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Protein

Apoptosis inhibitor 193R

Gene

IIV6-193R

Organism
Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays a role early in infection by preventing host cell apoptosis.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi74 – 741ZincPROSITE-ProRule annotation
Metal bindingi77 – 771ZincPROSITE-ProRule annotation
Metal bindingi94 – 941ZincPROSITE-ProRule annotation
Metal bindingi105 – 1051ZincPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri163 – 19735RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro

GO - Biological processi

  1. suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Host-virus interaction, Inhibition of host caspases by virus, Modulation of host cell apoptosis by virus

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiI32.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Apoptosis inhibitor 193R
Gene namesi
ORF Names:IIV6-193R
OrganismiInvertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus)
Taxonomic identifieri176652 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeIridovirus
Virus hostiAcheta domesticus (House cricket) [TaxID: 6997]
Chilo suppressalis (striped riceborer) [TaxID: 168631]
Gryllus bimaculatus (Two-spotted cricket) [TaxID: 6999]
Gryllus campestris [TaxID: 58607]
Spodoptera frugiperda (Fall armyworm) [TaxID: 7108]
ProteomesiUP000001359 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Apoptosis inhibitor 193RPRO_0000122384Add
BLAST

Expressioni

Keywords - Developmental stagei

Early protein

Structurei

3D structure databases

ProteinModelPortaliP47732.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati37 – 10872BIRAdd
BLAST
Repeati134 – 13961
Repeati140 – 14562
Repeati146 – 15163

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 151183 X 6 AA tandem repeatsAdd
BLAST

Sequence similaritiesi

Belongs to the IIV-6 193R family.Curated
Contains 1 BIR repeat.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri163 – 19735RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Family and domain databases

Gene3Di1.10.1170.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR001370. BIR.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00653. BIR. 1 hit.
[Graphical view]
SMARTiSM00238. BIR. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50143. BIR_REPEAT_2. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47732-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTCGIYNSD NEEFSQENDG ENDGGDKIIK NLPFASYDER LNSFQNWPIQ
60 70 80 90 100
LLPSKEQLSR AGFIYLNIGD QVQCFYCDLK LKEWKRSDNP FEEHKKHTQD
110 120 130 140 150
LKINCLFVKS IEFDNFVKNH SESCFQNPIT NNINQDLDHN QDLDHNQDLD
160 170 180 190 200
QNSTTSDCDV LTCKICFTNK ITKVLIPCGH SSCYECVFKL QTCPICKNNF

IKINNLFI
Length:208
Mass (Da):24,142
Last modified:July 25, 2003 - v2
Checksum:i41A2E2FC18833390
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303741 Genomic DNA. Translation: AAB94481.1.
PIRiT03183.
RefSeqiNP_149656.1. NC_003038.1.

Genome annotation databases

GeneIDi1733224.
KEGGivg:1733224.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303741 Genomic DNA. Translation: AAB94481.1.
PIRiT03183.
RefSeqiNP_149656.1. NC_003038.1.

3D structure databases

ProteinModelPortaliP47732.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI32.010.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1733224.
KEGGivg:1733224.

Family and domain databases

Gene3Di1.10.1170.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR001370. BIR.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00653. BIR. 1 hit.
[Graphical view]
SMARTiSM00238. BIR. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50143. BIR_REPEAT_2. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the first complete DNA sequence of an invertebrate iridovirus: coding strategy of the genome of Chilo iridescent virus."
    Jakob N.J., Mueller K., Bahr U., Darai G.
    Virology 286:182-196(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Comparative genomic analysis of the family Iridoviridae: re-annotating and defining the core set of iridovirus genes."
    Eaton H.E., Metcalf J., Penny E., Tcherepanov V., Upton C., Brunetti C.R.
    Virol. J. 4:11-11(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
  3. "Open reading frame 193R of Chilo iridescent virus encodes a functional inhibitor of apoptosis (IAP)."
    Ince I.A., Westenberg M., Vlak J.M., Demirbag Z., Nalcacioglu R., van Oers M.M.
    Virology 376:124-131(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiVF193_IIV6
AccessioniPrimary (citable) accession number: P47732
Secondary accession number(s): O55770
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 25, 2003
Last modified: April 1, 2015
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.