P47722 (DEOC_MYCPI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyribose-phosphate aldolase
Short name=DERA
EC=4.1.2.4

Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase
Phosphodeoxyriboaldolase
Short name=Deoxyriboaldolase

Gene names

Name:

deoC

Organism

Mycoplasma pirum

Taxonomic identifier

2122 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	220 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate By similarity. HAMAP-Rule MF_00114
Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP-Rule MF_00114
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP-Rule MF_00114
Subcellular location	Cytoplasm HAMAP-Rule MF_00114.
Sequence similarities	Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Gene Ontology (GO)
Biological_process	carbohydrate catabolic process Inferred from electronic annotation. Source: HAMAP deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro deoxyribose phosphate catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 220	220	Deoxyribose-phosphate aldolase HAMAP-Rule MF_00114		PRO_0000057244
Sites
	Active site	150	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	182	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P47722 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: E3BB251D8AAA8C78	FASTA	220	24,421
	10 20 30 40 50 60 MNYNSLFDHT LLRADASVEE IKQLCDEAVK FNFFSVCVNP SYVPYVKEQL HNSSVKICTV 70 80 90 100 110 120 VGFPLGQTST KQKVYETKIA IKEGADEIDM VLNISEFKEN CACVVNEIRK YKKVCKKKIL 130 140 150 160 170 180 KVIVETALLS ENEIEKATLV VIDGGADFIK TSTGFSSRGA SIKDIEIMKN VIEKNNSKLK 190 200 210 220 IKASGGIKTL TFVEELIKAG AERIGSSKSV EIIKETLNKN

References

[1]	"Identification of Mycoplasma pirum genes involved in the salvage pathways for nucleosides." Tham T.N., Ferris S., Kovacic R., Montagnier L., Blanchard A. J. Bacteriol. 175:5281-5285(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BER.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L13289 Genomic DNA. Translation: AAA25431.1.
PIR	B53312.
3D structure databases
ProteinModelPortal	P47722.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00002; UER00468.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
HAMAP	MF_00114. DeoC_type1.
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/FbaB/lacD_aldolase. [Graphical view]
PANTHER	PTHR10889. PTHR10889. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. deoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOC_MYCPI

Accession

Primary (citable) accession number: P47722

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	April 3, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program