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P47752

- S1PR2_RAT

UniProt

P47752 - S1PR2_RAT

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Protein

Sphingosine 1-phosphate receptor 2

Gene
S1pr2, Edg5
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: RGD
  2. sphingosine-1-phosphate receptor activity Source: InterPro

GO - Biological processi

  1. negative regulation of excitatory postsynaptic membrane potential Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingosine 1-phosphate receptor 2
Short name:
S1P receptor 2
Short name:
S1P2
Alternative name(s):
AGR16
Endothelial differentiation G-protein coupled receptor 5
G-protein coupled receptor H218
Sphingosine 1-phosphate receptor Edg-5
Short name:
S1P receptor Edg-5
Gene namesi
Name:S1pr2
Synonyms:Edg5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi68334. S1pr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434Extracellular By similarityAdd
BLAST
Transmembranei35 – 5925Helical; Name=1; By similarityAdd
BLAST
Topological domaini60 – 667Cytoplasmic By similarity
Transmembranei67 – 9529Helical; Name=2; By similarityAdd
BLAST
Topological domaini96 – 10914Extracellular By similarityAdd
BLAST
Transmembranei110 – 12819Helical; Name=3; By similarityAdd
BLAST
Topological domaini129 – 14719Cytoplasmic By similarityAdd
BLAST
Transmembranei148 – 17326Helical; Name=4; By similarityAdd
BLAST
Topological domaini174 – 18916Extracellular By similarityAdd
BLAST
Transmembranei190 – 21021Helical; Name=5; By similarityAdd
BLAST
Topological domaini211 – 23323Cytoplasmic By similarityAdd
BLAST
Transmembranei234 – 25522Helical; Name=6; By similarityAdd
BLAST
Topological domaini256 – 27116Extracellular By similarityAdd
BLAST
Transmembranei272 – 29221Helical; Name=7; By similarityAdd
BLAST
Topological domaini293 – 35260Cytoplasmic By similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352Sphingosine 1-phosphate receptor 2PRO_0000069429Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi19 – 191N-linked (GlcNAc...) Reviewed prediction
Lipidationi305 – 3051S-palmitoyl cysteine By similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP47752.

PTM databases

PhosphoSiteiP47752.

Expressioni

Tissue specificityi

Expressed in all developing tissues with highest levels detected in primitive, transformed cells. Relative abundance: lung > kidney = skin = gut > spleen > brain > liver.

Gene expression databases

GenevestigatoriP47752.

Structurei

3D structure databases

ProteinModelPortaliP47752.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG149362.
GeneTreeiENSGT00750000117544.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiP47752.
KOiK04292.
OMAiKFHSAMY.
OrthoDBiEOG708W0B.
PhylomeDBiP47752.
TreeFamiTF330052.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR004063. EDG5_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF17. PTHR22750:SF17. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01525. EDG5RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47752-1 [UniParc]FASTAAdd to Basket

« Hide

MGGLYSEYLN PEKVQEHYNY TKETLDMQET PSRKVASAFI IILCCAIVVE    50
NLLVLIAVAR NSKFHSAMYL FLGNLAASDL LAGVAFVANT LLSGPVTLSL 100
TPLQWFAREG SAFITLSASV FSLLAIAIER QVAIAKVKLY GSDKSCRMLM 150
LIGASWLISL ILGGLPILGW NCLDHLEACS TVLPLYAKHY VLCVVTIFSV 200
ILLAIVALYV RIYFVVRSSH ADVAGPQTLA LLKTVTIVLG VFIICWLPAF 250
SILLLDSTCP VRACPVLYKA HYFFAFATLN SLLNPVIYTW RSRDLRREVL 300
RPLLCWRQGK GATGRRGGNP GHRLLPLRSS SSLERGLHMP TSPTFLEGNT 350
VV 352
Length:352
Mass (Da):38,735
Last modified:February 1, 1996 - v1
Checksum:i9C933A18E756CE1E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB016931 mRNA. Translation: BAA32454.1.
U10699 mRNA. Translation: AAA19241.1.
AF022138 mRNA. Translation: AAC53494.1.
PIRiJC1465.
RefSeqiNP_058888.1. NM_017192.1.
UniGeneiRn.2491.

Genome annotation databases

EnsembliENSRNOT00000028034; ENSRNOP00000028034; ENSRNOG00000020653.
GeneIDi29415.
KEGGirno:29415.
UCSCiRGD:68334. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB016931 mRNA. Translation: BAA32454.1 .
U10699 mRNA. Translation: AAA19241.1 .
AF022138 mRNA. Translation: AAC53494.1 .
PIRi JC1465.
RefSeqi NP_058888.1. NM_017192.1.
UniGenei Rn.2491.

3D structure databases

ProteinModelPortali P47752.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 276.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P47752.

Proteomic databases

PaxDbi P47752.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000028034 ; ENSRNOP00000028034 ; ENSRNOG00000020653 .
GeneIDi 29415.
KEGGi rno:29415.
UCSCi RGD:68334. rat.

Organism-specific databases

CTDi 9294.
RGDi 68334. S1pr2.

Phylogenomic databases

eggNOGi NOG149362.
GeneTreei ENSGT00750000117544.
HOGENOMi HOG000233501.
HOVERGENi HBG103071.
InParanoidi P47752.
KOi K04292.
OMAi KFHSAMY.
OrthoDBi EOG708W0B.
PhylomeDBi P47752.
TreeFami TF330052.

Miscellaneous databases

NextBioi 609092.
PROi P47752.

Gene expression databases

Genevestigatori P47752.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR004063. EDG5_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view ]
PANTHERi PTHR22750:SF17. PTHR22750:SF17. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01525. EDG5RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of a novel putative G protein-coupled receptor expressed in the cardiovascular system."
    Okazaki H., Ishizaka N., Sakurai T., Kurokawa K., Goto K., Kumada M., Takuwa Y.
    Biochem. Biophys. Res. Commun. 190:1104-1109(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Aortic smooth muscle.
  2. "Cloning and characterization of a putative G-protein coupled receptor potentially involved in development."
    Maclennan A.J., Browe C.S., Gaskin A.A., Lado D.C., Shaw G.
    Mol. Cell. Neurosci. 5:201-209(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain and Lung.
  3. "Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids."
    An S., Bleu T., Huang W., Hallmark O.G., Coughlin S.R., Goetzl E.J.
    FEBS Lett. 417:279-282(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  4. "Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5."
    Ancellin N., Hla T.
    J. Biol. Chem. 274:18997-19002(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHARMACOLOGICAL CHARACTERIZATION.

Entry informationi

Entry nameiS1PR2_RAT
AccessioniPrimary (citable) accession number: P47752
Secondary accession number(s): Q54AI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 14, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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