Reviewed,
UniProtKB/Swiss-Prot P47771 (ALDH2_YEAST)
Last modified
November 25, 2008.
Version 71.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Aldehyde dehydrogenase [NAD(P)+] 1 EC=1.2.1.5 | ||||||||
| Gene names |
| ||||||||
| Organism | Saccharomyces cerevisiae (Baker's yeast) [Complete proteome] | ||||||||
| Taxonomic identifier | 4932 [NCBI] | ||||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 506 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H. |
| Subcellular location | CytoplasmPotential. |
| Miscellaneous | Present with 2070 molecules/cell in log phase SD medium. |
| Sequence similarities | Belongs to the aldehyde dehydrogenase family. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | beta-alanine biosynthetic process Inferred from mutant phenotype. Source: SGD oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW polyamine catabolic processInferred from genetic interaction. Source: SGD |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | aldehyde dehydrogenase (NAD) activity Inferred from mutant phenotype. Source: SGD aldehyde dehydrogenase [NAD(P)+] activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 506 | 506 | Aldehyde dehydrogenase [NAD(P)+] 1 | PRO_0000056439 | |||||
Sites | |||||||||
| Active site | 268 | 1 | Proton acceptor By similarity | ||||||
| Active site | 302 | 1 | Nucleophile By similarity | ||||||
| Site | 169 | 1 | Transition state stabilizer By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 23 | 1 | L → C in CAA59975. Ref.1 | ||||||
| Sequence conflict | 462 | 1 | S → Q in CAA59975. Ref.1 | ||||||
| Sequence conflict | 486 – 488 | 3 | QSG → DNV in CAA59975. Ref.1 | ||||||
| Sequence conflict | 497 | 1 | A → S in CAA59975. Ref.1 | ||||||
| Sequence conflict | 500 – 501 | 2 | IN → MD in CAA59975. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A genomic locus in Saccharomyces cerevisiae with four genes up-regulated by osmotic stress." Miralles V.J., Serrano R. Mol. Microbiol. 17:653-662(1995) [PubMed: 8801420] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: DBY939. |
| [2] | "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. Barrell B.G.Nature 387:90-93(1997) [PubMed: 9169872] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972. |
| [3] | "A proposal for nomenclature of aldehyde dehydrogenases in Saccharomyces cerevisiae and characterization of the stress-inducible ALD2 and ALD3 genes." Navarro-Avino J.P., Prasad R., Miralles V.J., Benito R.M., Serrano R. Yeast 15:829-842(1999) [PubMed: 10407263] [Abstract] Cited for: CHARACTERIZATION. |
| [4] | "Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X85987 Genomic DNA. Translation: CAA59975.1. Z49705 Genomic DNA. Translation: CAA89806.1. | |
| PIR | S54615. S70189. |
| RefSeq | NP_013893.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1O04 based on UniProtKB P05091. |
| ModBase | Search... |
Proteomic databases | |
| PeptideAtlas | P47771. |
Genome annotation databases | |
| Ensembl | YMR170C. Saccharomyces cerevisiae. [Contig view] |
| GeneID | 855206. |
| GenomeReviews | Gene locus YMR170C in contig Z71257_GR. |
| KEGG | sce:YMR170C. |
| NMPDR | fig|4932.3.peg.4943. |
Organism-specific databases | |
| CYGD | YMR170c. |
| SGD | S000004780. ALD2. |
| Yeast-GFP | Search... |
Phylogenomic databases | |
| HOGENOM | P47771. |
Enzyme and pathway databases | |
| BioCyc | MetaCyc:MON-13667. |
Gene expression databases | |
| ArrayExpress | P47771. |
| GermOnline | YMR170C. Saccharomyces cerevisiae. |
Family and domain databases | |
| InterPro | IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. [Graphical view] |
| Gene3D | G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit. |
| PANTHER | PTHR11699. Aldehyde_dehyd. 1 hit. |
| Pfam | PF00171. Aldedh. 1 hit. [Graphical view] |
| PROSITE | PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| LinkHub | P47771. |
| NextBio | 978702. |
Entry information
| Entry name | ALDH2_YEAST | ||||||||
| Accession | Primary (citable) accession number: P47771 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
| Yeast chromosome XIII Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names |

Clusters with


