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P47741

- TNR4_MOUSE

UniProt

P47741 - TNR4_MOUSE

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Protein
Tumor necrosis factor receptor superfamily member 4
Gene
Tnfrsf4, Ox40, Txgp1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity By similarity.

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. tumor necrosis factor-activated receptor activity Source: MGI

GO - Biological processi

  1. cellular defense response Source: MGI
  2. inflammatory response Source: MGI
  3. negative regulation of activation-induced cell death of T cells Source: BHF-UCL
  4. negative regulation of cytokine secretion Source: MGI
  5. negative regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL
  6. negative regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  7. negative regulation of transcription, DNA-templated Source: BHF-UCL
  8. positive regulation of B cell proliferation Source: BHF-UCL
  9. positive regulation of immunoglobulin secretion Source: BHF-UCL
  10. regulation of apoptotic process Source: MGI
  11. regulation of protein kinase activity Source: MGI
  12. tumor necrosis factor-mediated signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 4
Alternative name(s):
OX40 antigen
OX40L receptor
CD_antigen: CD134
Gene namesi
Name:Tnfrsf4
Synonyms:Ox40, Txgp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:104512. Tnfrsf4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 211192Extracellular Reviewed prediction
Add
BLAST
Transmembranei212 – 23625Helical; Reviewed prediction
Add
BLAST
Topological domaini237 – 27236Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 272253Tumor necrosis factor receptor superfamily member 4
PRO_0000034555Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 38 By similarity
Disulfide bondi39 ↔ 52 By similarity
Disulfide bondi42 ↔ 60 By similarity
Disulfide bondi63 ↔ 77 By similarity
Disulfide bondi80 ↔ 95 By similarity
Disulfide bondi83 ↔ 103 By similarity
Disulfide bondi105 ↔ 123 By similarity
Disulfide bondi126 ↔ 139 By similarity
Glycosylationi144 – 1441N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi145 ↔ 164 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP47741.

Expressioni

Gene expression databases

GenevestigatoriP47741.

Interactioni

Subunit structurei

Interacts with TRAF2, TRAF3 and TRAF5 By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
Traf2P394293EBI-520001,EBI-520016
Traf3Q608033EBI-520001,EBI-520135

Protein-protein interaction databases

DIPiDIP-6239N.
IntActiP47741. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliP47741.
SMRiP47741. Positions 25-166.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati26 – 6136TNFR-Cys 1
Add
BLAST
Repeati62 – 10342TNFR-Cys 2
Add
BLAST
Repeati104 – 12421TNFR-Cys 3; truncated
Add
BLAST
Repeati125 – 16541TNFR-Cys 4
Add
BLAST

Sequence similaritiesi

Contains 4 TNFR-Cys repeats.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43906.
HOGENOMiHOG000049154.
HOVERGENiHBG005031.
InParanoidiP47741.
KOiK05142.
PhylomeDBiP47741.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020445. TNFR_4.
[Graphical view]
PfamiPF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSiPR01921. TNFACTORR4.
SMARTiSM00208. TNFR. 3 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47741-1 [UniParc]FASTAAdd to Basket

« Hide

MYVWVQQPTA LLLLALTLGV TARRLNCVKH TYPSGHKCCR ECQPGHGMVS    50
RCDHTRDTLC HPCETGFYNE AVNYDTCKQC TQCNHRSGSE LKQNCTPTQD 100
TVCRCRPGTQ PRQDSGYKLG VDCVPCPPGH FSPGNNQACK PWTNCTLSGK 150
QTRHPASDSL DAVCEDRSLL ATLLWETQRP TFRPTTVQST TVWPRTSELP 200
SPPTLVTPEG PAFAVLLGLG LGLLAPLTVL LALYLLRKAW RLPNTPKPCW 250
GNSFRTPIQE EHTDAHFTLA KI 272
Length:272
Mass (Da):30,154
Last modified:February 1, 1996 - v1
Checksum:i06E7BB4156F0D08E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151A → G in CAA59476. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z21674 mRNA. Translation: CAA79772.1.
X85214 Genomic DNA. Translation: CAA59476.1.
CCDSiCCDS19055.1.
PIRiI48700.
RefSeqiNP_035789.1. NM_011659.2.
UniGeneiMm.13885.

Genome annotation databases

GeneIDi22163.
KEGGimmu:22163.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z21674 mRNA. Translation: CAA79772.1 .
X85214 Genomic DNA. Translation: CAA59476.1 .
CCDSi CCDS19055.1.
PIRi I48700.
RefSeqi NP_035789.1. NM_011659.2.
UniGenei Mm.13885.

3D structure databases

ProteinModelPortali P47741.
SMRi P47741. Positions 25-166.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-6239N.
IntActi P47741. 4 interactions.

Proteomic databases

PRIDEi P47741.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 22163.
KEGGi mmu:22163.

Organism-specific databases

CTDi 7293.
MGIi MGI:104512. Tnfrsf4.

Phylogenomic databases

eggNOGi NOG43906.
HOGENOMi HOG000049154.
HOVERGENi HBG005031.
InParanoidi P47741.
KOi K05142.
PhylomeDBi P47741.

Miscellaneous databases

NextBioi 302094.
PROi P47741.
SOURCEi Search...

Gene expression databases

Genevestigatori P47741.

Family and domain databases

InterProi IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020445. TNFR_4.
[Graphical view ]
Pfami PF00020. TNFR_c6. 2 hits.
[Graphical view ]
PRINTSi PR01921. TNFACTORR4.
SMARTi SM00208. TNFR. 3 hits.
[Graphical view ]
PROSITEi PS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions."
    Calderhead D.M., Buhlmann J.E., van den Eertwegh A.J., Claassen E., Noelle R.J., Fell H.
    J. Immunol. 151:5261-5271(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "Gene structure and chromosomal localization of the mouse homologue of rat OX40 protein."
    Birkeland M.L., Copeland N.G., Gilbert D.J., Jenkins N.A., Barclay A.N.
    Eur. J. Immunol. 25:926-930(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiTNR4_MOUSE
AccessioniPrimary (citable) accession number: P47741
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi