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Protein

Sphingosine 1-phosphate receptor 2

Gene

S1pr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: RGD
  2. sphingosine-1-phosphate receptor activity Source: InterPro

GO - Biological processi

  1. negative regulation of excitatory postsynaptic membrane potential Source: Ensembl
  2. positive regulation of establishment of endothelial barrier Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_303520. Lysosphingolipid and LPA receptors.
REACT_339234. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingosine 1-phosphate receptor 2
Short name:
S1P receptor 2
Short name:
S1P2
Alternative name(s):
AGR16
Endothelial differentiation G-protein coupled receptor 5
G-protein coupled receptor H218
Sphingosine 1-phosphate receptor Edg-5
Short name:
S1P receptor Edg-5
Gene namesi
Name:S1pr2
Synonyms:Edg5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi68334. S1pr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434ExtracellularBy similarityAdd
BLAST
Transmembranei35 – 5925Helical; Name=1By similarityAdd
BLAST
Topological domaini60 – 667CytoplasmicBy similarity
Transmembranei67 – 9529Helical; Name=2By similarityAdd
BLAST
Topological domaini96 – 10914ExtracellularBy similarityAdd
BLAST
Transmembranei110 – 12819Helical; Name=3By similarityAdd
BLAST
Topological domaini129 – 14719CytoplasmicBy similarityAdd
BLAST
Transmembranei148 – 17326Helical; Name=4By similarityAdd
BLAST
Topological domaini174 – 18916ExtracellularBy similarityAdd
BLAST
Transmembranei190 – 21021Helical; Name=5By similarityAdd
BLAST
Topological domaini211 – 23323CytoplasmicBy similarityAdd
BLAST
Transmembranei234 – 25522Helical; Name=6By similarityAdd
BLAST
Topological domaini256 – 27116ExtracellularBy similarityAdd
BLAST
Transmembranei272 – 29221Helical; Name=7By similarityAdd
BLAST
Topological domaini293 – 35260CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352Sphingosine 1-phosphate receptor 2PRO_0000069429Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis
Lipidationi305 – 3051S-palmitoyl cysteineBy similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP47752.

PTM databases

PhosphoSiteiP47752.

Expressioni

Tissue specificityi

Expressed in all developing tissues with highest levels detected in primitive, transformed cells. Relative abundance: lung > kidney = skin = gut > spleen > brain > liver.

Gene expression databases

GenevestigatoriP47752.

Structurei

3D structure databases

ProteinModelPortaliP47752.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG149362.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiP47752.
KOiK04292.
OMAiKFHSAMY.
OrthoDBiEOG708W0B.
PhylomeDBiP47752.
TreeFamiTF330052.

Family and domain databases

InterProiIPR004063. EDG5_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF17. PTHR22750:SF17. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01525. EDG5RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47752-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGLYSEYLN PEKVQEHYNY TKETLDMQET PSRKVASAFI IILCCAIVVE
60 70 80 90 100
NLLVLIAVAR NSKFHSAMYL FLGNLAASDL LAGVAFVANT LLSGPVTLSL
110 120 130 140 150
TPLQWFAREG SAFITLSASV FSLLAIAIER QVAIAKVKLY GSDKSCRMLM
160 170 180 190 200
LIGASWLISL ILGGLPILGW NCLDHLEACS TVLPLYAKHY VLCVVTIFSV
210 220 230 240 250
ILLAIVALYV RIYFVVRSSH ADVAGPQTLA LLKTVTIVLG VFIICWLPAF
260 270 280 290 300
SILLLDSTCP VRACPVLYKA HYFFAFATLN SLLNPVIYTW RSRDLRREVL
310 320 330 340 350
RPLLCWRQGK GATGRRGGNP GHRLLPLRSS SSLERGLHMP TSPTFLEGNT

VV
Length:352
Mass (Da):38,735
Last modified:January 31, 1996 - v1
Checksum:i9C933A18E756CE1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016931 mRNA. Translation: BAA32454.1.
U10699 mRNA. Translation: AAA19241.1.
AF022138 mRNA. Translation: AAC53494.1.
PIRiJC1465.
RefSeqiNP_058888.1. NM_017192.1.
UniGeneiRn.2491.

Genome annotation databases

EnsembliENSRNOT00000028034; ENSRNOP00000028034; ENSRNOG00000020653.
GeneIDi29415.
KEGGirno:29415.
UCSCiRGD:68334. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016931 mRNA. Translation: BAA32454.1.
U10699 mRNA. Translation: AAA19241.1.
AF022138 mRNA. Translation: AAC53494.1.
PIRiJC1465.
RefSeqiNP_058888.1. NM_017192.1.
UniGeneiRn.2491.

3D structure databases

ProteinModelPortaliP47752.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

GuidetoPHARMACOLOGYi276.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP47752.

Proteomic databases

PaxDbiP47752.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028034; ENSRNOP00000028034; ENSRNOG00000020653.
GeneIDi29415.
KEGGirno:29415.
UCSCiRGD:68334. rat.

Organism-specific databases

CTDi9294.
RGDi68334. S1pr2.

Phylogenomic databases

eggNOGiNOG149362.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiP47752.
KOiK04292.
OMAiKFHSAMY.
OrthoDBiEOG708W0B.
PhylomeDBiP47752.
TreeFamiTF330052.

Enzyme and pathway databases

ReactomeiREACT_303520. Lysosphingolipid and LPA receptors.
REACT_339234. G alpha (i) signalling events.

Miscellaneous databases

NextBioi609092.
PROiP47752.

Gene expression databases

GenevestigatoriP47752.

Family and domain databases

InterProiIPR004063. EDG5_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF17. PTHR22750:SF17. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01525. EDG5RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of a novel putative G protein-coupled receptor expressed in the cardiovascular system."
    Okazaki H., Ishizaka N., Sakurai T., Kurokawa K., Goto K., Kumada M., Takuwa Y.
    Biochem. Biophys. Res. Commun. 190:1104-1109(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Aortic smooth muscle.
  2. "Cloning and characterization of a putative G-protein coupled receptor potentially involved in development."
    Maclennan A.J., Browe C.S., Gaskin A.A., Lado D.C., Shaw G.
    Mol. Cell. Neurosci. 5:201-209(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain and Lung.
  3. "Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids."
    An S., Bleu T., Huang W., Hallmark O.G., Coughlin S.R., Goetzl E.J.
    FEBS Lett. 417:279-282(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  4. "Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5."
    Ancellin N., Hla T.
    J. Biol. Chem. 274:18997-19002(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHARMACOLOGICAL CHARACTERIZATION.

Entry informationi

Entry nameiS1PR2_RAT
AccessioniPrimary (citable) accession number: P47752
Secondary accession number(s): Q54AI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 1996
Last sequence update: January 31, 1996
Last modified: March 31, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.