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P47771

- ALDH2_YEAST

UniProt

P47771 - ALDH2_YEAST

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Protein

Aldehyde dehydrogenase [NAD(P)+] 1

Gene

ALD2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Cytoplasmic aldehyde dehydrogenase involved in ethanol oxidation. Required for pantothenic acid production through the conversion of 3-aminopropanal to beta-alanine, an intermediate in pantothenic acid (vitamin B5) and coenzyme A (CoA) biosynthesis.1 Publication

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei169 – 1691Transition state stabilizerBy similarity
Active sitei268 – 2681Proton acceptorPROSITE-ProRule annotation
Active sitei302 – 3021NucleophilePROSITE-ProRule annotation

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: SGD

GO - Biological processi

  1. beta-alanine biosynthetic process Source: SGD
  2. cellular aldehyde metabolic process Source: SGD
  3. pantothenate biosynthetic process Source: UniProtKB-KW
  4. polyamine catabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13667.
YEAST:YMR170C-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase [NAD(P)+] 1 (EC:1.2.1.3)
Gene namesi
Name:ALD2
Synonyms:ALD5
Ordered Locus Names:YMR170C
ORF Names:YM8520.19C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR170c.
SGDiS000004780. ALD2.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506Aldehyde dehydrogenase [NAD(P)+] 1PRO_0000056439Add
BLAST

Proteomic databases

MaxQBiP47771.
PeptideAtlasiP47771.

Expressioni

Inductioni

Expression is under the control of MSN2 and MSN4, and is induced during diauxic shift and osmotic stress.1 Publication

Gene expression databases

GenevestigatoriP47771.

Interactioni

Protein-protein interaction databases

BioGridi35348. 17 interactions.
IntActiP47771. 3 interactions.
MINTiMINT-2781711.
STRINGi4932.YMR170C.

Structurei

3D structure databases

ProteinModelPortaliP47771.
SMRiP47771. Positions 21-502.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

GeneTreeiENSGT00760000120053.
HOGENOMiHOG000271505.
InParanoidiP47771.
KOiK00129.
OMAiREMPTLA.
OrthoDBiEOG7S226Z.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47771-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPTLYTDIEI PQLKISLKQP LGLFINNEFC PSSDGKTIET VNPATGEPIT
60 70 80 90 100
SFQAANEKDV DKAVKAARAA FDNVWSKTSS EQRGIYLSNL LKLIEEEQDT
110 120 130 140 150
LAALETLDAG KPYHSNAKGD LAQILQLTRY FAGSADKFDK GATIPLTFNK
160 170 180 190 200
FAYTLKVPFG VVAQIVPWNY PLAMACWKLQ GALAAGNTVI IKPAENTSLS
210 220 230 240 250
LLYFATLIKK AGFPPGVVNI VPGYGSLVGQ ALASHMDIDK ISFTGSTKVG
260 270 280 290 300
GFVLEASGQS NLKDVTLECG GKSPALVFED ADLDKAIDWI AAGIFYNSGQ
310 320 330 340 350
NCTANSRVYV QSSIYDKFVE KFKETAKKEW DVAGKFDPFD EKCIVGPVIS
360 370 380 390 400
STQYDRIKSY IERGKREEKL DMFQTSEFPI GGAKGYFIPP TIFTDVPQTS
410 420 430 440 450
KLLQDEIFGP VVVVSKFTNY DDALKLANDT CYGLASAVFT KDVKKAHMFA
460 470 480 490 500
RDIKAGTVWI NSSNDEDVTV PFGGFKMSGI GRELGQSGVD TYLQTKAVHI

NLSLDN
Length:506
Mass (Da):55,188
Last modified:October 1, 1996 - v2
Checksum:iDD708CBD51BEAB39
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231L → C in CAA59975. (PubMed:8801420)Curated
Sequence conflicti462 – 4621S → Q in CAA59975. (PubMed:8801420)Curated
Sequence conflicti486 – 4883QSG → DNV in CAA59975. (PubMed:8801420)Curated
Sequence conflicti497 – 4971A → S in CAA59975. (PubMed:8801420)Curated
Sequence conflicti500 – 5012IN → MD in CAA59975. (PubMed:8801420)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X85987 Genomic DNA. Translation: CAA59975.1.
Z49705 Genomic DNA. Translation: CAA89806.1.
BK006946 Genomic DNA. Translation: DAA10066.1.
PIRiS70189. S54615.
RefSeqiNP_013893.1. NM_001182674.1.

Genome annotation databases

EnsemblFungiiYMR170C; YMR170C; YMR170C.
GeneIDi855206.
KEGGisce:YMR170C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X85987 Genomic DNA. Translation: CAA59975.1 .
Z49705 Genomic DNA. Translation: CAA89806.1 .
BK006946 Genomic DNA. Translation: DAA10066.1 .
PIRi S70189. S54615.
RefSeqi NP_013893.1. NM_001182674.1.

3D structure databases

ProteinModelPortali P47771.
SMRi P47771. Positions 21-502.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35348. 17 interactions.
IntActi P47771. 3 interactions.
MINTi MINT-2781711.
STRINGi 4932.YMR170C.

Proteomic databases

MaxQBi P47771.
PeptideAtlasi P47771.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR170C ; YMR170C ; YMR170C .
GeneIDi 855206.
KEGGi sce:YMR170C.

Organism-specific databases

CYGDi YMR170c.
SGDi S000004780. ALD2.

Phylogenomic databases

GeneTreei ENSGT00760000120053.
HOGENOMi HOG000271505.
InParanoidi P47771.
KOi K00129.
OMAi REMPTLA.
OrthoDBi EOG7S226Z.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-13667.
YEAST:YMR170C-MONOMER.

Miscellaneous databases

NextBioi 978702.

Gene expression databases

Genevestigatori P47771.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A genomic locus in Saccharomyces cerevisiae with four genes up-regulated by osmotic stress."
    Miralles V.J., Serrano R.
    Mol. Microbiol. 17:653-662(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DBY939.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "A proposal for nomenclature of aldehyde dehydrogenases in Saccharomyces cerevisiae and characterization of the stress-inducible ALD2 and ALD3 genes."
    Navarro-Avino J.P., Prasad R., Miralles V.J., Benito R.M., Serrano R.
    Yeast 15:829-842(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, INDUCTION.
  5. "Specialization of function among aldehyde dehydrogenases: the ALD2 and ALD3 genes are required for beta-alanine biosynthesis in Saccharomyces cerevisiae."
    White W.H., Skatrud P.L., Xue Z., Toyn J.H.
    Genetics 163:69-77(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiALDH2_YEAST
AccessioniPrimary (citable) accession number: P47771
Secondary accession number(s): D6VZZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2070 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3