Reviewed, UniProtKB/Swiss-Prot P47718 (CDD_MYCPI)

Names and origin

Protein names

Recommended name:
    Cytidine deaminase
      Short name=CDA
    EC=3.5.4.5
Alternative name(s):
    Cytidine aminohydrolase

Gene names

Name:

cdd

Organism

Mycoplasma pirum

Taxonomic identifier

2122 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	133 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity.
Catalytic activity	Cytidine + H2O = uridine + NH3.
Cofactor	Binds 1 zinc ion By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	cytidine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	cytidine deaminase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 133	133	Cytidine deaminase		PRO_0000171680
Regions
	Region	42 – 44	3	Substrate binding By similarity
Sites
	Active site	55	1	Proton donor By similarity
	Metal binding	53	1	Zinc; catalytic By similarity
	Metal binding	88	1	Zinc; catalytic By similarity
	Metal binding	91	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	P47718-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 19CB3314EEAF12C4	FASTA	133	15,018
	10 20 30 40 50 60 MKEKDIYFQK LNELISNAYV PYSNFRVSCL LLTDGGWFAG VNIENSAYSP TICAERSAVS 70 80 90 100 110 120 SMITSGFKQI FKVYILTDTI VKDIGTPCGV CRQVLSEFAK PETPIITYNL KGEKFFYTLE 130 QLLPFAFNKD ALK

References

[1]	"Identification of Mycoplasma pirum genes involved in the salvage pathways for nucleosides." Tham T.N., Ferris S., Kovacic R., Montagnier L., Blanchard A. J. Bacteriol. 175:5281-5285(1993) [PubMed: 8349569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BER.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L13289 Genomic DNA. Translation: AAA25433.1.
PIR	D53312.
3D structure databases
HSSP	HSSP built from PDB template 1JTK based on UniProtKB P19079.
ModBase	Search...
Enzyme and pathway databases
BRENDA	3.5.4.5. 291264.
Family and domain databases
InterPro	IPR016192. APOBEC/CMP_deaminase_Zn-bd. IPR002125. CMP_dCMP_Zn_bd. IPR006262. Cyt_deam_tetra. [Graphical view]
PANTHER	PTHR11644:SF2. Cyt_deam_tetra. 1 hit.
Pfam	PF00383. dCMP_cyt_deam_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR01354. cyt_deam_tetra. 1 hit.
PROSITE	PS00903. CYT_DCMP_DEAMINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDD_MYCPI

Accession

Primary (citable) accession number: P47718

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	June 16, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)