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P47732

- VF193_IIV6

UniProt

P47732 - VF193_IIV6

Protein

Apoptosis inhibitor 193R

Gene

IIV6-193R

Organism
Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 2 (25 Jul 2003)
      Previous versions | rss
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    Functioni

    Plays a role early in infection by preventing host cell apoptosis.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi74 – 741ZincPROSITE-ProRule annotation
    Metal bindingi77 – 771ZincPROSITE-ProRule annotation
    Metal bindingi94 – 941ZincPROSITE-ProRule annotation
    Metal bindingi105 – 1051ZincPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri163 – 19735RING-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB-KW

    Keywords - Biological processi

    Apoptosis, Host-virus interaction, Inhibition of host caspases by virus, Modulation of host cell apoptosis by virus

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Apoptosis inhibitor 193R
    Gene namesi
    ORF Names:IIV6-193R
    OrganismiInvertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus)
    Taxonomic identifieri176652 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeIridovirus
    Virus hostiAcheta domesticus (House cricket) [TaxID: 6997]
    Chilo suppressalis (striped riceborer) [TaxID: 168631]
    Gryllus bimaculatus (Two-spotted cricket) [TaxID: 6999]
    Gryllus campestris [TaxID: 58607]
    Spodoptera frugiperda (Fall armyworm) [TaxID: 7108]
    ProteomesiUP000001359: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 208208Apoptosis inhibitor 193RPRO_0000122384Add
    BLAST

    Expressioni

    Keywords - Developmental stagei

    Early protein

    Structurei

    3D structure databases

    ProteinModelPortaliP47732.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati37 – 10872BIRAdd
    BLAST
    Repeati134 – 13961
    Repeati140 – 14562
    Repeati146 – 15163

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni134 – 151183 X 6 AA tandem repeatsAdd
    BLAST

    Sequence similaritiesi

    Belongs to the IIV-6 193R family.Curated
    Contains 1 BIR repeat.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri163 – 19735RING-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Family and domain databases

    Gene3Di1.10.1170.10. 1 hit.
    3.30.40.10. 1 hit.
    InterProiIPR001370. BIR.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF00653. BIR. 1 hit.
    [Graphical view]
    SMARTiSM00238. BIR. 1 hit.
    SM00184. RING. 1 hit.
    [Graphical view]
    PROSITEiPS50143. BIR_REPEAT_2. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47732-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDTCGIYNSD NEEFSQENDG ENDGGDKIIK NLPFASYDER LNSFQNWPIQ    50
    LLPSKEQLSR AGFIYLNIGD QVQCFYCDLK LKEWKRSDNP FEEHKKHTQD 100
    LKINCLFVKS IEFDNFVKNH SESCFQNPIT NNINQDLDHN QDLDHNQDLD 150
    QNSTTSDCDV LTCKICFTNK ITKVLIPCGH SSCYECVFKL QTCPICKNNF 200
    IKINNLFI 208
    Length:208
    Mass (Da):24,142
    Last modified:July 25, 2003 - v2
    Checksum:i41A2E2FC18833390
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF303741 Genomic DNA. Translation: AAB94481.1.
    PIRiT03183.
    RefSeqiNP_149656.1. NC_003038.1.

    Genome annotation databases

    GeneIDi1733224.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF303741 Genomic DNA. Translation: AAB94481.1 .
    PIRi T03183.
    RefSeqi NP_149656.1. NC_003038.1.

    3D structure databases

    ProteinModelPortali P47732.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1733224.

    Family and domain databases

    Gene3Di 1.10.1170.10. 1 hit.
    3.30.40.10. 1 hit.
    InterProi IPR001370. BIR.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF00653. BIR. 1 hit.
    [Graphical view ]
    SMARTi SM00238. BIR. 1 hit.
    SM00184. RING. 1 hit.
    [Graphical view ]
    PROSITEi PS50143. BIR_REPEAT_2. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the first complete DNA sequence of an invertebrate iridovirus: coding strategy of the genome of Chilo iridescent virus."
      Jakob N.J., Mueller K., Bahr U., Darai G.
      Virology 286:182-196(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Comparative genomic analysis of the family Iridoviridae: re-annotating and defining the core set of iridovirus genes."
      Eaton H.E., Metcalf J., Penny E., Tcherepanov V., Upton C., Brunetti C.R.
      Virol. J. 4:11-11(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
    3. "Open reading frame 193R of Chilo iridescent virus encodes a functional inhibitor of apoptosis (IAP)."
      Ince I.A., Westenberg M., Vlak J.M., Demirbag Z., Nalcacioglu R., van Oers M.M.
      Virology 376:124-131(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiVF193_IIV6
    AccessioniPrimary (citable) accession number: P47732
    Secondary accession number(s): O55770
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: July 25, 2003
    Last modified: October 1, 2014
    This is version 71 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3