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P47746

- CNR1_MOUSE

UniProt

P47746 - CNR1_MOUSE

Protein

Cannabinoid receptor 1

Gene

Cnr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca2+ channel current.

    GO - Molecular functioni

    1. cannabinoid receptor activity Source: UniProtKB
    2. drug binding Source: Ensembl

    GO - Biological processi

    1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: UniProtKB
    2. aging Source: Ensembl
    3. axonal fasciculation Source: MGI
    4. glucose homeostasis Source: MGI
    5. maternal process involved in female pregnancy Source: Ensembl
    6. memory Source: Ensembl
    7. negative regulation of action potential Source: Ensembl
    8. negative regulation of blood pressure Source: Ensembl
    9. negative regulation of dopamine secretion Source: Ensembl
    10. negative regulation of fatty acid beta-oxidation Source: Ensembl
    11. negative regulation of mast cell activation Source: Ensembl
    12. negative regulation of nitric-oxide synthase activity Source: Ensembl
    13. positive regulation of acute inflammatory response to antigenic stimulus Source: Ensembl
    14. positive regulation of apoptotic process Source: Ensembl
    15. positive regulation of blood pressure Source: Ensembl
    16. positive regulation of fever generation Source: Ensembl
    17. positive regulation of neuron projection development Source: Ensembl
    18. regulation of feeding behavior Source: Ensembl
    19. regulation of insulin secretion Source: Ensembl
    20. regulation of penile erection Source: Ensembl
    21. regulation of synaptic transmission, GABAergic Source: Ensembl
    22. regulation of synaptic transmission, glutamatergic Source: Ensembl
    23. response to cocaine Source: Ensembl
    24. response to ethanol Source: Ensembl
    25. response to lipopolysaccharide Source: Ensembl
    26. response to morphine Source: Ensembl
    27. response to nicotine Source: Ensembl
    28. response to nutrient Source: Ensembl
    29. sensory perception of pain Source: Ensembl
    30. spermatogenesis Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cannabinoid receptor 1
    Short name:
    CB-R
    Short name:
    CB1
    Alternative name(s):
    Brain-type cannabinoid receptor
    Gene namesi
    Name:Cnr1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:104615. Cnr1.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: MGI
    2. growth cone Source: MGI
    3. integral component of membrane Source: UniProtKB-KW
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 473473Cannabinoid receptor 1PRO_0000069316Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi84 – 841N-linked (GlcNAc...)Sequence Analysis
    Lipidationi416 – 4161S-palmitoyl cysteineBy similarity

    Post-translational modificationi

    Palmitoylation at Cys-416 is important for recruitment at both plasma membrane and lipid rafts.By similarity

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP47746.
    PRIDEiP47746.

    PTM databases

    PhosphoSiteiP47746.

    Expressioni

    Gene expression databases

    ArrayExpressiP47746.
    BgeeiP47746.
    CleanExiMM_CNR1.
    GenevestigatoriP47746.

    Interactioni

    Subunit structurei

    Interacts (via C-terminus) with CNRIP1.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP47746.
    SMRiP47746. Positions 117-417.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 117117ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini144 – 15512CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini177 – 18812ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini214 – 23320CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini257 – 27418ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini301 – 34545CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini367 – 37812ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini401 – 47373CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei118 – 14326Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei156 – 17621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei189 – 21325Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei234 – 25623Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei275 – 30026Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei346 – 36621Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei379 – 40022Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148018.
    GeneTreeiENSGT00750000117286.
    HOGENOMiHOG000049272.
    HOVERGENiHBG051045.
    InParanoidiP47746.
    KOiK04277.
    OMAiVAFCVMW.
    OrthoDBiEOG7CK36K.
    PhylomeDBiP47746.
    TreeFamiTF330052.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000810. Canbinoid_rcpt_1.
    IPR002230. Cnbnoid_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR22750:SF10. PTHR22750:SF10. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037995. Cnoid_rcpt_1. 1 hit.
    PRINTSiPR00522. CANABINOID1R.
    PR00362. CANNABINOIDR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47746-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSILDGLAD TTFRTITTDL LYVGSNDIQY EDIKGDMASK LGYFPQKFPL    50
    TSFRGSPFQE KMTAGDNSPL VPAGDTTNIT EFYNKSLSSF KENEDNIQCG 100
    ENFMDMECFM ILNPSQQLAI AVLSLTLGTF TVLENLLVLC VILHSRSLRC 150
    RPSYHFIGSL AVADLLGSVI FVYSFVDFHV FHRKDSPNVF LFKLGGVTAS 200
    FTASVGSLFL TAIDRYISIH RPLAYKRIVT RPKAVVAFCL MWTIAIVIAV 250
    LPLLGWNCKK LQSVCSDIFP LIDETYLMFW IGVTSVLLLF IVYAYMYILW 300
    KAHSHAVRMI QRGTQKSIII HTSEDGKVQV TRPDQARMDI RLAKTLVLIL 350
    VVLIICWGPL LAIMVYDVFG KMNKLIKTVF AFCSMLCLLN STVNPIIYAL 400
    RSKDLRHAFR SMFPSCEGTA QPLDNSMGDS DCLHKHANNT ASMHRAAESC 450
    IKSTVKIAKV TMSVSTDTSA EAL 473
    Length:473
    Mass (Da):52,831
    Last modified:February 1, 1996 - v1
    Checksum:iE504168191CB6429
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti9 – 91A → G in AAA57202. (PubMed:8777318)Curated
    Sequence conflicti115 – 1151S → R in AAA57202. (PubMed:8777318)Curated
    Sequence conflicti211 – 2111T → R in AAA57202. (PubMed:8777318)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U17985 mRNA. Translation: AAA57202.1.
    U40709 mRNA. Translation: AAA91176.1.
    Y18374 Genomic DNA. Translation: CAB42647.1.
    AY522555 Genomic DNA. Translation: AAS91801.1.
    AY522554 mRNA. Translation: AAS91800.1.
    U22948 Genomic DNA. Translation: AAA64413.1.
    AF153345 mRNA. Translation: AAD34624.1.
    AK139417 mRNA. Translation: BAE24003.1.
    BC070447 mRNA. Translation: AAH70447.1.
    BC079564 mRNA. Translation: AAH79564.1.
    CCDSiCCDS18025.1.
    RefSeqiNP_031752.1. NM_007726.3.
    XP_006537654.1. XM_006537591.1.
    XP_006537655.1. XM_006537592.1.
    XP_006537656.1. XM_006537593.1.
    XP_006537657.1. XM_006537594.1.
    XP_006537658.1. XM_006537595.1.
    UniGeneiMm.7992.

    Genome annotation databases

    EnsembliENSMUST00000057188; ENSMUSP00000055797; ENSMUSG00000044288.
    ENSMUST00000084736; ENSMUSP00000081787; ENSMUSG00000044288.
    GeneIDi12801.
    KEGGimmu:12801.
    UCSCiuc008sfw.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U17985 mRNA. Translation: AAA57202.1 .
    U40709 mRNA. Translation: AAA91176.1 .
    Y18374 Genomic DNA. Translation: CAB42647.1 .
    AY522555 Genomic DNA. Translation: AAS91801.1 .
    AY522554 mRNA. Translation: AAS91800.1 .
    U22948 Genomic DNA. Translation: AAA64413.1 .
    AF153345 mRNA. Translation: AAD34624.1 .
    AK139417 mRNA. Translation: BAE24003.1 .
    BC070447 mRNA. Translation: AAH70447.1 .
    BC079564 mRNA. Translation: AAH79564.1 .
    CCDSi CCDS18025.1.
    RefSeqi NP_031752.1. NM_007726.3.
    XP_006537654.1. XM_006537591.1.
    XP_006537655.1. XM_006537592.1.
    XP_006537656.1. XM_006537593.1.
    XP_006537657.1. XM_006537594.1.
    XP_006537658.1. XM_006537595.1.
    UniGenei Mm.7992.

    3D structure databases

    ProteinModelPortali P47746.
    SMRi P47746. Positions 117-417.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P47746.
    ChEMBLi CHEMBL3037.
    GuidetoPHARMACOLOGYi 56.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P47746.

    Proteomic databases

    PaxDbi P47746.
    PRIDEi P47746.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000057188 ; ENSMUSP00000055797 ; ENSMUSG00000044288 .
    ENSMUST00000084736 ; ENSMUSP00000081787 ; ENSMUSG00000044288 .
    GeneIDi 12801.
    KEGGi mmu:12801.
    UCSCi uc008sfw.1. mouse.

    Organism-specific databases

    CTDi 1268.
    MGIi MGI:104615. Cnr1.

    Phylogenomic databases

    eggNOGi NOG148018.
    GeneTreei ENSGT00750000117286.
    HOGENOMi HOG000049272.
    HOVERGENi HBG051045.
    InParanoidi P47746.
    KOi K04277.
    OMAi VAFCVMW.
    OrthoDBi EOG7CK36K.
    PhylomeDBi P47746.
    TreeFami TF330052.

    Miscellaneous databases

    NextBioi 282226.
    PROi P47746.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P47746.
    Bgeei P47746.
    CleanExi MM_CNR1.
    Genevestigatori P47746.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000810. Canbinoid_rcpt_1.
    IPR002230. Cnbnoid_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR22750:SF10. PTHR22750:SF10. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037995. Cnoid_rcpt_1. 1 hit.
    PRINTSi PR00522. CANABINOID1R.
    PR00362. CANNABINOIDR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of a cDNA encoding the mouse brain-type cannabinoid receptor protein."
      Chakrabarti A., Onaivi E.S., Chaudhuri G.
      DNA Seq. 5:385-388(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    2. "Determination of the cannabinoid receptors in mouse x rat hybridoma NG108-15 cells and rat GH4C1 cells."
      Ho B.Y., Zhao J.
      Neurosci. Lett. 212:123-126(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice."
      Ledent C., Valverde O., Cossu G., Petitet F., Aubert J.F., Beslot F., Boehme G.A., Imperato A., Pedrazzini T., Roques B.P., Vassart G., Fratta W., Parmentier M.
      Science 283:401-404(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    4. "Structure, expression and regulation of the cannabinoid receptor gene (CB1) in Huntington's disease transgenic mice."
      McCaw E.A., Hu H., Gomez G.T., Hebb A.L., Kelly M.E., Denovan-Wright E.M.
      Eur. J. Biochem. 271:4909-4920(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: C57BL/6 X CBA.
    5. Bonner T.I.
      Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129.
    6. "cDNA cloning and expression analysis of mouse cannabinoid receptor (CB1) gene."
      Yuan Z.-Q., Li L., Qiu B.-S., Song D.-K.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    7. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Brain cortex.
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiCNR1_MOUSE
    AccessioniPrimary (citable) accession number: P47746
    Secondary accession number(s): Q5SF33
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3