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Protein

Aldehyde dehydrogenase, dimeric NADP-preferring

Gene

Aldh3a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:25286108). Preferentially oxidizes aromatic aldehyde substrates (PubMed:11784860). Comprises about 50 percent of corneal epithelial soluble proteins (PubMed:11784860). May play a role in preventing corneal damage caused by ultraviolet light (PubMed:10376761).By similarityCurated3 Publications

Catalytic activityi

An aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei210By similarity1
Active sitei244By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi188 – 193NAD or NADPBy similarity6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

BRENDAi1.2.1.5. 3474.
ReactomeiR-MMU-211945. Phase 1 - Functionalization of compounds.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase, dimeric NADP-preferring (EC:1.2.1.51 Publication)
Alternative name(s):
Aldehyde dehydrogenase 4
Aldehyde dehydrogenase family 3 member A1
Dioxin-inducible aldehyde dehydrogenase 3
Gene namesi
Name:Aldh3a1
Synonyms:Ahd-4, Ahd4, Aldh3, Aldh4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1353451. Aldh3a1.

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: UniProtKB
  • endoplasmic reticulum Source: MGI
  • extracellular space Source: MGI
  • integral component of membrane Source: MGI
  • intracellular membrane-bounded organelle Source: MGI
  • nucleoplasm Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000564712 – 453Aldehyde dehydrogenase, dimeric NADP-preferringAdd BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei178N6-acetyllysineBy similarity1
Modified residuei194N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP47739.
PaxDbiP47739.
PeptideAtlasiP47739.
PRIDEiP47739.

PTM databases

PhosphoSitePlusiP47739.

Expressioni

Tissue specificityi

Constitutively expressed in cornea, stomach, skin, bladder and lungs. Lowest expression levels in lungs and bladder.1 Publication

Gene expression databases

BgeeiENSMUSG00000019102.
CleanExiMM_ALDH3A1.
ExpressionAtlasiP47739. baseline and differential.
GenevisibleiP47739. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi198065. 1 interactor.
IntActiP47739. 1 interactor.
MINTiMINT-4087533.
STRINGi10090.ENSMUSP00000019246.

Structurei

3D structure databases

ProteinModelPortaliP47739.
SMRiP47739.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiKOG2456. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00390000002825.
HOVERGENiHBG050483.
InParanoidiP47739.
KOiK00129.
OMAiRIINSQH.
OrthoDBiEOG091G05HC.
TreeFamiTF314264.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF036492. ALDH. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47739-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNISSIVNR ARDAFNSGKT RPLQFRVEQL EALQRMINEN LKGISKALAS
60 70 80 90 100
NLRKNEWTSY YEEVAHVLDE IDFTIKGLSD WAEDEPVAKT RQTQEDDLYI
110 120 130 140 150
HSEPLGVVLV IGAWNYPFNL TIQPMVGAIA AGNAVVLKPS EVSDHMADLL
160 170 180 190 200
STLIPQYMDK DLYPVIKGGV PETTELLKEK FDHIMYTGST AVGKIVMAAA
210 220 230 240 250
AKHLTPVTLE LGGKSPCYVD KDCDLDVACR RIAWGKFMNS GQTCVAPDYI
260 270 280 290 300
LCDPSIQNEI VEKLKKSLKD FYGEDAKQSH DYGRIINDRH FQRVINLIDS
310 320 330 340 350
KKVAHGGTWD QPSRYIAPTI LVDVDPQSPV MQEEIFGPVM PIVCVRSLDE
360 370 380 390 400
AIKFINQREK PLALYVFSNN DKVIKKMIAE TSSGGVTAND VIVHITVPTL
410 420 430 440 450
PFGGVGNSGM GAYHGKKSFE TFSHRRSCLV RSLRNEEANK ARYPPSPAKM

PRH
Length:453
Mass (Da):50,481
Last modified:October 3, 2012 - v2
Checksum:i7B4EA1CC56B5FAA1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88A → G in AAA20670 (PubMed:8148869).Curated1
Sequence conflicti88A → R in AAD15964 (PubMed:10376761).Curated1

Polymorphismi

There are two alleles, Ald3a1a and Ald3a1c. Ald3a1c codes for a low activity enzyme and is associated with extensive corneal clouding after exposure to ultraviolet light. Ald3a1a encodes the high activity enzyme.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti154I → N in allele Ald3a1c. 1 Publication1
Natural varianti305H → R in allele Ald3a1c. 1 Publication1
Natural varianti352I → V in allele Ald3a1c. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12785 mRNA. Translation: AAA20670.1.
AF072815 mRNA. Translation: AAD15964.1.
AL646093 Genomic DNA. Translation: CAI25900.1.
CCDSiCCDS24808.1.
RefSeqiNP_001106196.1. NM_001112725.1.
NP_031462.2. NM_007436.2.
XP_006532089.1. XM_006532026.1.
XP_006532090.1. XM_006532027.3.
UniGeneiMm.4257.

Genome annotation databases

EnsembliENSMUST00000019246; ENSMUSP00000019246; ENSMUSG00000019102.
ENSMUST00000108716; ENSMUSP00000104356; ENSMUSG00000019102.
GeneIDi11670.
KEGGimmu:11670.
UCSCiuc007jhd.2. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12785 mRNA. Translation: AAA20670.1.
AF072815 mRNA. Translation: AAD15964.1.
AL646093 Genomic DNA. Translation: CAI25900.1.
CCDSiCCDS24808.1.
RefSeqiNP_001106196.1. NM_001112725.1.
NP_031462.2. NM_007436.2.
XP_006532089.1. XM_006532026.1.
XP_006532090.1. XM_006532027.3.
UniGeneiMm.4257.

3D structure databases

ProteinModelPortaliP47739.
SMRiP47739.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198065. 1 interactor.
IntActiP47739. 1 interactor.
MINTiMINT-4087533.
STRINGi10090.ENSMUSP00000019246.

PTM databases

PhosphoSitePlusiP47739.

Proteomic databases

MaxQBiP47739.
PaxDbiP47739.
PeptideAtlasiP47739.
PRIDEiP47739.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019246; ENSMUSP00000019246; ENSMUSG00000019102.
ENSMUST00000108716; ENSMUSP00000104356; ENSMUSG00000019102.
GeneIDi11670.
KEGGimmu:11670.
UCSCiuc007jhd.2. mouse.

Organism-specific databases

CTDi218.
MGIiMGI:1353451. Aldh3a1.

Phylogenomic databases

eggNOGiKOG2456. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00390000002825.
HOVERGENiHBG050483.
InParanoidiP47739.
KOiK00129.
OMAiRIINSQH.
OrthoDBiEOG091G05HC.
TreeFamiTF314264.

Enzyme and pathway databases

BRENDAi1.2.1.5. 3474.
ReactomeiR-MMU-211945. Phase 1 - Functionalization of compounds.

Miscellaneous databases

PROiP47739.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019102.
CleanExiMM_ALDH3A1.
ExpressionAtlasiP47739. baseline and differential.
GenevisibleiP47739. MM.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF036492. ALDH. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAL3A1_MOUSE
AccessioniPrimary (citable) accession number: P47739
Secondary accession number(s): B1ATI7, Q9R203
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.