Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P47753 (CAZA1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
F-actin-capping protein subunit alpha-1
Alternative name(s):
CapZ alpha-1
Gene names
Name:Capza1
Synonyms:Cappa1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length286 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.

Subunit structure

Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53. Interacts with S100B and S100A By similarity.

Subcellular location

Cytoplasmcytoskeleton By similarity.

Sequence similarities

Belongs to the F-actin-capping protein alpha subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 286285F-actin-capping protein subunit alpha-1
PRO_0000208625

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue191N6-acetyllysine Ref.4
Modified residue971N6-acetyllysine By similarity

Experimental info

Sequence conflict2221V → I in AAC00566. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P47753 [UniParc].

Last modified January 23, 2007. Version 4.
Checksum: 6FE97BCE5D9B9D3A

FASTA28632,940
        10         20         30         40         50         60 
MADFEDRVSD EEKVRIAAKF ITHAPPGEFN EVFNDVRLLL NNDNLLREGA AHAFAQYNMD 

        70         80         90        100        110        120 
QFTPVKIEGY DDQVLITEHG DLGNSRFLDP RNQISFKFDH LRKEASDPQP EDVDGGLKSW 

       130        140        150        160        170        180 
RESCDSALRA YVKDHYSNGF CTVYAKTIDG QQTIIACIES HQFQPKNFWN GRWRSEWKFT 

       190        200        210        220        230        240 
ITPPSAQVVG VLKIQVHYYE DGNVQLVSHK DVQDSVTVSN EVQTTKEFIK IIESAENEYQ 

       250        260        270        280 
TAISENYQTM SDTTFKALRR QLPVTRTKID WNKILSYKIG KEMQNA 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"Vertebrates have conserved capping protein alpha isoforms with specific expression patterns."
Hart M.C., Korshunova Y.O., Cooper J.A.
Cell Motil. Cytoskeleton 38:120-132(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-286.
Tissue: Muscle.
[3]Lubec G., Yang J.W., Zigmond M.
Submitted (JUL-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 194-210.
Tissue: Brain.
[4]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-19, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC016232 mRNA. Translation: AAH16232.1.
U16740 mRNA. Translation: AAC00566.1.
RefSeqNP_033927.2. NM_009797.2.
UniGeneMm.19142.

3D structure databases

ProteinModelPortalP47753.
SMRP47753. Positions 7-281.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198477. 23 interactions.
IntActP47753. 23 interactions.
MINTMINT-1856502.

PTM databases

PhosphoSiteP47753.

2D gel databases

REPRODUCTION-2DPAGEP47753.

Proteomic databases

PaxDbP47753.
PRIDEP47753.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID12340.
KEGGmmu:12340.

Organism-specific databases

CTD829.
MGIMGI:106227. Capza1.

Phylogenomic databases

eggNOGNOG261759.
HOVERGENHBG050810.
InParanoidP47753.
KOK10364.
PhylomeDBP47753.

Gene expression databases

GenevestigatorP47753.

Family and domain databases

InterProIPR002189. CapZ_alpha.
IPR017865. F-actin_cap_asu_CS.
[Graphical view]
PANTHERPTHR10653. PTHR10653. 1 hit.
PfamPF01267. F-actin_cap_A. 1 hit.
[Graphical view]
PRINTSPR00191. FACTINCAPA.
PROSITEPS00748. F_ACTIN_CAPPING_A_1. 1 hit.
PS00749. F_ACTIN_CAPPING_A_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCAPZA1. mouse.
NextBio280968.
PROP47753.
SOURCESearch...

Entry information

Entry nameCAZA1_MOUSE
AccessionPrimary (citable) accession number: P47753
Secondary accession number(s): Q91YN7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 114 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot