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P47741 (TNR4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tumor necrosis factor receptor superfamily member 4
Alternative name(s):
OX40 antigen
OX40L receptor
CD_antigen=CD134
Gene names
Name:Tnfrsf4
Synonyms:Ox40, Txgp1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length272 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for TNFSF4/OX40L/GP34.

Subunit structure

Interacts with TRAF2, TRAF3 and TRAF5 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Contains 4 TNFR-Cys repeats.

Ontologies

Keywords
   Cellular componentMembrane
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular defense response

Inferred from mutant phenotype PubMed 10586044. Source: MGI

inflammatory response

Inferred from mutant phenotype PubMed 14730361. Source: MGI

negative regulation of activation-induced cell death of T cells

Inferred from mutant phenotype PubMed 11567634. Source: BHF-UCL

negative regulation of cytokine secretion

Inferred from physical interaction PubMed 14635034. Source: MGI

negative regulation of extrinsic apoptotic signaling pathway

Inferred from mutant phenotype PubMed 11567634. Source: BHF-UCL

negative regulation of sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 7749983. Source: BHF-UCL

negative regulation of transcription, DNA-templated

Inferred from direct assay PubMed 7749983. Source: BHF-UCL

positive regulation of B cell proliferation

Inferred from mutant phenotype PubMed 7749983. Source: BHF-UCL

positive regulation of immunoglobulin secretion

Inferred from direct assay PubMed 7749983. Source: BHF-UCL

regulation of apoptotic process

Inferred from mutant phenotype PubMed 14730361. Source: MGI

regulation of protein kinase activity

Inferred from mutant phenotype PubMed 14730361. Source: MGI

tumor necrosis factor-mediated signaling pathway

Inferred from physical interaction PubMed 14635034. Source: GOC

   Cellular_componentexternal side of plasma membrane

Inferred from direct assay PubMed 16301745PubMed 19008373. Source: MGI

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from direct assay PubMed 10586044. Source: MGI

   Molecular_functiontumor necrosis factor-activated receptor activity

Inferred from physical interaction PubMed 14635034. Source: MGI

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Traf2P394293EBI-520001,EBI-520016
Traf3Q608033EBI-520001,EBI-520135

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 272253Tumor necrosis factor receptor superfamily member 4
PRO_0000034555

Regions

Topological domain20 – 211192Extracellular Potential
Transmembrane212 – 23625Helical; Potential
Topological domain237 – 27236Cytoplasmic Potential
Repeat26 – 6136TNFR-Cys 1
Repeat62 – 10342TNFR-Cys 2
Repeat104 – 12421TNFR-Cys 3; truncated
Repeat125 – 16541TNFR-Cys 4

Amino acid modifications

Glycosylation1441N-linked (GlcNAc...) Potential
Disulfide bond27 ↔ 38 By similarity
Disulfide bond39 ↔ 52 By similarity
Disulfide bond42 ↔ 60 By similarity
Disulfide bond63 ↔ 77 By similarity
Disulfide bond80 ↔ 95 By similarity
Disulfide bond83 ↔ 103 By similarity
Disulfide bond105 ↔ 123 By similarity
Disulfide bond126 ↔ 139 By similarity
Disulfide bond145 ↔ 164 By similarity

Experimental info

Sequence conflict151A → G in CAA59476. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P47741 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 06E7BB4156F0D08E

FASTA27230,154
        10         20         30         40         50         60 
MYVWVQQPTA LLLLALTLGV TARRLNCVKH TYPSGHKCCR ECQPGHGMVS RCDHTRDTLC 

        70         80         90        100        110        120 
HPCETGFYNE AVNYDTCKQC TQCNHRSGSE LKQNCTPTQD TVCRCRPGTQ PRQDSGYKLG 

       130        140        150        160        170        180 
VDCVPCPPGH FSPGNNQACK PWTNCTLSGK QTRHPASDSL DAVCEDRSLL ATLLWETQRP 

       190        200        210        220        230        240 
TFRPTTVQST TVWPRTSELP SPPTLVTPEG PAFAVLLGLG LGLLAPLTVL LALYLLRKAW 

       250        260        270 
RLPNTPKPCW GNSFRTPIQE EHTDAHFTLA KI 

« Hide

References

[1]"Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions."
Calderhead D.M., Buhlmann J.E., van den Eertwegh A.J., Claassen E., Noelle R.J., Fell H.
J. Immunol. 151:5261-5271(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[2]"Gene structure and chromosomal localization of the mouse homologue of rat OX40 protein."
Birkeland M.L., Copeland N.G., Gilbert D.J., Jenkins N.A., Barclay A.N.
Eur. J. Immunol. 25:926-930(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z21674 mRNA. Translation: CAA79772.1.
X85214 Genomic DNA. Translation: CAA59476.1.
PIRI48700.
RefSeqNP_035789.1. NM_011659.2.
UniGeneMm.13885.

3D structure databases

ProteinModelPortalP47741.
SMRP47741. Positions 25-166.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-6239N.
IntActP47741. 4 interactions.

Proteomic databases

PRIDEP47741.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID22163.
KEGGmmu:22163.

Organism-specific databases

CTD7293.
MGIMGI:104512. Tnfrsf4.

Phylogenomic databases

eggNOGNOG43906.
HOGENOMHOG000049154.
HOVERGENHBG005031.
InParanoidP47741.
KOK05142.
PhylomeDBP47741.

Gene expression databases

GenevestigatorP47741.

Family and domain databases

InterProIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020445. TNFR_4.
[Graphical view]
PfamPF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSPR01921. TNFACTORR4.
SMARTSM00208. TNFR. 3 hits.
[Graphical view]
PROSITEPS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio302094.
PROP47741.
SOURCESearch...

Entry information

Entry nameTNR4_MOUSE
AccessionPrimary (citable) accession number: P47741
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot