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P47750

- TSHR_MOUSE

UniProt

P47750 - TSHR_MOUSE

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Protein
Thyrotropin receptor
Gene
Tshr
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5).

GO - Molecular functioni

  1. thyroid-stimulating hormone receptor activity Source: MGI
Complete GO annotation...

GO - Biological processi

  1. B cell differentiation Source: MGI
  2. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  3. adult locomotory behavior Source: MGI
  4. positive regulation of multicellular organism growth Source: MGI
  5. regulation of locomotion Source: MGI
  6. thyroid-stimulating hormone signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Thyrotropin receptor
Alternative name(s):
Thyroid-stimulating hormone receptor
Short name:
TSH-R
Gene namesi
Name:Tshr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:98849. Tshr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 413392Extracellular Reviewed prediction
Add
BLAST
Transmembranei414 – 44128Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini442 – 4509Cytoplasmic Reviewed prediction
Transmembranei451 – 47323Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini474 – 49421Extracellular Reviewed prediction
Add
BLAST
Transmembranei495 – 51723Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini518 – 53720Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei538 – 56023Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini561 – 58020Extracellular Reviewed prediction
Add
BLAST
Transmembranei581 – 60222Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini603 – 62523Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei626 – 64924Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini650 – 66011Extracellular Reviewed prediction
Add
BLAST
Transmembranei661 – 68222Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini683 – 76482Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: MGI
  3. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Tshr are the cause of hyt/hyt hypothyroidism, an autosomal recessive, fetal-onset, severe hypothyroidism related to TSH hyporesponsiveness and associated with elevated TSH.

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 By similarity
Add
BLAST
Chaini22 – 764743Thyrotropin receptor
PRO_0000012787Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 41 By similarity
Glycosylationi77 – 771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi99 – 991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi177 – 1771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi198 – 1981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi302 – 3021N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi494 ↔ 569 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP47750.
PRIDEiP47750.

PTM databases

PhosphoSiteiP47750.

Expressioni

Gene expression databases

BgeeiP47750.
CleanExiMM_TSHR.
GenevestigatoriP47750.

Interactioni

Subunit structurei

Interacts (via the PDZ-binding motif) with SCRIB; regulates TSHR trafficking and function By similarity.

Structurei

3D structure databases

ProteinModelPortaliP47750.
SMRiP47750. Positions 24-305, 411-686.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati100 – 12425LRR 1
Add
BLAST
Repeati125 – 15026LRR 2
Add
BLAST
Repeati151 – 17424LRR 3
Add
BLAST
Repeati176 – 19924LRR 4
Add
BLAST
Repeati200 – 22324LRR 5
Add
BLAST
Repeati225 – 24824LRR 6
Add
BLAST
Repeati264 – 28825LRR 7
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi762 – 7643PDZ-binding

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG285844.
GeneTreeiENSGT00730000110262.
HOGENOMiHOG000045902.
HOVERGENiHBG003521.
InParanoidiQ562E4.
KOiK04249.
OMAiSCYVKIY.
OrthoDBiEOG73BVCG.
PhylomeDBiP47750.
TreeFamiTF316814.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002131. Gphrmn_rcpt_fam.
IPR026906. LRR_5.
IPR002274. TSH_rcpt.
[Graphical view]
PANTHERiPTHR24372. PTHR24372. 1 hit.
PTHR24372:SF0. PTHR24372:SF0. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
PF13306. LRR_5. 2 hits.
[Graphical view]
PRINTSiPR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
PR01145. TSHRECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47750-1 [UniParc]FASTAAdd to Basket

« Hide

MRPGSLLLLV LLLALSRSLR GKECASPPCE CHQEDDFRVT CKELHRIPSL    50
PPSTQTLKLI ETHLKTIPSL AFSSLPNISR IYLSIDATLQ RLEPHSFYNL 100
SKMTHIEIRN TRSLTYIDPD ALTELPLLKF LGIFNTGLRI FPDLTKIYST 150
DIFFILEITD NPYMTSVPEN AFQGLCNETL TLKLYNNGFT SVQGHAFNGT 200
KLDAVYLNKN KYLTAIDNDA FGGVYSGPTL LDVSSTSVTA LPSKGLEHLK 250
ELIAKDTWTL KKLPLSLSFL HLTRADLSYP SHCCAFKNQK KIRGILESLM 300
CNESSIRNLR QRKSVNILRG PIYQEYEEDP GDNSVGYKQN SKFQESPSNS 350
HYYVFFEEQE DEVVGFGQEL KNPQEETLQA FESHYDYTVC GDNEDMVCTP 400
KSDEFNPCED IMGYRFLRIV VWFVSLLALL GNIFVLLILL TSHYKLTVPR 450
FLMCNLAFAD FCMGVYLLLI ASVDLYTHSE YYNHAIDWQT GPGCNTAGFF 500
TVFASELSVY TLTVITLERW YAITFAMRLD RKIRLRHAYT IMAGGWVSCF 550
LLALLPMVGI SSYAKVSICL PMDTDTPLAL AYIVLVLLLN VVAFVVVCSC 600
YVKIYITVRN PQYNPRDKDT KIAKRMAVLI FTDFMCMAPI SFYALSALMN 650
KPLITVTNSK ILLVLFYPLN SCANPFLYAI FTKAFQRDVF ILLSKFGICK 700
RQAQAYQGQR VCPNNSTGIQ IQKIPQDTRQ SLPNMQDTYE LLGNSQLAPK 750
LQGQISEEYK QTAL 764
Length:764
Mass (Da):86,583
Last modified:October 1, 1996 - v2
Checksum:i6ADD2CC72F018317
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti556 – 5561P → L in hypothyroidism.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti312 – 3121R → S in BAB29408. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U02601 mRNA. Translation: AAA53209.1.
U02602 mRNA. Translation: AAB60455.1.
AK014519 mRNA. Translation: BAB29408.1.
AK029084 mRNA. Translation: BAC26286.1.
BC086691 mRNA. Translation: AAH86691.1.
BC092523 mRNA. Translation: AAH92523.1.
CCDSiCCDS26088.1.
PIRiI48882.
RefSeqiNP_035778.3. NM_011648.5.
UniGeneiMm.173847.

Genome annotation databases

EnsembliENSMUST00000021346; ENSMUSP00000021346; ENSMUSG00000020963.
GeneIDi22095.
KEGGimmu:22095.
UCSCiuc007okq.2. mouse.

Cross-referencesi

Web resourcesi

GRIS

Glycoprotein-hormone Receptors Information System

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U02601 mRNA. Translation: AAA53209.1 .
U02602 mRNA. Translation: AAB60455.1 .
AK014519 mRNA. Translation: BAB29408.1 .
AK029084 mRNA. Translation: BAC26286.1 .
BC086691 mRNA. Translation: AAH86691.1 .
BC092523 mRNA. Translation: AAH92523.1 .
CCDSi CCDS26088.1.
PIRi I48882.
RefSeqi NP_035778.3. NM_011648.5.
UniGenei Mm.173847.

3D structure databases

ProteinModelPortali P47750.
SMRi P47750. Positions 24-305, 411-686.
ModBasei Search...

Chemistry

GuidetoPHARMACOLOGYi 255.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P47750.

Proteomic databases

PaxDbi P47750.
PRIDEi P47750.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021346 ; ENSMUSP00000021346 ; ENSMUSG00000020963 .
GeneIDi 22095.
KEGGi mmu:22095.
UCSCi uc007okq.2. mouse.

Organism-specific databases

CTDi 7253.
MGIi MGI:98849. Tshr.

Phylogenomic databases

eggNOGi NOG285844.
GeneTreei ENSGT00730000110262.
HOGENOMi HOG000045902.
HOVERGENi HBG003521.
InParanoidi Q562E4.
KOi K04249.
OMAi SCYVKIY.
OrthoDBi EOG73BVCG.
PhylomeDBi P47750.
TreeFami TF316814.

Miscellaneous databases

NextBioi 301940.
PROi P47750.
SOURCEi Search...

Gene expression databases

Bgeei P47750.
CleanExi MM_TSHR.
Genevestigatori P47750.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002131. Gphrmn_rcpt_fam.
IPR026906. LRR_5.
IPR002274. TSH_rcpt.
[Graphical view ]
PANTHERi PTHR24372. PTHR24372. 1 hit.
PTHR24372:SF0. PTHR24372:SF0. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
PF13306. LRR_5. 2 hits.
[Graphical view ]
PRINTSi PR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
PR01145. TSHRECEPTOR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a point mutation in the thyrotropin receptor of the hyt/hyt hypothyroid mouse."
    Stein S.A., Oates E.L., Hall C.R., Grumbles R.M., Fernandez L.M., Taylor N.A., Puett D., Jin S.
    Mol. Endocrinol. 8:129-138(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Thyroid.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Skin.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Eye.

Entry informationi

Entry nameiTSHR_MOUSE
AccessioniPrimary (citable) accession number: P47750
Secondary accession number(s): Q562E4, Q9D697
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi