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Protein

Sphingosine 1-phosphate receptor 2

Gene

S1pr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-418594. G alpha (i) signalling events.
R-RNO-419408. Lysosphingolipid and LPA receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingosine 1-phosphate receptor 2
Short name:
S1P receptor 2
Short name:
S1P2
Alternative name(s):
AGR16
Endothelial differentiation G-protein coupled receptor 5
G-protein coupled receptor H218
Sphingosine 1-phosphate receptor Edg-5
Short name:
S1P receptor Edg-5
Gene namesi
Name:S1pr2
Synonyms:Edg5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi68334. S1pr2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularBy similarityAdd BLAST34
Transmembranei35 – 59Helical; Name=1By similarityAdd BLAST25
Topological domaini60 – 66CytoplasmicBy similarity7
Transmembranei67 – 95Helical; Name=2By similarityAdd BLAST29
Topological domaini96 – 109ExtracellularBy similarityAdd BLAST14
Transmembranei110 – 128Helical; Name=3By similarityAdd BLAST19
Topological domaini129 – 147CytoplasmicBy similarityAdd BLAST19
Transmembranei148 – 173Helical; Name=4By similarityAdd BLAST26
Topological domaini174 – 189ExtracellularBy similarityAdd BLAST16
Transmembranei190 – 210Helical; Name=5By similarityAdd BLAST21
Topological domaini211 – 233CytoplasmicBy similarityAdd BLAST23
Transmembranei234 – 255Helical; Name=6By similarityAdd BLAST22
Topological domaini256 – 271ExtracellularBy similarityAdd BLAST16
Transmembranei272 – 292Helical; Name=7By similarityAdd BLAST21
Topological domaini293 – 352CytoplasmicBy similarityAdd BLAST60

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3616360.
GuidetoPHARMACOLOGYi276.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694291 – 352Sphingosine 1-phosphate receptor 2Add BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi19N-linked (GlcNAc...)Sequence analysis1
Lipidationi305S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP47752.
PRIDEiP47752.

PTM databases

iPTMnetiP47752.
PhosphoSitePlusiP47752.

Expressioni

Tissue specificityi

Expressed in all developing tissues with highest levels detected in primitive, transformed cells. Relative abundance: lung > kidney = skin = gut > spleen > brain > liver.

Gene expression databases

BgeeiENSRNOG00000020653.
GenevisibleiP47752. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028034.

Chemistry databases

BindingDBiP47752.

Structurei

3D structure databases

ProteinModelPortaliP47752.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHTX. Eukaryota.
ENOG41100F8. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiP47752.
KOiK04292.
OMAiDYACPVR.
OrthoDBiEOG091G0DD4.
PhylomeDBiP47752.
TreeFamiTF330052.

Family and domain databases

InterProiIPR004063. EDG5_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF17. PTHR22750:SF17. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01525. EDG5RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47752-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGLYSEYLN PEKVQEHYNY TKETLDMQET PSRKVASAFI IILCCAIVVE
60 70 80 90 100
NLLVLIAVAR NSKFHSAMYL FLGNLAASDL LAGVAFVANT LLSGPVTLSL
110 120 130 140 150
TPLQWFAREG SAFITLSASV FSLLAIAIER QVAIAKVKLY GSDKSCRMLM
160 170 180 190 200
LIGASWLISL ILGGLPILGW NCLDHLEACS TVLPLYAKHY VLCVVTIFSV
210 220 230 240 250
ILLAIVALYV RIYFVVRSSH ADVAGPQTLA LLKTVTIVLG VFIICWLPAF
260 270 280 290 300
SILLLDSTCP VRACPVLYKA HYFFAFATLN SLLNPVIYTW RSRDLRREVL
310 320 330 340 350
RPLLCWRQGK GATGRRGGNP GHRLLPLRSS SSLERGLHMP TSPTFLEGNT

VV
Length:352
Mass (Da):38,735
Last modified:February 1, 1996 - v1
Checksum:i9C933A18E756CE1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016931 mRNA. Translation: BAA32454.1.
U10699 mRNA. Translation: AAA19241.1.
AF022138 mRNA. Translation: AAC53494.1.
PIRiJC1465.
RefSeqiNP_058888.1. NM_017192.1.
UniGeneiRn.2491.

Genome annotation databases

EnsembliENSRNOT00000028034; ENSRNOP00000028034; ENSRNOG00000020653.
GeneIDi29415.
KEGGirno:29415.
UCSCiRGD:68334. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016931 mRNA. Translation: BAA32454.1.
U10699 mRNA. Translation: AAA19241.1.
AF022138 mRNA. Translation: AAC53494.1.
PIRiJC1465.
RefSeqiNP_058888.1. NM_017192.1.
UniGeneiRn.2491.

3D structure databases

ProteinModelPortaliP47752.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028034.

Chemistry databases

BindingDBiP47752.
ChEMBLiCHEMBL3616360.
GuidetoPHARMACOLOGYi276.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP47752.
PhosphoSitePlusiP47752.

Proteomic databases

PaxDbiP47752.
PRIDEiP47752.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028034; ENSRNOP00000028034; ENSRNOG00000020653.
GeneIDi29415.
KEGGirno:29415.
UCSCiRGD:68334. rat.

Organism-specific databases

CTDi9294.
RGDi68334. S1pr2.

Phylogenomic databases

eggNOGiENOG410IHTX. Eukaryota.
ENOG41100F8. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiP47752.
KOiK04292.
OMAiDYACPVR.
OrthoDBiEOG091G0DD4.
PhylomeDBiP47752.
TreeFamiTF330052.

Enzyme and pathway databases

ReactomeiR-RNO-418594. G alpha (i) signalling events.
R-RNO-419408. Lysosphingolipid and LPA receptors.

Miscellaneous databases

PROiP47752.

Gene expression databases

BgeeiENSRNOG00000020653.
GenevisibleiP47752. RN.

Family and domain databases

InterProiIPR004063. EDG5_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF17. PTHR22750:SF17. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01525. EDG5RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS1PR2_RAT
AccessioniPrimary (citable) accession number: P47752
Secondary accession number(s): Q54AI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.