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P47717 (TYPH_MYCPI) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine phosphorylase

EC=2.4.2.4
Alternative name(s):
TdRPase
Gene names
Name:deoA
OrganismMycoplasma pirum
Taxonomic identifier2122 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length419 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.

Catalytic activity

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 419419Thymidine phosphorylase
PRO_0000059080

Sequences

Sequence LengthMass (Da)Tools
P47717 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: C1620F2EF33929E3

FASTA41947,279
        10         20         30         40         50         60 
MNIIEIIELK KNKKKLSQDQ INFCISGLVN KSIPDYQISA LLMAIWFNGL DDNELYFLTK 

        70         80         90        100        110        120 
AMIDSGKIYK FHPEYKKILI DKHSTGGIGD KVSIALRPIL VSFDLGVAKL SGRGLGFTGG 

       130        140        150        160        170        180 
TIDKLESINV NTDIDLKNSK KILNIANMFI VGQTNDIVPA DKLLYALRDV TGTVDSLPLI 

       190        200        210        220        230        240 
AASILSKKFA LESDYIFIDI KYGQGAFCHD IETAKKISNI MKNLAKKFKR KVYFVLSDMN 

       250        260        270        280        290        300 
EVLGNTVGNA IEVKEAIDFL KNNSDVGTYF KKLMFDLVTL ILLKTKKCKT KKEAKEKINY 

       310        320        330        340        350        360 
VLENKIAFNN FCNWIELQNG NIAKIKNDTF FKPKYWTNIA AWKSGKISYK SIIELAEIGV 

       370        380        390        400        410 
DLGSGRRKKE DKIDFQAGIY LHAKSNEKIK IKDKILTLYS SKPIKQDLID KAKKIIKIS 

« Hide

References

[1]"Identification of Mycoplasma pirum genes involved in the salvage pathways for nucleosides."
Tham T.N., Ferris S., Kovacic R., Montagnier L., Blanchard A.
J. Bacteriol. 175:5281-5285(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: BER.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L13289 Genomic DNA. Translation: AAA25432.1.
PIRC53312.

3D structure databases

ProteinModelPortalP47717.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
InterProIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
[Graphical view]
PANTHERPTHR10515. PTHR10515. 1 hit.
PfamPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFPIRSF000478. TP_PyNP. 1 hit.
SMARTSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsTIGR02644. Y_phosphoryl. 1 hit.
PROSITEPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYPH_MYCPI
AccessionPrimary (citable) accession number: P47717
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 16, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families