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P47752 (S1PR2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sphingosine 1-phosphate receptor 2

Short name=S1P receptor 2
Short name=S1P2
Alternative name(s):
AGR16
Endothelial differentiation G-protein coupled receptor 5
G-protein coupled receptor H218
Sphingosine 1-phosphate receptor Edg-5
Short name=S1P receptor Edg-5
Gene names
Name:S1pr2
Synonyms:Edg5
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length352 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in all developing tissues with highest levels detected in primitive, transformed cells. Relative abundance: lung > kidney = skin = gut > spleen > brain > liver.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 352352Sphingosine 1-phosphate receptor 2
PRO_0000069429

Regions

Topological domain1 – 3434Extracellular By similarity
Transmembrane35 – 5925Helical; Name=1; By similarity
Topological domain60 – 667Cytoplasmic By similarity
Transmembrane67 – 9529Helical; Name=2; By similarity
Topological domain96 – 10914Extracellular By similarity
Transmembrane110 – 12819Helical; Name=3; By similarity
Topological domain129 – 14719Cytoplasmic By similarity
Transmembrane148 – 17326Helical; Name=4; By similarity
Topological domain174 – 18916Extracellular By similarity
Transmembrane190 – 21021Helical; Name=5; By similarity
Topological domain211 – 23323Cytoplasmic By similarity
Transmembrane234 – 25522Helical; Name=6; By similarity
Topological domain256 – 27116Extracellular By similarity
Transmembrane272 – 29221Helical; Name=7; By similarity
Topological domain293 – 35260Cytoplasmic By similarity

Amino acid modifications

Lipidation3051S-palmitoyl cysteine By similarity
Glycosylation191N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P47752 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 9C933A18E756CE1E

FASTA35238,735
        10         20         30         40         50         60 
MGGLYSEYLN PEKVQEHYNY TKETLDMQET PSRKVASAFI IILCCAIVVE NLLVLIAVAR 

        70         80         90        100        110        120 
NSKFHSAMYL FLGNLAASDL LAGVAFVANT LLSGPVTLSL TPLQWFAREG SAFITLSASV 

       130        140        150        160        170        180 
FSLLAIAIER QVAIAKVKLY GSDKSCRMLM LIGASWLISL ILGGLPILGW NCLDHLEACS 

       190        200        210        220        230        240 
TVLPLYAKHY VLCVVTIFSV ILLAIVALYV RIYFVVRSSH ADVAGPQTLA LLKTVTIVLG 

       250        260        270        280        290        300 
VFIICWLPAF SILLLDSTCP VRACPVLYKA HYFFAFATLN SLLNPVIYTW RSRDLRREVL 

       310        320        330        340        350 
RPLLCWRQGK GATGRRGGNP GHRLLPLRSS SSLERGLHMP TSPTFLEGNT VV 

« Hide

References

[1]"Molecular cloning of a novel putative G protein-coupled receptor expressed in the cardiovascular system."
Okazaki H., Ishizaka N., Sakurai T., Kurokawa K., Goto K., Kumada M., Takuwa Y.
Biochem. Biophys. Res. Commun. 190:1104-1109(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Aortic smooth muscle.
[2]"Cloning and characterization of a putative G-protein coupled receptor potentially involved in development."
Maclennan A.J., Browe C.S., Gaskin A.A., Lado D.C., Shaw G.
Mol. Cell. Neurosci. 5:201-209(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain and Lung.
[3]"Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids."
An S., Bleu T., Huang W., Hallmark O.G., Coughlin S.R., Goetzl E.J.
FEBS Lett. 417:279-282(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[4]"Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5."
Ancellin N., Hla T.
J. Biol. Chem. 274:18997-19002(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: PHARMACOLOGICAL CHARACTERIZATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB016931 mRNA. Translation: BAA32454.1.
U10699 mRNA. Translation: AAA19241.1.
AF022138 mRNA. Translation: AAC53494.1.
PIRJC1465.
RefSeqNP_058888.1. NM_017192.1.
UniGeneRn.2491.

3D structure databases

ProteinModelPortalP47752.
ModBaseSearch...
MobiDBSearch...

Chemistry

GuidetoPHARMACOLOGY276.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP47752.

Proteomic databases

PaxDbP47752.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000028034; ENSRNOP00000028034; ENSRNOG00000020653.
GeneID29415.
KEGGrno:29415.
UCSCRGD:68334. rat.

Organism-specific databases

CTD9294.
RGD68334. S1pr2.

Phylogenomic databases

eggNOGNOG149362.
GeneTreeENSGT00750000117544.
HOGENOMHOG000233501.
HOVERGENHBG103071.
InParanoidP47752.
KOK04292.
OMAKFHSAMY.
OrthoDBEOG708W0B.
PhylomeDBP47752.
TreeFamTF330052.

Gene expression databases

GenevestigatorP47752.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR004063. EDG5_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view]
PANTHERPTHR22750:SF17. PTHR22750:SF17. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01525. EDG5RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio609092.
PROP47752.

Entry information

Entry nameS1PR2_RAT
AccessionPrimary (citable) accession number: P47752
Secondary accession number(s): Q54AI6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 14, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries