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Protein

Adenosine receptor A1

Gene

ADORA1

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A1
Gene namesi
Name:ADORA1
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010ExtracellularSequence analysis
Transmembranei11 – 3323Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini34 – 4613CytoplasmicSequence analysisAdd
BLAST
Transmembranei47 – 6923Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini70 – 8011ExtracellularSequence analysisAdd
BLAST
Transmembranei81 – 10222Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini103 – 12321CytoplasmicSequence analysisAdd
BLAST
Transmembranei124 – 14623Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini147 – 17630ExtracellularSequence analysisAdd
BLAST
Transmembranei177 – 20125Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini202 – 23534CytoplasmicSequence analysisAdd
BLAST
Transmembranei236 – 25924Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini260 – 2678ExtracellularSequence analysis
Transmembranei268 – 29225Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini293 – 32634CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2304404.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Adenosine receptor A1PRO_0000068990Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi80 ↔ 169PROSITE-ProRule annotation
Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence analysis
Lipidationi309 – 3091S-palmitoyl cysteineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Interactioni

Protein-protein interaction databases

DIPiDIP-440N.
STRINGi10141.ENSCPOP00000004686.

Chemistry

BindingDBiP47745.

Structurei

3D structure databases

ProteinModelPortaliP47745.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00550000074524.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
InParanoidiP47745.
OMAiMAWAANG.
OrthoDBiEOG79SDXQ.
TreeFamiTF325296.

Family and domain databases

InterProiIPR001068. Adeno_A1_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00552. ADENOSINEA1R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47745-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHSVSAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIAS
60 70 80 90 100
LAVADVAVGA LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILALLA
110 120 130 140 150
IAVDRYLRVK IPLRYKTVVT PRRAAVAIAG CWILSLVVGL TPMFGWNNLS
160 170 180 190 200
KIEMAWAANG SVGEPVIKCE FEKVISMEYM VYFNFFVWVL PPLLLMVLIY
210 220 230 240 250
LEVFYLIRKQ LSKKVSASSG DPQKYYGKEL KIAKSLALIL FLFALSWLPL
260 270 280 290 300
HILNCITLFC PTCHKPTILT YIAIFLTHGN SAMNPIVYAF RIQKFRVTFL
310 320
KIWNDHFRCQ PEPPIDEDLP EEKVDD
Length:326
Mass (Da):36,493
Last modified:February 1, 1996 - v1
Checksum:iA2E8D594F5D6A233
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04279 mRNA. Translation: AAB60505.1.
PIRiI48096.
RefSeqiNP_001166382.1. NM_001172911.1.
XP_013013249.1. XM_013157795.1.
XP_013013250.1. XM_013157796.1.
XP_013013251.1. XM_013157797.1.
XP_013013252.1. XM_013157798.1.

Genome annotation databases

EnsembliENSCPOT00000005268; ENSCPOP00000004686; ENSCPOG00000005213.
GeneIDi100135472.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04279 mRNA. Translation: AAB60505.1.
PIRiI48096.
RefSeqiNP_001166382.1. NM_001172911.1.
XP_013013249.1. XM_013157795.1.
XP_013013250.1. XM_013157796.1.
XP_013013251.1. XM_013157797.1.
XP_013013252.1. XM_013157798.1.

3D structure databases

ProteinModelPortaliP47745.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-440N.
STRINGi10141.ENSCPOP00000004686.

Chemistry

BindingDBiP47745.
ChEMBLiCHEMBL2304404.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCPOT00000005268; ENSCPOP00000004686; ENSCPOG00000005213.
GeneIDi100135472.

Organism-specific databases

CTDi134.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00550000074524.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
InParanoidiP47745.
OMAiMAWAANG.
OrthoDBiEOG79SDXQ.
TreeFamiTF325296.

Miscellaneous databases

PROiP47745.

Family and domain databases

InterProiIPR001068. Adeno_A1_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00552. ADENOSINEA1R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of a pharmacologically distinct A1 adenosine receptor from guinea pig brain."
    Meng F., Xie G.X., Chalmers D., Morgan C., Watson S.J. Jr., Akil H.
    Brain Res. Mol. Brain Res. 26:143-155(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Hartley.
    Tissue: Brain.

Entry informationi

Entry nameiAA1R_CAVPO
AccessioniPrimary (citable) accession number: P47745
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 8, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.