P47729 (DPO3_MYCPU) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 91.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: DNA polymerase III PolC-type Short name=PolIII EC=2.7.7.7 | ||||
| Gene names |
| ||||
| Organism | Mycoplasma pulmonis (strain UAB CTIP) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 272635 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma ›  |
Protein attributes
| Sequence length | 1435 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. HAMAP-Rule MF_00356 |
| Catalytic activity | Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). HAMAP-Rule MF_00356 |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the DNA polymerase type-C family. PolC subfamily. Contains 1 exonuclease domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | DNA replication |
| Cellular component | Cytoplasm |
| Molecular function | DNA-directed DNA polymerase Exonuclease Hydrolase Nuclease Nucleotidyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological_process | DNA-dependent DNA replication Inferred from electronic annotation. Source: HAMAP nucleic acid phosphodiester bond hydrolysisInferred from electronic annotation. Source: GOC |
| Cellular_component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | 3'-5' exonuclease activity Inferred from electronic annotation. Source: HAMAP DNA bindingInferred from electronic annotation. Source: HAMAP DNA-directed DNA polymerase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1435 | 1435 | DNA polymerase III PolC-type HAMAP-Rule MF_00356 | PRO_0000204584 | |||||
Regions | |||||||||
| Domain | 404 – 562 | 159 | Exonuclease | ||||||
Experimental info | |||||||||
| Sequence conflict | 786 – 787 | 2 | NP → S in AAA18178. Ref.1 | ||||||
| Sequence conflict | 1233 | 1 | R → KE in AAA18178. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "DNA polymerase III of Mycoplasma pulmonis: isolation and characterization of the enzyme and its structural gene, polC." Barnes M.H., Tarantino P.M. Jr., Spacciapoli P., Brown N.C., Yu H., Dybvig K. Mol. Microbiol. 13:843-854(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: KD735-15. |
| [2] | "The complete genome sequence of the murine respiratory pathogen Mycoplasma pulmonis." Chambaud I., Heilig R., Ferris S., Barbe V., Samson D., Galisson F., Moszer I., Dybvig K., Wroblewski H., Viari A., Rocha E.P.C., Blanchard A. Nucleic Acids Res. 29:2145-2153(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: UAB CTIP. |
| [3] | "Regulation of a restriction and modification system via DNA inversion in Mycoplasma pulmonis." Dybvig K., Yu H. Mol. Microbiol. 12:547-560(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1408-1435. Strain: KD735-16. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U06833 Genomic DNA. Translation: AAA18178.1. AL445565 Genomic DNA. Translation: CAC13848.1. L25415 Genomic DNA. Translation: AAA65635.1. |
| PIR | C90596. S54697. |
| RefSeq | NP_326506.1. NC_002771.1. |
3D structure databases | |
| ProteinModelPortal | P47729. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 272635.MYPU_6750. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | CAC13848; CAC13848; CAC13848. |
| GeneID | 911075. |
| KEGG | mpu:MYPU_6750. |
| PATRIC | 20024304. VBIMycPul29704_0688. |
Organism-specific databases | |
| GenoList | MYPU_6750. |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG2176. |
| HOGENOM | HOG000058064. |
| KO | K03763. |
| OMA | IYGMEAN. |
| ProtClustDB | PRK00448. |
Family and domain databases | |
| HAMAP | MF_00356. DNApol_PolC. |
| InterPro | IPR011708. DNA_pol3_alpha. IPR006054. DnaQ. IPR006055. Exonuclease. IPR013520. Exonuclease_RNaseT/DNA_pol3. IPR004013. PHP_C. IPR003141. Pol/His_phosphatase_N. IPR006308. PolC_gram_pos. IPR012337. RNaseH-like_dom. [Graphical view] |
| Pfam | PF07733. DNA_pol3_alpha. 1 hit. PF02811. PHP. 1 hit. PF00929. RNase_T. 1 hit. [Graphical view] |
| SMART | SM00479. EXOIII. 1 hit. SM00481. POLIIIAc. 1 hit. [Graphical view] |
| SUPFAM | SSF53098. RNaseH_fold. 1 hit. |
| TIGRFAMs | TIGR00573. dnaq. 1 hit. TIGR01405. polC_Gram_pos. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | DPO3_MYCPU | ||||||||
| Accession | Primary (citable) accession number: P47729 Secondary accession number(s): Q79E72 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |