme A (CoA) biosynthesis.1 Publication

Miscellaneous

Present with 2070 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei169Transition state stabilizerBy similarity1
Active sitei268Proton acceptorPROSITE-ProRule annotation1
Active sitei302NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

  • aldehyde dehydrogenase (NAD) activity Source: SGD

GO - Biological processi

  • beta-alanine biosynthetic process Source: SGD
  • cellular aldehyde metabolic process Source: SGD
  • pantothenate biosynthetic process Source: UniProtKB-KW
  • polyamine catabolic process Source: SGD

Keywordsi

Molecular functionOxidoreductase
Biological processPantothenate biosynthesis
LigandNAD

Enzyme and pathway databases

BioCyciMetaCyc:YMR170C-MONOMER
YEAST:YMR170C-MONOMER
ReactomeiR-SCE-70895 Branched-chain amino acid catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase [NAD(P)+] 1 (EC:1.2.1.3)
Gene namesi
Name:ALD2
Synonyms:ALD5
Ordered Locus Names:YMR170C
ORF Names:YM8520.19C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR170C
SGDiS000004780 ALD2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000564391 – 506Aldehyde dehydrogenase [NAD(P)+] 1Add BLAST506

Proteomic databases

MaxQBiP47771
PaxDbiP47771
PRIDEiP47771

Expressioni

Inductioni

Expression is under the control of MSN2 and MSN4, and is induced during diauxic shift and osmotic stress.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi35348, 50 interactors
IntActiP47771, 3 interactors
MINTiP47771
STRINGi4932.YMR170C

Structurei

3D structure databases

ProteinModelPortaliP47771
SMRiP47771
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

GeneTreeiENSGT00910000144256
HOGENOMiHOG000271505
InParanoidiP47771
KOiK00129
OMAiRHVMIKH
OrthoDBiEOG092C1LLH

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

P47771-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTLYTDIEI PQLKISLKQP LGLFINNEFC PSSDGKTIET VNPATGEPIT
60 70 80 90 100
SFQAANEKDV DKAVKAARAA FDNVWSKTSS EQRGIYLSNL LKLIEEEQDT
110 120 130 140 150
LAALETLDAG KPYHSNAKGD LAQILQLTRY FAGSADKFDK GATIPLTFNK
160 170 180 190 200
FAYTLKVPFG VVAQIVPWNY PLAMACWKLQ GALAAGNTVI IKPAENTSLS
210 220 230 240 250
LLYFATLIKK AGFPPGVVNI VPGYGSLVGQ ALASHMDIDK ISFTGSTKVG
260 270 280 290 300
GFVLEASGQS NLKDVTLECG GKSPALVFED ADLDKAIDWI AAGIFYNSGQ
310 320 330 340 350
NCTANSRVYV QSSIYDKFVE KFKETAKKEW DVAGKFDPFD EKCIVGPVIS
360 370 380 390 400
STQYDRIKSY IERGKREEKL DMFQTSEFPI GGAKGYFIPP TIFTDVPQTS
410 420 430 440 450
KLLQDEIFGP VVVVSKFTNY DDALKLANDT CYGLASAVFT KDVKKAHMFA
460 470 480 490 500
RDIKAGTVWI NSSNDEDVTV PFGGFKMSGI GRELGQSGVD TYLQTKAVHI

NLSLDN
Length:506
Mass (Da):55,188
Last modified:October 1, 1996 - v2
Checksum:iDD708CBD51BEAB39
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23L → C in CAA59975 (PubMed:8801420).Curated1
Sequence conflicti462S → Q in CAA59975 (PubMed:8801420).Curated1
Sequence conflicti486 – 488QSG → DNV in CAA59975 (PubMed:8801420).Curated3
Sequence conflicti497A → S in CAA59975 (PubMed:8801420).Curated1
Sequence conflicti500 – 501IN → MD in CAA59975 (PubMed:8801420).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85987 Genomic DNA Translation: CAA59975.1
Z49705 Genomic DNA Translation: CAA89806.1
BK006946 Genomic DNA Translation: DAA10066.1
PIRiS70189 S54615
RefSeqiNP_013893.1, NM_001182674.1

Genome annotation databases

EnsemblFungiiYMR170C; YMR170C; YMR170C
GeneIDi855206
KEGGisce:YMR170C

Similar proteinsi

Entry informationi

Entry nameiALDH2_YEAST
AccessioniPrimary (citable) accession number: P47771
Secondary accession number(s): D6VZZ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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