Reviewed,
UniProtKB/Swiss-Prot P47718 (CDD_MYCPI)
Last modified
February 9, 2010.
Version 48.
History...
Clusters with 100%,
90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Cytidine deaminase Short name=CDA EC=3.5.4.5 Alternative name(s): Cytidine aminohydrolase | ||
| Gene names |
| ||
| Organism | Mycoplasma pirum | ||
| Taxonomic identifier | 2122 [NCBI] | ||
| Taxonomic lineage | Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma |
Protein attributes
| Sequence length | 133 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity. |
| Catalytic activity | Cytidine + H2O = uridine + NH3. |
| Cofactor | Binds 1 zinc ion By similarity. |
| Subunit structure | Homodimer By similarity. |
| Sequence similarities | Belongs to the cytidine and deoxycytidylate deaminase family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Metal-binding Zinc |
| Molecular function | Hydrolase |
| Gene Ontology (GO) | |
| Biological process | cytidine metabolic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | cytidine deaminase activity Inferred from electronic annotation. Source: EC zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 133 | 133 | Cytidine deaminase | PRO_0000171680 | |||||
Regions | |||||||||
| Region | 42 – 44 | 3 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Active site | 55 | 1 | Proton donor By similarity | ||||||
| Metal binding | 53 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 88 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 91 | 1 | Zinc; catalytic By similarity | ||||||
Sequences
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References
| [1] | "Identification of Mycoplasma pirum genes involved in the salvage pathways for nucleosides." Tham T.N., Ferris S., Kovacic R., Montagnier L., Blanchard A. J. Bacteriol. 175:5281-5285(1993) [PubMed: 8349569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BER. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | L13289 Genomic DNA. Translation: AAA25433.1. |
| PIR | D53312. |
3D structure databases | |
| SMR | P47718. Positions 1-133. |
| ModBase | Search... |
Enzyme and pathway databases | |
| BRENDA | 3.5.4.5. 291264. |
Family and domain databases | |
| InterPro | IPR016192. APOBEC/CMP_deaminase_Zn-bd. IPR002125. CMP_dCMP_Zn_bd. IPR006262. Cyt_deam_tetra. IPR016193. Cytidine_deaminase-like. [Graphical view] |
| PANTHER | PTHR11644:SF2. Cyt_deam_tetra. 1 hit. |
| Pfam | PF00383. dCMP_cyt_deam_1. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01354. cyt_deam_tetra. 1 hit. |
| PROSITE | PS00903. CYT_DCMP_DEAMINASES. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CDD_MYCPI | ||||||||
| Accession | Primary (citable) accession number: P47718 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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