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P47718 (CDD_MYCPI) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytidine deaminase

Short name=CDA
EC=3.5.4.5
Alternative name(s):
Cytidine aminohydrolase
Gene names
Name:cdd
OrganismMycoplasma pirum
Taxonomic identifier2122 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length133 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity.

Catalytic activity

Cytidine + H2O = uridine + NH3.

2'deoxycytidine + H2O = 2'-deoxyuridine + NH3.

Cofactor

Binds 1 zinc ion By similarity.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the cytidine and deoxycytidylate deaminase family.

Contains 1 CMP/dCMP deaminase zinc-binding domain.

Ontologies

Keywords
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
Gene Ontology (GO)
   Molecular_functioncytidine deaminase activity

Inferred from electronic annotation. Source: UniProtKB-EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 133133Cytidine deaminase
PRO_0000171680

Regions

Domain1 – 103103CMP/dCMP deaminase zinc-binding
Region42 – 443Substrate binding By similarity

Sites

Active site551Proton donor By similarity
Metal binding531Zinc; catalytic By similarity
Metal binding881Zinc; catalytic By similarity
Metal binding911Zinc; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
P47718 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 19CB3314EEAF12C4

FASTA13315,018
        10         20         30         40         50         60 
MKEKDIYFQK LNELISNAYV PYSNFRVSCL LLTDGGWFAG VNIENSAYSP TICAERSAVS 

        70         80         90        100        110        120 
SMITSGFKQI FKVYILTDTI VKDIGTPCGV CRQVLSEFAK PETPIITYNL KGEKFFYTLE 

       130 
QLLPFAFNKD ALK 

« Hide

References

[1]"Identification of Mycoplasma pirum genes involved in the salvage pathways for nucleosides."
Tham T.N., Ferris S., Kovacic R., Montagnier L., Blanchard A.
J. Bacteriol. 175:5281-5285(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: BER.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L13289 Genomic DNA. Translation: AAA25433.1.
PIRD53312.

3D structure databases

ProteinModelPortalP47718.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR006262. Cyt_deam_tetra.
IPR016193. Cytidine_deaminase-like.
[Graphical view]
PfamPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
SUPFAMSSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR01354. cyt_deam_tetra. 1 hit.
PROSITEPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDD_MYCPI
AccessionPrimary (citable) accession number: P47718
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 16, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families