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P47741

- TNR4_MOUSE

UniProt

P47741 - TNR4_MOUSE

Protein

Tumor necrosis factor receptor superfamily member 4

Gene

Tnfrsf4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. tumor necrosis factor-activated receptor activity Source: MGI

    GO - Biological processi

    1. cellular defense response Source: MGI
    2. inflammatory response Source: MGI
    3. negative regulation of activation-induced cell death of T cells Source: BHF-UCL
    4. negative regulation of cytokine secretion Source: MGI
    5. negative regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL
    6. negative regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
    7. negative regulation of transcription, DNA-templated Source: BHF-UCL
    8. positive regulation of B cell proliferation Source: BHF-UCL
    9. positive regulation of immunoglobulin secretion Source: BHF-UCL
    10. regulation of apoptotic process Source: MGI
    11. regulation of protein kinase activity Source: MGI
    12. tumor necrosis factor-mediated signaling pathway Source: GOC

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor receptor superfamily member 4
    Alternative name(s):
    OX40 antigen
    OX40L receptor
    CD_antigen: CD134
    Gene namesi
    Name:Tnfrsf4
    Synonyms:Ox40, Txgp1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:104512. Tnfrsf4.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 272253Tumor necrosis factor receptor superfamily member 4PRO_0000034555Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi27 ↔ 38PROSITE-ProRule annotation
    Disulfide bondi39 ↔ 52PROSITE-ProRule annotation
    Disulfide bondi42 ↔ 60PROSITE-ProRule annotation
    Disulfide bondi63 ↔ 77PROSITE-ProRule annotation
    Disulfide bondi80 ↔ 95PROSITE-ProRule annotation
    Disulfide bondi83 ↔ 103PROSITE-ProRule annotation
    Disulfide bondi105 ↔ 123PROSITE-ProRule annotation
    Disulfide bondi126 ↔ 139PROSITE-ProRule annotation
    Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi145 ↔ 164PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP47741.

    Expressioni

    Gene expression databases

    GenevestigatoriP47741.

    Interactioni

    Subunit structurei

    Interacts with TRAF2, TRAF3 and TRAF5.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Traf2P394293EBI-520001,EBI-520016
    Traf3Q608033EBI-520001,EBI-520135

    Protein-protein interaction databases

    DIPiDIP-6239N.
    IntActiP47741. 4 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP47741.
    SMRiP47741. Positions 25-166.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 211192ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini237 – 27236CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei212 – 23625HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati26 – 6136TNFR-Cys 1Add
    BLAST
    Repeati62 – 10342TNFR-Cys 2Add
    BLAST
    Repeati104 – 12421TNFR-Cys 3; truncatedAdd
    BLAST
    Repeati125 – 16541TNFR-Cys 4Add
    BLAST

    Sequence similaritiesi

    Contains 4 TNFR-Cys repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG43906.
    HOGENOMiHOG000049154.
    HOVERGENiHBG005031.
    InParanoidiP47741.
    KOiK05142.
    PhylomeDBiP47741.

    Family and domain databases

    InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
    IPR020445. TNFR_4.
    [Graphical view]
    PfamiPF00020. TNFR_c6. 2 hits.
    [Graphical view]
    PRINTSiPR01921. TNFACTORR4.
    SMARTiSM00208. TNFR. 3 hits.
    [Graphical view]
    PROSITEiPS00652. TNFR_NGFR_1. 2 hits.
    PS50050. TNFR_NGFR_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P47741-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYVWVQQPTA LLLLALTLGV TARRLNCVKH TYPSGHKCCR ECQPGHGMVS    50
    RCDHTRDTLC HPCETGFYNE AVNYDTCKQC TQCNHRSGSE LKQNCTPTQD 100
    TVCRCRPGTQ PRQDSGYKLG VDCVPCPPGH FSPGNNQACK PWTNCTLSGK 150
    QTRHPASDSL DAVCEDRSLL ATLLWETQRP TFRPTTVQST TVWPRTSELP 200
    SPPTLVTPEG PAFAVLLGLG LGLLAPLTVL LALYLLRKAW RLPNTPKPCW 250
    GNSFRTPIQE EHTDAHFTLA KI 272
    Length:272
    Mass (Da):30,154
    Last modified:February 1, 1996 - v1
    Checksum:i06E7BB4156F0D08E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti15 – 151A → G in CAA59476. (PubMed:7737295)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z21674 mRNA. Translation: CAA79772.1.
    X85214 Genomic DNA. Translation: CAA59476.1.
    CCDSiCCDS19055.1.
    PIRiI48700.
    RefSeqiNP_035789.1. NM_011659.2.
    UniGeneiMm.13885.

    Genome annotation databases

    GeneIDi22163.
    KEGGimmu:22163.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z21674 mRNA. Translation: CAA79772.1 .
    X85214 Genomic DNA. Translation: CAA59476.1 .
    CCDSi CCDS19055.1.
    PIRi I48700.
    RefSeqi NP_035789.1. NM_011659.2.
    UniGenei Mm.13885.

    3D structure databases

    ProteinModelPortali P47741.
    SMRi P47741. Positions 25-166.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-6239N.
    IntActi P47741. 4 interactions.

    Proteomic databases

    PRIDEi P47741.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 22163.
    KEGGi mmu:22163.

    Organism-specific databases

    CTDi 7293.
    MGIi MGI:104512. Tnfrsf4.

    Phylogenomic databases

    eggNOGi NOG43906.
    HOGENOMi HOG000049154.
    HOVERGENi HBG005031.
    InParanoidi P47741.
    KOi K05142.
    PhylomeDBi P47741.

    Miscellaneous databases

    NextBioi 302094.
    PROi P47741.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori P47741.

    Family and domain databases

    InterProi IPR001368. TNFR/NGFR_Cys_rich_reg.
    IPR020445. TNFR_4.
    [Graphical view ]
    Pfami PF00020. TNFR_c6. 2 hits.
    [Graphical view ]
    PRINTSi PR01921. TNFACTORR4.
    SMARTi SM00208. TNFR. 3 hits.
    [Graphical view ]
    PROSITEi PS00652. TNFR_NGFR_1. 2 hits.
    PS50050. TNFR_NGFR_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions."
      Calderhead D.M., Buhlmann J.E., van den Eertwegh A.J., Claassen E., Noelle R.J., Fell H.
      J. Immunol. 151:5261-5271(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    2. "Gene structure and chromosomal localization of the mouse homologue of rat OX40 protein."
      Birkeland M.L., Copeland N.G., Gilbert D.J., Jenkins N.A., Barclay A.N.
      Eur. J. Immunol. 25:926-930(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiTNR4_MOUSE
    AccessioniPrimary (citable) accession number: P47741
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3