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Protein

Neuron-specific protein family member 2

Gene

Nsg2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Neuron-specific protein family member 2
Alternative name(s):
Protein 8.5
Protein p19
Gene namesi
Name:Nsg2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1202070. Nsg2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7171CytoplasmicSequence analysisAdd
BLAST
Transmembranei72 – 9221Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini93 – 17179LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 171171Neuron-specific protein family member 2PRO_0000164367Add
BLAST

Proteomic databases

EPDiP47759.
PaxDbiP47759.
PRIDEiP47759.

PTM databases

iPTMnetiP47759.
PhosphoSiteiP47759.

Expressioni

Tissue specificityi

Specifically expressed in neural and neuroendocrine tissues.

Developmental stagei

Highly expressed at day 20 (E20) of embryonic development.

Gene expression databases

BgeeiP47759.
CleanExiMM_NSG2.
ExpressionAtlasiP47759. baseline and differential.
GenevisibleiP47759. MM.

Interactioni

Protein-protein interaction databases

IntActiP47759. 1 interaction.
MINTiMINT-4104164.
STRINGi10090.ENSMUSP00000020537.

Family & Domainsi

Sequence similaritiesi

Belongs to the NSG family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ7J. Eukaryota.
ENOG4111F06. LUCA.
HOGENOMiHOG000030909.
HOVERGENiHBG012403.
InParanoidiP47759.
OMAiPDGFIYK.
OrthoDBiEOG7J4488.
PhylomeDBiP47759.
TreeFamiTF332232.

Family and domain databases

InterProiIPR009431. Calcyon_neuron-sp.
[Graphical view]
PfamiPF06387. Calcyon. 1 hit.
[Graphical view]
PIRSFiPIRSF002383. Calcyon. 1 hit.

Sequencei

Sequence statusi: Complete.

P47759-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKLNSNPGE KGAKPPSVED GFQTVPLITP LEVNHLQLAA PEKVIVKTRT
60 70 80 90 100
EYQPEQRNKG KFRVPKIAEF TVTILVSLAL AFLACIVFLV VYKAFTYDHS
110 120 130 140 150
CPEGFVYKHK RCIPASLDAY YSSQDPSSRS RFYTVISHYS VAKQSTARAI
160 170
GPWLSAAAVI HEPKPPKTQG H
Length:171
Mass (Da):19,000
Last modified:February 1, 1996 - v1
Checksum:i7A601049DBFD6869
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17259 mRNA. Translation: AAA67764.1.
AK011563 mRNA. Translation: BAB27700.1.
AK075612 mRNA. Translation: BAC35857.1.
BC018224 mRNA. Translation: AAH18224.1.
CCDSiCCDS24516.1.
PIRiA55629.
RefSeqiNP_001277609.1. NM_001290680.1.
NP_001277610.1. NM_001290681.1.
NP_032767.1. NM_008741.4.
UniGeneiMm.3304.

Genome annotation databases

EnsembliENSMUST00000020537; ENSMUSP00000020537; ENSMUSG00000020297.
GeneIDi18197.
KEGGimmu:18197.
UCSCiuc007iiw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17259 mRNA. Translation: AAA67764.1.
AK011563 mRNA. Translation: BAB27700.1.
AK075612 mRNA. Translation: BAC35857.1.
BC018224 mRNA. Translation: AAH18224.1.
CCDSiCCDS24516.1.
PIRiA55629.
RefSeqiNP_001277609.1. NM_001290680.1.
NP_001277610.1. NM_001290681.1.
NP_032767.1. NM_008741.4.
UniGeneiMm.3304.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP47759. 1 interaction.
MINTiMINT-4104164.
STRINGi10090.ENSMUSP00000020537.

PTM databases

iPTMnetiP47759.
PhosphoSiteiP47759.

Proteomic databases

EPDiP47759.
PaxDbiP47759.
PRIDEiP47759.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020537; ENSMUSP00000020537; ENSMUSG00000020297.
GeneIDi18197.
KEGGimmu:18197.
UCSCiuc007iiw.2. mouse.

Organism-specific databases

CTDi18197.
MGIiMGI:1202070. Nsg2.

Phylogenomic databases

eggNOGiENOG410IJ7J. Eukaryota.
ENOG4111F06. LUCA.
HOGENOMiHOG000030909.
HOVERGENiHBG012403.
InParanoidiP47759.
OMAiPDGFIYK.
OrthoDBiEOG7J4488.
PhylomeDBiP47759.
TreeFamiTF332232.

Miscellaneous databases

ChiTaRSiNsg2. mouse.
NextBioi293556.
PROiP47759.
SOURCEiSearch...

Gene expression databases

BgeeiP47759.
CleanExiMM_NSG2.
ExpressionAtlasiP47759. baseline and differential.
GenevisibleiP47759. MM.

Family and domain databases

InterProiIPR009431. Calcyon_neuron-sp.
[Graphical view]
PfamiPF06387. Calcyon. 1 hit.
[Graphical view]
PIRSFiPIRSF002383. Calcyon. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A 19-kDa protein belonging to a new family is expressed in the Golgi apparatus of neural cells."
    Saberan-Djoneidi D., Marey-Semper I., Picart R., Studler J.-M., Tougard C., Glowinski J., Levi-Strauss M.
    J. Biol. Chem. 270:1888-1893(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiNSG2_MOUSE
AccessioniPrimary (citable) accession number: P47759
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: March 16, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.