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Reviewed, UniProtKB/Swiss-Prot P47740 (AL3A2_MOUSE)

Last modified November 25, 2008. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Fatty aldehyde dehydrogenase
    EC=1.2.1.3
Alternative name(s):
    Aldehyde dehydrogenase family 3 member A2
      Short name=Aldehyde dehydrogenase 3
Gene names
Name: Aldh3a2
Synonyms: Ahd-3, Ahd3, Aldh3, Aldh4
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length484 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Catalytic activity

An aldehyde + NAD(+) + H(2)O = an acid + NADH.

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 484484Fatty aldehyde dehydrogenase
PRO_0000056475

Regions

Topological domain1 – 463463Cytoplasmic
Transmembrane464 – 48017 Potential
Nucleotide binding185 – 1906NAD Potential
Motif481 – 4844Prevents secretion from ER By similarity

Sites

Active site2071 By similarity
Active site2411 By similarity

Sequences

Sequence LengthMass (Da)Tools
P47740-1 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 098A49260D376C81

FASTA48453,943
        10         20         30         40         50         60 
MERQVLRLRQ AFRSGRSRLL RFRLQQLEAL RRMVQEREKE ILAAIAADLS KSELNAYSHE 

        70         80         90        100        110        120 
VITILGEIDF MLGNLPELAS ARPAKKNLLT MMDEAYVQPE PLGVVLIIGA WNYPFVLTMQ 

       130        140        150        160        170        180 
PLVGAIAAGN AAIVKPSELS ENTAKILAEL LPQYLDQDLY AIVNGGIPET TELLKQRFDH 

       190        200        210        220        230        240 
ILYTGNTAVG KIVMEAAAKH LTPVTLELGG KSPCYIDRDC DLDVACRRVA WGKYMNCGQT 

       250        260        270        280        290        300 
CIAPDYILCE ASLQNQIVQK IKETVKDFYG ENIKASPDYE RIINLRHFKR LQSLLKGQKI 

       310        320        330        340        350        360 
AFGGEMDEAT RYLAPTILTD VDPNSKVMQE EIFGPILPIV SVKNVDEAIN FINDREKPLA 

       370        380        390        400        410        420 
LYVFSRNNKL IKRVIDETSS GGVTGNDVIM HFTVNSLPFG GVGASGMGAY HGKYSFDAFS 

       430        440        450        460        470        480 
HQRPCLLKGL KGESVNKLRY PPNSESKVSW AKFFLLKQFN KGRLGMLLFV CLVAVAAVIV 


KDQL 

« Hide

References

[1]"Mouse microsomal class 3 aldehyde dehydrogenase: AHD3 cDNA sequence, inducibility by dioxin and clofibrate, and genetic mapping."
Vasiliou V., Kozak C.A., Lindahl R., Nebert D.W.
DNA Cell Biol. 15:235-245(1996) [PubMed: 8634152] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6 X CBA.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

U14390 mRNA. Translation: AAB06232.1.
UniGeneMm.398221

3D structure databases

HSSPHSSP built from PDB template 1AD3 based on UniProtKB P11883.
ModBaseSearch...

PTM databases

PhosphoSiteP47740.

Genome annotation databases

EnsemblENSMUSG00000010025. Mus musculus. [Contig view]

Organism-specific databases

MGIMGI:1353452. Aldh3a2.

Phylogenomic databases

HOVERGENP47740.

Gene expression databases

ArrayExpressP47740.
CleanExMM_ALDH3A2.
GermOnlineENSMUSG00000010025. Mus musculus.

Family and domain databases

InterProIPR016160. Ald_DHase_CS.
IPR016162. Ald_DHase_N.
IPR012394. Ald_DHase_NAD(P).
IPR015590. Aldehyde_DHase.
[Graphical view]
Gene3DG3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PTHR11699:SF15. ALDH. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFPIRSF036492. ALDH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

Entry information

Entry nameAL3A2_MOUSE
AccessionPrimary (citable) accession number: P47740
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 25, 2008
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents