Reviewed, UniProtKB/Swiss-Prot P47740 (AL3A2_MOUSE)

Names and origin

Protein names

Recommended name:
    Fatty aldehyde dehydrogenase
    EC=1.2.1.3
Alternative name(s):
    Aldehyde dehydrogenase family 3 member A2
      Short name=Aldehyde dehydrogenase 3

Gene names

Name:	Aldh3a2
Synonyms:	Ahd-3, Ahd3, Aldh3, Aldh4

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	484 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	An aldehyde + NAD(+) + H(2)O = an acid + NADH.
Subcellular location	Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	cellular aldehyde metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from direct assay. Source: MGI
Molecular function	aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC aldehyde dehydrogenase [NAD(P)+] activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 484	484	Fatty aldehyde dehydrogenase		PRO_0000056475
Regions
	Topological domain	1 – 463	463	Cytoplasmic
	Transmembrane	464 – 480	17	Potential
	Nucleotide binding	185 – 190	6	NAD Potential
	Motif	481 – 484	4	Prevents secretion from ER By similarity
Sites
	Active site	207	1	By similarity
	Active site	241	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P47740-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 098A49260D376C81	FASTA	484	53,943
	10 20 30 40 50 60 MERQVLRLRQ AFRSGRSRLL RFRLQQLEAL RRMVQEREKE ILAAIAADLS KSELNAYSHE 70 80 90 100 110 120 VITILGEIDF MLGNLPELAS ARPAKKNLLT MMDEAYVQPE PLGVVLIIGA WNYPFVLTMQ 130 140 150 160 170 180 PLVGAIAAGN AAIVKPSELS ENTAKILAEL LPQYLDQDLY AIVNGGIPET TELLKQRFDH 190 200 210 220 230 240 ILYTGNTAVG KIVMEAAAKH LTPVTLELGG KSPCYIDRDC DLDVACRRVA WGKYMNCGQT 250 260 270 280 290 300 CIAPDYILCE ASLQNQIVQK IKETVKDFYG ENIKASPDYE RIINLRHFKR LQSLLKGQKI 310 320 330 340 350 360 AFGGEMDEAT RYLAPTILTD VDPNSKVMQE EIFGPILPIV SVKNVDEAIN FINDREKPLA 370 380 390 400 410 420 LYVFSRNNKL IKRVIDETSS GGVTGNDVIM HFTVNSLPFG GVGASGMGAY HGKYSFDAFS 430 440 450 460 470 480 HQRPCLLKGL KGESVNKLRY PPNSESKVSW AKFFLLKQFN KGRLGMLLFV CLVAVAAVIV KDQL

References

[1]	"Mouse microsomal class 3 aldehyde dehydrogenase: AHD3 cDNA sequence, inducibility by dioxin and clofibrate, and genetic mapping." Vasiliou V., Kozak C.A., Lindahl R., Nebert D.W. DNA Cell Biol. 15:235-245(1996) [PubMed: 8634152] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6 X CBA. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U14390 mRNA. Translation: AAB06232.1.
UniGene	Mm.398221
3D structure databases
HSSP	HSSP built from PDB template 1AD3 based on UniProtKB P11883.
ModBase	Search...
PTM databases
PhosphoSite	P47740.
Genome annotation databases
Ensembl	ENSMUSG00000010025. Mus musculus. [Contig view]
Organism-specific databases
MGI	MGI:1353452. Aldh3a2.
Phylogenomic databases
HOVERGEN	P47740.
Gene expression databases
ArrayExpress	P47740.
CleanEx	MM_ALDH3A2.
GermOnline	ENSMUSG00000010025. Mus musculus.
Family and domain databases
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR012394. Ald_DHase_NAD(P). IPR015590. Aldehyde_DHase. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit. PTHR11699:SF15. ALDH. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PIRSF	PIRSF036492. ALDH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

AL3A2_MOUSE

Accession

Primary (citable) accession number: P47740

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	November 25, 2008
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)