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P47750

- TSHR_MOUSE

UniProt

P47750 - TSHR_MOUSE

Protein

Thyrotropin receptor

Gene

Tshr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5).

    GO - Molecular functioni

    1. thyroid-stimulating hormone receptor activity Source: MGI

    GO - Biological processi

    1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
    2. adult locomotory behavior Source: MGI
    3. B cell differentiation Source: MGI
    4. positive regulation of multicellular organism growth Source: MGI
    5. regulation of locomotion Source: MGI
    6. thyroid-stimulating hormone signaling pathway Source: GOC

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thyrotropin receptor
    Alternative name(s):
    Thyroid-stimulating hormone receptor
    Short name:
    TSH-R
    Gene namesi
    Name:Tshr
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:98849. Tshr.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: MGI
    3. receptor complex Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Defects in Tshr are the cause of hyt/hyt hypothyroidism, an autosomal recessive, fetal-onset, severe hypothyroidism related to TSH hyporesponsiveness and associated with elevated TSH.

    Keywords - Diseasei

    Disease mutation

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121By similarityAdd
    BLAST
    Chaini22 – 764743Thyrotropin receptorPRO_0000012787Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 41PROSITE-ProRule annotation
    Glycosylationi77 – 771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi494 ↔ 569PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP47750.
    PRIDEiP47750.

    PTM databases

    PhosphoSiteiP47750.

    Expressioni

    Gene expression databases

    BgeeiP47750.
    CleanExiMM_TSHR.
    GenevestigatoriP47750.

    Interactioni

    Subunit structurei

    Interacts (via the PDZ-binding motif) with SCRIB; regulates TSHR trafficking and function.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP47750.
    SMRiP47750. Positions 24-305, 411-686.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 413392ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini442 – 4509CytoplasmicSequence Analysis
    Topological domaini474 – 49421ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini518 – 53720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini561 – 58020ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini603 – 62523CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini650 – 66011ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini683 – 76482CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei414 – 44128Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei451 – 47323Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei495 – 51723Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei538 – 56023Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei581 – 60222Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei626 – 64924Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei661 – 68222Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati100 – 12425LRR 1Add
    BLAST
    Repeati125 – 15026LRR 2Add
    BLAST
    Repeati151 – 17424LRR 3Add
    BLAST
    Repeati176 – 19924LRR 4Add
    BLAST
    Repeati200 – 22324LRR 5Add
    BLAST
    Repeati225 – 24824LRR 6Add
    BLAST
    Repeati264 – 28825LRR 7Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi762 – 7643PDZ-binding

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.PROSITE-ProRule annotation
    Contains 7 LRR (leucine-rich) repeats.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG285844.
    GeneTreeiENSGT00730000110262.
    HOGENOMiHOG000045902.
    HOVERGENiHBG003521.
    InParanoidiQ562E4.
    KOiK04249.
    OMAiSCYVKIY.
    OrthoDBiEOG73BVCG.
    PhylomeDBiP47750.
    TreeFamiTF316814.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002131. Gphrmn_rcpt_fam.
    IPR026906. LRR_5.
    IPR002274. TSH_rcpt.
    [Graphical view]
    PANTHERiPTHR24372. PTHR24372. 1 hit.
    PTHR24372:SF0. PTHR24372:SF0. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    PF13306. LRR_5. 2 hits.
    [Graphical view]
    PRINTSiPR00373. GLYCHORMONER.
    PR00237. GPCRRHODOPSN.
    PR01145. TSHRECEPTOR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P47750-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRPGSLLLLV LLLALSRSLR GKECASPPCE CHQEDDFRVT CKELHRIPSL    50
    PPSTQTLKLI ETHLKTIPSL AFSSLPNISR IYLSIDATLQ RLEPHSFYNL 100
    SKMTHIEIRN TRSLTYIDPD ALTELPLLKF LGIFNTGLRI FPDLTKIYST 150
    DIFFILEITD NPYMTSVPEN AFQGLCNETL TLKLYNNGFT SVQGHAFNGT 200
    KLDAVYLNKN KYLTAIDNDA FGGVYSGPTL LDVSSTSVTA LPSKGLEHLK 250
    ELIAKDTWTL KKLPLSLSFL HLTRADLSYP SHCCAFKNQK KIRGILESLM 300
    CNESSIRNLR QRKSVNILRG PIYQEYEEDP GDNSVGYKQN SKFQESPSNS 350
    HYYVFFEEQE DEVVGFGQEL KNPQEETLQA FESHYDYTVC GDNEDMVCTP 400
    KSDEFNPCED IMGYRFLRIV VWFVSLLALL GNIFVLLILL TSHYKLTVPR 450
    FLMCNLAFAD FCMGVYLLLI ASVDLYTHSE YYNHAIDWQT GPGCNTAGFF 500
    TVFASELSVY TLTVITLERW YAITFAMRLD RKIRLRHAYT IMAGGWVSCF 550
    LLALLPMVGI SSYAKVSICL PMDTDTPLAL AYIVLVLLLN VVAFVVVCSC 600
    YVKIYITVRN PQYNPRDKDT KIAKRMAVLI FTDFMCMAPI SFYALSALMN 650
    KPLITVTNSK ILLVLFYPLN SCANPFLYAI FTKAFQRDVF ILLSKFGICK 700
    RQAQAYQGQR VCPNNSTGIQ IQKIPQDTRQ SLPNMQDTYE LLGNSQLAPK 750
    LQGQISEEYK QTAL 764
    Length:764
    Mass (Da):86,583
    Last modified:October 1, 1996 - v2
    Checksum:i6ADD2CC72F018317
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti312 – 3121R → S in BAB29408. (PubMed:16141072)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti556 – 5561P → L in hypothyroidism.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U02601 mRNA. Translation: AAA53209.1.
    U02602 mRNA. Translation: AAB60455.1.
    AK014519 mRNA. Translation: BAB29408.1.
    AK029084 mRNA. Translation: BAC26286.1.
    BC086691 mRNA. Translation: AAH86691.1.
    BC092523 mRNA. Translation: AAH92523.1.
    CCDSiCCDS26088.1.
    PIRiI48882.
    RefSeqiNP_035778.3. NM_011648.5.
    UniGeneiMm.173847.

    Genome annotation databases

    EnsembliENSMUST00000021346; ENSMUSP00000021346; ENSMUSG00000020963.
    GeneIDi22095.
    KEGGimmu:22095.
    UCSCiuc007okq.2. mouse.

    Cross-referencesi

    Web resourcesi

    GRIS

    Glycoprotein-hormone Receptors Information System

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U02601 mRNA. Translation: AAA53209.1 .
    U02602 mRNA. Translation: AAB60455.1 .
    AK014519 mRNA. Translation: BAB29408.1 .
    AK029084 mRNA. Translation: BAC26286.1 .
    BC086691 mRNA. Translation: AAH86691.1 .
    BC092523 mRNA. Translation: AAH92523.1 .
    CCDSi CCDS26088.1.
    PIRi I48882.
    RefSeqi NP_035778.3. NM_011648.5.
    UniGenei Mm.173847.

    3D structure databases

    ProteinModelPortali P47750.
    SMRi P47750. Positions 24-305, 411-686.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 255.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P47750.

    Proteomic databases

    PaxDbi P47750.
    PRIDEi P47750.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021346 ; ENSMUSP00000021346 ; ENSMUSG00000020963 .
    GeneIDi 22095.
    KEGGi mmu:22095.
    UCSCi uc007okq.2. mouse.

    Organism-specific databases

    CTDi 7253.
    MGIi MGI:98849. Tshr.

    Phylogenomic databases

    eggNOGi NOG285844.
    GeneTreei ENSGT00730000110262.
    HOGENOMi HOG000045902.
    HOVERGENi HBG003521.
    InParanoidi Q562E4.
    KOi K04249.
    OMAi SCYVKIY.
    OrthoDBi EOG73BVCG.
    PhylomeDBi P47750.
    TreeFami TF316814.

    Miscellaneous databases

    NextBioi 301940.
    PROi P47750.
    SOURCEi Search...

    Gene expression databases

    Bgeei P47750.
    CleanExi MM_TSHR.
    Genevestigatori P47750.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002131. Gphrmn_rcpt_fam.
    IPR026906. LRR_5.
    IPR002274. TSH_rcpt.
    [Graphical view ]
    PANTHERi PTHR24372. PTHR24372. 1 hit.
    PTHR24372:SF0. PTHR24372:SF0. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    PF13306. LRR_5. 2 hits.
    [Graphical view ]
    PRINTSi PR00373. GLYCHORMONER.
    PR00237. GPCRRHODOPSN.
    PR01145. TSHRECEPTOR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a point mutation in the thyrotropin receptor of the hyt/hyt hypothyroid mouse."
      Stein S.A., Oates E.L., Hall C.R., Grumbles R.M., Fernandez L.M., Taylor N.A., Puett D., Jin S.
      Mol. Endocrinol. 8:129-138(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Thyroid.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Skin.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Eye.

    Entry informationi

    Entry nameiTSHR_MOUSE
    AccessioniPrimary (citable) accession number: P47750
    Secondary accession number(s): Q562E4, Q9D697
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3