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Protein

Calretinin

Gene

Calb2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Calretinin is a calcium-binding protein which is abundant in auditory neurons.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi29 – 40121CuratedAdd
BLAST
Calcium bindingi76 – 87122; possibly ancestralCuratedAdd
BLAST
Calcium bindingi120 – 131123CuratedAdd
BLAST
Calcium bindingi164 – 175124CuratedAdd
BLAST
Calcium bindingi208 – 219125CuratedAdd
BLAST
Calcium bindingi251 – 262126; possibly ancestralCuratedAdd
BLAST

GO - Molecular functioni

  • calcium ion binding Source: RGD

GO - Biological processi

  • regulation of cytosolic calcium ion concentration Source: RGD
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calretinin
Short name:
CR
Gene namesi
Name:Calb2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi620981. Calb2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • gap junction Source: Ensembl
  • nucleus Source: RGD
  • terminal bouton Source: ParkinsonsUK-UCL
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271CalretininPRO_0000073481Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei214 – 2141PhosphotyrosineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP47728.
PRIDEiP47728.

2D gel databases

World-2DPAGE0004:P47728.

PTM databases

iPTMnetiP47728.

Expressioni

Gene expression databases

GenevisibleiP47728. RN.

Interactioni

Protein-protein interaction databases

IntActiP47728. 1 interaction.
STRINGi10116.ENSRNOP00000022943.

Structurei

3D structure databases

ProteinModelPortaliP47728.
SMRiP47728. Positions 10-268.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 5136EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini63 – 9836EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini107 – 14236EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini151 – 18636EF-hand 4PROSITE-ProRule annotationAdd
BLAST
Domaini195 – 23036EF-hand 5PROSITE-ProRule annotationAdd
BLAST
Domaini235 – 27036EF-hand 6PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the calbindin family.Curated
Contains 6 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000013118.
HOGENOMiHOG000231866.
HOVERGENiHBG000855.
InParanoidiP47728.
OMAiTYRKSVM.
OrthoDBiEOG71G9VB.
PhylomeDBiP47728.
TreeFamiTF325083.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR029646. CALB2.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PANTHERiPTHR19972:SF4. PTHR19972:SF4. 1 hit.
PfamiPF13405. EF-hand_6. 1 hit.
PF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 5 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS00018. EF_HAND_1. 5 hits.
PS50222. EF_HAND_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47728-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPQQQPPY LHLAELTASQ FLEIWKHFDA DGNGYIEGKE LENFFQELEK
60 70 80 90 100
ARKGSGMMSK SDNFGEKMKE FMQKYDKNSD GKIEMAELAQ ILPTEENFLL
110 120 130 140 150
CFRQHVGSSA EFMEAWRKYD TDRSGYIEAN ELKGFLSDLL KKANRPYDEP
160 170 180 190 200
KLQEYTQTIL RMFDLNGDGK LGLSEMSRLL PVQENFLLKF QGMKLTSEEF
210 220 230 240 250
NAIFTFYDKD GSGYIDENEL DALLKDLYEK NKKEMNIQQL TTYRKSVMSL
260 270
AEAGKLYRKD LEIVLCSEPP M
Length:271
Mass (Da):31,405
Last modified:February 1, 1996 - v1
Checksum:iD2676AD7130DAACD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66974 mRNA. Translation: CAA47385.1.
BC087603 mRNA. Translation: AAH87603.1.
PIRiS25006.
RefSeqiNP_446440.1. NM_053988.1.
UniGeneiRn.10321.

Genome annotation databases

EnsembliENSRNOT00000022943; ENSRNOP00000022943; ENSRNOG00000016977.
GeneIDi117059.
KEGGirno:117059.
UCSCiRGD:620981. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66974 mRNA. Translation: CAA47385.1.
BC087603 mRNA. Translation: AAH87603.1.
PIRiS25006.
RefSeqiNP_446440.1. NM_053988.1.
UniGeneiRn.10321.

3D structure databases

ProteinModelPortaliP47728.
SMRiP47728. Positions 10-268.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP47728. 1 interaction.
STRINGi10116.ENSRNOP00000022943.

PTM databases

iPTMnetiP47728.

2D gel databases

World-2DPAGE0004:P47728.

Proteomic databases

PaxDbiP47728.
PRIDEiP47728.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022943; ENSRNOP00000022943; ENSRNOG00000016977.
GeneIDi117059.
KEGGirno:117059.
UCSCiRGD:620981. rat.

Organism-specific databases

CTDi794.
RGDi620981. Calb2.

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000013118.
HOGENOMiHOG000231866.
HOVERGENiHBG000855.
InParanoidiP47728.
OMAiTYRKSVM.
OrthoDBiEOG71G9VB.
PhylomeDBiP47728.
TreeFamiTF325083.

Miscellaneous databases

NextBioi619912.
PROiP47728.

Gene expression databases

GenevisibleiP47728. RN.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR029646. CALB2.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PANTHERiPTHR19972:SF4. PTHR19972:SF4. 1 hit.
PfamiPF13405. EF-hand_6. 1 hit.
PF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 5 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS00018. EF_HAND_1. 5 hits.
PS50222. EF_HAND_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Calretinin is expressed in the Leydig cells of rat testis."
    Strauss K.I., Jacobowitz D.M.
    Biochim. Biophys. Acta 1219:435-440(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Lubec G., Afjehi-Sadat L., Kang S.U.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 83-103; 134-141; 152-161; 171-178 AND 246-255, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain and Spinal cord.
  4. "Brain calbindin-D28k and an Mr 29,000 calcium binding protein in cerebellum are different but related proteins: evidence obtained from sequence analysis by tandem mass spectrometry."
    Gabrielides C., McCormack A.L., Hunt D.F., Christakos S.
    Biochemistry 30:656-662(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE.
  5. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-214, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCALB2_RAT
AccessioniPrimary (citable) accession number: P47728
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 11, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.