##gff-version 3 P47750 UniProtKB Signal peptide 1 21 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P47750 UniProtKB Chain 22 764 . . . ID=PRO_0000012787;Note=Thyrotropin receptor P47750 UniProtKB Topological domain 22 413 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P47750 UniProtKB Transmembrane 414 441 . . . Note=Helical%3B Name%3D1;Ontology_term=ECO:0000255;evidence=ECO:0000255 P47750 UniProtKB Topological domain 442 450 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P47750 UniProtKB Transmembrane 451 473 . . . Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255 P47750 UniProtKB Topological domain 474 494 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P47750 UniProtKB Transmembrane 495 517 . . . Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255 P47750 UniProtKB Topological domain 518 537 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P47750 UniProtKB Transmembrane 538 560 . . . Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255 P47750 UniProtKB Topological domain 561 580 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P47750 UniProtKB Transmembrane 581 602 . . . Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255 P47750 UniProtKB Topological domain 603 625 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P47750 UniProtKB Transmembrane 626 649 . . . Note=Helical%3B Name%3D6;Ontology_term=ECO:0000255;evidence=ECO:0000255 P47750 UniProtKB Topological domain 650 660 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P47750 UniProtKB Transmembrane 661 682 . . . Note=Helical%3B Name%3D7;Ontology_term=ECO:0000255;evidence=ECO:0000255 P47750 UniProtKB Topological domain 683 764 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P47750 UniProtKB Repeat 100 124 . . . Note=LRR 1 P47750 UniProtKB Repeat 125 150 . . . Note=LRR 2 P47750 UniProtKB Repeat 151 174 . . . Note=LRR 3 P47750 UniProtKB Repeat 176 199 . . . Note=LRR 4 P47750 UniProtKB Repeat 200 223 . . . Note=LRR 5 P47750 UniProtKB Repeat 225 248 . . . Note=LRR 6 P47750 UniProtKB Repeat 264 288 . . . Note=LRR 7 P47750 UniProtKB Motif 762 764 . . . Note=PDZ-binding P47750 UniProtKB Modified residue 385 385 . . . Note=Sulfotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P16473 P47750 UniProtKB Glycosylation 77 77 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P47750 UniProtKB Glycosylation 99 99 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P47750 UniProtKB Glycosylation 177 177 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P47750 UniProtKB Glycosylation 198 198 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P47750 UniProtKB Glycosylation 302 302 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P47750 UniProtKB Disulfide bond 31 41 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00521 P47750 UniProtKB Disulfide bond 494 569 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00521 P47750 UniProtKB Natural variant 556 556 . . . Note=In hypothyroidism. P->L P47750 UniProtKB Sequence conflict 312 312 . . . Note=R->S;Ontology_term=ECO:0000305;evidence=ECO:0000305