ID   VF193_IIV6              Reviewed;         208 AA.
AC   P47732; O55770;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2003, sequence version 2.
DT   27-MAR-2024, entry version 103.
DE   RecName: Full=Apoptosis inhibitor 193R;
GN   ORFNames=IIV6-193R;
OS   Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Pimascovirales; Iridoviridae; Betairidovirinae; Iridovirus.
OX   NCBI_TaxID=176652;
OH   NCBI_TaxID=6997; Acheta domesticus (House cricket).
OH   NCBI_TaxID=168631; Chilo suppressalis (Asiatic rice borer moth).
OH   NCBI_TaxID=6999; Gryllus bimaculatus (Two-spotted cricket).
OH   NCBI_TaxID=58607; Gryllus campestris.
OH   NCBI_TaxID=7108; Spodoptera frugiperda (Fall armyworm).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11448171; DOI=10.1006/viro.2001.0963;
RA   Jakob N.J., Mueller K., Bahr U., Darai G.;
RT   "Analysis of the first complete DNA sequence of an invertebrate iridovirus:
RT   coding strategy of the genome of Chilo iridescent virus.";
RL   Virology 286:182-196(2001).
RN   [2]
RP   GENOME REANNOTATION.
RX   PubMed=17239238; DOI=10.1186/1743-422x-4-11;
RA   Eaton H.E., Metcalf J., Penny E., Tcherepanov V., Upton C., Brunetti C.R.;
RT   "Comparative genomic analysis of the family Iridoviridae: re-annotating and
RT   defining the core set of iridovirus genes.";
RL   Virol. J. 4:11-11(2007).
RN   [3]
RP   FUNCTION.
RX   PubMed=18420249; DOI=10.1016/j.virol.2008.03.009;
RA   Ince I.A., Westenberg M., Vlak J.M., Demirbag Z., Nalcacioglu R.,
RA   van Oers M.M.;
RT   "Open reading frame 193R of Chilo iridescent virus encodes a functional
RT   inhibitor of apoptosis (IAP).";
RL   Virology 376:124-131(2008).
CC   -!- FUNCTION: Plays a role early in infection by preventing host cell
CC       apoptosis. {ECO:0000269|PubMed:18420249}.
CC   -!- SIMILARITY: Belongs to the IIV-6 193R family. {ECO:0000305}.
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DR   EMBL; AF303741; AAB94481.1; -; Genomic_DNA.
DR   PIR; T03183; T03183.
DR   RefSeq; NP_149656.1; NC_003038.1.
DR   SMR; P47732; -.
DR   GeneID; 1733224; -.
DR   KEGG; vg:1733224; -.
DR   OrthoDB; 9255at10239; -.
DR   Proteomes; UP000001359; Genome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0039526; P:perturbation by virus of host apoptosis; IEA:UniProtKB-KW.
DR   GO; GO:0019050; P:suppression by virus of host apoptotic process; IEA:UniProtKB-KW.
DR   CDD; cd00022; BIR; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR001370; BIR_rpt.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR10044:SF139; DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2; 1.
DR   PANTHER; PTHR10044; INHIBITOR OF APOPTOSIS; 1.
DR   Pfam; PF00653; BIR; 1.
DR   Pfam; PF13920; zf-C3HC4_3; 1.
DR   SMART; SM00238; BIR; 1.
DR   SMART; SM00184; RING; 1.
DR   SUPFAM; SSF57924; Inhibitor of apoptosis (IAP) repeat; 1.
DR   PROSITE; PS50143; BIR_REPEAT_2; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Early protein; Host-virus interaction;
KW   Inhibition of host caspases by virus; Metal-binding;
KW   Modulation of host cell apoptosis by virus; Reference proteome; Repeat;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..208
FT                   /note="Apoptosis inhibitor 193R"
FT                   /id="PRO_0000122384"
FT   REPEAT          37..108
FT                   /note="BIR"
FT   REPEAT          134..139
FT                   /note="1"
FT   REPEAT          140..145
FT                   /note="2"
FT   REPEAT          146..151
FT                   /note="3"
FT   ZN_FING         163..197
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          134..151
FT                   /note="3 X 6 AA tandem repeats"
FT   BINDING         74
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         77
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         94
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         105
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
SQ   SEQUENCE   208 AA;  24142 MW;  41A2E2FC18833390 CRC64;
     MDTCGIYNSD NEEFSQENDG ENDGGDKIIK NLPFASYDER LNSFQNWPIQ LLPSKEQLSR
     AGFIYLNIGD QVQCFYCDLK LKEWKRSDNP FEEHKKHTQD LKINCLFVKS IEFDNFVKNH
     SESCFQNPIT NNINQDLDHN QDLDHNQDLD QNSTTSDCDV LTCKICFTNK ITKVLIPCGH
     SSCYECVFKL QTCPICKNNF IKINNLFI
//