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P47752

- S1PR2_RAT

UniProt

P47752 - S1PR2_RAT

Protein

Sphingosine 1-phosphate receptor 2

Gene

S1pr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: RGD
    2. sphingosine-1-phosphate receptor activity Source: InterPro

    GO - Biological processi

    1. negative regulation of excitatory postsynaptic membrane potential Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sphingosine 1-phosphate receptor 2
    Short name:
    S1P receptor 2
    Short name:
    S1P2
    Alternative name(s):
    AGR16
    Endothelial differentiation G-protein coupled receptor 5
    G-protein coupled receptor H218
    Sphingosine 1-phosphate receptor Edg-5
    Short name:
    S1P receptor Edg-5
    Gene namesi
    Name:S1pr2
    Synonyms:Edg5
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 8

    Organism-specific databases

    RGDi68334. S1pr2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 352352Sphingosine 1-phosphate receptor 2PRO_0000069429Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis
    Lipidationi305 – 3051S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP47752.

    PTM databases

    PhosphoSiteiP47752.

    Expressioni

    Tissue specificityi

    Expressed in all developing tissues with highest levels detected in primitive, transformed cells. Relative abundance: lung > kidney = skin = gut > spleen > brain > liver.

    Gene expression databases

    GenevestigatoriP47752.

    Structurei

    3D structure databases

    ProteinModelPortaliP47752.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3434ExtracellularBy similarityAdd
    BLAST
    Topological domaini60 – 667CytoplasmicBy similarity
    Topological domaini96 – 10914ExtracellularBy similarityAdd
    BLAST
    Topological domaini129 – 14719CytoplasmicBy similarityAdd
    BLAST
    Topological domaini174 – 18916ExtracellularBy similarityAdd
    BLAST
    Topological domaini211 – 23323CytoplasmicBy similarityAdd
    BLAST
    Topological domaini256 – 27116ExtracellularBy similarityAdd
    BLAST
    Topological domaini293 – 35260CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 5925Helical; Name=1By similarityAdd
    BLAST
    Transmembranei67 – 9529Helical; Name=2By similarityAdd
    BLAST
    Transmembranei110 – 12819Helical; Name=3By similarityAdd
    BLAST
    Transmembranei148 – 17326Helical; Name=4By similarityAdd
    BLAST
    Transmembranei190 – 21021Helical; Name=5By similarityAdd
    BLAST
    Transmembranei234 – 25522Helical; Name=6By similarityAdd
    BLAST
    Transmembranei272 – 29221Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG149362.
    GeneTreeiENSGT00750000117544.
    HOGENOMiHOG000233501.
    HOVERGENiHBG103071.
    InParanoidiP47752.
    KOiK04292.
    OMAiKFHSAMY.
    OrthoDBiEOG708W0B.
    PhylomeDBiP47752.
    TreeFamiTF330052.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR004063. EDG5_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR004061. S1P_rcpt.
    [Graphical view]
    PANTHERiPTHR22750:SF17. PTHR22750:SF17. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01525. EDG5RECEPTOR.
    PR00237. GPCRRHODOPSN.
    PR01523. S1PRECEPTOR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47752-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGGLYSEYLN PEKVQEHYNY TKETLDMQET PSRKVASAFI IILCCAIVVE    50
    NLLVLIAVAR NSKFHSAMYL FLGNLAASDL LAGVAFVANT LLSGPVTLSL 100
    TPLQWFAREG SAFITLSASV FSLLAIAIER QVAIAKVKLY GSDKSCRMLM 150
    LIGASWLISL ILGGLPILGW NCLDHLEACS TVLPLYAKHY VLCVVTIFSV 200
    ILLAIVALYV RIYFVVRSSH ADVAGPQTLA LLKTVTIVLG VFIICWLPAF 250
    SILLLDSTCP VRACPVLYKA HYFFAFATLN SLLNPVIYTW RSRDLRREVL 300
    RPLLCWRQGK GATGRRGGNP GHRLLPLRSS SSLERGLHMP TSPTFLEGNT 350
    VV 352
    Length:352
    Mass (Da):38,735
    Last modified:February 1, 1996 - v1
    Checksum:i9C933A18E756CE1E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB016931 mRNA. Translation: BAA32454.1.
    U10699 mRNA. Translation: AAA19241.1.
    AF022138 mRNA. Translation: AAC53494.1.
    PIRiJC1465.
    RefSeqiNP_058888.1. NM_017192.1.
    UniGeneiRn.2491.

    Genome annotation databases

    EnsembliENSRNOT00000028034; ENSRNOP00000028034; ENSRNOG00000020653.
    GeneIDi29415.
    KEGGirno:29415.
    UCSCiRGD:68334. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB016931 mRNA. Translation: BAA32454.1 .
    U10699 mRNA. Translation: AAA19241.1 .
    AF022138 mRNA. Translation: AAC53494.1 .
    PIRi JC1465.
    RefSeqi NP_058888.1. NM_017192.1.
    UniGenei Rn.2491.

    3D structure databases

    ProteinModelPortali P47752.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 276.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P47752.

    Proteomic databases

    PaxDbi P47752.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000028034 ; ENSRNOP00000028034 ; ENSRNOG00000020653 .
    GeneIDi 29415.
    KEGGi rno:29415.
    UCSCi RGD:68334. rat.

    Organism-specific databases

    CTDi 9294.
    RGDi 68334. S1pr2.

    Phylogenomic databases

    eggNOGi NOG149362.
    GeneTreei ENSGT00750000117544.
    HOGENOMi HOG000233501.
    HOVERGENi HBG103071.
    InParanoidi P47752.
    KOi K04292.
    OMAi KFHSAMY.
    OrthoDBi EOG708W0B.
    PhylomeDBi P47752.
    TreeFami TF330052.

    Miscellaneous databases

    NextBioi 609092.
    PROi P47752.

    Gene expression databases

    Genevestigatori P47752.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR004063. EDG5_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR004061. S1P_rcpt.
    [Graphical view ]
    PANTHERi PTHR22750:SF17. PTHR22750:SF17. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01525. EDG5RECEPTOR.
    PR00237. GPCRRHODOPSN.
    PR01523. S1PRECEPTOR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a novel putative G protein-coupled receptor expressed in the cardiovascular system."
      Okazaki H., Ishizaka N., Sakurai T., Kurokawa K., Goto K., Kumada M., Takuwa Y.
      Biochem. Biophys. Res. Commun. 190:1104-1109(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Aortic smooth muscle.
    2. "Cloning and characterization of a putative G-protein coupled receptor potentially involved in development."
      Maclennan A.J., Browe C.S., Gaskin A.A., Lado D.C., Shaw G.
      Mol. Cell. Neurosci. 5:201-209(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain and Lung.
    3. "Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids."
      An S., Bleu T., Huang W., Hallmark O.G., Coughlin S.R., Goetzl E.J.
      FEBS Lett. 417:279-282(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    4. "Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5."
      Ancellin N., Hla T.
      J. Biol. Chem. 274:18997-19002(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHARMACOLOGICAL CHARACTERIZATION.

    Entry informationi

    Entry nameiS1PR2_RAT
    AccessioniPrimary (citable) accession number: P47752
    Secondary accession number(s): Q54AI6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3