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Protein

Nociceptin receptor

Gene

OPRL1

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei110 – 1101Important for G protein-mediated signalingBy similarity
Sitei130 – 1301Important for G protein-mediated signalingBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Behavior

Names & Taxonomyi

Protein namesi
Recommended name:
Nociceptin receptor
Alternative name(s):
Kappa-type 3 opioid receptor
Short name:
KOR-3
Orphanin FQ receptor
XOR
Gene namesi
Name:OPRL1
Synonyms:OOR
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity
  • Cytoplasmic vesicle By similarity

  • Note: Ligand binding leads to receptor internalization into cytoplasmic vesicles, decreasing the amount of available receptor at the cell surface. Internalization may require phosphorylation. Can recycle to the cell membrane (By similarity).By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4848ExtracellularBy similarityAdd
BLAST
Transmembranei49 – 7426Helical; Name=1By similarityAdd
BLAST
Topological domaini75 – 8713CytoplasmicBy similarityAdd
BLAST
Transmembranei88 – 10922Helical; Name=2By similarityAdd
BLAST
Topological domaini110 – 12415ExtracellularBy similarityAdd
BLAST
Transmembranei125 – 14622Helical; Name=3By similarityAdd
BLAST
Topological domaini147 – 16519CytoplasmicBy similarityAdd
BLAST
Transmembranei166 – 18823Helical; Name=4By similarityAdd
BLAST
Topological domaini189 – 21123ExtracellularBy similarityAdd
BLAST
Transmembranei212 – 23625Helical; Name=5By similarityAdd
BLAST
Topological domaini237 – 26428CytoplasmicBy similarityAdd
BLAST
Transmembranei265 – 28521Helical; Name=6By similarityAdd
BLAST
Topological domaini286 – 30015ExtracellularBy similarityAdd
BLAST
Transmembranei301 – 32222Helical; Name=7By similarityAdd
BLAST
Topological domaini323 – 37048CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL5492.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Nociceptin receptorPRO_0000069979Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence analysis
Glycosylationi28 – 281N-linked (GlcNAc...)Sequence analysis
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence analysis
Disulfide bondi123 ↔ 200PROSITE-ProRule annotation
Lipidationi334 – 3341S-palmitoyl cysteineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000013520.

Chemistry

BindingDBiP47748.

Structurei

3D structure databases

ProteinModelPortaliP47748.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000230486.
HOVERGENiHBG106919.
InParanoidiP47748.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001418. Opioid_rcpt.
IPR001420. X_opioid_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00384. OPIOIDR.
PR00547. XOPIOIDR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47748-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESLFPAPFW EVLYGSHLQG NLSLLSPNHS GLPPHLLLNA SHSAFLPLGL
60 70 80 90 100
KVTIVGLYLA VCIGGLLGNC LVMYVILRHT KMKTATNIYI FNLALADTLV
110 120 130 140 150
LLTLPFQATD ILLGFWPFGN TLCKTVIAID YYNMFTSTFT LTAMSVDRYV
160 170 180 190 200
AICHPIRALD VRTSSKAQAV NVAIWALALV VGVPVAIMGS AQVEDEEIEC
210 220 230 240 250
LVEIPDPQDY WGPVFAVSIF LFSFIIPVLI ISVCYSLMIR RLHGVRLLSG
260 270 280 290 300
SREKDRNLRR ITRLVLVVVA VFVGCWTPVQ VFVLVQGLGV QPGSETTVAI
310 320 330 340 350
LRFCTALGYV NSCLNPILYA FLDENFKACF RKFCCASALH REMQVSDRVR
360 370
SIAKDVALGC KTTETVPRPA
Length:370
Mass (Da):40,789
Last modified:February 1, 1996 - v1
Checksum:iDAA807CE24283573
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04369 mRNA. Translation: AAA58332.1.
RefSeqiNP_001166462.1. NM_001172991.1.

Genome annotation databases

GeneIDi100135588.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04369 mRNA. Translation: AAA58332.1.
RefSeqiNP_001166462.1. NM_001172991.1.

3D structure databases

ProteinModelPortaliP47748.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000013520.

Chemistry

BindingDBiP47748.
ChEMBLiCHEMBL5492.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100135588.

Organism-specific databases

CTDi4987.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000230486.
HOVERGENiHBG106919.
InParanoidiP47748.

Miscellaneous databases

PROiP47748.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001418. Opioid_rcpt.
IPR001420. X_opioid_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00384. OPIOIDR.
PR00547. XOPIOIDR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Xie G.
    Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Hartley.
    Tissue: Brain.

Entry informationi

Entry nameiOPRX_CAVPO
AccessioniPrimary (citable) accession number: P47748
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 6, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.