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P47740

- AL3A2_MOUSE

UniProt

P47740 - AL3A2_MOUSE

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Protein

Fatty aldehyde dehydrogenase

Gene

Aldh3a2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (By similarity).By similarity

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei207 – 2071By similarity
Active sitei241 – 2411By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi185 – 1906NADSequence Analysis

GO - Molecular functioni

  1. aldehyde dehydrogenase [NAD(P)+] activity Source: InterPro
  2. long-chain-alcohol oxidase activity Source: Ensembl
  3. long-chain-aldehyde dehydrogenase activity Source: Ensembl
  4. medium-chain-aldehyde dehydrogenase activity Source: Ensembl

GO - Biological processi

  1. cellular aldehyde metabolic process Source: InterPro
  2. central nervous system development Source: Ensembl
  3. epidermis development Source: Ensembl
  4. peripheral nervous system development Source: Ensembl
  5. phytol metabolic process Source: Ensembl
  6. sesquiterpenoid metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty aldehyde dehydrogenase (EC:1.2.1.3)
Alternative name(s):
Aldehyde dehydrogenase 3
Aldehyde dehydrogenase family 3 member A2
Gene namesi
Name:Aldh3a2
Synonyms:Ahd-3, Ahd3, Aldh3, Aldh4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1353452. Aldh3a2.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
  2. extracellular vesicular exosome Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. mitochondrial inner membrane Source: MGI
  5. mitochondrion Source: MGI
  6. peroxisome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 484484Fatty aldehyde dehydrogenasePRO_0000056475Add
BLAST

Proteomic databases

MaxQBiP47740.
PaxDbiP47740.
PRIDEiP47740.

PTM databases

PhosphoSiteiP47740.

Expressioni

Gene expression databases

BgeeiP47740.
CleanExiMM_ALDH3A2.
ExpressionAtlasiP47740. baseline and differential.
GenevestigatoriP47740.

Interactioni

Protein-protein interaction databases

IntActiP47740. 4 interactions.
MINTiMINT-4087555.
STRINGi10090.ENSMUSP00000067767.

Structurei

3D structure databases

ProteinModelPortaliP47740.
SMRiP47740. Positions 1-443.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 463463CytoplasmicAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei464 – 48017HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi481 – 4844Prevents secretion from ERBy similarity

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1012.
GeneTreeiENSGT00390000002825.
HOGENOMiHOG000271515.
HOVERGENiHBG050483.
InParanoidiP47740.
KOiK00128.
TreeFamiTF314264.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF036492. ALDH. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47740-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERQVLRLRQ AFRSGRSRPL RFRLQQLEAL RRMVQEREKE ILAAIAADLS
60 70 80 90 100
KSELNAYSHE VITILGEIDF MLGNLPELAS ARPAKKNLLT MMDEAYVQPE
110 120 130 140 150
PLGVVLIIGA WNYPFVLTMQ PLVGAIAAGN AAIVKPSELS ENTAKILAEL
160 170 180 190 200
LPQYLDQDLY AIVNGGIPET TELLKQRFDH ILYTGNTAVG KIVMEAAAKH
210 220 230 240 250
LTPVTLELGG KSPCYIDRDC DLDVACRRIA WGKYMNCGQT CIAPDYILCE
260 270 280 290 300
ASLQNQIVQK IKETVKDFYG ENIKASPDYE RIINLRHFKR LQSLLKGQKI
310 320 330 340 350
AFGGEMDEAT RYLAPTILTD VDPNSKVMQE EIFGPILPIV SVKNVDEAIN
360 370 380 390 400
FINDREKPLA LYVFSRNNKL IKRVIDETSS GGVTGNDVIM HFTVNSLPFG
410 420 430 440 450
GVGASGMGAY HGKYSFDTFS HQRPCLLKGL KGESVNKLRY PPNSESKVSW
460 470 480
AKFFLLKQFN KGRLGMLLFV CLVAVAAVIV KDQL
Length:484
Mass (Da):53,971
Last modified:July 27, 2011 - v2
Checksum:iDFC67C96C757832A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191P → L in AAB06232. (PubMed:8634152)Curated
Sequence conflicti229 – 2291I → V in AAB06232. (PubMed:8634152)Curated
Sequence conflicti418 – 4181T → A in AAB06232. (PubMed:8634152)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U14390 mRNA. Translation: AAB06232.1.
AK079639 mRNA. Translation: BAC37712.1.
AK140932 mRNA. Translation: BAE24523.1.
AK159246 mRNA. Translation: BAE34928.1.
AK163040 mRNA. Translation: BAE37166.1.
AK169157 mRNA. Translation: BAE40936.1.
AK170195 mRNA. Translation: BAE41628.1.
AL672172 Genomic DNA. Translation: CAI24063.1.
BC003797 mRNA. Translation: AAH03797.1.
CCDSiCCDS24809.1.
RefSeqiNP_031463.2. NM_007437.4.
UniGeneiMm.398221.

Genome annotation databases

EnsembliENSMUST00000074127; ENSMUSP00000073764; ENSMUSG00000010025.
GeneIDi11671.
KEGGimmu:11671.
UCSCiuc007jhf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U14390 mRNA. Translation: AAB06232.1 .
AK079639 mRNA. Translation: BAC37712.1 .
AK140932 mRNA. Translation: BAE24523.1 .
AK159246 mRNA. Translation: BAE34928.1 .
AK163040 mRNA. Translation: BAE37166.1 .
AK169157 mRNA. Translation: BAE40936.1 .
AK170195 mRNA. Translation: BAE41628.1 .
AL672172 Genomic DNA. Translation: CAI24063.1 .
BC003797 mRNA. Translation: AAH03797.1 .
CCDSi CCDS24809.1.
RefSeqi NP_031463.2. NM_007437.4.
UniGenei Mm.398221.

3D structure databases

ProteinModelPortali P47740.
SMRi P47740. Positions 1-443.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P47740. 4 interactions.
MINTi MINT-4087555.
STRINGi 10090.ENSMUSP00000067767.

PTM databases

PhosphoSitei P47740.

Proteomic databases

MaxQBi P47740.
PaxDbi P47740.
PRIDEi P47740.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000074127 ; ENSMUSP00000073764 ; ENSMUSG00000010025 .
GeneIDi 11671.
KEGGi mmu:11671.
UCSCi uc007jhf.1. mouse.

Organism-specific databases

CTDi 224.
MGIi MGI:1353452. Aldh3a2.

Phylogenomic databases

eggNOGi COG1012.
GeneTreei ENSGT00390000002825.
HOGENOMi HOG000271515.
HOVERGENi HBG050483.
InParanoidi P47740.
KOi K00128.
TreeFami TF314264.

Miscellaneous databases

ChiTaRSi ALDH3A2. mouse.
NextBioi 279299.
PROi P47740.
SOURCEi Search...

Gene expression databases

Bgeei P47740.
CleanExi MM_ALDH3A2.
ExpressionAtlasi P47740. baseline and differential.
Genevestigatori P47740.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
PIRSFi PIRSF036492. ALDH. 1 hit.
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse microsomal class 3 aldehyde dehydrogenase: AHD3 cDNA sequence, inducibility by dioxin and clofibrate, and genetic mapping."
    Vasiliou V., Kozak C.A., Lindahl R., Nebert D.W.
    DNA Cell Biol. 15:235-245(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X CBA.
    Tissue: Liver.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Head, Spinal cord, Stomach and Thymus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.

Entry informationi

Entry nameiAL3A2_MOUSE
AccessioniPrimary (citable) accession number: P47740
Secondary accession number(s): Q99L64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3