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Protein

Cannabinoid receptor 1

Gene

Cnr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca2+ channel current.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-373076. Class A/1 (Rhodopsin-like receptors).
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Cannabinoid receptor 1
Short name:
CB-R
Short name:
CB1
Alternative name(s):
Brain-type cannabinoid receptor
Gene namesi
Name:Cnr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:104615. Cnr1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 117ExtracellularSequence analysisAdd BLAST117
Transmembranei118 – 143Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini144 – 155CytoplasmicSequence analysisAdd BLAST12
Transmembranei156 – 176Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini177 – 188ExtracellularSequence analysisAdd BLAST12
Transmembranei189 – 213Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini214 – 233CytoplasmicSequence analysisAdd BLAST20
Transmembranei234 – 256Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini257 – 274ExtracellularSequence analysisAdd BLAST18
Transmembranei275 – 300Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini301 – 345CytoplasmicSequence analysisAdd BLAST45
Transmembranei346 – 366Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini367 – 378ExtracellularSequence analysisAdd BLAST12
Transmembranei379 – 400Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini401 – 473CytoplasmicSequence analysisAdd BLAST73

GO - Cellular componenti

  • axon Source: MGI
  • growth cone Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • intracellular membrane-bounded organelle Source: Ensembl
  • membrane raft Source: Ensembl
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3037.
GuidetoPHARMACOLOGYi56.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693161 – 473Cannabinoid receptor 1Add BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi78N-linked (GlcNAc...)Sequence analysis1
Glycosylationi84N-linked (GlcNAc...)Sequence analysis1
Lipidationi416S-palmitoyl cysteineBy similarity1
Modified residuei426PhosphoserineCombined sources1
Modified residuei430PhosphoserineCombined sources1

Post-translational modificationi

Palmitoylation at Cys-416 is important for recruitment at both plasma membrane and lipid rafts.By similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiP47746.
PaxDbiP47746.
PeptideAtlasiP47746.
PRIDEiP47746.

PTM databases

iPTMnetiP47746.
PhosphoSitePlusiP47746.
SwissPalmiP47746.

Expressioni

Gene expression databases

BgeeiENSMUSG00000044288.
CleanExiMM_CNR1.
GenevisibleiP47746. MM.

Interactioni

Subunit structurei

Interacts (via C-terminus) with CNRIP1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055797.

Chemistry databases

BindingDBiP47746.

Structurei

3D structure databases

ProteinModelPortaliP47746.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000049272.
HOVERGENiHBG051045.
InParanoidiP47746.
KOiK04277.
OMAiVAFCVMW.
OrthoDBiEOG091G05O3.
PhylomeDBiP47746.
TreeFamiTF330052.

Family and domain databases

InterProiIPR000810. Canbinoid_rcpt_1.
IPR002230. Cnbnoid_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PIRSFiPIRSF037995. Cnoid_rcpt_1. 1 hit.
PRINTSiPR00522. CANABINOID1R.
PR00362. CANNABINOIDR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47746-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSILDGLAD TTFRTITTDL LYVGSNDIQY EDIKGDMASK LGYFPQKFPL
60 70 80 90 100
TSFRGSPFQE KMTAGDNSPL VPAGDTTNIT EFYNKSLSSF KENEDNIQCG
110 120 130 140 150
ENFMDMECFM ILNPSQQLAI AVLSLTLGTF TVLENLLVLC VILHSRSLRC
160 170 180 190 200
RPSYHFIGSL AVADLLGSVI FVYSFVDFHV FHRKDSPNVF LFKLGGVTAS
210 220 230 240 250
FTASVGSLFL TAIDRYISIH RPLAYKRIVT RPKAVVAFCL MWTIAIVIAV
260 270 280 290 300
LPLLGWNCKK LQSVCSDIFP LIDETYLMFW IGVTSVLLLF IVYAYMYILW
310 320 330 340 350
KAHSHAVRMI QRGTQKSIII HTSEDGKVQV TRPDQARMDI RLAKTLVLIL
360 370 380 390 400
VVLIICWGPL LAIMVYDVFG KMNKLIKTVF AFCSMLCLLN STVNPIIYAL
410 420 430 440 450
RSKDLRHAFR SMFPSCEGTA QPLDNSMGDS DCLHKHANNT ASMHRAAESC
460 470
IKSTVKIAKV TMSVSTDTSA EAL
Length:473
Mass (Da):52,831
Last modified:February 1, 1996 - v1
Checksum:iE504168191CB6429
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9A → G in AAA57202 (PubMed:8777318).Curated1
Sequence conflicti115S → R in AAA57202 (PubMed:8777318).Curated1
Sequence conflicti211T → R in AAA57202 (PubMed:8777318).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17985 mRNA. Translation: AAA57202.1.
U40709 mRNA. Translation: AAA91176.1.
Y18374 Genomic DNA. Translation: CAB42647.1.
AY522555 Genomic DNA. Translation: AAS91801.1.
AY522554 mRNA. Translation: AAS91800.1.
U22948 Genomic DNA. Translation: AAA64413.1.
AF153345 mRNA. Translation: AAD34624.1.
AK139417 mRNA. Translation: BAE24003.1.
BC070447 mRNA. Translation: AAH70447.1.
BC079564 mRNA. Translation: AAH79564.1.
CCDSiCCDS18025.1.
RefSeqiNP_031752.1. NM_007726.3.
XP_006537654.1. XM_006537591.2.
XP_006537655.1. XM_006537592.3.
XP_006537656.1. XM_006537593.3.
XP_006537657.1. XM_006537594.2.
XP_006537658.1. XM_006537595.2.
XP_017175428.1. XM_017319939.1.
UniGeneiMm.7992.

Genome annotation databases

EnsembliENSMUST00000057188; ENSMUSP00000055797; ENSMUSG00000044288.
ENSMUST00000084736; ENSMUSP00000081787; ENSMUSG00000044288.
GeneIDi12801.
KEGGimmu:12801.
UCSCiuc008sfw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17985 mRNA. Translation: AAA57202.1.
U40709 mRNA. Translation: AAA91176.1.
Y18374 Genomic DNA. Translation: CAB42647.1.
AY522555 Genomic DNA. Translation: AAS91801.1.
AY522554 mRNA. Translation: AAS91800.1.
U22948 Genomic DNA. Translation: AAA64413.1.
AF153345 mRNA. Translation: AAD34624.1.
AK139417 mRNA. Translation: BAE24003.1.
BC070447 mRNA. Translation: AAH70447.1.
BC079564 mRNA. Translation: AAH79564.1.
CCDSiCCDS18025.1.
RefSeqiNP_031752.1. NM_007726.3.
XP_006537654.1. XM_006537591.2.
XP_006537655.1. XM_006537592.3.
XP_006537656.1. XM_006537593.3.
XP_006537657.1. XM_006537594.2.
XP_006537658.1. XM_006537595.2.
XP_017175428.1. XM_017319939.1.
UniGeneiMm.7992.

3D structure databases

ProteinModelPortaliP47746.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055797.

Chemistry databases

BindingDBiP47746.
ChEMBLiCHEMBL3037.
GuidetoPHARMACOLOGYi56.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP47746.
PhosphoSitePlusiP47746.
SwissPalmiP47746.

Proteomic databases

MaxQBiP47746.
PaxDbiP47746.
PeptideAtlasiP47746.
PRIDEiP47746.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057188; ENSMUSP00000055797; ENSMUSG00000044288.
ENSMUST00000084736; ENSMUSP00000081787; ENSMUSG00000044288.
GeneIDi12801.
KEGGimmu:12801.
UCSCiuc008sfw.1. mouse.

Organism-specific databases

CTDi1268.
MGIiMGI:104615. Cnr1.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000049272.
HOVERGENiHBG051045.
InParanoidiP47746.
KOiK04277.
OMAiVAFCVMW.
OrthoDBiEOG091G05O3.
PhylomeDBiP47746.
TreeFamiTF330052.

Enzyme and pathway databases

ReactomeiR-MMU-373076. Class A/1 (Rhodopsin-like receptors).
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiP47746.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044288.
CleanExiMM_CNR1.
GenevisibleiP47746. MM.

Family and domain databases

InterProiIPR000810. Canbinoid_rcpt_1.
IPR002230. Cnbnoid_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PIRSFiPIRSF037995. Cnoid_rcpt_1. 1 hit.
PRINTSiPR00522. CANABINOID1R.
PR00362. CANNABINOIDR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNR1_MOUSE
AccessioniPrimary (citable) accession number: P47746
Secondary accession number(s): Q5SF33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.