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Protein

Tumor necrosis factor receptor superfamily member 4

Gene

Tnfrsf4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity (By similarity).By similarity

GO - Molecular functioni

  • tumor necrosis factor-activated receptor activity Source: MGI

GO - Biological processi

  • cellular defense response Source: MGI
  • immune response Source: GO_Central
  • inflammatory response Source: MGI
  • multicellular organism development Source: GO_Central
  • negative regulation of activation-induced cell death of T cells Source: BHF-UCL
  • negative regulation of cytokine secretion Source: MGI
  • negative regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL
  • negative regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  • negative regulation of transcription, DNA-templated Source: BHF-UCL
  • positive regulation of B cell proliferation Source: BHF-UCL
  • positive regulation of immunoglobulin secretion Source: BHF-UCL
  • regulation of apoptotic process Source: MGI
  • regulation of protein kinase activity Source: MGI
  • response to lipopolysaccharide Source: GO_Central

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 4
Alternative name(s):
OX40 antigen
OX40L receptor
CD_antigen: CD134
Gene namesi
Name:Tnfrsf4
Synonyms:Ox40, Txgp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:104512. Tnfrsf4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 211ExtracellularSequence analysisAdd BLAST192
Transmembranei212 – 236HelicalSequence analysisAdd BLAST25
Topological domaini237 – 272CytoplasmicSequence analysisAdd BLAST36

GO - Cellular componenti

  • external side of plasma membrane Source: MGI
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: MGI

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000003455520 – 272Tumor necrosis factor receptor superfamily member 4Add BLAST253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 38PROSITE-ProRule annotation
Disulfide bondi39 ↔ 52PROSITE-ProRule annotation
Disulfide bondi42 ↔ 60PROSITE-ProRule annotation
Disulfide bondi63 ↔ 77PROSITE-ProRule annotation
Disulfide bondi80 ↔ 95PROSITE-ProRule annotation
Disulfide bondi83 ↔ 103PROSITE-ProRule annotation
Disulfide bondi105 ↔ 123PROSITE-ProRule annotation
Disulfide bondi126 ↔ 139PROSITE-ProRule annotation
Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi145 ↔ 164PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP47741.
PaxDbiP47741.
PRIDEiP47741.

Interactioni

Subunit structurei

Interacts with TRAF2, TRAF3 and TRAF5.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

DIPiDIP-6239N.
IntActiP47741. 4 interactors.
STRINGi10090.ENSMUSP00000030952.

Structurei

3D structure databases

ProteinModelPortaliP47741.
SMRiP47741.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati26 – 61TNFR-Cys 1Add BLAST36
Repeati62 – 103TNFR-Cys 2Add BLAST42
Repeati104 – 124TNFR-Cys 3; truncatedAdd BLAST21
Repeati125 – 165TNFR-Cys 4Add BLAST41

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0US. Eukaryota.
ENOG4111DUJ. LUCA.
HOGENOMiHOG000049154.
HOVERGENiHBG005031.
InParanoidiP47741.
KOiK05142.
PhylomeDBiP47741.

Family and domain databases

CDDicd13406. TNFRSF4. 1 hit.
InterProiView protein in InterPro
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020445. TNFR_4.
IPR034022. TNFRSF4_N.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
PfamiView protein in Pfam
PF00020. TNFR_c6. 2 hits.
PRINTSiPR01921. TNFACTORR4.
SMARTiView protein in SMART
SM01411. Ephrin_rec_like. 2 hits.
SM00208. TNFR. 3 hits.
PROSITEiView protein in PROSITE
PS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47741-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYVWVQQPTA LLLLALTLGV TARRLNCVKH TYPSGHKCCR ECQPGHGMVS
60 70 80 90 100
RCDHTRDTLC HPCETGFYNE AVNYDTCKQC TQCNHRSGSE LKQNCTPTQD
110 120 130 140 150
TVCRCRPGTQ PRQDSGYKLG VDCVPCPPGH FSPGNNQACK PWTNCTLSGK
160 170 180 190 200
QTRHPASDSL DAVCEDRSLL ATLLWETQRP TFRPTTVQST TVWPRTSELP
210 220 230 240 250
SPPTLVTPEG PAFAVLLGLG LGLLAPLTVL LALYLLRKAW RLPNTPKPCW
260 270
GNSFRTPIQE EHTDAHFTLA KI
Length:272
Mass (Da):30,154
Last modified:February 1, 1996 - v1
Checksum:i06E7BB4156F0D08E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15A → G in CAA59476 (PubMed:7737295).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21674 mRNA. Translation: CAA79772.1.
X85214 Genomic DNA. Translation: CAA59476.1.
CCDSiCCDS19055.1.
PIRiI48700.
RefSeqiNP_035789.1. NM_011659.2.
UniGeneiMm.13885.

Genome annotation databases

GeneIDi22163.
KEGGimmu:22163.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTNR4_MOUSE
AccessioniPrimary (citable) accession number: P47741
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 10, 2017
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot