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P47740

- AL3A2_MOUSE

UniProt

P47740 - AL3A2_MOUSE

Protein

Fatty aldehyde dehydrogenase

Gene

Aldh3a2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid By similarity.By similarity

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei207 – 2071By similarity
    Active sitei241 – 2411By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi185 – 1906NADSequence Analysis

    GO - Molecular functioni

    1. aldehyde dehydrogenase [NAD(P)+] activity Source: InterPro
    2. long-chain-alcohol oxidase activity Source: Ensembl
    3. long-chain-aldehyde dehydrogenase activity Source: Ensembl
    4. medium-chain-aldehyde dehydrogenase activity Source: Ensembl

    GO - Biological processi

    1. cellular aldehyde metabolic process Source: InterPro
    2. central nervous system development Source: Ensembl
    3. epidermis development Source: Ensembl
    4. peripheral nervous system development Source: Ensembl
    5. phytol metabolic process Source: Ensembl
    6. sesquiterpenoid metabolic process Source: Ensembl

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fatty aldehyde dehydrogenase (EC:1.2.1.3)
    Alternative name(s):
    Aldehyde dehydrogenase 3
    Aldehyde dehydrogenase family 3 member A2
    Gene namesi
    Name:Aldh3a2
    Synonyms:Ahd-3, Ahd3, Aldh3, Aldh4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1353452. Aldh3a2.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. mitochondrial inner membrane Source: MGI
    5. mitochondrion Source: MGI
    6. peroxisome Source: Ensembl

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 484484Fatty aldehyde dehydrogenasePRO_0000056475Add
    BLAST

    Proteomic databases

    MaxQBiP47740.
    PaxDbiP47740.
    PRIDEiP47740.

    PTM databases

    PhosphoSiteiP47740.

    Expressioni

    Gene expression databases

    ArrayExpressiP47740.
    BgeeiP47740.
    CleanExiMM_ALDH3A2.
    GenevestigatoriP47740.

    Interactioni

    Protein-protein interaction databases

    IntActiP47740. 4 interactions.
    MINTiMINT-4087555.
    STRINGi10090.ENSMUSP00000067767.

    Structurei

    3D structure databases

    ProteinModelPortaliP47740.
    SMRiP47740. Positions 1-443.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 463463CytoplasmicAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei464 – 48017HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi481 – 4844Prevents secretion from ERBy similarity

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1012.
    GeneTreeiENSGT00390000002825.
    HOGENOMiHOG000271515.
    HOVERGENiHBG050483.
    KOiK00128.
    TreeFamiTF314264.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR012394. Aldehyde_DH_NAD(P).
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036492. ALDH. 1 hit.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47740-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERQVLRLRQ AFRSGRSRPL RFRLQQLEAL RRMVQEREKE ILAAIAADLS    50
    KSELNAYSHE VITILGEIDF MLGNLPELAS ARPAKKNLLT MMDEAYVQPE 100
    PLGVVLIIGA WNYPFVLTMQ PLVGAIAAGN AAIVKPSELS ENTAKILAEL 150
    LPQYLDQDLY AIVNGGIPET TELLKQRFDH ILYTGNTAVG KIVMEAAAKH 200
    LTPVTLELGG KSPCYIDRDC DLDVACRRIA WGKYMNCGQT CIAPDYILCE 250
    ASLQNQIVQK IKETVKDFYG ENIKASPDYE RIINLRHFKR LQSLLKGQKI 300
    AFGGEMDEAT RYLAPTILTD VDPNSKVMQE EIFGPILPIV SVKNVDEAIN 350
    FINDREKPLA LYVFSRNNKL IKRVIDETSS GGVTGNDVIM HFTVNSLPFG 400
    GVGASGMGAY HGKYSFDTFS HQRPCLLKGL KGESVNKLRY PPNSESKVSW 450
    AKFFLLKQFN KGRLGMLLFV CLVAVAAVIV KDQL 484
    Length:484
    Mass (Da):53,971
    Last modified:July 27, 2011 - v2
    Checksum:iDFC67C96C757832A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti19 – 191P → L in AAB06232. (PubMed:8634152)Curated
    Sequence conflicti229 – 2291I → V in AAB06232. (PubMed:8634152)Curated
    Sequence conflicti418 – 4181T → A in AAB06232. (PubMed:8634152)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U14390 mRNA. Translation: AAB06232.1.
    AK079639 mRNA. Translation: BAC37712.1.
    AK140932 mRNA. Translation: BAE24523.1.
    AK159246 mRNA. Translation: BAE34928.1.
    AK163040 mRNA. Translation: BAE37166.1.
    AK169157 mRNA. Translation: BAE40936.1.
    AK170195 mRNA. Translation: BAE41628.1.
    AL672172 Genomic DNA. Translation: CAI24063.1.
    BC003797 mRNA. Translation: AAH03797.1.
    CCDSiCCDS24809.1.
    RefSeqiNP_031463.2. NM_007437.4.
    UniGeneiMm.398221.

    Genome annotation databases

    EnsembliENSMUST00000074127; ENSMUSP00000073764; ENSMUSG00000010025.
    GeneIDi11671.
    KEGGimmu:11671.
    UCSCiuc007jhf.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U14390 mRNA. Translation: AAB06232.1 .
    AK079639 mRNA. Translation: BAC37712.1 .
    AK140932 mRNA. Translation: BAE24523.1 .
    AK159246 mRNA. Translation: BAE34928.1 .
    AK163040 mRNA. Translation: BAE37166.1 .
    AK169157 mRNA. Translation: BAE40936.1 .
    AK170195 mRNA. Translation: BAE41628.1 .
    AL672172 Genomic DNA. Translation: CAI24063.1 .
    BC003797 mRNA. Translation: AAH03797.1 .
    CCDSi CCDS24809.1.
    RefSeqi NP_031463.2. NM_007437.4.
    UniGenei Mm.398221.

    3D structure databases

    ProteinModelPortali P47740.
    SMRi P47740. Positions 1-443.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P47740. 4 interactions.
    MINTi MINT-4087555.
    STRINGi 10090.ENSMUSP00000067767.

    PTM databases

    PhosphoSitei P47740.

    Proteomic databases

    MaxQBi P47740.
    PaxDbi P47740.
    PRIDEi P47740.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000074127 ; ENSMUSP00000073764 ; ENSMUSG00000010025 .
    GeneIDi 11671.
    KEGGi mmu:11671.
    UCSCi uc007jhf.1. mouse.

    Organism-specific databases

    CTDi 224.
    MGIi MGI:1353452. Aldh3a2.

    Phylogenomic databases

    eggNOGi COG1012.
    GeneTreei ENSGT00390000002825.
    HOGENOMi HOG000271515.
    HOVERGENi HBG050483.
    KOi K00128.
    TreeFami TF314264.

    Miscellaneous databases

    ChiTaRSi ALDH3A2. mouse.
    NextBioi 279299.
    PROi P47740.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P47740.
    Bgeei P47740.
    CleanExi MM_ALDH3A2.
    Genevestigatori P47740.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR012394. Aldehyde_DH_NAD(P).
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036492. ALDH. 1 hit.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse microsomal class 3 aldehyde dehydrogenase: AHD3 cDNA sequence, inducibility by dioxin and clofibrate, and genetic mapping."
      Vasiliou V., Kozak C.A., Lindahl R., Nebert D.W.
      DNA Cell Biol. 15:235-245(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6 X CBA.
      Tissue: Liver.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Head, Spinal cord, Stomach and Thymus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiAL3A2_MOUSE
    AccessioniPrimary (citable) accession number: P47740
    Secondary accession number(s): Q99L64
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3