P47717 (TYPH_MYCPI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidine phosphorylase
EC=2.4.2.4

Alternative name(s):
TdRPase

Gene names

Name:

deoA

Organism

Mycoplasma pirum

Taxonomic identifier

2122 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	419 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
Catalytic activity	Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Gene Ontology (GO)
Biological_process	pyrimidine nucleobase metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleoside metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	phosphorylase activity Inferred from electronic annotation. Source: InterPro pyrimidine-nucleoside phosphorylase activity Inferred from electronic annotation. Source: InterPro thymidine phosphorylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 419	419	Thymidine phosphorylase		PRO_0000059080

Sequences

	Sequence		Length	Mass (Da)
	P47717 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: C1620F2EF33929E3	FASTA	419	47,279
	10 20 30 40 50 60 MNIIEIIELK KNKKKLSQDQ INFCISGLVN KSIPDYQISA LLMAIWFNGL DDNELYFLTK 70 80 90 100 110 120 AMIDSGKIYK FHPEYKKILI DKHSTGGIGD KVSIALRPIL VSFDLGVAKL SGRGLGFTGG 130 140 150 160 170 180 TIDKLESINV NTDIDLKNSK KILNIANMFI VGQTNDIVPA DKLLYALRDV TGTVDSLPLI 190 200 210 220 230 240 AASILSKKFA LESDYIFIDI KYGQGAFCHD IETAKKISNI MKNLAKKFKR KVYFVLSDMN 250 260 270 280 290 300 EVLGNTVGNA IEVKEAIDFL KNNSDVGTYF KKLMFDLVTL ILLKTKKCKT KKEAKEKINY 310 320 330 340 350 360 VLENKIAFNN FCNWIELQNG NIAKIKNDTF FKPKYWTNIA AWKSGKISYK SIIELAEIGV 370 380 390 400 410 DLGSGRRKKE DKIDFQAGIY LHAKSNEKIK IKDKILTLYS SKPIKQDLID KAKKIIKIS

References

[1]	"Identification of Mycoplasma pirum genes involved in the salvage pathways for nucleosides." Tham T.N., Ferris S., Kovacic R., Montagnier L., Blanchard A. J. Bacteriol. 175:5281-5285(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BER.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L13289 Genomic DNA. Translation: AAA25432.1.
PIR	C53312.
3D structure databases
ProteinModelPortal	P47717.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.40.1030.10. 1 hit. 3.90.1170.30. 1 hit.
InterPro	IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR013102. PYNP_C. IPR018090. Pyrmidine_PPas_bac/euk. IPR000053. Pyrmidine_PPase. IPR017872. Pyrmidine_PPase_CS. [Graphical view]
PANTHER	PTHR10515. PTHR10515. 1 hit.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view]
PIRSF	PIRSF000478. TP_PyNP. 1 hit.
SMART	SM00941. PYNP_C. 1 hit. [Graphical view]
SUPFAM	SSF47648. Glyco_trans_3. 1 hit. SSF52418. Glyco_trans_3. 1 hit. SSF54680. PYNP_C. 1 hit.
TIGRFAMs	TIGR02644. Y_phosphoryl. 1 hit.
PROSITE	PS00647. THYMID_PHOSPHORYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYPH_MYCPI

Accession

Primary (citable) accession number: P47717

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	April 3, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program