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P47717

- TYPH_MYCPI

UniProt

P47717 - TYPH_MYCPI

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Protein

Thymidine phosphorylase

Gene

deoA

Organism
Mycoplasma pirum
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.

Catalytic activityi

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.

GO - Molecular functioni

  1. phosphorylase activity Source: InterPro
  2. pyrimidine-nucleoside phosphorylase activity Source: InterPro
  3. thymidine phosphorylase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyrimidine nucleobase metabolic process Source: InterPro
  2. pyrimidine nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine phosphorylase (EC:2.4.2.4)
Alternative name(s):
TdRPase
Gene namesi
Name:deoA
OrganismiMycoplasma pirum
Taxonomic identifieri2122 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 419419Thymidine phosphorylasePRO_0000059080Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP47717.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
InterProiIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000478. TP_PyNP. 1 hit.
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR02644. Y_phosphoryl. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47717-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNIIEIIELK KNKKKLSQDQ INFCISGLVN KSIPDYQISA LLMAIWFNGL
60 70 80 90 100
DDNELYFLTK AMIDSGKIYK FHPEYKKILI DKHSTGGIGD KVSIALRPIL
110 120 130 140 150
VSFDLGVAKL SGRGLGFTGG TIDKLESINV NTDIDLKNSK KILNIANMFI
160 170 180 190 200
VGQTNDIVPA DKLLYALRDV TGTVDSLPLI AASILSKKFA LESDYIFIDI
210 220 230 240 250
KYGQGAFCHD IETAKKISNI MKNLAKKFKR KVYFVLSDMN EVLGNTVGNA
260 270 280 290 300
IEVKEAIDFL KNNSDVGTYF KKLMFDLVTL ILLKTKKCKT KKEAKEKINY
310 320 330 340 350
VLENKIAFNN FCNWIELQNG NIAKIKNDTF FKPKYWTNIA AWKSGKISYK
360 370 380 390 400
SIIELAEIGV DLGSGRRKKE DKIDFQAGIY LHAKSNEKIK IKDKILTLYS
410
SKPIKQDLID KAKKIIKIS
Length:419
Mass (Da):47,279
Last modified:February 1, 1996 - v1
Checksum:iC1620F2EF33929E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13289 Genomic DNA. Translation: AAA25432.1.
PIRiC53312.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13289 Genomic DNA. Translation: AAA25432.1 .
PIRi C53312.

3D structure databases

ProteinModelPortali P47717.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
InterProi IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
[Graphical view ]
PANTHERi PTHR10515. PTHR10515. 1 hit.
Pfami PF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF000478. TP_PyNP. 1 hit.
SMARTi SM00941. PYNP_C. 1 hit.
[Graphical view ]
SUPFAMi SSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsi TIGR02644. Y_phosphoryl. 1 hit.
PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of Mycoplasma pirum genes involved in the salvage pathways for nucleosides."
    Tham T.N., Ferris S., Kovacic R., Montagnier L., Blanchard A.
    J. Bacteriol. 175:5281-5285(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BER.

Entry informationi

Entry nameiTYPH_MYCPI
AccessioniPrimary (citable) accession number: P47717
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 1, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3