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P47746

- CNR1_MOUSE

UniProt

P47746 - CNR1_MOUSE

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Protein
Cannabinoid receptor 1
Gene
Cnr1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca2+ channel current.

GO - Molecular functioni

  1. cannabinoid receptor activity Source: UniProtKB
  2. drug binding Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: UniProtKB
  2. aging Source: Ensembl
  3. glucose homeostasis Source: MGI
  4. maternal process involved in female pregnancy Source: Ensembl
  5. memory Source: Ensembl
  6. negative regulation of action potential Source: Ensembl
  7. negative regulation of blood pressure Source: Ensembl
  8. negative regulation of dopamine secretion Source: Ensembl
  9. negative regulation of fatty acid beta-oxidation Source: Ensembl
  10. negative regulation of mast cell activation Source: Ensembl
  11. negative regulation of nitric-oxide synthase activity Source: Ensembl
  12. positive regulation of acute inflammatory response to antigenic stimulus Source: Ensembl
  13. positive regulation of apoptotic process Source: Ensembl
  14. positive regulation of blood pressure Source: Ensembl
  15. positive regulation of fever generation Source: Ensembl
  16. positive regulation of neuron projection development Source: Ensembl
  17. regulation of feeding behavior Source: Ensembl
  18. regulation of insulin secretion Source: Ensembl
  19. regulation of penile erection Source: Ensembl
  20. regulation of synaptic transmission, GABAergic Source: Ensembl
  21. regulation of synaptic transmission, glutamatergic Source: Ensembl
  22. response to cocaine Source: Ensembl
  23. response to ethanol Source: Ensembl
  24. response to lipopolysaccharide Source: Ensembl
  25. response to morphine Source: Ensembl
  26. response to nicotine Source: Ensembl
  27. response to nutrient Source: Ensembl
  28. sensory perception of pain Source: Ensembl
  29. spermatogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Cannabinoid receptor 1
Short name:
CB-R
Short name:
CB1
Alternative name(s):
Brain-type cannabinoid receptor
Gene namesi
Name:Cnr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:104615. Cnr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 117117Extracellular Reviewed prediction
Add
BLAST
Transmembranei118 – 14326Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini144 – 15512Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei156 – 17621Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini177 – 18812Extracellular Reviewed prediction
Add
BLAST
Transmembranei189 – 21325Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini214 – 23320Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei234 – 25623Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini257 – 27418Extracellular Reviewed prediction
Add
BLAST
Transmembranei275 – 30026Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini301 – 34545Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei346 – 36621Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini367 – 37812Extracellular Reviewed prediction
Add
BLAST
Transmembranei379 – 40022Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini401 – 47373Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473Cannabinoid receptor 1
PRO_0000069316Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi78 – 781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi84 – 841N-linked (GlcNAc...) Reviewed prediction
Lipidationi416 – 4161S-palmitoyl cysteine By similarity

Post-translational modificationi

Palmitoylation at Cys-416 is important for recruitment at both plasma membrane and lipid rafts By similarity.

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP47746.
PRIDEiP47746.

PTM databases

PhosphoSiteiP47746.

Expressioni

Gene expression databases

ArrayExpressiP47746.
BgeeiP47746.
CleanExiMM_CNR1.
GenevestigatoriP47746.

Interactioni

Subunit structurei

Interacts (via C-terminus) with CNRIP1 By similarity.

Structurei

3D structure databases

ProteinModelPortaliP47746.
SMRiP47746. Positions 117-417.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148018.
GeneTreeiENSGT00750000117286.
HOGENOMiHOG000049272.
HOVERGENiHBG051045.
InParanoidiP47746.
KOiK04277.
OMAiVAFCVMW.
OrthoDBiEOG7CK36K.
PhylomeDBiP47746.
TreeFamiTF330052.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000810. Canbinoid_rcpt_1.
IPR002230. Cnbnoid_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR22750:SF10. PTHR22750:SF10. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PIRSFiPIRSF037995. Cnoid_rcpt_1. 1 hit.
PRINTSiPR00522. CANABINOID1R.
PR00362. CANNABINOIDR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47746-1 [UniParc]FASTAAdd to Basket

« Hide

MKSILDGLAD TTFRTITTDL LYVGSNDIQY EDIKGDMASK LGYFPQKFPL    50
TSFRGSPFQE KMTAGDNSPL VPAGDTTNIT EFYNKSLSSF KENEDNIQCG 100
ENFMDMECFM ILNPSQQLAI AVLSLTLGTF TVLENLLVLC VILHSRSLRC 150
RPSYHFIGSL AVADLLGSVI FVYSFVDFHV FHRKDSPNVF LFKLGGVTAS 200
FTASVGSLFL TAIDRYISIH RPLAYKRIVT RPKAVVAFCL MWTIAIVIAV 250
LPLLGWNCKK LQSVCSDIFP LIDETYLMFW IGVTSVLLLF IVYAYMYILW 300
KAHSHAVRMI QRGTQKSIII HTSEDGKVQV TRPDQARMDI RLAKTLVLIL 350
VVLIICWGPL LAIMVYDVFG KMNKLIKTVF AFCSMLCLLN STVNPIIYAL 400
RSKDLRHAFR SMFPSCEGTA QPLDNSMGDS DCLHKHANNT ASMHRAAESC 450
IKSTVKIAKV TMSVSTDTSA EAL 473
Length:473
Mass (Da):52,831
Last modified:February 1, 1996 - v1
Checksum:iE504168191CB6429
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91A → G in AAA57202. 1 Publication
Sequence conflicti115 – 1151S → R in AAA57202. 1 Publication
Sequence conflicti211 – 2111T → R in AAA57202. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U17985 mRNA. Translation: AAA57202.1.
U40709 mRNA. Translation: AAA91176.1.
Y18374 Genomic DNA. Translation: CAB42647.1.
AY522555 Genomic DNA. Translation: AAS91801.1.
AY522554 mRNA. Translation: AAS91800.1.
U22948 Genomic DNA. Translation: AAA64413.1.
AF153345 mRNA. Translation: AAD34624.1.
AK139417 mRNA. Translation: BAE24003.1.
BC070447 mRNA. Translation: AAH70447.1.
BC079564 mRNA. Translation: AAH79564.1.
CCDSiCCDS18025.1.
RefSeqiNP_031752.1. NM_007726.3.
XP_006537654.1. XM_006537591.1.
XP_006537655.1. XM_006537592.1.
XP_006537656.1. XM_006537593.1.
XP_006537657.1. XM_006537594.1.
XP_006537658.1. XM_006537595.1.
UniGeneiMm.7992.

Genome annotation databases

EnsembliENSMUST00000057188; ENSMUSP00000055797; ENSMUSG00000044288.
ENSMUST00000084736; ENSMUSP00000081787; ENSMUSG00000044288.
GeneIDi12801.
KEGGimmu:12801.
UCSCiuc008sfw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U17985 mRNA. Translation: AAA57202.1 .
U40709 mRNA. Translation: AAA91176.1 .
Y18374 Genomic DNA. Translation: CAB42647.1 .
AY522555 Genomic DNA. Translation: AAS91801.1 .
AY522554 mRNA. Translation: AAS91800.1 .
U22948 Genomic DNA. Translation: AAA64413.1 .
AF153345 mRNA. Translation: AAD34624.1 .
AK139417 mRNA. Translation: BAE24003.1 .
BC070447 mRNA. Translation: AAH70447.1 .
BC079564 mRNA. Translation: AAH79564.1 .
CCDSi CCDS18025.1.
RefSeqi NP_031752.1. NM_007726.3.
XP_006537654.1. XM_006537591.1.
XP_006537655.1. XM_006537592.1.
XP_006537656.1. XM_006537593.1.
XP_006537657.1. XM_006537594.1.
XP_006537658.1. XM_006537595.1.
UniGenei Mm.7992.

3D structure databases

ProteinModelPortali P47746.
SMRi P47746. Positions 117-417.
ModBasei Search...

Chemistry

BindingDBi P47746.
ChEMBLi CHEMBL3037.
GuidetoPHARMACOLOGYi 56.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P47746.

Proteomic databases

PaxDbi P47746.
PRIDEi P47746.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000057188 ; ENSMUSP00000055797 ; ENSMUSG00000044288 .
ENSMUST00000084736 ; ENSMUSP00000081787 ; ENSMUSG00000044288 .
GeneIDi 12801.
KEGGi mmu:12801.
UCSCi uc008sfw.1. mouse.

Organism-specific databases

CTDi 1268.
MGIi MGI:104615. Cnr1.

Phylogenomic databases

eggNOGi NOG148018.
GeneTreei ENSGT00750000117286.
HOGENOMi HOG000049272.
HOVERGENi HBG051045.
InParanoidi P47746.
KOi K04277.
OMAi VAFCVMW.
OrthoDBi EOG7CK36K.
PhylomeDBi P47746.
TreeFami TF330052.

Miscellaneous databases

NextBioi 282226.
PROi P47746.
SOURCEi Search...

Gene expression databases

ArrayExpressi P47746.
Bgeei P47746.
CleanExi MM_CNR1.
Genevestigatori P47746.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000810. Canbinoid_rcpt_1.
IPR002230. Cnbnoid_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR22750:SF10. PTHR22750:SF10. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF037995. Cnoid_rcpt_1. 1 hit.
PRINTSi PR00522. CANABINOID1R.
PR00362. CANNABINOIDR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of a cDNA encoding the mouse brain-type cannabinoid receptor protein."
    Chakrabarti A., Onaivi E.S., Chaudhuri G.
    DNA Seq. 5:385-388(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  2. "Determination of the cannabinoid receptors in mouse x rat hybridoma NG108-15 cells and rat GH4C1 cells."
    Ho B.Y., Zhao J.
    Neurosci. Lett. 212:123-126(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice."
    Ledent C., Valverde O., Cossu G., Petitet F., Aubert J.F., Beslot F., Boehme G.A., Imperato A., Pedrazzini T., Roques B.P., Vassart G., Fratta W., Parmentier M.
    Science 283:401-404(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  4. "Structure, expression and regulation of the cannabinoid receptor gene (CB1) in Huntington's disease transgenic mice."
    McCaw E.A., Hu H., Gomez G.T., Hebb A.L., Kelly M.E., Denovan-Wright E.M.
    Eur. J. Biochem. 271:4909-4920(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: C57BL/6 X CBA.
  5. Bonner T.I.
    Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.
  6. "cDNA cloning and expression analysis of mouse cannabinoid receptor (CB1) gene."
    Yuan Z.-Q., Li L., Qiu B.-S., Song D.-K.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  7. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain cortex.
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiCNR1_MOUSE
AccessioniPrimary (citable) accession number: P47746
Secondary accession number(s): Q5SF33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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