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P47732

- VF193_IIV6

UniProt

P47732 - VF193_IIV6

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Protein

Apoptosis inhibitor 193R

Gene
IIV6-193R
Organism
Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Plays a role early in infection by preventing host cell apoptosis.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi74 – 741Zinc By similarity
Metal bindingi77 – 771Zinc By similarity
Metal bindingi94 – 941Zinc By similarity
Metal bindingi105 – 1051Zinc By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri163 – 19735RING-typeAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro

GO - Biological processi

  1. suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Host-virus interaction, Inhibition of host caspases by virus, Modulation of host cell apoptosis by virus

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Apoptosis inhibitor 193R
Gene namesi
ORF Names:IIV6-193R
OrganismiInvertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus)
Taxonomic identifieri176652 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeIridovirus
Virus hostiAcheta domesticus (House cricket) [TaxID: 6997]
Chilo suppressalis (striped riceborer) [TaxID: 168631]
Gryllus bimaculatus (Two-spotted cricket) [TaxID: 6999]
Gryllus campestris [TaxID: 58607]
Spodoptera frugiperda (Fall armyworm) [TaxID: 7108]
ProteomesiUP000001359: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Apoptosis inhibitor 193RPRO_0000122384Add
BLAST

Expressioni

Keywords - Developmental stagei

Early protein

Structurei

3D structure databases

ProteinModelPortaliP47732.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati37 – 10872BIRAdd
BLAST
Repeati134 – 13961
Repeati140 – 14562
Repeati146 – 15163

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 151183 X 6 AA tandem repeatsAdd
BLAST

Sequence similaritiesi

Belongs to the IIV-6 193R family.
Contains 1 BIR repeat.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri163 – 19735RING-typeAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Family and domain databases

Gene3Di1.10.1170.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR001370. BIR.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00653. BIR. 1 hit.
[Graphical view]
SMARTiSM00238. BIR. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50143. BIR_REPEAT_2. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47732-1 [UniParc]FASTAAdd to Basket

« Hide

MDTCGIYNSD NEEFSQENDG ENDGGDKIIK NLPFASYDER LNSFQNWPIQ    50
LLPSKEQLSR AGFIYLNIGD QVQCFYCDLK LKEWKRSDNP FEEHKKHTQD 100
LKINCLFVKS IEFDNFVKNH SESCFQNPIT NNINQDLDHN QDLDHNQDLD 150
QNSTTSDCDV LTCKICFTNK ITKVLIPCGH SSCYECVFKL QTCPICKNNF 200
IKINNLFI 208
Length:208
Mass (Da):24,142
Last modified:July 25, 2003 - v2
Checksum:i41A2E2FC18833390
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF303741 Genomic DNA. Translation: AAB94481.1.
PIRiT03183.
RefSeqiNP_149656.1. NC_003038.1.

Genome annotation databases

GeneIDi1733224.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF303741 Genomic DNA. Translation: AAB94481.1 .
PIRi T03183.
RefSeqi NP_149656.1. NC_003038.1.

3D structure databases

ProteinModelPortali P47732.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1733224.

Family and domain databases

Gene3Di 1.10.1170.10. 1 hit.
3.30.40.10. 1 hit.
InterProi IPR001370. BIR.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF00653. BIR. 1 hit.
[Graphical view ]
SMARTi SM00238. BIR. 1 hit.
SM00184. RING. 1 hit.
[Graphical view ]
PROSITEi PS50143. BIR_REPEAT_2. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the first complete DNA sequence of an invertebrate iridovirus: coding strategy of the genome of Chilo iridescent virus."
    Jakob N.J., Mueller K., Bahr U., Darai G.
    Virology 286:182-196(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Comparative genomic analysis of the family Iridoviridae: re-annotating and defining the core set of iridovirus genes."
    Eaton H.E., Metcalf J., Penny E., Tcherepanov V., Upton C., Brunetti C.R.
    Virol. J. 4:11-11(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
  3. "Open reading frame 193R of Chilo iridescent virus encodes a functional inhibitor of apoptosis (IAP)."
    Ince I.A., Westenberg M., Vlak J.M., Demirbag Z., Nalcacioglu R., van Oers M.M.
    Virology 376:124-131(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiVF193_IIV6
AccessioniPrimary (citable) accession number: P47732
Secondary accession number(s): O55770
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 25, 2003
Last modified: February 19, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3